메뉴 건너뛰기




Volumn 6, Issue 2, 2010, Pages 71-82

Inflammatory lipid mediators in adipocyte function and obesity

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ARACHIDONIC ACID; C REACTIVE PROTEIN; EPOXYICOSATRIENOIC ACID; G PROTEIN COUPLED RECEPTOR; LEUKOTRIENE; NONSTEROID ANTIINFLAMMATORY AGENT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PROSTACYCLIN; PROSTAGLANDIN E2; SALICYLIC ACID; THROMBOCYTE ACTIVATING FACTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

EID: 76149111947     PISSN: 17595029     EISSN: 17595037     Source Type: Journal    
DOI: 10.1038/nrendo.2009.264     Document Type: Review
Times cited : (254)

References (145)
  • 1
    • 34249883300 scopus 로고    scopus 로고
    • Obesity: The two faces of fat
    • Powell, K. Obesity: the two faces of fat. Nature 447, 525-527 (2007).
    • (2007) Nature , vol.447 , pp. 525-527
    • Powell, K.1
  • 2
    • 33845914986 scopus 로고    scopus 로고
    • Mechanisms linking obesity with cardiovascular disease
    • van Gaal, L. F., Mertens, I. L. & De Block, C. E. Mechanisms linking obesity with cardiovascular disease. Nature 444, 875-880 (2006).
    • (2006) Nature , vol.444 , pp. 875-880
    • Van Gaal, L.F.1    Mertens, I.L.2    De Block, C.E.3
  • 3
    • 17144380822 scopus 로고    scopus 로고
    • The metabolic syndrome
    • Eckel, r. H., Grundy, S. M. & Zimmet, P. Z. The metabolic syndrome. Lancet 365, 1415-1428 (2005).
    • (2005) Lancet , vol.365 , pp. 1415-1428
    • Eckel, R.H.1    Grundy, S.M.2    Zimmet, P.Z.3
  • 4
    • 25144459980 scopus 로고    scopus 로고
    • The metabolic syndrome - A new worldwide definition
    • DOI 10.1016/S0140-6736(05)67402-8, PII S0140673605674028
    • Alberti, K. G., Zimmet, P. & Shaw, J. The metabolic syndrome-a new worldwide definition. Lancet 366, 1059-1062 (2005). (Pubitemid 41338752)
    • (2005) Lancet , vol.366 , Issue.9491 , pp. 1059-1062
    • Alberti, K.G.M.M.1    Zimmet, P.2    Shaw, J.3
  • 5
    • 15444366991 scopus 로고    scopus 로고
    • Metabolic syndrome: A comprehensive perspective based on interactions between obesity diabetes and inflammation
    • Dandona, P., Aljada, A., Chaudhuri, A., Mohanty, P. & Garg, r. Metabolic syndrome: a comprehensive perspective based on interactions between obesity, diabetes, and inflammation. Circulation 111, 1448-1454 (2005).
    • (2005) Circulation , vol.111 , pp. 1448-1454
    • Dandona, P.1    Aljada, A.2    Chaudhuri, A.3    Mohanty, P.4    Garg, R.5
  • 6
    • 0034455878 scopus 로고    scopus 로고
    • Glucose challenge stimulates reactive oxygen species (rOS) generation by leucocytes
    • Mohanty, P. et al. Glucose challenge stimulates reactive oxygen species (rOS) generation by leucocytes. J. Clin. Endocrinol. Metab. 85, 2970-2973 (2000).
    • (2000) J. Clin. Endocrinol. Metab. , vol.85 , pp. 2970-2973
    • Mohanty, P.1
  • 7
    • 3042702611 scopus 로고    scopus 로고
    • Glucose intake induces an increase in activator protein 1 and early growth response 1 binding activities, in the expression of tissue factor and matrix metalloproteinase in mononuclear cells, and in plasma tissue factor and matrix metalloproteinase concentrations
    • Aljada, A. et al. Glucose intake induces an increase in activator protein 1 and early growth response 1 binding activities, in the expression of tissue factor and matrix metalloproteinase in mononuclear cells, and in plasma tissue factor and matrix metalloproteinase concentrations. Am. J. Clin. Nutr. 80, 51-57 (2004).
    • (2004) Am. J. Clin. Nutr. , vol.80 , pp. 51-57
    • Aljada, A.1
  • 8
    • 0035666553 scopus 로고    scopus 로고
    • Is obesity an inflammatory condition?
    • Das, U. N. Is obesity an inflammatory condition? Nutrition 17, 953-966 (2001).
    • (2001) Nutrition , vol.17 , pp. 953-966
    • Das, U.N.1
  • 9
    • 0242696221 scopus 로고    scopus 로고
    • Lipid overload and overflow: Metabolic trauma and the metabolic syndrome
    • Unger, r. H. Lipid overload and overflow: metabolic trauma and the metabolic syndrome. Trends Endocrinol. Metab. 14, 398-403 (2003).
    • (2003) Trends Endocrinol. Metab. , vol.14 , pp. 398-403
    • Unger, R.H.1
  • 10
    • 1442275317 scopus 로고    scopus 로고
    • Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes
    • Pickup, J. C. Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. Diabetes Care 27, 813-823 (2004).
    • (2004) Diabetes Care , vol.27 , pp. 813-823
    • Pickup, J.C.1
  • 11
    • 0038691972 scopus 로고    scopus 로고
    • Low-grade systemic inflammation and the development of type 2 diabetes: The atherosclerosis risk in communities study
    • Duncan, B. B. et al. Low-grade systemic inflammation and the development of type 2 diabetes: the atherosclerosis risk in communities study. Diabetes 52, 1799 - 1805 (2003).
    • (2003) Diabetes , vol.52 , pp. 1799-1805
    • Duncan, B.B.1
  • 12
    • 34347354309 scopus 로고    scopus 로고
    • Macrophage-specific PPAr? controls alternative activation and improves insulin resistance
    • Odegaard, J. I. et al. Macrophage-specific PPAr? controls alternative activation and improves insulin resistance. Nature 447, 1116-1120 (2007).
    • (2007) Nature , vol.447 , pp. 1116-1120
    • Odegaard, J.I.1
  • 13
    • 67149137856 scopus 로고    scopus 로고
    • Expansion and contraction: The mighty, mighty fatty acid
    • Plutzky, J. Expansion and contraction: the mighty, mighty fatty acid. Nat. Med. 15, 618-619 (2009).
    • (2009) Nat. Med. , vol.15 , pp. 618-619
    • Plutzky, J.1
  • 14
    • 18244370762 scopus 로고    scopus 로고
    • Inflammation, stress, and diabetes
    • wellen, K. E. & Hotamisligil, G. S. Inflammation, stress, and diabetes. J. Clin. Invest. 115, 1111-1119 (2005).
    • (2005) J. Clin. Invest. , vol.115 , pp. 1111-1119
    • Wellen, K.E.1    Hotamisligil, G.S.2
  • 15
    • 33745896155 scopus 로고    scopus 로고
    • Recent advances in the relationship between obesity, inflammation, and insulin resistance
    • Bastard, J. P. et al. recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur. Cytokine Netw. 17, 4-12 (2006).
    • (2006) Eur. Cytokine Netw. , vol.17 , pp. 4-12
    • Bastard, J.P.1
  • 16
    • 1542545604 scopus 로고    scopus 로고
    • Endothelial dysfunction in obesity and insulin resistance: A road to diabetes and heart disease
    • Caballero, A. E. Endothelial dysfunction in obesity and insulin resistance: a road to diabetes and heart disease. Obes. Res. 11, 1278-1289 (2003).
    • (2003) Obes. Res. , vol.11 , pp. 1278-1289
    • Caballero, A.E.1
  • 17
    • 0033537013 scopus 로고    scopus 로고
    • Elevated C-reactive protein levels in overweight and obese adults
    • visser, M., Bouter, L. M., McQuillan, G. M., wener, M. H. & Harris, T. B. Elevated C-reactive protein levels in overweight and obese adults. JAMA 282, 2131-2135 (1999).
