Nonviral gene transfer as a tool for studying transcription regulation of xenobiotic metabolizing enzymes

Advanced Drug Delivery Reviews

Volumn 62, Issue 13, 2010, Pages 1250-1256

  Bonamassa, Barbara ^a   Liu, Dexi ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Cationic lipid; Drug metabolism; Electroporation; Gene delivery; Hydrodynamic gene delivery; Nonviral vector; Nuclear receptor; Transcription factor; Xenobiotics

Indexed keywords

CATIONIC LIPIDS; DRUG METABOLISMS; ELECTROPORATION; GENE DELIVERY; NONVIRAL VECTORS; NUCLEAR RECEPTORS; XENOBIOTICS;

BIOCHEMISTRY; CATALYSTS; ENZYMES; FLUID DYNAMICS; GENE THERAPY; GENE TRANSFER; HYDRODYNAMICS; METABOLISM; PHYSIOLOGY; TRANSCRIPTION FACTORS;

TRANSCRIPTION;

CALCIUM PHOSPHATE; CELL NUCLEUS RECEPTOR; CHITOSAN; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450; CYTOCHROME P450 2C9; DEXTRAN; DRUG METABOLIZING ENZYME; HISTONE; LIPOPLEX; LIPOSOME; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PLASMID DNA; POLYAMIDOAMINE; POLYETHYLENEIMINE; POLYLYSINE; PREGNANE X RECEPTOR; PROTAMINE; SMALL INTERFERING RNA; XENOBIOTIC AGENT;

ELECTROPORATION; GENE CONTROL; GENE EXPRESSION; GENE GUN; GENE TRANSFER; HUMAN; HYDRODYNAMICS BASED TRANSFECTION; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRECIPITATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN INTERACTION; REPORTER GENE; REVIEW; TRANSCRIPTION REGULATION;

ANIMALS; GENE EXPRESSION REGULATION; GENE TRANSFER TECHNIQUES; HUMANS; METABOLIC DETOXICATION, DRUG; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RESPONSE ELEMENTS; XENOBIOTICS;

EID: 78650175993     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.addr.2010.08.005     Document Type: Review

References (148)

