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Volumn 580, Issue 22, 2006, Pages 5385-5391

JNK mediates TGF-β1-induced epithelial mesenchymal transdifferentiation of mouse transformed keratinocytes

Author keywords

EMT; JNK; Keratinocytes; TGF 1; uPA

Indexed keywords

ACTIN; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ANTISENSE OLIGODEOXYNUCLEOTIDE; FIBRONECTIN; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE 1; TRANSFORMING GROWTH FACTOR BETA1; UROKINASE; UVOMORULIN; VIMENTIN;

EID: 33748776858     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2006.09.003     Document Type: Article
Times cited : (93)

References (36)
  • 1
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D., and Weinberg R.A. The hallmarks of cancer. Cell 100 1 (2000) 57-70
    • (2000) Cell , vol.100 , Issue.1 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 0035906987 scopus 로고    scopus 로고
    • Epithelial mesenchymal interactions in cancer development
    • Martinez-Arias A. Epithelial mesenchymal interactions in cancer development. Cell 105 (2001) 425-431
    • (2001) Cell , vol.105 , pp. 425-431
    • Martinez-Arias, A.1
  • 3
    • 0034678908 scopus 로고    scopus 로고
    • Transcriptional control by the TGF-beta/Smad signaling system
    • Massague J., and Wotton D. Transcriptional control by the TGF-beta/Smad signaling system. EMBO J. 19 8 (2003) 1745-1754
    • (2003) EMBO J. , vol.19 , Issue.8 , pp. 1745-1754
    • Massague, J.1    Wotton, D.2
  • 4
    • 0036587571 scopus 로고    scopus 로고
    • Transforming growth factor beta signal transduction
    • Dennler S., Goumans M.J., and ten Dijke P. Transforming growth factor beta signal transduction. J. Leukoc. Biol. 71 5 (2002) 731-740
    • (2002) J. Leukoc. Biol. , vol.71 , Issue.5 , pp. 731-740
    • Dennler, S.1    Goumans, M.J.2    ten Dijke, P.3
  • 5
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-beta signaling from cell membrane to the nucleus
    • Shi Y., and Massague J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 113 6 (2003) 685-700
    • (2003) Cell , vol.113 , Issue.6 , pp. 685-700
    • Shi, Y.1    Massague, J.2
  • 6
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-independent pathways in TGF-beta family signalling
    • Derynck R., and Zhang Y.E. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 425 6958 (2003) 577-584
    • (2003) Nature , vol.425 , Issue.6958 , pp. 577-584
    • Derynck, R.1    Zhang, Y.E.2
  • 7
    • 0026612306 scopus 로고
    • Activation of p21ras by transforming growth factor beta in epithelial cells
    • Mulder K.M., and Morris S.L. Activation of p21ras by transforming growth factor beta in epithelial cells. J. Biol. Chem. 267 8 (1992) 5029-5031
    • (1992) J. Biol. Chem. , vol.267 , Issue.8 , pp. 5029-5031
    • Mulder, K.M.1    Morris, S.L.2
  • 8
    • 0034710545 scopus 로고    scopus 로고
    • Blockade of Smad4 in transformed keratinocytes containing a Ras oncogene leads to hyperactivation of the Ras-dependent Erk signalling pathway associated with progression to undifferentiated carcinomas
    • Iglesias M., Frontelo P., Gamallo C., and Quintanilla M. Blockade of Smad4 in transformed keratinocytes containing a Ras oncogene leads to hyperactivation of the Ras-dependent Erk signalling pathway associated with progression to undifferentiated carcinomas. Oncogene 19 36 (2000) 4134-4145
    • (2000) Oncogene , vol.19 , Issue.36 , pp. 4134-4145
    • Iglesias, M.1    Frontelo, P.2    Gamallo, C.3    Quintanilla, M.4
  • 9
    • 0030751329 scopus 로고    scopus 로고
    • MT, Mulder KM. 1997. Transforming growth factor-beta signaling in epithelial cells. Pharmacol Ther. 75(1):21-41.