    • (1999) JAMA , vol.282 , pp. 2131-2135
    • Visser, M.1    Bouter, L.M.2    McQuillan, G.M.3    Wener, M.H.4    Harris, T.B.5
  • 18
    • 0037840403 scopus 로고    scopus 로고
    • Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: A randomized trial
    • Esposito, K. et al. Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial. JAMA 289, 1799 - 1804 (2003).
    • (2003) JAMA , vol.289 , pp. 1799-1804
    • Esposito, K.1
  • 19
    • 0037469255 scopus 로고    scopus 로고
    • C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: An 8-year follow-up of 14,719 initially healthy American women
    • ridker, P. M., Buring, J. E., Cook, N. r. & rifai, N. C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14,719 initially healthy American women. Circulation 107, 391-397 (2003).
    • (2003) Circulation , vol.107 , pp. 391-397
    • Ridker, P.M.1    Buring, J.E.2    Cook, N.R.3    Rifai, N.4
  • 20
    • 85047681547 scopus 로고    scopus 로고
    • Inhibitory effect of a two day fast on reactive oxygen species (rOS) generation by leucocytes and plasma orthotyrosine and meta-tyrosine concentrations
    • Dandona, P. et al. Inhibitory effect of a two day fast on reactive oxygen species (rOS) generation by leucocytes and plasma orthotyrosine and meta-tyrosine concentrations. J. Clin. Endocrinol. Metab. 86, 2899-2902 (2001).
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , pp. 2899-2902
    • Dandona, P.1
  • 21
    • 67650095384 scopus 로고    scopus 로고
    • Superoxide production by NAD(P)H oxidase and mitochondria is increased in genetically obese and hyperglycemic rat heart and aorta before the development of cardiac dysfunction. The role of glucose-6-phosphate dehydrogenase-derived NADPH
    • Serpillon, S. et al. Superoxide production by NAD(P)H oxidase and mitochondria is increased in genetically obese and hyperglycemic rat heart and aorta before the development of cardiac dysfunction. The role of glucose-6-phosphate dehydrogenase-derived NADPH. Am. J. Physiol. Heart Circ. Physiol. 297, H153-H162 (2009).
    • (2009) Am. J. Physiol. Heart Circ. Physiol. , vol.297
    • Serpillon, S.1
  • 22
    • 70350565467 scopus 로고    scopus 로고
    • Neutrophil activation in morbid obesity, chronic activation of acute inflammation
    • Nijhuis, J. et al. Neutrophil activation in morbid obesity, chronic activation of acute inflammation. Obesity 17, 2014-2018 (2009).
    • (2009) Obesity , vol.17 , pp. 2014-2018
    • Nijhuis, J.1
  • 23
    • 58549095307 scopus 로고    scopus 로고
    • Insulin as an anti-inflammatory and antiatherogenic modulator
    • Dandona. P., Chaudhuri, A., Ghanim, H. & Mohanty, P. Insulin as an anti-inflammatory and antiatherogenic modulator. J. Am. Coll. Cardiol. 53 (Suppl. 1), S14-S20 (2009).
    • (2009) J. Am. Coll. Cardiol. , vol.53 , Issue.SUPPL. 1
    • Dandona., P.1    Chaudhuri, A.2    Ghanim, H.3    Mohanty, P.4
  • 24
    • 1842453995 scopus 로고    scopus 로고
    • Differential effects of glucose and alcohol on reactive oxygen species generation and intranuclear nuclear factorkappaB in mononuclear cells
    • Dhindsa, S. et al. Differential effects of glucose and alcohol on reactive oxygen species generation and intranuclear nuclear factorkappaB in mononuclear cells. Metabolism 53, 330-334 (2004).
    • (2004) Metabolism , vol.53 , pp. 330-334
    • Dhindsa, S.1
  • 25
    • 0035979775 scopus 로고    scopus 로고
    • Reversal of obesity- and dietinduced insulin resistance with salicylates or targeted disruption of Ikk?
    • Yuan, M. et al. reversal of obesity- and dietinduced insulin resistance with salicylates or targeted disruption of Ikk?. Science 293, 1673-1677 (2001).
    • (2001) Science , vol.293 , pp. 1673-1677
    • Yuan, M.1
  • 27
    • 0034127660 scopus 로고    scopus 로고
    • Altered cardiac collagen and associated changes in diastolic function of infarcted rat hearts
    • van Kerckhoven, r., Kalkman, E. A., Saxena, P. r. & Schoemaker, r. G. Altered cardiac collagen and associated changes in diastolic function of infarcted rat hearts. Cardiovasc. Res. 46, 316-323 (2000).
    • (2000) Cardiovasc. Res. , vol.46 , pp. 316-323
    • Van Kerckhoven, R.1    Kalkman, E.A.2    Saxena, P.R.3    Schoemaker, R.G.4
  • 28
    • 34247170807 scopus 로고    scopus 로고
    • Interleukin-1-receptor antagonist in type 2 diabetes mellitus
    • Larsen, C. M. et al. Interleukin-1-receptor antagonist in type 2 diabetes mellitus. N. Engl. J. Med. 356, 1517-1526 (2007).
    • (2007) N. Engl. J. Med. , vol.356 , pp. 1517-1526
    • Larsen, C.M.1
  • 29
    • 69549105888 scopus 로고    scopus 로고
    • Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes
    • Larsen, C. M. et al. Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes. Diabetes Care 32, 1663-1668 (2009).
    • (2009) Diabetes Care , vol.32 , pp. 1663-1668
    • Larsen, C.M.1
  • 30
    • 52949098281 scopus 로고    scopus 로고
    • Evidence of systemic inflammation and estimation of coronary artery disease risk: A population perspective
    • wilson, P. w. Evidence of systemic inflammation and estimation of coronary artery disease risk: a population perspective. Am. J. Med. 121 (Suppl. 1), S15-S20 (2008).
    • (2008) Am. J. Med. , vol.121 , Issue.SUPPL. 1
    • Wilson, P.W.1
  • 31
    • 52949144507 scopus 로고    scopus 로고
    • Role of inflammation in atherosclerosis associated with rheumatoid arthritis
    • Libby, P. role of inflammation in atherosclerosis associated with rheumatoid arthritis. Am. J. Med. 121 (Suppl. 1), S21-S31 (2008).
    • (2008) Am. J. Med. , vol.121 , Issue.SUPPL. 1
    • Libby, P.1
  • 32
    • 0141564521 scopus 로고    scopus 로고
    • Angiotensin II receptor blocker valsartan suppresses reactive oxygen species generation in leukocytes, nuclear factor-kappa B, in mononuclear cells of normal subjects: Evidence of an antiinflammatory action
    • Dandona, P. et al. Angiotensin II receptor blocker valsartan suppresses reactive oxygen species generation in leukocytes, nuclear factor-kappa B, in mononuclear cells of normal subjects: evidence of an antiinflammatory action. J. Clin. Endocrinol. Metab. 88, 4496-4501 (2003).
    • (2003) J. Clin. Endocrinol. Metab. , vol.88 , pp. 4496-4501
    • Dandona, P.1
  • 33
    • 28244466397 scopus 로고    scopus 로고
    • Inflammatory markers and the metabolic syndrome: Insights from therapeutic interventions
    • Koh, K. K., Han, S. H. & Quon, M. J. Inflammatory markers and the metabolic syndrome: insights from therapeutic interventions. J. Am. Coll. Cardiol. 46, 1978-1985 (2005).
    • (2005) J. Am. Coll. Cardiol. , vol.46 , pp. 1978-1985
    • Koh, K.K.1    Han, S.H.2    Quon, M.J.3
  • 34
    • 55449119983 scopus 로고    scopus 로고
    • Pleiotropic effects of statins: Implications for a wide range of diseases
    • Paraskevas, K. I., Stathopoulos, v. & Mikhailidis, D. P. Pleiotropic effects of statins: implications for a wide range of diseases. Curr. Vasc. Pharmacol. 6, 237-239 (2008).
