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Volumn 193, Issue 1-2, 2010, Pages 8-22

Emergence of the phosphoinositide 3-kinase-akt- mammalian target of rapamycin axis in transforming growth factor-β-induced epithelial- mesenchymal transition

Author keywords

Cell invasion; Epithelial mesenchymal transition; Metastasis; Smad signaling

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; P21 ACTIVATED KINASE 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P110; PROTEIN P85; RAS PROTEIN; RHEB PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TUBERIN;

EID: 78650510746     PISSN: 14226405     EISSN: None     Source Type: Journal    
DOI: 10.1159/000320172     Document Type: Article
Times cited : (86)

References (126)
  • 1
    • 67650996280 scopus 로고    scopus 로고
    • Epithelialmesenchymal transitions: The importance of changing cell state in development and disease
    • Acloque, H., M. S. Adams, K. Fishwick, M. Bronner-Fraser, M. A. Nieto (2009) Epithelialmesenchymal transitions: the importance of changing cell state in development and disease. J Clin Invest 119:1438-1449.
    • (2009) J. Clin. Invest. , vol.119 , pp. 1438-1449
    • Acloque, H.1    Adams, M.S.2    Fishwick, K.3    Bronner-Fraser, M.4    Nieto, M.A.5
  • 6
    • 12144266241 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: Implications for the epithelial-mesenchymal transition
    • Bachelder, R. E., S. O. Yoon, C. Franci, A. G. de Herreros, A. M. Mercurio (2005) Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: implications for the epithelial-mesenchymal transition. J Cell Biol 168:29-33.
    • (2005) J. Cell. Biol. , vol.168 , pp. 29-33
    • Bachelder, R.E.1    Yoon, S.O.2    Franci, C.3    De Herreros, A.G.4    Mercurio, A.M.5
  • 7
    • 0036674213 scopus 로고    scopus 로고
    • P38 mitogen-activated protein kinase is required for TGF-β-mediated fibroblastic transdifferentiation and cell migration
    • Bakin, A. V., C. Rinehart, A. K. Tomlinson, C. L. Arteaga (2002) p38 mitogen-activated protein kinase is required for TGF-β-mediated fibroblastic transdifferentiation and cell migration. J Cell Sci 115:3193-3206.
    • (2002) J. Cell. Sci. , vol.115 , pp. 3193-3206
    • Bakin, A.V.1    Rinehart, C.2    Tomlinson, A.K.3    Arteaga, C.L.4
  • 8
    • 0034711307 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase function is required for transforming growth factor-β-mediated epithelial to mesenchymal transition and cell migration
    • Bakin, A. V., A. K. Tomlinson, N. A. Bhowmick, H. L. Moses, C. L. Arteaga (2000) Phosphatidylinositol 3-kinase function is required for transforming growth factor-β-mediated epithelial to mesenchymal transition and cell migration. J Biol Chem 275:36803-36810.
    • (2000) J. Biol. Chem. , vol.275 , pp. 36803-36810
    • Bakin, A.V.1    Tomlinson, A.K.2    Bhowmick, N.A.3    Moses, H.L.4    Arteaga, C.L.5
  • 9
    • 23844528776 scopus 로고    scopus 로고
    • The Snail genes as inducers of cell movement and survival: Implications in development and cancer
    • Barrallo-Gimeno, A., M. A. Nieto (2005) The Snail genes as inducers of cell movement and survival: implications in development and cancer. Development 132:3151-3161.
    • (2005) Development , vol.132 , pp. 3151-3161
    • Barrallo-Gimeno, A.1    Nieto, M.A.2
  • 13
    • 33745515023 scopus 로고    scopus 로고
    • Tumour microenvironment: TGF-β: The molecular Jekyll and Hyde of cancer
    • Bierie, B., H. L. Moses (2006b) Tumour microenvironment: TGF-β: the molecular Jekyll and Hyde of cancer. Nat Rev Cancer 6:506-520.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 506-520
    • Bierie, B.1    Moses, H.L.2
  • 14
    • 71449100603 scopus 로고    scopus 로고
    • Strategies for TGF-β modulation: A review of recent patents
    • Bonafoux, D., W. C. Lee (2009) Strategies for TGF-β modulation: a review of recent patents. Expert Opin Ther Pat 19:1759-1769.
    • (2009) Expert Opin. Ther. Pat. , vol.19 , pp. 1759-1769
    • Bonafoux, D.1    Lee, W.C.2
  • 15
    • 54049084380 scopus 로고    scopus 로고
    • A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition
    • Bracken, C. P., PA. Gregory, N. Kolesnikoff, A. G. Bert, J. Wang, M. F. Shannon, G. J. Goodall (2008) A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition. Cancer Res 68:7846-7854.
    • (2008) Cancer Res. , vol.68 , pp. 7846-7854
    • Bracken, C.P.1    Gregory, P.A.2    Kolesnikoff, N.3    Bert, A.G.4    Wang, J.5    Shannon, M.F.6    Goodall, G.J.7
  • 16
    • 44649163918 scopus 로고    scopus 로고
    • A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells
    • Burk, U., J. Schubert, U. Wellner, O. Schmalhofer, E. Vincan, S. Spaderna, T. Brabletz (2008) A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells. EMBO Rep 9:582-589.