  • 10
    • 0343517552 scopus 로고    scopus 로고
    • Involvement of the Ras/MAPK signaling pathway in the modulation of urokinase production and cellular invasiveness by transforming growth factor-beta(1) in transformed keratinocytes
    • Santibanez J.F., Iglesias M., Frontelo P., Martinez J., and Quintanilla M. Involvement of the Ras/MAPK signaling pathway in the modulation of urokinase production and cellular invasiveness by transforming growth factor-beta(1) in transformed keratinocytes. Biochem. Biophys. Res. Commun. 273 2 (2000) 521-527
    • (2000) Biochem. Biophys. Res. Commun. , vol.273 , Issue.2 , pp. 521-527
    • Santibanez, J.F.1    Iglesias, M.2    Frontelo, P.3    Martinez, J.4    Quintanilla, M.5
  • 11
    • 0031059867 scopus 로고    scopus 로고
    • Involvement of extracellular signal-regulated kinase 2 and stress-activated protein kinase/Jun N-terminal kinase activation by transforming growth factor β in the negative growth control of breast cancer cells
    • Frey R.S., and Mulder K.M. Involvement of extracellular signal-regulated kinase 2 and stress-activated protein kinase/Jun N-terminal kinase activation by transforming growth factor β in the negative growth control of breast cancer cells. Cancer Res. 57 (1997) 628-633
    • (1997) Cancer Res. , vol.57 , pp. 628-633
    • Frey, R.S.1    Mulder, K.M.2
  • 12
    • 0033531954 scopus 로고    scopus 로고
    • Hematopoietic progenitor kinase 1 is a component of transforming growth factor beta-induced c-Jun N-terminal kinase signaling cascade
    • Zhou G., Lee S.C., Yao Z., and Tan T.H. Hematopoietic progenitor kinase 1 is a component of transforming growth factor beta-induced c-Jun N-terminal kinase signaling cascade. J. Biol. Chem. 274 19 (1999) 13133-13138
    • (1999) J. Biol. Chem. , vol.274 , Issue.19 , pp. 13133-13138
    • Zhou, G.1    Lee, S.C.2    Yao, Z.3    Tan, T.H.4
  • 13
    • 0042307513 scopus 로고    scopus 로고
    • The two faces of transforming growth factor beta in carcinogenesis
    • Roberts A.B., and Wakefield L.M. The two faces of transforming growth factor beta in carcinogenesis. Proc. Natl. Acad. Sci. USA 100 15 (2003) 8621-8623
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , Issue.15 , pp. 8621-8623
    • Roberts, A.B.1    Wakefield, L.M.2
  • 14
    • 0032547895 scopus 로고    scopus 로고
    • TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis
    • Oft M., Heider K.H., and Beug H. TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis. Curr. Biol. 8 23 (1998) 1243-1252
    • (1998) Curr. Biol. , vol.8 , Issue.23 , pp. 1243-1252
    • Oft, M.1    Heider, K.H.2    Beug, H.3
  • 15
    • 0029101527 scopus 로고
    • Chronic exposure of cultured transformed mouse epidermal cells to transforming growth factor-beta 1 induces an epithelial-mesenchymal transdifferentiation and a spindle tumoral phenotype
    • Caulin C., Scholl F.G., Frontelo P., Gamallo C., and Quintanilla M. Chronic exposure of cultured transformed mouse epidermal cells to transforming growth factor-beta 1 induces an epithelial-mesenchymal transdifferentiation and a spindle tumoral phenotype. Cell Growth Differ. 6 8 (1995) 1027-1035
    • (1995) Cell Growth Differ. , vol.6 , Issue.8 , pp. 1027-1035
    • Caulin, C.1    Scholl, F.G.2    Frontelo, P.3    Gamallo, C.4    Quintanilla, M.5
  • 16
    • 0029662049 scopus 로고    scopus 로고
    • TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells
    • Oft M., Peli J., Rudaz C., Schwarz H., Beug H., and Reichmann E. TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells. Genes Dev. 10 19 (1996) 2462-2477
    • (1996) Genes Dev. , vol.10 , Issue.19 , pp. 2462-2477
    • Oft, M.1    Peli, J.2    Rudaz, C.3    Schwarz, H.4    Beug, H.5    Reichmann, E.6
  • 17
    • 0028981659 scopus 로고
    • Heterodimerization of c-Jun with ATF-2 and c-Fos is required for positive and negative regulation of the human urokinase enhancer
    • De Cesare D., Vallone D., Caracciolo A., Sassone-Corsi P., Nerlov C., and Verde P. Heterodimerization of c-Jun with ATF-2 and c-Fos is required for positive and negative regulation of the human urokinase enhancer. Oncogene 11 2 (1995) 365-376
    • (1995) Oncogene , vol.11 , Issue.2 , pp. 365-376
    • De Cesare, D.1    Vallone, D.2    Caracciolo, A.3    Sassone-Corsi, P.4    Nerlov, C.5    Verde, P.6
  • 18
    • 0030978840 scopus 로고    scopus 로고
    • Transcriptional activation of the matrix metalloproteinase-9 gene in an H-ras and v-myc transformed rat embryo cell line
    • Himelstein B.P., Lee E.J., Sato H., Seiki M., and Muschel R.J. Transcriptional activation of the matrix metalloproteinase-9 gene in an H-ras and v-myc transformed rat embryo cell line. Oncogene 14 16 (1997) 1995-1998
    • (1997) Oncogene , vol.14 , Issue.16 , pp. 1995-1998
    • Himelstein, B.P.1    Lee, E.J.2    Sato, H.3    Seiki, M.4    Muschel, R.J.5
  • 19
    • 0030605403 scopus 로고    scopus 로고
    • The regulation of AP-1 activity by mitogen-activated protein kinases
    • Karin M. The regulation of AP-1 activity by mitogen-activated protein kinases. Philos. Trans. R Soc. Lond. B Biol. Sci. 351 1336 (1996) 127-134
    • (1996) Philos. Trans. R Soc. Lond. B Biol. Sci. , vol.351 , Issue.1336 , pp. 127-134
    • Karin, M.1
  • 20
    • 0033377867 scopus 로고    scopus 로고
    • TGF-(beta) type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells
    • Piek E., Moustakas A., Kurisaki A., Heldin C.H., and ten Dijke P. TGF-(beta) type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells. J. Cell Sci. 112 Pt 24 (1999) 4557-4568
    • (1999) J. Cell Sci. , vol.112 , Issue.PART 24 , pp. 4557-4568
    • Piek, E.1    Moustakas, A.2    Kurisaki, A.3    Heldin, C.H.4    ten Dijke, P.5
  • 21
    • 0036304111 scopus 로고    scopus 로고
    • Metastasis is driven by sequential elevation of H-ras and Smad2 levels
    • Oft M., Akhurst R.J., and Balmain A. Metastasis is driven by sequential elevation of H-ras and Smad2 levels. Nat. Cell Biol. 4 7 (2002) 487-494
    • (2002) Nat. Cell Biol. , vol.4 , Issue.7 , pp. 487-494
    • Oft, M.1    Akhurst, R.J.2    Balmain, A.3
  • 22
    • 0026602416 scopus 로고
    • Expression of simple epithelial cytokeratins in mouse epidermal keratinocytes harboring Harvey ras gene alterations
    • Diaz-Guerra M., Haddow S., Bauluz C., Jorcano J.L., Cano A., Balmain A., and Quintanilla M. Expression of simple epithelial cytokeratins in mouse epidermal keratinocytes harboring Harvey ras gene alterations. Cancer Res. 52 3 (1992) 680-687
    • (1992) Cancer Res. , vol.52 , Issue.3 , pp. 680-687
    • Diaz-Guerra, M.1    Haddow, S.2    Bauluz, C.3    Jorcano, J.L.4    Cano, A.5    Balmain, A.6    Quintanilla, M.7
  • 23
    • 0036595629 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in tumour progression
    • Thiery J.P. Epithelial-mesenchymal transitions in tumour progression. Nat. Rev. Cancer 2 6 (2002) 442-454