    • (2008) Curr. Vasc. Pharmacol. , vol.6 , pp. 237-239
    • Paraskevas, K.I.1    Stathopoulos, V.2    Mikhailidis, D.P.3
  • 35
    • 64749093381 scopus 로고    scopus 로고
    • Pleiotropic effects of drugs inhibiting the renin-angiotensin-aldosterone system
    • Jankowski, P., Safar, M. E. & Benetos, A. Pleiotropic effects of drugs inhibiting the renin-angiotensin-aldosterone system. Curr. Pharm. Des. 15, 571-584 (2009).
    • (2009) Curr. Pharm. Des. , vol.15 , pp. 571-584
    • Jankowski, P.1    Safar, M.E.2    Benetos, A.3
  • 36
    • 0034919027 scopus 로고    scopus 로고
    • Troglitazone reduces the expression of PPAr? while stimulating that of PPAr? in mononuclear cells in obese subjects
    • Aljada, A. et al. Troglitazone reduces the expression of PPAr? while stimulating that of PPAr? in mononuclear cells in obese subjects. J. Clin. Endocrinol. Metab. 86, 3130-3133 (2001).
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , pp. 3130-3133
    • Aljada, A.1
  • 37
    • 2942655390 scopus 로고    scopus 로고
    • Evidence for a potent antiinflammatory effect of rosiglitazone
    • Mohanty, P. et al. Evidence for a potent antiinflammatory effect of rosiglitazone. J. Clin. Endocrinol. Metab. 89, 2728-2735 (2004).
    • (2004) J. Clin. Endocrinol. Metab. , vol.89 , pp. 2728-2735
    • Mohanty, P.1
  • 38
    • 65949095803 scopus 로고    scopus 로고
    • Autophagy regulates lipid metabolism
    • Singh, r. et al. Autophagy regulates lipid metabolism. Nature 458, 1131-1135 (2009).
    • (2009) Nature , vol.458 , pp. 1131-1135
    • Singh, R.1
  • 39
    • 59649089306 scopus 로고    scopus 로고
    • AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency
    • Jaworski, K. et al. AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency. Nat. Med. 15, 159-168 (2009).
    • (2009) Nat. Med. , vol.15 , pp. 159-168
    • Jaworski, K.1
  • 41
    • 56449105671 scopus 로고    scopus 로고
    • Before they were fat: Adipocyte progenitors
    • Park, K. w., Halperin, D. S. & Tontonoz, P. Before they were fat: adipocyte progenitors. Cell. Metab. 8, 454-457 (2008).
    • (2008) Cell. Metab. , vol.8 , pp. 454-457
    • Park, K.W.1    Halperin, D.S.2    Tontonoz, P.3
  • 43
    • 49649107853 scopus 로고    scopus 로고
    • An emerging risk factor for obesity: Does disequilibrium of polyunsaturated fatty acid metabolism contribute to excessive adipose tissue development?
    • Ailhaud, G., Guesnet, P. & Cunnane, S. C. An emerging risk factor for obesity: does disequilibrium of polyunsaturated fatty acid metabolism contribute to excessive adipose tissue development? Br. J. Nutr. 100, 461-470 (2008).
    • (2008) Br. J. Nutr. , vol.100 , pp. 461-470
    • Ailhaud, G.1    Guesnet, P.2    Cunnane, S.C.3
  • 44
    • 0348230958 scopus 로고    scopus 로고
    • Obesity is associated with macrophage accumulation in adipose tissue
    • weisberg, S. P. et al. Obesity is associated with macrophage accumulation in adipose tissue. J. Clin. Invest. 112, 1796 - 1808 (2003).
    • (2003) J. Clin. Invest. , vol.112 , pp. 1796-1808
    • Weisberg, S.P.1
  • 45
    • 20444501459 scopus 로고    scopus 로고
    • The adipose organ. Prostaglandins Leukot
    • Cinti, S. The adipose organ. Prostaglandins Leukot. Essent. Fatty Acids 73, 9-15 (2005).
    • (2005) Essent. Fatty Acids , vol.73 , pp. 9-15
    • Cinti, S.1
  • 46
    • 68349137821 scopus 로고    scopus 로고
    • Normalization of obesityassociated insulin resistance through immunotherapy
    • winer, S. et al. Normalization of obesityassociated insulin resistance through immunotherapy. Nat. Med. 15, 921-929 (2009).
    • (2009) Nat. Med. , vol.15 , pp. 921-929
    • Winer, S.1
  • 47
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • Hotamisligil, G. S. Inflammation and metabolic disorders. Nature 444, 860-867 (2006).
    • (2006) Nature , vol.444 , pp. 860-867
    • Hotamisligil, G.S.1
  • 49
    • 68349148211 scopus 로고    scopus 로고
    • Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
    • Feuerer, M. et al. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat. Med. 15, 930-939 (2009).
    • (2009) Nat. Med. , vol.15 , pp. 930-939
    • Feuerer, M.1
  • 50
    • 68349150756 scopus 로고    scopus 로고
    • CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
    • Nishimura, S. et al. CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat. Med. 15, 914-920 (2009).
    • (2009) Nat. Med. , vol.15 , pp. 914-920
    • Nishimura, S.1
  • 51
    • 0037180812 scopus 로고    scopus 로고
    • Points of control in inflammation
    • Nathan, C. Points of control in inflammation. Nature 420, 846-852 (2002).
    • (2002) Nature , vol.420 , pp. 846-852
    • Nathan, C.1
  • 52
    • 47949099098 scopus 로고    scopus 로고
    • Origin and physiological roles of inflammation
    • Medzhitov, r. Origin and physiological roles of inflammation. Nature 454, 428-435 (2008).
    • (2008) Nature , vol.454 , pp. 428-435
    • Medzhitov, R.1
  • 53
    • 0038660699 scopus 로고    scopus 로고
    • Preadipocyte conversion to macrophage. Evidence of plasticity
    • Charriere, G. et al. Preadipocyte conversion to macrophage. Evidence of plasticity. J. Biol. Chem. 278, 9850-9855 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 9850-9855
    • Charriere, G.1
  • 54
    • 7744226149 scopus 로고    scopus 로고
    • Weight loss regulates inflammation-related genes in white adipose tissue of obese subjects
    • Clement, K. et al. weight loss regulates inflammation-related genes in white adipose tissue of obese subjects. FASEB J. 18, 1657-1669 (2004).
    • (2004) FASEB J. , vol.18 , pp. 1657-1669
    • Clement, K.1
  • 55
    • 4043151653 scopus 로고    scopus 로고
    • Macrophage inhibitory factor, plasminogen activator inhibitor-1, other acute phase proteins, and inflammatory mediators normalize as a result of weight loss in morbidly obese subjects treated with gastric restrictive surgery
    • van Dielen, F. M., Buurman, w. A., Hadfoune, M., Nijhuis, J. & Greve, J. w. Macrophage inhibitory factor, plasminogen activator inhibitor-1, other acute phase proteins, and inflammatory mediators normalize as a result of weight loss in morbidly obese subjects treated with gastric restrictive surgery. J. Clin. Endocrinol. Metab. 89, 4062-4068 (2004).
    • (2004) J. Clin. Endocrinol. Metab. , vol.89 , pp. 4062-4068
    • Van Dielen, F.M.1    Buurman, W.A.2    Hadfoune, M.3    Nijhuis, J.4    Greve, J.W.5
  • 56
    • 2642539496 scopus 로고    scopus 로고
    • The chronic inflammatory hypothesis for the morbidity associated with morbid obesity: Implications and effects of weight loss
    • Cottam, D. r. et al. The chronic inflammatory hypothesis for the morbidity associated with morbid obesity: implications and effects of weight loss. Obes. Surg. 14, 589-600 (2004).
    • (2004) Obes. Surg. , vol.14 , pp. 589-600
    • Cottam, D.R.1
  • 57
    • 26244435944 scopus 로고    scopus 로고
    • Keynote review: The adipocyte as a drug discovery target
    • Nawrocki, A. r. & Scherer, P. E. Keynote review: the adipocyte as a drug discovery target. Drug Discov. Today 10, 1219-1230 (2005).