    • (2008) EMBO Rep. , vol.9 , pp. 582-589
    • Burk, U.1    Schubert, J.2    Wellner, U.3    Schmalhofer, O.4    Vincan, E.5    Spaderna, S.6    Brabletz, T.7
  • 18
    • 77649261101 scopus 로고    scopus 로고
    • TGF-β-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEI
    • Chaudhury, A., G. S. Hussey, P. S. Ray, G. Jin, P. L. Fox, P. H. Howe (2010) TGF-β-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEI. Nat Cell Biol 12:286-293.
    • (2010) Nat. Cell. Biol. , vol.12 , pp. 286-293
    • Chaudhury, A.1    Hussey, G.S.2    Ray, P.S.3    Jin, G.4    Fox, P.L.5    Howe, P.H.6
  • 19
    • 33845787629 scopus 로고    scopus 로고
    • Snail is required for transforming growth factor-β-induced epithelial-mesenchymal transition by activating PI3 kinase/Akt signal pathway
    • Cho, H. J., K. E. Baek, S. Saika, M. J. Jeong, J. Yoo (2007) Snail is required for transforming growth factor-β-induced epithelial-mesenchymal transition by activating PI3 kinase/Akt signal pathway. Biochem Biophys Res Commun 353:337-343.
    • (2007) Biochem. Biophys. Res. Commun. , vol.353 , pp. 337-343
    • Cho, H.J.1    Baek, K.E.2    Saika, S.3    Jeong, M.J.4    Yoo, J.5
  • 20
    • 34447103569 scopus 로고    scopus 로고
    • Rho activation is required for transforming growth factor-β-induced epithelial-mesenchymal transition in lens epithelial cells
    • Cho, H. J., J. Yoo (2007) Rho activation is required for transforming growth factor-β-induced epithelial-mesenchymal transition in lens epithelial cells. Cell Biol Int 31:1225-1230.
    • (2007) Cell. Biol. Int. , vol.31 , pp. 1225-1230
    • Cho, H.J.1    Yoo, J.2
  • 24
    • 33644534795 scopus 로고    scopus 로고
    • The tumor suppressor Smad4 is required for transforming growth factor-β-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells
    • Deckers, M., M. van Dinther, J. Buijs, I. Que, C. Lowik, G. van der Pluijm, P. ten Dijke (2006) The tumor suppressor Smad4 is required for transforming growth factor-β-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells. Cancer Res 66:2202-2209.
    • (2006) Cancer Res. , vol.66 , pp. 2202-2209
    • Deckers, M.1    Van Dinther, M.2    Buijs, J.3    Que, I.4    Lowik, C.5    Van Der Pluijm, G.6    Ten Dijke, P.7
  • 25
    • 0034785348 scopus 로고    scopus 로고
    • TGF-β signaling in tumor suppression and cancer progression
    • Derynck, R., R. J. Akhurst, A. Balmain (2001) TGF-β signaling in tumor suppression and cancer progression. Nat Genet 29:117-129.
    • (2001) Nat. Genet. , vol.29 , pp. 117-129
    • Derynck, R.1    Akhurst, R.J.2    Balmain, A.3
  • 26
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-independent pathways in TGF-β family signaling
    • Derynck, R., Y. E. Zhang (2003) Smad-dependent and Smad-independent pathways in TGF-β family signaling. Nature 425:577-584.
    • (2003) Nature , vol.425 , pp. 577-584
    • Derynck, R.1    Zhang, Y.E.2
  • 28
    • 23044466047 scopus 로고    scopus 로고
    • Specificity and versatility in TGF-β signaling through Smads
    • Feng, X. H., R. Derynck (2005) Specificity and versatility in TGF-β signaling through Smads. Annu Rev Cell Dev Biol 21:659-693.
    • (2005) Annu Rev. Cell. Dev. Biol. , vol.21 , pp. 659-693
    • Feng, X.H.1    Derynck, R.2
  • 29
    • 69249208791 scopus 로고    scopus 로고
    • The Akt kinases: Isoform specificity in metabolism and cancer
    • Gonzalez, E., T. E. McGraw (2009) The Akt kinases: isoform specificity in metabolism and cancer. Cell Cycle 8:2502-2508.
    • (2009) Cell. Cycle , vol.8 , pp. 2502-2508
    • Gonzalez, E.1    McGraw, T.E.2
  • 30
    • 60149093710 scopus 로고    scopus 로고
    • Bone morphogenetic proteins induce pancreatic cancer cell invasiveness through a Smad1-dependent mechanism that involves matrix metalloproteinase-2
    • Gordon, K. J., K. C. Kirkbride, T. How, GC. Blobe (2009) Bone morphogenetic proteins induce pancreatic cancer cell invasiveness through a Smad1-dependent mechanism that involves matrix metalloproteinase-2. Carcinogenesis 30:238-248.
    • (2009) Carcinogenesis , vol.30 , pp. 238-248
    • Gordon, K.J.1    Kirkbride, K.C.2    How, T.3    Blobe, G.C.4
  • 31
    • 18744362996 scopus 로고    scopus 로고
    • Transforming growth factor-β and epidermal growth factor synergistically stimulate epithelial to mesenchymal transition (EMT) through a MEK-dependent mechanism in primary cultured pig thyrocytes
    • Grande, M., A. Franzen, J. O. Karlsson, L. E. Ericson, N. E. Heldin, M. Nilsson (2002) Transforming growth factor-β and epidermal growth factor synergistically stimulate epithelial to mesenchymal transition (EMT) through a MEK-dependent mechanism in primary cultured pig thyrocytes. J Cell Sci 115:4227-4236.