    • (2002) Nat. Rev. Cancer , vol.2 , Issue.6 , pp. 442-454
    • Thiery, J.P.1
  • 24
    • 0034668172 scopus 로고    scopus 로고
    • Induction and regulation of epithelial-mesenchymal transitions
    • Boyer B., Valles A.M., and Edme N. Induction and regulation of epithelial-mesenchymal transitions. Biochem. Pharmacol. 60 8 (2000) 1091-1099
    • (2000) Biochem. Pharmacol. , vol.60 , Issue.8 , pp. 1091-1099
    • Boyer, B.1    Valles, A.M.2    Edme, N.3
  • 25
    • 0347052797 scopus 로고    scopus 로고
    • Molecular aspects of epithelial cell plasticity: implications for local tumor invasion and metastasis
    • Review
    • Gotzmann J., Mikula M., Eger A., Schulte-Hermann R., Foisner R., Beug H., and Mikulits W. Molecular aspects of epithelial cell plasticity: implications for local tumor invasion and metastasis. Mutat. Res. 566 1 (2004) 9-20 Review
    • (2004) Mutat. Res. , vol.566 , Issue.1 , pp. 9-20
    • Gotzmann, J.1    Mikula, M.2    Eger, A.3    Schulte-Hermann, R.4    Foisner, R.5    Beug, H.6    Mikulits, W.7
  • 26
    • 1842421169 scopus 로고    scopus 로고
    • Requirement of TGF-beta receptor-dependent activation of c-Jun N-terminal kinases (JNKs)/stress-activated protein kinases (Sapks) for TGF-beta up-regulation of the urokinase-type plasminogen activator receptor
    • Yue J., Sun B., Liu G., and Mulder K.M. Requirement of TGF-beta receptor-dependent activation of c-Jun N-terminal kinases (JNKs)/stress-activated protein kinases (Sapks) for TGF-beta up-regulation of the urokinase-type plasminogen activator receptor. J. Cell Physiol. 199 2 (2004) 284-292
    • (2004) J. Cell Physiol. , vol.199 , Issue.2 , pp. 284-292
    • Yue, J.1    Sun, B.2    Liu, G.3    Mulder, K.M.4
  • 27
    • 0037423374 scopus 로고    scopus 로고
    • Elucidation of Smad requirement in transforming growth factor-beta type I receptor-induced responses
    • Itoh S., Thorikay M., Kowanetz M., Moustakas A., Itoh F., Heldin C.H., and ten Dijke P. Elucidation of Smad requirement in transforming growth factor-beta type I receptor-induced responses. J. Biol. Chem. 278 6 (2003) 3751-3761
    • (2003) J. Biol. Chem. , vol.278 , Issue.6 , pp. 3751-3761
    • Itoh, S.1    Thorikay, M.2    Kowanetz, M.3    Moustakas, A.4    Itoh, F.5    Heldin, C.H.6    ten Dijke, P.7
  • 28
    • 1542305671 scopus 로고    scopus 로고
    • Transforming growth factor-beta1-dependent urokinase up-regulation and promotion of invasion are involved in Src-MAPK-dependent signaling in human ovarian cancer cells
    • Tanaka Y., Kobayashi H., Suzuki M., Kanayama N., and Terao T. Transforming growth factor-beta1-dependent urokinase up-regulation and promotion of invasion are involved in Src-MAPK-dependent signaling in human ovarian cancer cells. J. Biol. Chem. 279 10 (2004) 8567-8576
    • (2004) J. Biol. Chem. , vol.279 , Issue.10 , pp. 8567-8576
    • Tanaka, Y.1    Kobayashi, H.2    Suzuki, M.3    Kanayama, N.4    Terao, T.5
  • 29
    • 0031857536 scopus 로고    scopus 로고
    • UV irradiation induces the murine urokinase-type plasminogen activator gene via the c-Jun N-terminal kinase signaling pathway: requirement of an AP1 enhancer element
    • Miralles F., Parra M., Caelles C., Nagamine Y., Felez J., and Munoz-Canoves P. UV irradiation induces the murine urokinase-type plasminogen activator gene via the c-Jun N-terminal kinase signaling pathway: requirement of an AP1 enhancer element. Mol. Cell Biol. 18 8 (1998) 4537-4547