    • (2005) Drug Discov. Today , vol.10 , pp. 1219-1230
    • Nawrocki, A.R.1    Scherer, P.E.2
  • 58
    • 0031898610 scopus 로고    scopus 로고
    • PPAr-gamma: Adipogenic regulator and thiazolidinedione receptor
    • Spiegelman, B. M. PPAr-gamma: adipogenic regulator and thiazolidinedione receptor. Diabetes 47, 507-514 (1998).
    • (1998) Diabetes , vol.47 , pp. 507-514
    • Spiegelman, B.M.1
  • 59
    • 0025951065 scopus 로고
    • Regulation of adipose cell differentiation. I. Fatty acids are inducers of the AP2 gene expression
    • Amri, E. Z., Bertrand, B., Ailhaud, G. & Grimaldi, P. regulation of adipose cell differentiation. I. Fatty acids are inducers of the AP2 gene expression. J. Lipid Res. 32, 1449-1456 (1991).
    • (1991) J. Lipid Res. , vol.32 , pp. 1449-1456
    • Amri, E.Z.1    Bertrand, B.2    Ailhaud, G.3    Grimaldi, P.4
  • 60
    • 0030580282 scopus 로고    scopus 로고
    • Evidence for a novel regulatory pathway activated by (carba) prostacyclin in preadipose and adipose cells
    • Aubert, J., Ailhaud, G. & Negrel, r. Evidence for a novel regulatory pathway activated by (carba) prostacyclin in preadipose and adipose cells. FEBS Lett. 397, 117-121 (1996).
    • (1996) FEBS Lett. , vol.397 , pp. 117-121
    • Aubert, J.1    Ailhaud, G.2    Negrel, R.3
  • 61
    • 0026635508 scopus 로고
    • Cellular and molecular aspects of adipose tissue development
    • Ailhaud, G., Grimaldi, P. & Negrel, r. Cellular and molecular aspects of adipose tissue development. Annu. Rev. Nutr. 12, 207-233 (1992).
    • (1992) Annu. Rev. Nutr. , vol.12 , pp. 207-233
    • Ailhaud, G.1    Grimaldi, P.2    Negrel, R.3
  • 62
    • 0026690460 scopus 로고
    • Some new aspects on adipose tissue development
    • Ailhaud, G. Some new aspects on adipose tissue development. Diabetes Metab. Rev. 8, 3-7 (1992).
    • (1992) Diabetes Metab. Rev. , vol.8 , pp. 3-7
    • Ailhaud, G.1
  • 63
    • 0030297919 scopus 로고    scopus 로고
    • Adipogenesis and obesity: Rounding out the big picture
    • Spiegelman, B. M. & Flier, J. S. Adipogenesis and obesity: rounding out the big picture. Cell 87, 377-389 (1996).
    • (1996) Cell , vol.87 , pp. 377-389
    • Spiegelman, B.M.1    Flier, J.S.2
  • 64
    • 0024440502 scopus 로고
    • Promoting effect of glucocorticoids on the differentiation of human adipocyte precursor cells cultured in a chemically defined medium
    • Hauner, H. et al. Promoting effect of glucocorticoids on the differentiation of human adipocyte precursor cells cultured in a chemically defined medium. J. Clin. Invest. 84, 1663-1670 (1989).
    • (1989) J. Clin. Invest. , vol.84 , pp. 1663-1670
    • Hauner, H.1
  • 65
    • 65249119361 scopus 로고    scopus 로고
    • Lipid mediators in health and disease: Enzymes and receptors as therapeutic targets for the regulation of immunity and inflammation
    • Shimizu, T. Lipid mediators in health and disease: enzymes and receptors as therapeutic targets for the regulation of immunity and inflammation. Annu. Rev. Pharmacol. Toxicol. 49, 123-150 (2009).
    • (2009) Annu. Rev. Pharmacol. Toxicol. , vol.49 , pp. 123-150
    • Shimizu, T.1
  • 66
    • 72249106180 scopus 로고    scopus 로고
    • Increase in plasma endotoxin concentrations and the expression of Toll like receptors and suppressor of cytokine signaling-3 in mononuclear cells following a high fat high carbohydrate meal: Implications for insulin resistance
    • Ghanim, H. et al. Increase in plasma endotoxin concentrations and the expression of Toll like receptors and suppressor of cytokine signaling-3 in mononuclear cells following a high fat high carbohydrate meal: implications for insulin resistance. Diabetes Care 32, 2281-2287 (2009).
    • (2009) Diabetes Care , vol.32 , pp. 2281-2287
    • Ghanim, H.1
  • 67
    • 33846438949 scopus 로고    scopus 로고
    • Anti-inflammatory effects of insulin and pro-inflammatory effects of glucose: Relevance to the management of acute myocardial infarction and other acute coronary syndromes
    • Dandona, P., Chaudhuri, A., Ghanim, H. & Mohanty, P. Anti-inflammatory effects of insulin and pro-inflammatory effects of glucose: relevance to the management of acute myocardial infarction and other acute coronary syndromes. Rev. Cardiovasc. Med. 7 (Suppl. 2), S25-S34 (2006).
    • (2006) Rev. Cardiovasc. Med. , vol.7 , Issue.SUPPL. 2
    • Dandona, P.1    Chaudhuri, A.2    Ghanim, H.3    Mohanty, P.4
  • 68
    • 2142761098 scopus 로고    scopus 로고
    • The link between insulin resistance syndrome and inflammatory markers
    • Dandona, P. The link between insulin resistance syndrome and inflammatory markers. Endocr. Pract. 9 (Suppl. 2), 53-57 (2003).
    • (2003) Endocr. Pract. , vol.9 , Issue.SUPPL. 2 , pp. 53-57
    • Dandona, P.1
  • 69
    • 0038645822 scopus 로고    scopus 로고
    • The potential influence of inflammation and insulin resistance on the pathogenesis and treatment of atherosclerosisrelated complications in type 2 diabetes
    • Dandona, P., Aljada, A., Chaudhuri, A. & Bandyopadhyay, A. The potential influence of inflammation and insulin resistance on the pathogenesis and treatment of atherosclerosisrelated complications in type 2 diabetes. J. Clin. Endocrinol. Metab. 88, 2422-2429 (2003).
    • (2003) J. Clin. Endocrinol. Metab. , vol.88 , pp. 2422-2429
    • Dandona, P.1    Aljada, A.2    Chaudhuri, A.3    Bandyopadhyay, A.4
  • 70
    • 34447649721 scopus 로고    scopus 로고
    • Adipose tissue arachidonic acid and the metabolic syndrome in Costa rican adults
    • williams, E. S., Baylin, A. & Campos, H. Adipose tissue arachidonic acid and the metabolic syndrome in Costa rican adults. Clin. Nutr. 26, 474-482 (2007).
    • (2007) Clin. Nutr. , vol.26 , pp. 474-482
    • Williams, E.S.1    Baylin, A.2    Campos, H.3
  • 71
    • 0034751831 scopus 로고    scopus 로고
    • Site-specific differences in the fatty acid composition of abdominal adipose tissue in an obese population from a Mediterranean area: Relation with dietary fatty acids, plasma lipid profile, serum insulin, and central obesity
    • Garaulet, M. et al. Site-specific differences in the fatty acid composition of abdominal adipose tissue in an obese population from a Mediterranean area: relation with dietary fatty acids, plasma lipid profile, serum insulin, and central obesity. Am. J. Clin. Nutr. 74, 585-591 (2001).
    • (2001) Am. J. Clin. Nutr. , vol.74 , pp. 585-591
    • Garaulet, M.1
  • 72
    • 0029866888 scopus 로고    scopus 로고
    • Long-chain polyunsaturated fatty acids in plasma lipids of obese children
    • Decsi, T., Molnar, D. & Koletzko, B. Long-chain polyunsaturated fatty acids in plasma lipids of obese children. Lipids 31, 305-311 (1996).
    • (1996) Lipids , vol.31 , pp. 305-311
    • Decsi, T.1    Molnar, D.2    Koletzko, B.3
  • 73
    • 2342526656 scopus 로고    scopus 로고
    • Association of adipose tissue arachidonic acid content with BMI and overweight status in children from Cyprus and Crete
    • Savva, S. C. et al. Association of adipose tissue arachidonic acid content with BMI and overweight status in children from Cyprus and Crete. Br. J. Nutr. 91, 643-649 (2004).