    • (2002) J. Cell. Sci. , vol.115 , pp. 4227-4236
    • Grande, M.1    Franzen, A.2    Karlsson, J.O.3    Ericson, L.E.4    Heldin, N.E.5    Nilsson, M.6
  • 34
    • 34347220473 scopus 로고    scopus 로고
    • Defining the role of mTOR in cancer
    • Guertin, D. A., D. M. Sabatini (2007) Defining the role of mTOR in cancer. Cancer Cell 12:9-22.
    • (2007) Cancer Cell. , vol.12 , pp. 9-22
    • Guertin, D.A.1    Sabatini, D.M.2
  • 35
    • 68149096799 scopus 로고    scopus 로고
    • The pharmacology of mTOR inhibition
    • Guertin, D. A., D. M. Sabatini (2009) The pharmacology of mTOR inhibition. Sci Signal 2: pe24.
    • (2009) Sci. Signal , vol.2
    • Guertin, D.A.1    Sabatini, D.M.2
  • 37
    • 70449457461 scopus 로고    scopus 로고
    • Involvement of mTORC1 and mTORC2 in regulation of glioblastoma multiforme growth and motility
    • Gulati, N., M. Karsy, L. Albert, R. Murali, M. Jhanwar-Uniyal (2009) Involvement of mTORC1 and mTORC2 in regulation of glioblastoma multiforme growth and motility. Int J Oncol 35:731-740.
    • (2009) Int. J. Oncol. , vol.35 , pp. 731-740
    • Gulati, N.1    Karsy, M.2    Albert, L.3    Murali, R.4    Jhanwar-Uniyal, M.5
  • 39
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR
    • Hay, N., N. Sonenberg (2004) Upstream and downstream of mTOR. Genes Dev 18:1926-1945.
    • (2004) Genes Dev. , vol.18 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 40
    • 27744569843 scopus 로고    scopus 로고
    • MTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events
    • Holz, M. K., B. A. Ballif, S. P. Gygi, J. Blenis (2005) mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. Cell 123:569-580.
    • (2005) Cell. , vol.123 , pp. 569-580
    • Holz, M.K.1    Ballif, B.A.2    Gygi, S.P.3    Blenis, J.4
  • 41
    • 48749122568 scopus 로고    scopus 로고
    • Keratinocyte-specific Smad2 ablation results in increased epithelialmesenchymal transition during skin cancer formation and progression
    • Hoot, K. E., J. Lighthall, G Han, S. L. Lu, A. Li, W. Ju, M. Kulesz-Martin, E. Böttinger, X. J. Wang (2008) Keratinocyte-specific Smad2 ablation results in increased epithelialmesenchymal transition during skin cancer formation and progression. J Clin Invest 118:2722-2732.
    • (2008) J. Clin. Invest. , vol.118 , pp. 2722-2732
    • Hoot, K.E.1    Lighthall, J.2    Han, G.3    Lu, S.L.4    Li, A.5    Ju, W.6    Kulesz-Martin, M.7    Böttinger, E.8    Wang, X.J.9
  • 48
    • 0346724511 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and its implications for fibrosis
    • Kalluri, R., E. G. Neilson (2003) Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest 112:1776-1784.
    • (2003) J. Clin. Invest. , vol.112 , pp. 1776-1784
    • Kalluri, R.1    Neilson, E.G.2
  • 49
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • Kalluri, R., R. A. Weinberg (2009) The basics of epithelial-mesenchymal transition. J Clin Invest 119:1420-1428.
    • (2009) J. Clin. Invest. , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 50
    • 0038369998 scopus 로고    scopus 로고
    • A selfenabling TGF-β response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells
    • Kang, Y., C. R. Chen, J. Massagué (2003) A selfenabling TGF-β response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells. Mol Cell 11:915-926.
    • (2003) Mol. Cell. , vol.11 , pp. 915-926
    • Kang, Y.1    Chen, C.R.2    Massagué, J.3
  • 51
  • 52
    • 36248974666 scopus 로고    scopus 로고
    • The Mullerian duct: Recent insights into its development and regression
    • Klattig, J., C. Englert (2007) The Mullerian duct: recent insights into its development and regression. Sex Dev 1:271-278.
    • (2007) Sex Dev. , vol.1 , pp. 271-278
    • Klattig, J.1    Englert, C.2
  • 53
    • 65649153358 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition: A cancer researcher's conceptual friend and foe
    • Klymkowsky, M. W., P. Savagner (2009) Epithelial-mesenchymal transition: a cancer researcher's conceptual friend and foe. Am J Pathol 174:1588-1593.
    • (2009) Am. J. Pathol. , vol.174 , pp. 1588-1593
    • Klymkowsky, M.W.1    Savagner, P.2
  • 55
    • 55849123946 scopus 로고    scopus 로고
    • Micro-RNA-155 is regulated by the transforming growth factor-β/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA
    • Kong, W., H. Yang, L. He, J. J. Zhao, D. Coppola, W. S. Dalton, J. Q. Cheng (2008) Micro-RNA-155 is regulated by the transforming growth factor-β/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA. Mol Cell Biol 28:6773-6784.
