Hematopoietic NF-κB1 deficiency results in small atherosclerotic lesions with an inflammatory phenotype

Blood

Volumn 103, Issue 3, 2004, Pages 934-940

  Kanters, Edwin ^b   Gijbels, Marion J J ^b   Van Der Made, Ingeborg ^b   Vergouwe, Monique N ^b   Heeringa, Peter ^b   Kraal, Georg ^b   Hofker, Marten H ^b   De Winther, Menno P J ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; LIPOPROTEIN; NUCLEAR FACTOR KAPPA B 1; OXIDIZED LOW DENSITY LIPOPROTEIN; PROTEIN P50; SCAVENGER RECEPTOR; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; IMMUNOGLOBULIN RECEPTOR; LIPOPROTEIN RECEPTOR; LOW DENSITY LIPOPROTEIN RECEPTOR; MEMBRANE PROTEIN; SCARB1 PROTEIN, MOUSE; SCAVENGER RECEPTOR A; SCAVENGER RECEPTOR B;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; BLOOD VESSEL WALL; BONE MARROW; CELL COUNT; CONTROLLED STUDY; CYTOKINE PRODUCTION; FOAM CELL; INFLAMMATION; LIPID DIET; MACROPHAGE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; ARTERIOSCLEROSIS; BONE MARROW CELL; C57BL MOUSE; ENDOCYTOSIS; FEMALE; GENETICS; IMMUNOLOGY; MACROPHAGE ACTIVATION; METABOLISM; MOUSE MUTANT; PATHOLOGY; PATHOPHYSIOLOGY; RADIATION CHIMERA; SECRETION;

ANIMALS; ARTERIOSCLEROSIS; BONE MARROW CELLS; CYTOKINES; ENDOCYTOSIS; FEMALE; INFLAMMATION; LIPOPROTEINS; MACROPHAGE ACTIVATION; MACROPHAGES; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NF-KAPPA B; PHENOTYPE; RADIATION CHIMERA; RECEPTORS, IMMUNOLOGIC; RECEPTORS, LDL; RECEPTORS, LIPOPROTEIN; RECEPTORS, SCAVENGER; SCAVENGER RECEPTORS, CLASS A; SCAVENGER RECEPTORS, CLASS B;

EID: 1442327145     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2003-05-1450     Document Type: Article

References (33)