    • (2004) Br. J. Nutr. , vol.91 , pp. 643-649
    • Savva, S.C.1
  • 74
    • 0034019490 scopus 로고    scopus 로고
    • Dietary supplementation of arachidonic acid is associated with higher whole body weight and bone mineral density in growing pigs
    • weiler, H. A. Dietary supplementation of arachidonic acid is associated with higher whole body weight and bone mineral density in growing pigs. Pediatr. Res. 47, 692-697 (2000).
    • (2000) Pediatr. Res. , vol.47 , pp. 692-697
    • Weiler, H.A.1
  • 75
    • 0030706191 scopus 로고    scopus 로고
    • Effect of dietary linoleic/ alpha-linolenic acid ratio on growth and visual function of term infants
    • Jensen, C. L. et al. Effect of dietary linoleic/ alpha-linolenic acid ratio on growth and visual function of term infants. J. Pediatr. 131, 200-209 (1997).
    • (1997) J. Pediatr. , vol.131 , pp. 200-209
    • Jensen, C.L.1
  • 76
    • 54449092296 scopus 로고    scopus 로고
    • Identification and functional characterization of adipose-specific phospholipase A2 (AdPLA)
    • Duncan, r. E., Sarkadi-Nagy, E., Jaworski, K., Ahmadian, M. & Sul, H. S. Identification and functional characterization of adipose-specific phospholipase A2 (AdPLA). J. Biol. Chem. 283, 25428-25436 (2008).
    • (2008) J. Biol. Chem. , vol.283 , pp. 25428-25436
    • Duncan, R.E.1    Sarkadi-Nagy, E.2    Jaworski, K.3    Ahmadian, M.4    Sul, H.S.5
  • 77
    • 43049157535 scopus 로고    scopus 로고
    • Group IvA phospholipase A2 is associated with the storage of lipids in adipose tissue and liver
    • Ii, H., Hatakeyama, S., Tsutsumi, K., Sato, T. & Akiba, S. Group IvA phospholipase A2 is associated with the storage of lipids in adipose tissue and liver. Prostaglandins Other Lipid Mediat. 86, 12-17 (2008).
    • (2008) Prostaglandins Other Lipid Mediat. , vol.86 , pp. 12-17
    • Ii, H.1    Hatakeyama, S.2    Tsutsumi, K.3    Sato, T.4    Akiba, S.5
  • 78
    • 1942469349 scopus 로고    scopus 로고
    • Role of group v phospholipase A2 in zymosan-induced eicosanoid generation and vascular permeability revealed by targeted gene disruption
    • Satake, Y. et al. role of group v phospholipase A2 in zymosan-induced eicosanoid generation and vascular permeability revealed by targeted gene disruption. J. Biol. Chem. 279, 16488-16494 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 16488-16494
    • Satake, Y.1
  • 79
    • 0037201940 scopus 로고    scopus 로고
    • Phospholipase A2 regulation of arachidonic acid mobilization
    • Balsinde, J., winstead, M. v. & Dennis, E. A. Phospholipase A2 regulation of arachidonic acid mobilization. FEBS Lett. 531, 2-6 (2002).
    • (2002) FEBS Lett. , vol.531 , pp. 2-6
    • Balsinde, J.1    Winstead, M.V.2    Dennis, E.A.3
  • 80
    • 33646866410 scopus 로고    scopus 로고
    • Antifibrotic activity of an inhibitor of group IIA secretory phospholipase A2 in young spontaneously hypertensive rats
    • Levick, S. et al. Antifibrotic activity of an inhibitor of group IIA secretory phospholipase A2 in young spontaneously hypertensive rats. J. Immunol. 176, 7000-7007 (2006).
    • (2006) J. Immunol. , vol.176 , pp. 7000-7007
    • Levick, S.1
  • 81
    • 0037085469 scopus 로고    scopus 로고
    • Groups Iv, v, and X phospholipases A2s in human neutrophils: Role in eicosanoid production and gram-negative bacterial phospholipid hydrolysis
    • Degousee, N. et al. Groups, Iv, v, and X phospholipases A2s in human neutrophils: role in eicosanoid production and gram-negative bacterial phospholipid hydrolysis. J. Biol. Chem. 277, 5061-5073 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 5061-5073
    • Degousee, N.1
  • 82
    • 52949153587 scopus 로고    scopus 로고
    • Arachidonic-acid-derived eicosanoids: Roles in biology and immunopathology
    • Harizi, H., Corcuff, J. B. & Gualde, N. Arachidonic-acid-derived eicosanoids: roles in biology and immunopathology. Trends Mol. Med. 14, 461-469 (2008).
    • (2008) Trends Mol. Med. , vol.14 , pp. 461-469
    • Harizi, H.1    Corcuff, J.B.2    Gualde, N.3
  • 83
    • 0034931501 scopus 로고    scopus 로고
    • Genetic and pharmacological analysis of prostanoid receptor function
    • Narumiya, S. & FitzGerald, G. A. Genetic and pharmacological analysis of prostanoid receptor function. J. Clin. Invest. 108, 25-30 (2001).
    • (2001) J. Clin. Invest. , vol.108 , pp. 25-30
    • Narumiya, S.1    Fitzgerald, G.A.2
  • 84
    • 0034700110 scopus 로고    scopus 로고
    • Prostacyclin-mediated activation of peroxisome proliferator-activated receptor delta in colorectal cancer
    • Gupta, r. A. et al. Prostacyclin-mediated activation of peroxisome proliferator-activated receptor delta in colorectal cancer. Proc. Natl Acad. Sci. USA 97, 13275-13280 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 13275-13280
    • Gupta, R.A.1
  • 85
    • 0028972025 scopus 로고
    • 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAr gamma
    • Forman, B. M. et al. 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAr gamma. Cell 83, 803-812 (1995).
    • (1995) Cell , vol.83 , pp. 803-812
    • Forman, B.M.1
  • 86
    • 0032571276 scopus 로고    scopus 로고
    • Prostanoid receptor heterogeneity through alternative mrNA splicing
    • Pierce, K. L. & regan, J. w. Prostanoid receptor heterogeneity through alternative mrNA splicing. Life Sci. 62, 1479-1483 (1998).
    • (1998) Life Sci. , vol.62 , pp. 1479-1483
    • Pierce, K.L.1    Regan, J.W.2
  • 87
    • 34249729416 scopus 로고    scopus 로고
    • Prostaglandin e receptors
    • Sugimoto, Y. & Narumiya, S. Prostaglandin E receptors. J. Biol. Chem. 282, 11613-11617 (2007).
    • (2007) J. Biol. Chem. , vol.282 , pp. 11613-11617
    • Sugimoto, Y.1    Narumiya, S.2
  • 90
    • 0034537601 scopus 로고    scopus 로고
    • Secretory endocrine and autocrine/paracrine function of the adipocyte
    • Kim, S. & Moustaid-Moussa, N. Secretory, endocrine and autocrine/paracrine function of the adipocyte. J. Nutr. 130 (Suppl.), S3110-S3115 (2000).
    • (2000) J. Nutr. , vol.130 , Issue.SUPPL.
    • Kim, S.1    Moustaid-Moussa, N.2
  • 91
    • 0031942658 scopus 로고    scopus 로고
    • Arachidonic acid metabolites of the lipoxygenase as well as the cyclooxygenase pathway may be involved in regulating preadipocyte differentiation
    • Shillabeer, G., Kumar, v., Tibbo, E. & Lau, D. C. Arachidonic acid metabolites of the lipoxygenase as well as the cyclooxygenase pathway may be involved in regulating preadipocyte differentiation. Metabolism 47, 461-466 (1998).
    • (1998) Metabolism , vol.47 , pp. 461-466
    • Shillabeer, G.1    Kumar, V.2    Tibbo, E.3    Lau, D.C.4
  • 92
    • 0033775075 scopus 로고    scopus 로고
    • Eicosanoids as endogenous regulators of leptin release and lipolysis by mouse adipose tissue in primary culture
    • Fain, J. N., Leffler, C. w. & Bahouth, S. w. Eicosanoids as endogenous regulators of leptin release and lipolysis by mouse adipose tissue in primary culture. J. Lipid Res. 41, 1689-1694 (2000).