    • (2008) Mol. Cell. Biol. , vol.28 , pp. 6773-6784
    • Kong, W.1    Yang, H.2    He, L.3    Zhao, J.J.4    Coppola, D.5    Dalton, W.S.6    Cheng, J.Q.7
  • 56
    • 34547587877 scopus 로고    scopus 로고
    • Cell size and invasion in TGF-β-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway
    • Lamouille, S., R. Derynck (2007) Cell size and invasion in TGF-β-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway. J Cell Biol 178:437-451.
    • (2007) J. Cell. Biol. , vol.178 , pp. 437-451
    • Lamouille, S.1    Derynck, R.2
  • 57
    • 70350418625 scopus 로고    scopus 로고
    • MTOR signaling at a glance
    • Laplante, M., D. M. Sabatini (2009) mTOR signaling at a glance. J Cell Sci 122:3589-3594.
    • (2009) J. Cell. Sci. , vol.122 , pp. 3589-3594
    • Laplante, M.1    Sabatini, D.M.2
  • 58
    • 27844461512 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in development and cancer: Role of phosphatidylinositol 3-kinase/AKT pathways
    • Larue, L., A. Bellacosa (2005) Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3-kinase/AKT pathways. Oncogene 24:7443-7454.
    • (2005) Oncogene , vol.24 , pp. 7443-7454
    • Larue, L.1    Bellacosa, A.2
  • 60
    • 1642307942 scopus 로고    scopus 로고
    • Integrinlinked kinase function is required for transforming growth factor-β-mediated epithelial to mesenchymal transition
    • Lee, Y. I., Y. J. Kwon, C. K. Joo (2004) Integrinlinked kinase function is required for transforming growth factor-β-mediated epithelial to mesenchymal transition. Biochem Biophys Res Commun 316:997-1001.
    • (2004) Biochem. Biophys. Res. Commun. , vol.316 , pp. 997-1001
    • Lee, Y.I.1    Kwon, Y.J.2    Joo, C.K.3
  • 61
    • 33646381642 scopus 로고    scopus 로고
    • 1-induced phenotypic modulation of 10T1/2 cells to smooth muscle cells
    • 1-induced phenotypic modulation of 10T1/2 cells to smooth muscle cells. Cell Signal 18:1270-1278.
    • (2006) Cell. Signal , vol.18 , pp. 1270-1278
    • Lien, S.C.1    Usami, S.2    Chien, S.3    Chiu, J.J.4
  • 63
    • 33750858427 scopus 로고    scopus 로고
    • Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways
    • Liu, L., F. Li, J. A. Cardelli, K. A. Martin, J. Blenis, S. Huang (2006) Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways. Oncogene 25:7029-7040.
    • (2006) Oncogene , vol.25 , pp. 7029-7040
    • Liu, L.1    Li, F.2    Cardelli, J.A.3    Martin, K.A.4    Blenis, J.5    Huang, S.6
  • 64
  • 65
    • 31144440253 scopus 로고    scopus 로고
    • Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning
    • Ma, L., M. F. Lu, R. J. Schwartz, J. F. Martin (2005) Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning. Development 132:5601-5611.
    • (2005) Development , vol.132 , pp. 5601-5611
    • Ma, L.1    Lu, M.F.2    Schwartz, R.J.3    Martin, J.F.4
  • 66
    • 78650511931 scopus 로고    scopus 로고
    • Smaddening complexity: The role of Smad3 in epithelial-myofibroblast transition
    • Masszi, A., A. Kapus (2011) Smaddening complexity: The role of Smad3 in epithelial-myofibroblast transition. Cells Tissues Organs 193:41-52.
    • (2011) Cells Tissues Organs , vol.193 , pp. 41-52
    • Masszi, A.1    Kapus, A.2
  • 67
    • 47749087950 scopus 로고    scopus 로고
    • Integrin-linked kinase - Essential roles in physiology and cancer biology
    • McDonald, P. C., A. B. Fielding, S. Dedhar (2008) Integrin-linked kinase - essential roles in physiology and cancer biology. J Cell Sci 121:3121-3132.
    • (2008) J. Cell. Sci. , vol.121 , pp. 3121-3132
    • McDonald, P.C.1    Fielding, A.B.2    Dedhar, S.3
  • 68
    • 40749086831 scopus 로고    scopus 로고
    • Transforming growth factor-β and hepatocyte transdifferentiation in liver fibrogenesis
    • Meindl-Beinker, N. M., S. Dooley (2008) Transforming growth factor-β and hepatocyte transdifferentiation in liver fibrogenesis. J Gastroenterol Hepatol 23 (suppl 1): S122-S127.
    • (2008) J. Gastroenterol. Hepatol. , vol.23 , Issue.1 SUPPL.
    • Meindl-Beinker, N.M.1    Dooley, S.2
  • 69
    • 34250695906 scopus 로고    scopus 로고
    • Multiple transforming growth factor-β isoforms and receptors function during epithelial-mesenchymal cell transformation in the embryonic heart
    • Mercado-Pimentel, M. E., R. B. Runyan (2007) Multiple transforming growth factor-β isoforms and receptors function during epithelial-mesenchymal cell transformation in the embryonic heart. Cells Tissues Organs 185:146-156.
    • (2007) Cells Tissues Organs , vol.185 , pp. 146-156
    • Mercado-Pimentel, M.E.1    Runyan, R.B.2
  • 70
    • 0028603343 scopus 로고
    • TGF-β induced transdifferentiation of mammary epithelial cells to mesenchymal cells: Involvement of type I receptors
    • Miettinen, P. J., R. Ebner, A. R. Lopez, R. Derynck (1994) TGF-β induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors. J Cell Biol 127:2021-2036.