1. Libby P, Ridker PM, Maseri A. Inflammation and atherosclerosis. Circulation. 2002;105:1135-1143.
2. Lusis AJ. Atherosclerosis. Nature. 2000;407:233-241.
3. Ross R. Atherosclerosis is an inflammatory disease. Am Heart J. 1999;138:S419-S420.
4. Li Q, Verma IM. NF-κB regulation in the immune system. Nat Rev Immunol. 2002;2:725-734.
5. Brand K, Page S, Rogler G, et al. Activated transcription factor nuclear factor-κ B is present in the atherosclerotic lesion. J Clin Invest. 1996;97:1715-1722.
6. Collins T. Endothelial nuclear factor-κ B and the initiation of the atherosclerotic lesion. Lab Invest. 1993;68:499-508.
7. Siebenlist U, Franzoso G, Brown K. Structure, regulation and function of NF-κ B. Annu Rev Cell Biol. 1994;10:405-455.
8. Bohuslav J, Kravchenko VV, Parry GC, et al. Regulation of an essential innate immune response by the pSO subunit of NF-κB. J Clin Invest. 1998;102:1645-1652.
9. Ishikawa H, Claudio E, Dambach D, et al. Chronic inflammation and susceptibility to bacterial infections in mice lacking the polypeptide (p) 105 precursor (NF-κB1) but expressing p50. J Exp Med. 1998;187:985-996.
10. Ishibashi S, Brown MS, Goldstein JL, et al. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. J Clin Invest. 1993;92:883-893.
11. Sha WC, Liou HC, Tuomanen EI, Baltimore D. Targeted disruption of the p50 subunit of NF-κ B leads to multifocal defects in immune responses. Cell. 1995;80:321-330.
12. Hume DA, Gordon S. Optimal conditions for proliferation of bone marrow-derived mouse macrophages in culture: the roles of CSF-1, serum, Ca2+, and adherence. J Cell Physiol. 1983;117:189-194.
13. Hendriks WL, van der BH, van Vark LC, Havekes LM. Lipoprotein lipase stimulates the binding and uptake of moderately oxidized low-density lipoprotein by J774 macrophages. Biochem J. 1996;314 (pt 2):563-568.
14. Takemura S, Braun A, Crowson C, et al. Lymphoid neogenesis in rheumatoid synovitis. J Immunol. 2001;167:1072-1080.
15. Krieger M, Herz J. Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor-related protein (LRP). Annu Rev Biochem. 1994;63:601-637.
16. Fitzgerald ML, Moore KJ, Freeman MW, Reed GL. Lipopolysaccharide induces scavenger receptor A expression in mouse macrophages: a divergent response relative to human THP-1 monocyte/macrophages. J Immunol. 2000;164:2692-2700.
17. Huh HY, Lo SK, Yesner LM, Silverstein RL. CD36 Induction on human monocytes upon adhesion to tumor necrosis factor-activated endothelial cells. J Biol Chem. 1995;270:6267-6271.
18. Yesner LM, Huh HY, Pearce SF, Silverstein RL. Regulation of monocyte CD36 and thrombospondin-1 expression by soluble mediators. Arterioscler Thromb Vasc Biol. 1996;16:1019-1025.
19. Fazio S, Linton MF. The inflamed plaque: cytokine production and cellular cholesterol balance in the vessel wall. Am J Cardiol. 2001;88:12E-15E.
20. Berliner JA, Navab M, Fogelman AM, et al. Atherosclerosis: basic mechanisms: oxidation, inflammation, and genetics. Circulation. 1995;91:2488-2496.
21. Cushing SD, Berliner JA, Valente AJ, et al. Minimally modified low density lipoprotein induces monocyte chemotactic protein 1 in human endothelial cells and smooth muscle cells. Proc Natl Acad Sci U S A. 1990;87:5134-5138.
22. Kastenbauer S, Ziegler-Heitbrock HW. NF-κB1 (p50) is upregulated in lipopolysaccharide tolerance and can block tumor necrosis factor gene expression. Infect Immun. 1999;67:1553-1559.
23. Frankenberger M, Ziegler-Heitbrock HW. LPS tolerance in monocytes/macrophages: three 3′ cytosines are required in the DNA binding motif for detection of upregulated NF-κ B p50 homodimers. Immunobiology. 1997;198:81-90.
24. Artis D, Shapira S, Mason N, et al. Differential requirement for NF-κ B family members in control of helminth infection and intestinal inflammation. J Immunol. 2002;169:4481-4487.
25. Campbell IK, Gerondakis S, O'Donnell K, Wicks IP. Distinct roles for the NF-κB1 (p50) and c-Rel transcription factors in inflammatory arthritis. J Clin Invest. 2000;105:1799-1806.
26. Kanters E, Pasparakis M, Gijbels MJ, et al. Inhibition of NF-κB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice. J Clin Invest. 2003;112:1176-1185.
27. Li Q, Antwerp DV, Mercurio F, Lee KF, Verma IM. Severe liver degeneration in mice lacking the IκB kinase 2 gene. Science. 1999;284:321-325.
28. Cariappa A, Liou HC, Horwitz BH, Pillai S. Nuclear factor κB is required for the development of marginal zone B lymphocytes. J Exp Med. 2000;192:1175.
29. Horwitz BH, Zelazowski P, Shen Y, et al. The p65 subunit of NF-κB is redundant with p50 during B cell proliferative responses, and is required for germline CH transcription and class switching to IgG3. J Immunol. 1999;162:1941-1946.
30. Grumont RJ, Rourke IJ, O'Reilly LA, et al. B lymphocytes differentially use the Rel and nuclear factor κ B1 (NF-κ B1) transcription factors to regulate cell cycle progression and apoptosis in quiescent and mitogen-activated cells. J Exp Med. 1998;187:663-674.
31. Zheng Y, Ouaaz F, Bruzzo P, et al. NF-κB RelA (p65) is essential for TNF-α-induced fas expression but dispensable for both TCR-induced expression and activation-induced cell death. J Immunol. 2001;166:4949-4957.
32. Hilliard B, Samoilova EB, Liu TS, Rostami A, Chen Y. Experimental autoimmune encephalomyelitis in NF-κB-deficient mice: roles of NF-κB in the activation and differentiation of autoreactive T cells. J Immunol. 1999;163:2937-2943.
33. Hansson GK, Libby P, Schonbeck U, Yan ZQ. Innate and adaptive immunity in the pathogenesis of atherosclerosis. Circ Res. 2002;91:281-291.