    • (2000) J. Lipid Res. , vol.41 , pp. 1689-1694
    • Fain, J.N.1    Leffler, C.W.2    Bahouth, S.W.3
  • 93
    • 0034637080 scopus 로고    scopus 로고
    • Regulation of leptin release by mammalian adipose tissue
    • Fain, J. N. & Bahouth, S. w. regulation of leptin release by mammalian adipose tissue. Biochem. Biophys. Res. Commun. 274, 571-575 (2000).
    • (2000) Biochem. Biophys. Res. Commun. , vol.274 , pp. 571-575
    • Fain, J.N.1    Bahouth, S.W.2
  • 94
    • 0033866432 scopus 로고    scopus 로고
    • Kupffer cell-derived prostaglandin E2 is involved in alcohol-induced fat accumulation in rat liver
    • Enomoto, N. et al. Kupffer cell-derived prostaglandin E2 is involved in alcohol-induced fat accumulation in rat liver. Am. J. Physiol. Gastrointest. Liver Physiol. 279, G100-G106 (2000).
    • (2000) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.279
    • Enomoto, N.1
  • 95
    • 33645995144 scopus 로고    scopus 로고
    • The 2-series prostaglandins suppress vLDL secretion in an inflammatory conditiondependent manner in primary rat hepatocytes
    • Perez, S., Aspichueta, P., Ochoa, B. & Chico, Y. The 2-series prostaglandins suppress vLDL secretion in an inflammatory conditiondependent manner in primary rat hepatocytes. Biochim. Biophys. Acta 1761, 160-171 (2006).
    • (2006) Biochim. Biophys. Acta , vol.1761 , pp. 160-171
    • Perez, S.1    Aspichueta, P.2    Ochoa, B.3    Chico, Y.4
  • 96
    • 10744233743 scopus 로고    scopus 로고
    • Arachidonic acid and prostacyclin signaling promote adipose tissue development: A human health concern?
    • Massiera, F. et al. Arachidonic acid and prostacyclin signaling promote adipose tissue development: a human health concern? J. Lipid Res. 44, 271-279 (2003).
    • (2003) J Lipid Res , vol.44 , pp. 271-279
    • Massiera, F.1
  • 97
    • 33845440071 scopus 로고    scopus 로고
    • Endogenous 15-deoxy-?12, 14-prostaglandin J2 synthesized by adipocytes during maturation phase contributes to upregulation of fat storage
    • Mazid, M. A. et al. Endogenous 15-deoxy-?12, 14-prostaglandin J2 synthesized by adipocytes during maturation phase contributes to upregulation of fat storage. FEBS Lett. 580, 6885-6890 (2006).
    • (2006) FEBS Lett , vol.580 , pp. 6885-6890
    • Mazid, M.A.1
  • 98
    • 0028126441 scopus 로고
    • Proliferation and differentiation of rat adipose precursor cells in chemically defined medium: Differential action of anti-adipogenic agents
    • vassaux, G., Negrel, r., Ailhaud, G. & Gaillard, D. Proliferation and differentiation of rat adipose precursor cells in chemically defined medium: differential action of anti-adipogenic agents. J. Cell Physiol. 161, 249-256 (1994).
    • (1994) J. Cell Physiol. , vol.161 , pp. 249-256
    • Vassaux, G.1    Negrel, R.2    Ailhaud, G.3    Gaillard, D.4
  • 99
    • 33845609092 scopus 로고    scopus 로고
    • Prostaglandin F2? inhibits adipocyte differentiation via a G?q-calcium-calcineurin-dependent signaling pathway
    • Liu, L. & Clipstone, N. A. Prostaglandin F2? inhibits adipocyte differentiation via a G?q-calcium-calcineurin-dependent signaling pathway. J. Cell Biochem. 100, 161-173 (2007).
    • (2007) J. Cell Biochem. , vol.100 , pp. 161-173
    • Liu, L.1    Clipstone, N.A.2
  • 100
    • 57049186709 scopus 로고    scopus 로고
    • Increased vascular thromboxane generation impairs dilation of skeletal muscle arterioles of obese Zucker rats with reduced oxygen tension
    • Goodwill, A. G., James, M. E. & Frisbee, J. C. Increased vascular thromboxane generation impairs dilation of skeletal muscle arterioles of obese Zucker rats with reduced oxygen tension. Am. J. Physiol. Heart Circ. Physiol. 295, H1522-H1528 (2008).
    • (2008) Am. J. Physiol. Heart Circ. Physiol. , vol.295
    • Goodwill, A.G.1    James, M.E.2    Frisbee, J.C.3
  • 102
    • 0038544490 scopus 로고    scopus 로고
    • Leukotriene receptors: State of the art
    • Brink, C. Leukotriene receptors: state of the art. Adv. Exp. Med. Biol. 525, 7-10 (2003).
    • (2003) Adv. Exp. Med. Biol. , vol.525 , pp. 7-10
    • Brink, C.1
  • 104
    • 34247123754 scopus 로고    scopus 로고
    • 5-Lipoxygenase-activating protein: A potential link between innate and adaptive immunity in atherosclerosis and adipose tissue inflammation
    • Back, M., Sultan, A., Ovchinnikova, O. & Hansson, G. K. 5-Lipoxygenase-activating protein: a potential link between innate and adaptive immunity in atherosclerosis and adipose tissue inflammation. Circ. Res. 100, 946-949 (2007).
    • (2007) Circ. Res. , vol.100 , pp. 946-949
    • Back, M.1    Sultan, A.2    Ovchinnikova, O.3    Hansson, G.K.4
  • 105
    • 0242468739 scopus 로고    scopus 로고
    • Adipocyte differentiation of 3T3-L1 preadipocytes is dependent on lipoxygenase activity during the initial stages of the differentiation process
    • Madsen, L. et al. Adipocyte differentiation of 3T3-L1 preadipocytes is dependent on lipoxygenase activity during the initial stages of the differentiation process. Biochem. J. 375, 539-549 (2003).
    • (2003) Biochem. J. , vol.375 , pp. 539-549
    • Madsen, L.1
  • 106
    • 57049099790 scopus 로고    scopus 로고
    • 12-Lipoxygenaseknockout mice are resistant to inflammatory effects of obesity induced by western diet
    • Nunemaker, C. S. et al. 12-Lipoxygenaseknockout mice are resistant to inflammatory effects of obesity induced by western diet. Am. J. Physiol. Endocrinol. Metab. 295, E1065-E1075 (2008).
    • (2008) Am. J. Physiol. Endocrinol. Metab. , vol.295
    • Nunemaker, C.S.1
  • 107
    • 38349174747 scopus 로고    scopus 로고
    • Leptin induces macrophage lipid body formation by a phosphatidylinositol 3-kinase- and mammalian target of rapamycin-dependent mechanism
    • Maya-Monteiro, C. M. et al. Leptin induces macrophage lipid body formation by a phosphatidylinositol 3-kinase- and mammalian target of rapamycin-dependent mechanism. J. Biol. Chem. 283, 2203-2210 (2008).
    • (2008) J. Biol. Chem. , vol.283 , pp. 2203-2210
    • Maya-Monteiro, C.M.1
  • 108
    • 0036771772 scopus 로고    scopus 로고
    • Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit peroxynitrite formation, NF-kappa B and AP-1 activation, and IL-8 gene expression in human leukocytes
    • Jozsef, L., Zouki, C., Petasis, N. A., Serhan, C. N. & Filep, J. G. Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit peroxynitrite formation, NF-kappa B and AP-1 activation, and IL-8 gene expression in human leukocytes. Proc. Natl Acad. Sci. USA 99, 13266-13271 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 13266-13271
    • Jozsef, L.1    Zouki, C.2    Petasis, N.A.3    Serhan, C.N.4    Filep, J.G.5
  • 109
    • 0036852720 scopus 로고    scopus 로고
    • Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor
    • Perretti, M. et al. Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor. Nat. Med. 8, 1296-1302 (2002).