    • (1994) J. Cell. Biol. , vol.127 , pp. 2021-2036
    • Miettinen, P.J.1    Ebner, R.2    Lopez, A.R.3    Derynck, R.4
  • 71
    • 74949093198 scopus 로고    scopus 로고
    • Transforming growth factor-β signaling in epithelial-mesenchymal transition and progression of cancer
    • Miyazono, K (2009) Transforming growth factor-β signaling in epithelial-mesenchymal transition and progression of cancer. Proc Jpn Acad Ser B Phys Biol Sci 85:314-323.
    • (2009) Proc. Jpn. Acad. Ser B Phys. Biol. Sci. , vol.85 , pp. 314-323
    • Miyazono, K.1
  • 72
    • 56749095797 scopus 로고    scopus 로고
    • Transcriptional regulation of cell polarity in EMT and cancer
    • Moreno-Bueno, G., F. Portillo, A. Cano (2008) Transcriptional regulation of cell polarity in EMT and cancer. Oncogene 27:6958-6969.
    • (2008) Oncogene , vol.27 , pp. 6958-6969
    • Moreno-Bueno, G.1    Portillo, F.2    Cano, A.3
  • 73
    • 24944497786 scopus 로고    scopus 로고
    • Non-Smad TGF-β signals
    • Moustakas, A., C. H. Heldin (2005) Non-Smad TGF-β signals. J Cell Sci 118:3573-3584.
    • (2005) J. Cell. Sci. , vol.118 , pp. 3573-3584
    • Moustakas, A.1    Heldin, C.H.2
  • 74
    • 34548175512 scopus 로고    scopus 로고
    • Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression
    • Moustakas, A., C. H. Heldin (2007) Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression. Cancer Sci 98:1512-1520.
    • (2007) Cancer Sci. , vol.98 , pp. 1512-1520
    • Moustakas, A.1    Heldin, C.H.2
  • 75
    • 0034141204 scopus 로고    scopus 로고
    • Mechanisms involved in valvuloseptal endocardial cushion formation in early cardiogenesis: Roles of transforming growth factor (TGF)-β and bone morphogenetic protein (BMP)
    • Nakajima, Y., T. Yamagishi, S. Hokari, H. Nakamura (2000) Mechanisms involved in valvuloseptal endocardial cushion formation in early cardiogenesis: roles of transforming growth factor (TGF)-β and bone morphogenetic protein (BMP). Anat Rec 258:119-127.
    • (2000) Anat Rec , vol.258 , pp. 119-127
    • Nakajima, Y.1    Yamagishi, T.2    Hokari, S.3    Nakamura, H.4
  • 76
    • 3342934231 scopus 로고    scopus 로고
    • Transforming growth factor-β (TGF-β) signaling in palatal growth, apoptosis and epithelial mesenchymal transformation (EMT)
    • Nawshad, A., D. LaGamba, E. D. Hay (2004) Transforming growth factor-β (TGF-β) signaling in palatal growth, apoptosis and epithelial mesenchymal transformation (EMT). Arch Oral Biol 49:675-689.
    • (2004) Arch. Oral Biol. , vol.49 , pp. 675-689
    • Nawshad, A.1    LaGamba, D.2    Hay, E.D.3
  • 77
    • 34247269026 scopus 로고    scopus 로고
    • Genetic determinants of cancer metastasis
    • Nguyen, D. X., J. Massagué (2007) Genetic determinants of cancer metastasis. Nat Rev Genet 8:341-352.
    • (2007) Nat. Rev. Genet. , vol.8 , pp. 341-352
    • Nguyen, D.X.1    Massagué, J.2
  • 78
    • 0032547895 scopus 로고    scopus 로고
    • TGF-β signaling is necessary for carcinoma cell invasiveness and metastasis
    • Oft, M., K. H. Heider, H. Beug (1998) TGF-β signaling is necessary for carcinoma cell invasiveness and metastasis. Curr Biol 8:1243-1252.
    • (1998) Curr. Biol. , vol.8 , pp. 1243-1252
    • Oft, M.1    Heider, K.H.2    Beug, H.3
  • 79
    • 14844364701 scopus 로고    scopus 로고
    • Regulation of the polarity protein Par6 by TGF-β receptors controls epithelial cell plasticity
    • Ozdamar, B., R. Bose, M. Barrios-Rodiles, H. R. Wang, Y Zhang, J. L. Wrana (2005) Regulation of the polarity protein Par6 by TGF-β receptors controls epithelial cell plasticity. Science 307:1603-1609.
    • (2005) Science , vol.307 , pp. 1603-1609
    • Ozdamar, B.1    Bose, R.2    Barrios-Rodiles, M.3    Wang, H.R.4    Zhang, Y.5    Wrana, J.L.6
  • 80
    • 58149236744 scopus 로고    scopus 로고
    • Roles of TGF-β in metastasis
    • Padua, D., J. Massagué (2009) Roles of TGF-β in metastasis. Cell Res 19:89-102.
    • (2009) Cell. Res. , vol.19 , pp. 89-102
    • Padua, D.1    Massagué, J.2
  • 81
    • 34249289041 scopus 로고    scopus 로고
    • Snail, Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype?
    • Peinado, H., D. Olmeda, A. Cano (2007) Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer 7:415-428.