    • (1998) Mol. Cell Biol. , vol.18 , Issue.8 , pp. 4537-4547
    • Miralles, F.1    Parra, M.2    Caelles, C.3    Nagamine, Y.4    Felez, J.5    Munoz-Canoves, P.6
  • 30
    • 0033104505 scopus 로고    scopus 로고
    • TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway
    • Hocevar B.A., Brown T.L., and Howe P.H. TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway. EMBO J. 18 5 (1999) 1345-1356
    • (1999) EMBO J. , vol.18 , Issue.5 , pp. 1345-1356
    • Hocevar, B.A.1    Brown, T.L.2    Howe, P.H.3
  • 31
    • 0034704889 scopus 로고    scopus 로고
    • The p150-Spir protein provides a link between c-Jun N-terminal kinase function and actin reorganization
    • Otto I.M., Raabe T., Rennefahrt U.E., Bork P., Rapp U.R., and Kerkhoff E. The p150-Spir protein provides a link between c-Jun N-terminal kinase function and actin reorganization. Curr. Biol. 10 6 (2000) 345-348
    • (2000) Curr. Biol. , vol.10 , Issue.6 , pp. 345-348
    • Otto, I.M.1    Raabe, T.2    Rennefahrt, U.E.3    Bork, P.4    Rapp, U.R.5    Kerkhoff, E.6
  • 32
    • 0035495401 scopus 로고    scopus 로고
    • Putting tumours in context
    • Bissell M.J., and Radisky D. Putting tumours in context. Nat. Rev. Cancer. 1 1 (2001) 46-54
    • (2001) Nat. Rev. Cancer. , vol.1 , Issue.1 , pp. 46-54
    • Bissell, M.J.1    Radisky, D.2
  • 33
    • 0033079605 scopus 로고    scopus 로고
    • The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene
    • Christofori G., and Semb H. The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene. Trends Biochem. Sci. 24 2 (1999) 73-76
    • (1999) Trends Biochem. Sci. , vol.24 , Issue.2 , pp. 73-76
    • Christofori, G.1    Semb, H.2
  • 34
    • 0028245813 scopus 로고
    • Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness
    • Birchmeier W., and Behrens J. Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness. Biochim. Biophys. Acta. 1198 1 (1994) 11-26
    • (1994) Biochim. Biophys. Acta. , vol.1198 , Issue.1 , pp. 11-26
    • Birchmeier, W.1    Behrens, J.2
  • 35
    • 0035147248 scopus 로고    scopus 로고
    • Co-expression of tenascin-C and vimentin in human breast cancer cells indicates phenotypic transdifferentiation during tumour progression: correlation with histopathological parameters, hormone receptors, and oncoproteins
    • Dandachi N., Hauser-Kronberger C., More E., Wiesener B., Hacker G.W., Dietze O., and Wirl G. Co-expression of tenascin-C and vimentin in human breast cancer cells indicates phenotypic transdifferentiation during tumour progression: correlation with histopathological parameters, hormone receptors, and oncoproteins. J. Pathol. 193 2 (2001) 181-189
    • (2001) J. Pathol. , vol.193 , Issue.2 , pp. 181-189
    • Dandachi, N.1    Hauser-Kronberger, C.2    More, E.3    Wiesener, B.4    Hacker, G.W.5    Dietze, O.6    Wirl, G.7
  • 36
    • 0032530921 scopus 로고    scopus 로고
    • Activation of p38 MAP kinase and JNK but not ERK is required for erythropoietin-induced erythroid differentiation
    • Nagata Y., Takahashi N., Davis R.J., and Todokoro K. Activation of p38 MAP kinase and JNK but not ERK is required for erythropoietin-induced erythroid differentiation. Blood 92 6 (1998) 1859-1869
    • (1998) Blood , vol.92 , Issue.6 , pp. 1859-1869
    • Nagata, Y.1    Takahashi, N.2    Davis, R.J.3    Todokoro, K.4


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