    • (2002) Nat. Med. , vol.8 , pp. 1296-1302
    • Perretti, M.1
  • 110
    • 0037152160 scopus 로고    scopus 로고
    • Resolvins: A family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals
    • Serhan, C. N. et al. resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals. J. Exp. Med. 196, 1025-1037 (2002).
    • (2002) J. Exp. Med. , vol.196 , pp. 1025-1037
    • Serhan, C.N.1
  • 111
    • 30044449982 scopus 로고    scopus 로고
    • Resolution of inflammation: The beginning programs the end
    • Serhan, C. N. & Savill, J. resolution of inflammation: the beginning programs the end. Nat. Immunol. 6, 1191-1197 (2005).
    • (2005) Nat. Immunol. , vol.6 , pp. 1191-1197
    • Serhan, C.N.1    Savill, J.2
  • 112
    • 42649089790 scopus 로고    scopus 로고
    • Resolving inflammation: Dual anti-inflammatory and pro-resolution lipid mediators
    • Serhan, C. N., Chiang, N. & van Dyke, T. E. resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators. Nat. Rev. Immunol. 8, 349-361 (2008).
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 349-361
    • Serhan, C.N.1    Chiang, N.2    Van Dyke, T.E.3
  • 113
  • 114
    • 33947375240 scopus 로고    scopus 로고
    • Action of epoxyeidosatrienoic acids on cellular function
    • Spector, A. A. & Norris, A. w. Action of epoxyeidosatrienoic acids on cellular function. Am. J. Physiol. Cell. Physiol. 292, C996-C1012 (2007).
    • (2007) Am. J. Physiol. Cell. Physiol. , vol.292
    • Spector, A.A.1    Norris, A.W.2
  • 115
    • 77249096825 scopus 로고    scopus 로고
    • Expression and regulation of soluble epoxide hydrolase in adipose tissue
    • doi:10.1038/oby.2009.227.
    • De Taeye, B. M. et al. Expression and regulation of soluble epoxide hydrolase in adipose tissue. Obesity doi:10.1038/oby.2009.227.
    • Obesity
    • De Taeye, B.M.1
  • 116
    • 34547468357 scopus 로고    scopus 로고
    • Angiotensin II up-regulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo
    • Ai, D. et al. Angiotensin II up-regulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo. Proc. Natl Acad. Sci. USA 104, 9018-9023 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 9018-9023
    • Ai, D.1
  • 117
    • 0021073537 scopus 로고
    • Differential induction of cytosolic epoxide hydrolase, microsomal epoxide hydrolase, and glutathione S-transferase activities
    • Hammock, B. D. & Ota, K. Differential induction of cytosolic epoxide hydrolase, microsomal epoxide hydrolase, and glutathione S-transferase activities. Toxicol. App. Pharmacol. 71, 254-265 (1983).
    • (1983) Toxicol. App. Pharmacol. , vol.71 , pp. 254-265
    • Hammock, B.D.1    Ota, K.2
  • 118
    • 0034176077 scopus 로고    scopus 로고
    • New role for epoxyeicosatrienoic acids as anti-inflammatory mediators
    • Campbell, w. B. New role for epoxyeicosatrienoic acids as anti-inflammatory mediators. Trends Pharmacol. Sci. 21, 125-127 (2000).
    • (2000) Trends Pharmacol. Sci. , vol.21 , pp. 125-127
    • Campbell, W.B.1
  • 119
    • 0033588034 scopus 로고    scopus 로고
    • Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids
    • Node, K. et al. Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids. Science 285, 1276-1279 (1999).
    • (1999) Science , vol.285 , pp. 1276-1279
    • Node, K.1
  • 120
    • 33748797975 scopus 로고    scopus 로고
    • Enhancement of antinociception by coadministration of nonsteroidal anti-inflammatory drugs and soluble epoxide hydrolase inhibitors
    • Schmelzer, K. r. et al. Enhancement of antinociception by coadministration of nonsteroidal anti-inflammatory drugs and soluble epoxide hydrolase inhibitors. Proc. Natl Acad. Sci. USA 103, 13646-13651 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 13646-13651
    • Schmelzer, K.R.1
  • 121
    • 33745222033 scopus 로고    scopus 로고
    • Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The Atherosclerosis risk in Communities (ArIC) study
    • Lee, C. r. et al. Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The Atherosclerosis risk in Communities (ArIC) study. Hum. Mol. Genet. 15, 1640-1649 (2006).
    • (2006) Hum. Mol. Genet. , vol.15 , pp. 1640-1649
    • Lee, C.R.1
  • 122
    • 17444380409 scopus 로고    scopus 로고
    • Association of soluble epoxide hydrolase gene polymorphism with insulin resistance in type 2 diabetic patients
    • Ohtoshi, K. et al. Association of soluble epoxide hydrolase gene polymorphism with insulin resistance in type 2 diabetic patients. Biochem. Biophys. Res. Commun. 331, 347-350 (2005).
    • (2005) Biochem. Biophys. Res. Commun. , vol.331 , pp. 347-350
    • Ohtoshi, K.1
  • 123
    • 45249124328 scopus 로고    scopus 로고
    • Genetic analysis of the soluble epoxide hydrolase gene, EPHX2, in subclinical cardiovascular disease in the Diabetes Heart Study
    • Burdon, K. P. et al. Genetic analysis of the soluble epoxide hydrolase gene, EPHX2, in subclinical cardiovascular disease in the Diabetes Heart Study. Diab. Vasc. Dis. Res. 5, 128-134 (2008).
    • (2008) Diab. Vasc. Dis. Res. , vol.5 , pp. 128-134
    • Burdon, K.P.1
  • 124
    • 38949116626 scopus 로고    scopus 로고
    • TNF? is a potent inducer of platelet-activating factor synthesis in adipocytes but not in preadipocytes. Differential regulation by PI3K
    • Gountopoulou, A., Leondaritis, G., Galanopoulou, D. & Mavri-vavayanni, M. TNF? is a potent inducer of platelet-activating factor synthesis in adipocytes but not in preadipocytes. Differential regulation by PI3K. Cytokine 41, 174-181 (2008).
    • (2008) Cytokine , vol.41 , pp. 174-181
    • Gountopoulou, A.1    Leondaritis, G.2    Galanopoulou, D.3    Mavri-Vavayanni, M.4
  • 125
    • 33750590489 scopus 로고    scopus 로고
    • Altered adipose and plasma sphingolipid metabolism in obesity: A potential mechanism for cardiovascular and metabolic risk
    • Samad, F., Hester, K. D., Yang, G., Hannun, Y. A. & Bielawski, J. Altered adipose and plasma sphingolipid metabolism in obesity: a potential mechanism for cardiovascular and metabolic risk. Diabetes 55, 2579-2587 (2006).
    • (2006) Diabetes , vol.55 , pp. 2579-2587
    • Samad, F.1    Hester, K.D.2    Yang, G.3    Hannun, Y.A.4    Bielawski, J.5
  • 126
    • 43249100162 scopus 로고    scopus 로고
    • Targeting the endocannabinoid system: To enhance or reduce?
    • Di Marzo, v. Targeting the endocannabinoid system: to enhance or reduce? Nat. Rev. Drug Discov. 7, 438-455 (2008).
    • (2008) Nat. Rev. Drug Discov. , vol.7 , pp. 438-455
    • Di Marzo, V.1
  • 127
    • 0031280012 scopus 로고    scopus 로고
    • Plasma PAF acetylhydrolase in non-insulin dependent diabetes mellitus and obesity: Effect of hyperinsulinemia and lovastatin treatment
    • Kudolo, G. B., Bressler, P. & DeFronzo, r. A. Plasma PAF acetylhydrolase in non-insulin dependent diabetes mellitus and obesity: effect of hyperinsulinemia and lovastatin treatment. J. Lipid Mediat. Cell Signal. 17, 97-113 (1997).