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 415-428
    • Peinado, H.1    Olmeda, D.2    Cano, A.3
  • 82
  • 84
    • 0035920152 scopus 로고    scopus 로고
    • A new role for E12/E47 in the repression of E-cadherin expression and epithelialmesenchymal transitions
    • Perez-Moreno, M. A., A. Locascio, I. Rodrigo, G. Dhondt, F. Portillo, M. A. Nieto, A. Cano (2001) A new role for E12/E47 in the repression of E-cadherin expression and epithelialmesenchymal transitions. J Biol Chem 276:27424-27431.
    • (2001) J. Biol. Chem. , vol.276 , pp. 27424-27431
    • Perez-Moreno, M.A.1    Locascio, A.2    Rodrigo, I.3    Dhondt, G.4    Portillo, F.5    Nieto, M.A.6    Cano, A.7
  • 85
    • 23144464750 scopus 로고    scopus 로고
    • Id family of helix-loop-helix proteins in cancer
    • Perk, J., A. Iavarone, R. Benezra (2005) Id family of helix-loop-helix proteins in cancer. Nat Rev Cancer 5:603-614.
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 603-614
    • Perk, J.1    Iavarone, A.2    Benezra, R.3
  • 86
    • 0033377867 scopus 로고    scopus 로고
    • TGF-β type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells
    • Piek, E., A. Moustakas, A. Kurisaki, C. H. Heldin, P. ten Dijke (1999) TGF-β type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells. J Cell Sci 112:4557-4568.
    • (1999) J. Cell. Sci. , vol.112 , pp. 4557-4568
    • Piek, E.1    Moustakas, A.2    Kurisaki, A.3    Heldin, C.H.4    Ten Dijke, P.5
  • 87
    • 53049108469 scopus 로고    scopus 로고
    • P70 S6 kinase promotes epithelial to mesenchymal transition through snail induction in ovarian cancer cells
    • Pon, Y. L., HY. Zhou, A. N. Cheung, HY. Ngan, A. S. Wong (2008) p70 S6 kinase promotes epithelial to mesenchymal transition through snail induction in ovarian cancer cells. Cancer Res 68:6524-6532.
    • (2008) Cancer Res. , vol.68 , pp. 6524-6532
    • Pon, Y.L.1    Zhou, H.Y.2    Cheung, A.N.3    Ngan, H.Y.4    Wong, A.S.5
  • 88
    • 0031817391 scopus 로고    scopus 로고
    • Transforming growth factor-β is essential for spindle cell conversion of mouse skin carcinoma in vivo: Implications for tumor invasion
    • Portella, G., S. A. Cumming, J. Liddell, W. Cui, H. Ireland, R. J. Akhurst, A. Balmain (1998) Transforming growth factor-β is essential for spindle cell conversion of mouse skin carcinoma in vivo: implications for tumor invasion. Cell Growth Differ 9:393-404.
    • (1998) Cell. Growth Differ , vol.9 , pp. 393-404
    • Portella, G.1    Cumming, S.A.2    Liddell, J.3    Cui, W.4    Ireland, H.5    Akhurst, R.J.6    Balmain, A.7
  • 89
    • 34347262496 scopus 로고    scopus 로고
    • Metastatic potential of 21T human breast cancer cells depends on Akt/protein kinase B activation
    • Qiao, M., J. D. Iglehart, A. B. Pardee (2007) Metastatic potential of 21T human breast cancer cells depends on Akt/protein kinase B activation. Cancer Res 67:5293-5299.
    • (2007) Cancer Res. , vol.67 , pp. 5293-5299
    • Qiao, M.1    Iglehart, J.D.2    Pardee, A.B.3
  • 90
    • 73449138471 scopus 로고    scopus 로고
    • Translation initiation: A critical signaling node in cancer
    • Robert, F., J. Pelletier (2009) Translation initiation: a critical signaling node in cancer. Expert Opin Ther Targets 13:1279-1293.
    • (2009) Expert Opin. Ther. Targets , vol.13 , pp. 1279-1293
    • Robert, F.1    Pelletier, J.2
  • 92
    • 0042347689 scopus 로고    scopus 로고
    • Id proteins in development, cell cycle and cancer
    • Ruzinova, M. B., R. Benezra (2003) Id proteins in development, cell cycle and cancer. Trends Cell Biol 13:410-418.
    • (2003) Trends Cell. Biol. , vol.13 , pp. 410-418
    • Ruzinova, M.B.1    Benezra, R.2
  • 93
    • 33748776858 scopus 로고    scopus 로고
    • 1-induced epithelial mesenchymal transdifferentiation of mouse transformed keratinocytes
    • 1-induced epithelial mesenchymal transdifferentiation of mouse transformed keratinocytes. FEBS Lett 580:5385-5391.
    • (2006) FEBS Lett. , vol.580 , pp. 5385-5391
    • Santibanez, J.F.1
  • 94
    • 3342895823 scopus 로고    scopus 로고
    • Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
    • Sarbassov, D. D., S. M. Ali, D. H. Kim, D. A. Guertin, R. R. Latek, H. Erdjument-Bromage, P. Tempst, D. M. Sabatini (2004) Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol 14:1296-1302.