    • (1997) J. Lipid Mediat. Cell Signal. , vol.17 , pp. 97-113
    • Kudolo, G.B.1    Bressler, P.2    Defronzo, R.A.3
  • 128
    • 33646456062 scopus 로고    scopus 로고
    • Platelet-activating factor acetylhydrolase concentration in children with abdominal obesity
    • Okada, T. et al. Platelet-activating factor acetylhydrolase concentration in children with abdominal obesity. Arterioscler. Thromb. Vasc. Biol. 26, e40-e41 (2006).
    • (2006) Arterioscler. Thromb. Vasc. Biol. , vol.26
    • Okada, T.1
  • 129
    • 57049102251 scopus 로고    scopus 로고
    • End of the line for cannabinoid receptor 1 as an anti-obesity target?
    • Jones, D. End of the line for cannabinoid receptor 1 as an anti-obesity target? Nat. Rev. Drug Discov. 7, 961-962 (2008).
    • (2008) Nat. Rev. Drug Discov. , vol.7 , pp. 961-962
    • Jones, D.1
  • 130
    • 33750510903 scopus 로고    scopus 로고
    • The obesity pipeline: Current strategies in the development of antiobesity drugs
    • Cooke, D. & Bloom, S. The obesity pipeline: current strategies in the development of antiobesity drugs. Nat. Rev. Drug Discov. 5, 919-931 (2006).
    • (2006) Nat. Rev. Drug Discov. , vol.5 , pp. 919-931
    • Cooke, D.1    Bloom, S.2
  • 131
    • 65649122618 scopus 로고    scopus 로고
    • Cannabinoid receptor antagonists: Pharmacological opportunities, clinical experience, and translational prognosis
    • Janero, D. r. & Makriyannis, A. Cannabinoid receptor antagonists: pharmacological opportunities, clinical experience, and translational prognosis. Expert Opin. Emerg. Drugs 14, 43-65 (2009).
    • (2009) Expert Opin. Emerg. Drugs , vol.14 , pp. 43-65
    • Janero, D.R.1    Makriyannis, A.2
  • 132
    • 0033984744 scopus 로고    scopus 로고
    • Inflammation obesity stress and coronary heart disease: Is interleukin-6 the link?
    • Yudkin, J. S., Kumari, M., Humphries, S. E. & Mohamed-Ali, v. Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link? Atherosclerosis 148, 209-214 (2000).
    • (2000) Atherosclerosis , vol.148 , pp. 209-214
    • Yudkin, J.S.1    Kumari, M.2    Humphries, S.E.3    Mohamed-Ali, V.4
  • 133
    • 9144223683 scopus 로고    scopus 로고
    • Chronic inflammation in fat plays a crucial role in the development of obesityrelated insulin resistance
    • Xu, H. et al. Chronic inflammation in fat plays a crucial role in the development of obesityrelated insulin resistance. J. Clin. Invest. 112, 1821-1830 (2003).
    • (2003) J. Clin. Invest. , vol.112 , pp. 1821-1830
    • Xu, H.1
  • 134
    • 0037453718 scopus 로고    scopus 로고
    • Peroxisome-proliferatoractivated receptor delta activates fat metabolism to prevent obesity
    • wang, Y. X. et al. Peroxisome-proliferatoractivated receptor delta activates fat metabolism to prevent obesity. Cell 113, 159-170 (2003).
    • (2003) Cell , vol.113 , pp. 159-170
    • Wang, Y.X.1
  • 135
    • 0037241112 scopus 로고    scopus 로고
    • Adipose-derived resistin and gutderived resistin-like molecule-beta selectively impair insulin action on glucose production
    • rajala, M. w., Obici, S., Scherer, P. E. & rossetti, L. Adipose-derived resistin and gutderived resistin-like molecule-beta selectively impair insulin action on glucose production. J. Clin. Invest. 111, 225-230 (2003).
    • (2003) J. Clin. Invest. , vol.111 , pp. 225-230
    • Rajala, M.W.1    Obici, S.2    Scherer, P.E.3    Rossetti, L.4
  • 136
    • 0348222671 scopus 로고    scopus 로고
    • Inflammation: The link between insulin resistance, obesity and diabetes
    • Dandona, P., Aljada, A. & Bandyopadhyay, A. Inflammation: the link between insulin resistance, obesity and diabetes. Trends Immunol. 25, 4-7 (2004).
    • (2004) Trends Immunol. , vol.25 , pp. 4-7
    • Dandona, P.1    Aljada, A.2    Bandyopadhyay, A.3
  • 137
    • 14644427890 scopus 로고    scopus 로고
    • Local and systemic insulin resistance resulting from hepatic activation of IKK-? and NF-kB
    • Cai, D. et al. Local and systemic insulin resistance resulting from hepatic activation of IKK-? and NF-kB. Nat. Med. 11, 183-190 (2005).
    • (2005) Nat. Med. , vol.11 , pp. 183-190
    • Cai, D.1
  • 138
    • 20044387026 scopus 로고    scopus 로고
    • IKK-? links inflammation to obesity-induced insulin resistance
    • Arkan, M. C. et al. IKK-? links inflammation to obesity-induced insulin resistance. Nat. Med. 11, 191-198 (2005).
    • (2005) Nat. Med. , vol.11 , pp. 191-198
    • Arkan, M.C.1
  • 139
    • 13444272949 scopus 로고    scopus 로고
    • Thiazolidinediones, metformin, and outcomes in older patients with diabetes and heart failure: An observational study
    • Masoudi, F. A. et al. Thiazolidinediones, metformin, and outcomes in older patients with diabetes and heart failure: an observational study. Circulation 111, 583-590 (2005).
    • (2005) Circulation , vol.111 , pp. 583-590
    • Masoudi, F.A.1
  • 140
    • 11244302456 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein-1 is produced in isolated adipocytes, associated with adiposity and reduced after weight loss in morbid obese subjects
    • Christiansen, T., richelsen, B. & Bruun, J. M. Monocyte chemoattractant protein-1 is produced in isolated adipocytes, associated with adiposity and reduced after weight loss in morbid obese subjects. Int. J. Obes. (Lond.) 29, 146-150 (2005).
    • (2005) Int. J. Obes. (Lond.) , vol.29 , pp. 146-150
    • Christiansen, T.1    Richelsen, B.2    Bruun, J.M.3
  • 141
    • 34247857663 scopus 로고    scopus 로고
    • Obesity: Inflammation, and insulin resistance
    • Shoelson, S. E., Herrero, L. & Naaz, A. Obesity, inflammation, and insulin resistance. Gastroenterology 132, 2169-2180 (2007).
    • (2007) Gastroenterology , vol.132 , pp. 2169-2180
    • Shoelson, S.E.1    Herrero, L.2    Naaz, A.3
  • 142
    • 34250169823 scopus 로고    scopus 로고
    • Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity
    • Kim, F. et al. Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity. Circ. Res. 100, 1589-1596 (2007).
    • (2007) Circ. Res. , vol.100 , pp. 1589-1596
    • Kim, F.1
  • 143
    • 47149096915 scopus 로고    scopus 로고
    • Adipose tissue macrophages, low grade inflammation and insulin resistance in human obesity
    • Heilbronn, L. K. & Campbell, L. v. Adipose tissue macrophages, low grade inflammation and insulin resistance in human obesity. Curr. Pharm. Des. 14, 1225-1230 (2008).
    • (2008) Curr. Pharm. Des. , vol.14 , pp. 1225-1230
    • Heilbronn, L.K.1    Campbell, L.V.2
  • 144
    • 48249125862 scopus 로고    scopus 로고
    • Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice
    • Cani, P. D. et al. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes 57, 1470-1481 (2008).
    • (2008) Diabetes , vol.57 , pp. 1470-1481
    • Cani, P.D.1
  • 145
    • 54049086276 scopus 로고    scopus 로고
    • Interferon-gamma, a Th1 cytokine, regulates fat inflammation: A role for adaptive immunity in obesity
    • rocha, v. Z. et al. Interferon-gamma, a Th1 cytokine, regulates fat inflammation: a role for adaptive immunity in obesity. Circ. Res. 103, 467-476 (2008).
    • (2008) Circ. Res. , vol.103 , pp. 467-476
    • Rocha, V.Z.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.