    • (2004) Curr. Biol. , vol.14 , pp. 1296-1302
    • Sarbassov, D.D.1    Ali, S.M.2    Kim, D.H.3    Guertin, D.A.4    Latek, R.R.5    Erdjument-Bromage, H.6    Tempst, P.7    Sabatini, D.M.8
  • 95
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • Sarbassov, D. D., D. A. Guertin, S. M. Ali, D. M. Sabatini (2005) Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307:1098-1101.
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 96
    • 24344489479 scopus 로고    scopus 로고
    • E-cadherin is regulated by the transcriptional repressor SLUG during Ras-mediated transformation of intestinal epithelial cells
    • Schmidt, C. R., Y. J. Gi, T. A. Patel, R. J. Coffey, R. D. Beauchamp, A. S. Pearson (2005) E-cadherin is regulated by the transcriptional repressor SLUG during Ras-mediated transformation of intestinal epithelial cells. Surgery 138:306-312.
    • (2005) Surgery , vol.138 , pp. 306-312
    • Schmidt, C.R.1    Gi, Y.J.2    Patel, T.A.3    Coffey, R.J.4    Beauchamp, R.D.5    Pearson, A.S.6
  • 98
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-β signaling from cell membrane to the nucleus
    • Shi, Y., J. Massagué (2003) Mechanisms of TGF-β signaling from cell membrane to the nucleus. Cell 113:685-700.
    • (2003) Cell. , vol.113 , pp. 685-700
    • Shi, Y.1    Massagué, J.2
  • 99
    • 34548496683 scopus 로고    scopus 로고
    • Differential regulation of epithelial and mesenchymal markers by deltaEF1 proteins in epithelial mesenchymal transition induced by TGF-β
    • Shirakihara, T., M. Saitoh, K. Miyazono (2007) Differential regulation of epithelial and mesenchymal markers by deltaEF1 proteins in epithelial mesenchymal transition induced by TGF-β. Mol Biol Cell 18:3533-3544.
    • (2007) Mol. Biol. Cell. , vol.18 , pp. 3533-3544
    • Shirakihara, T.1    Saitoh, M.2    Miyazono, K.3
  • 101
    • 33646862859 scopus 로고    scopus 로고
    • TGF-β-mediated RhoA expression is necessary for epithelialmesenchymal transition in the embryonic chick heart
    • Tavares, A. L., M. E. Mercado-Pimentel, R. B. Runyan, G. T. Kitten (2006) TGF-β-mediated RhoA expression is necessary for epithelialmesenchymal transition in the embryonic chick heart. Dev Dyn 235:1589-1598.
    • (2006) Dev. Dyn , vol.235 , pp. 1589-1598
    • Tavares, A.L.1    Mercado-Pimentel, M.E.2    Runyan, R.B.3    Kitten, G.T.4
  • 102
    • 34447319929 scopus 로고    scopus 로고
    • BMP4 induces EMT and Rho GTPase activation in human ovarian cancer cells
    • Theriault, B. L., T. G. Shepherd, M. L. Mujoomdar, MW. Nachtigal (2007) BMP4 induces EMT and Rho GTPase activation in human ovarian cancer cells. Carcinogenesis 28:1153-1162.
    • (2007) Carcinogenesis , vol.28 , pp. 1153-1162
    • Theriault, B.L.1    Shepherd, T.G.2    Mujoomdar, M.L.3    Nachtigal, M.W.4
  • 103
    • 0344845003 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and pathologies
    • Thiery, J. P (2003) Epithelial-mesenchymal transitions in development and pathologies. Curr Opin Cell Biol 15:740-746.
    • (2003) Curr. Opin. Cell. Biol. , vol.15 , pp. 740-746
    • Thiery, J.P.1
  • 104
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery, J. P, H. Acloque, RY. Huang, M. A. Nieto (2009) Epithelial-mesenchymal transitions in development and disease. Cell 139:871-890.
    • (2009) Cell. , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 105
    • 33244463813 scopus 로고    scopus 로고
    • Complex networks orchestrate epithelial-mesenchymal transitions
    • Thiery, J. P., J. P. Sleeman (2006) Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol 7:131-142.
    • (2006) Nat. Rev. Mol. Cell. Biol. , vol.7 , pp. 131-142
    • Thiery, J.P.1    Sleeman, J.P.2
  • 108
    • 16344378397 scopus 로고    scopus 로고
    • TGF-β and the Smad signaling pathway support transcriptomic reprogramming during epithelialmesenchymal cell transition
    • Valcourt, U., M. Kowanetz, H. Niimi, C. H. Heldin, A. Moustakas (2005) TGF-β and the Smad signaling pathway support transcriptomic reprogramming during epithelialmesenchymal cell transition. Mol Biol Cell 16:1987-2002.
    • (2005) Mol. Biol. Cell. , vol.16 , pp. 1987-2002
    • Valcourt, U.1    Kowanetz, M.2    Niimi, H.3    Heldin, C.H.4    Moustakas, A.5
  • 109
    • 15744394838 scopus 로고    scopus 로고
    • LIM-kinase 2 and cofilin phosphorylation mediate actin cytoskeleton reorganization induced by transforming growth factor-β
    • Vardouli, L., A. Moustakas, C. Stournaras (2005) LIM-kinase 2 and cofilin phosphorylation mediate actin cytoskeleton reorganization induced by transforming growth factor-β. J Biol Chem 280:11448-11457.
    • (2005) J. Biol. Chem. , vol.280 , pp. 11448-11457
    • Vardouli, L.1    Moustakas, A.2    Stournaras, C.3
  • 111
    • 34548411746 scopus 로고    scopus 로고
    • TGF-β-induced EMT: Mechanisms and implications for fibrotic lung disease
    • Willis, B. C., Z. Borok (2007) TGF-β-induced EMT: mechanisms and implications for fibrotic lung disease. Am J Physiol Lung Cell Mol Physiol 293: L525-L534.
    • (2007) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.293
    • Willis, B.C.1    Borok, Z.2
  • 112
    • 67650225263 scopus 로고    scopus 로고
    • Essential role of TGF-β signaling in glucose-induced cell hypertrophy
    • Wu, L., R. Derynck (2009) Essential role of TGF-β signaling in glucose-induced cell hypertrophy. Dev Cell 17:35-48.
    • (2009) Dev. Cell. , vol.17 , pp. 35-48
    • Wu, L.1    Derynck, R.2
  • 114
    • 59449090107 scopus 로고    scopus 로고
    • TGF-β-induced epithelial to mesenchymal transition
    • Xu, J., S. Lamouille, R. Derynck (2009) TGF-β-induced epithelial to mesenchymal transition. Cell Res 19:156-172.
    • (2009) Cell. Res. , vol.19 , pp. 156-172
    • Xu, J.1    Lamouille, S.2    Derynck, R.3
  • 115
    • 52049111663 scopus 로고    scopus 로고
    • TRAF6 mediates Smadindependent activation of JNK and p38 by TGF-β
    • Yamashita, M., K. Fatyol, C. Jin, X. Wang, Z. Liu, Y. E. Zhang (2008) TRAF6 mediates Smadindependent activation of JNK and p38 by TGF-β. Mol Cell 31:918-924.
    • (2008) Mol. Cell. , vol.31 , pp. 918-924
    • Yamashita, M.1    Fatyol, K.2    Jin, C.3    Wang, X.4    Liu, Z.5    Zhang, Y.E.6
  • 118
    • 15444372825 scopus 로고    scopus 로고
    • Type I transforming growth factor-β receptor binds to and activates phosphatidylinositol 3-kinase
    • Yi, J. Y., I. Shin, C. L. Arteaga (2005) Type I transforming growth factor-β receptor binds to and activates phosphatidylinositol 3-kinase. J Biol Chem 280:10870-10876.
    • (2005) J. Biol. Chem. , vol.280 , pp. 10870-10876
    • Yi, J.Y.1    Shin, I.2    Arteaga, C.L.3
  • 119
    • 65349132693 scopus 로고    scopus 로고
    • EMT, the cytoskeleton, and cancer cell invasion
    • Yilmaz, M., G. Christofori (2009) EMT, the cytoskeleton, and cancer cell invasion. Cancer Metastasis Rev 28:15-33.
    • (2009) Cancer Metastasis Rev. , vol.28 , pp. 15-33
    • Yilmaz, M.1    Christofori, G.2
  • 120
    • 0037099745 scopus 로고    scopus 로고
    • TGF-β receptor-activated p38 MAP kinase mediates Smad-independent TGF-β responses
    • Yu, L., M. C. Hebert, Y. E. Zhang (2002) TGF-β receptor-activated p38 MAP kinase mediates Smad-independent TGF-β responses. EMBO J 21:3749-3759.
    • (2002) EMBO J. , vol.21 , pp. 3749-3759
    • Yu, L.1    Hebert, M.C.2    Zhang, Y.E.3
  • 121
    • 24644487312 scopus 로고    scopus 로고
    • TGF-β and epithelial-to-mesenchymal transitions
    • Zavadil, J., E. P. Böttinger (2005) TGF-β and epithelial-to-mesenchymal transitions. Oncogene 24:5764-5774.
    • (2005) Oncogene , vol.24 , pp. 5764-5774
    • Zavadil, J.1    Böttinger, E.P.2
  • 124
    • 67650996754 scopus 로고    scopus 로고
    • Biomarkers for epithelial-mesenchymal transitions
    • Zeisberg, M., E. G. Neilson (2009) Biomarkers for epithelial-mesenchymal transitions. J Clin Invest 119:1429-1437.
    • (2009) J. Clin. Invest. , vol.119 , pp. 1429-1437
    • Zeisberg, M.1    Neilson, E.G.2
  • 125
    • 14844290237 scopus 로고    scopus 로고
    • Bone morphogenic protein-7 induces mesenchymal to epithelial transition in adult renal fibroblasts and facilitates regeneration of injured kidney
    • Zeisberg, M., A. A. Shah, R. Kalluri (2005) Bone morphogenic protein-7 induces mesenchymal to epithelial transition in adult renal fibroblasts and facilitates regeneration of injured kidney. J Biol Chem 280:8094-8100.
    • (2005) J. Biol. Chem. , vol.280 , pp. 8094-8100
    • Zeisberg, M.1    Shah, A.A.2    Kalluri, R.3
  • 126
    • 5444269904 scopus 로고    scopus 로고
    • Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition
    • Zhou, B. P., J. Deng, W. Xia, J. Xu, Y. M. Li, M. Gunduz, M. C. Hung (2004) Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat Cell Biol 6:93-940.
    • (2004) Nat. Cell. Biol. , vol.6 , pp. 93-940
    • Zhou, B.P.1    Deng, J.2    Xia, W.3    Xu, J.4    Li, Y.M.5    Gunduz, M.6    Hung, M.C.7


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