1. Gonzalez F.J., Gelboin H.V. Role of human cytochromes P450 in the metabolic activation of chemical carcinogens and toxins. Drug Metab. Rev. 1994, 26:165-183.
2. Nebert D.W., Russell D.W. Clinical importance of the cytochromes P450. Lancet 2002, 360:1155-1162.
3. Guengerich F.P. Cytochromes P450, drugs, and diseases. Mol. Interv. 2003, 3:194-204.
4. Ishikawa T. The ATP-dependent glutathione S-conjugate export pump. Trends Biochem. Sci. 1992, 17:463-468.
5. Gonzalez F.J. Human cytochromes P450: problems and prospects. Trends Pharmacol. Sci. 1992, 13:346-352.
6. Seliska M., Rozman D. Mammalian cytochromes P450-importance of tissue specificity. Biochim. Biophys. Acta 2007, 1770:435-466.
7. McCarver D.G., Hines R.N. The ontogeny of human drug-metabolizing enzymes: phase II conjugation enzymes and regulatory mechanisms. J. Pharmacol. Exp. Ther. 2002, 300:361-366.
8. Dean M., Rzhetsky A., Allikmets R. The human ATP-binding cassette (ABC) transporter superfamily. Genome Res. 2001, 11:1156-1166.
9. Nakata K., Tanaka Y., Nakano T., Adachi T., Tanaka H., Kaminuma T., Ishikawa T. Nuclear receptor-mediated transcriptional regulation in Phase I, II, and III xenobiotic metabolizing systems. Drug Metab. Pharmacokinet. 2006, 21:437-457.
10. Gómez-Lechón M.J., Donato M.T., Castell J.V., Jover R. Human hepatocytes as a tool for studying toxicity and drug metabolism. Curr. Drug Metab. 2003, 4:292-312.
11. Gómez-Lechón M.J., Donato M.T., Castell J.V., Jover R. Human hepatocytes in primary culture: the choice to investigate drug metabolism in man. Curr. Drug Metab. 2004, 5:443-462.
12. Donato M.T., Lahoz A., Castell J.V., Gómez-Lechón M.J. Cell lines: a tool for in vitro drug metabolism studies. Curr. Drug Metab. 2008, 9:1-11.
13. Wilkening S., Stahl F., Bader A. Comparison of primary human hepatocytes and hepatoma cell line HepG2 with regard to their biotransformation properties. Drug Metab. Dispos. 2003, 31:1035-1042.
14. Hewitt N.J., Hewitt P. Phase I and II enzyme characterization of two sources of HepG2 cell lines. Xenobiotica 2004, 34:243-256.
15. Jover R., Bort R., Gómez-Lechón M.J., Castell J.V. Re-expression of C/EBP alpha induces CYP2B6, CYP2C9 and CYP2D6 genes in HepG2 cells. FEBS Lett. 1998, 431:227-230.
16. Castell J.V., Jover R., Martínez-Jiménez C.P., Gómez-Lechón M.J. Hepatocyte cell lines: their use, scope and limitations in drug metabolism studies. Expert Opin. Drug Metab. Toxicol. 2006, 2:183-212.
17. Bogaards J.J., Bertrand M., Jackson P., Oudshoorn M.J., Weaver R.J., van Bladeren P.J., Walther B. Determining the best animal model for human cytochrome P450 activities: a comparison of mouse, rat, rabbit, dog, micropig, monkey and man. Xenobiotica 2000, 30:1131-1152.
18. Diaz D., Fabre I., Daujat M., Saint Aubert B., Bories P., Michel H., Maurel P. Omeprazole is an aryl hydrocarbon-like inducer of human hepatic cytochrome P450. Gastroenterology 1990, 99:737-747.
19. McDonnell W.M., Scheiman J.M., Traber P.G. Induction of cytochrome P450 1A gene (CYP1A) by omeprazole in the human alimentary tract. Gastroenterology 1992, 103:1509-1516.
20. Lu C., Li A.P. Species comparison in P450 induction: effects of dexamethasone, omeprazole, and rifampin on P450 isoforms 1A and 3A in primary cultured hepatocytes from man, Sprague-Dawley rat, minipig, and beagle dog. Chem. Biol. Interact. 2001, 134:271-281.
21. Hewitt N.J., Lechón M.J., Houston J.B., Hallifax D., Brown H.S., Maurel P., Kenna J.G., Gustavsson L., Lohmann C., Skonberg C., Guillouzo A., Tuschl G., Li A.P., LeCluyse E., Groothuis G.M., Hengstler J.G. Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies. Drug Metab. Rev. 2007, 39:159-234.
22. Xu L., Li A.P., Kaminski D.L., Ruh M.F. 2, 3, 7, 8 Tetrachlorodibenzo-p-dioxin induction of cytochrome P4501A in cultured rat and human hepatocytes. Chem. Biol. Interact. 2000, 124:173-189.
23. Nebert D.W., Gonzalez F.J. The P450 gene superfamily. Principles, Mechanisms and Biological Consequences of Induction 1990, 35-61. Taylor and Francis, London. K. Ruckpaul, H. Rein (Eds.).
24. Kocarek T.Q., Schuetz E.G., Strom S.C., Fisher R.A., Guzelian P.S. Comparative analysis of cytochrome P4503A induction in primary cultures of rat, rabbit, and human hepatocytes. Drug Metab. Dispos. 1995, 23:415-421.
25. Pavek P., Pospechova K., Svecova L., Syrova Z., Stejskalova L., Blazkova J., Dvorak Z., Blahos J. Intestinal cell-specific vitamin D receptor (VDR)-mediated transcriptional regulation of CYP3A4 gene. Biochem. Pharmacol. 2010, 79:277-287.
26. Mutoh S., Osabe M., Inoue K., Moore R., Pedersen L., Perera L., Rebolloso Y., Sueyoshi T., Negishi M. Dephosphorylation of threonine 38 is required for nuclear translocation and activation of human xenobiotic receptor CAR (NR1I3). J. Biol. Chem. 2009, 284:34785-34792.
27. Inoue K., Negishi M. Early growth response 1 loops the CYP2B6 promoter for synergistic activation by the distal and proximal nuclear receptors CAR and HNF4alpha. FEBS Lett. 2009, 583:2126-2130.
28. Yeung E.Y., Sueyoshi T., Negishi M., Chang T.K. Identification of Ginkgo biloba as a novel activator of pregnane X receptor. Drug Metab. Dispos. 2008, 36:2270-2276.
29. Li L., Chen T., Stanton J.D., Sueyoshi T., Negishi M., Wang H. The peripheral benzodiazepine receptor ligand 1-(2-chlorophenyl-methylpropyl)-3-isoquinoline-carboxamide is a novel antagonist of human constitutive androstane receptor. Mol. Pharmacol. 2008, 74:443-453.
30. Yamamoto Y., Negishi M. The antiapoptotic factor growth arrest and DNA-damage-inducible 45 beta regulates the nuclear receptor constitutive active/androstane receptor-mediated transcription. Drug Metab. Dispos. 2008, 36:1189-1193.
31. Inoue K., Negishi M. Nuclear receptor CAR requires early growth response 1 to activate the human cytochrome P450 2B6 gene. J. Biol. Chem. 2008, 283:10425-11032.
32. Osabe M., Sugatani J., Takemura A., Yamazaki Y., Ikari A., Kitamura N., Negishi M., Miwa M. Expression of CAR in SW480 and HepG2 cells during G1 is associated with cell proliferation. Biochem. Biophys. Res. Commun. 2008, 369:1027-1033.
33. Harmsen S., Koster A.S., Beijnen J.H., Schellens J.H., Meijerman I. Comparison of two immortalized human cell lines to study nuclear receptor-mediated CYP3A4 induction. Drug Metab. Dispos. 2008, 36:1166-11671.
34. Nakamura K., Moore R., Negishi M., Sueyoshi T. Nuclear pregnane X receptor cross-talk with FoxA2 to mediate drug-induced regulation of lipid metabolism in fasting mouse liver. J. Biol. Chem. 2007, 282:9768-9776.
35. Kodama S., Moore R., Yamamoto Y., Negishi M. Human nuclear pregnane X receptor cross-talk with CREB to repress cAMP activation of the glucose-6-phosphatase gene. Biochem. J. 2007, 407:373-381.
36. Koike C., Moore R., Negishi M. Extracellular signal-regulated kinase is an endogenous signal retaining the nuclear constitutive active/androstane receptor (CAR) in the cytoplasm of mouse primary hepatocytes. Mol. Pharmacol. 2007, 71:1217-1221.
37. Blaschke F., Takata Y., Caglayan E., Collins A., Tontonoz P., Hsueh W.A., Tangirala R.K. A nuclear receptor corepressor-dependent pathway mediates suppression of cytokine-induced C-reactive protein gene expression by liver X receptor. Circ. Res. 2006, 99:e88-e99.
38. Ohtsuka H., Abe T., Onogawa T., Kondo N., Sato T., Oshio H., Mizutamari H., Mikkaichi T., Oikawa M., Rikiyama T., Katayose Y., Unno M. Farnesoid X receptor, hepatocyte nuclear factors 1alpha and 3beta are essential for transcriptional activation of the liver-specific organic anion transporter-2 gene. J. Gastroenterol. 2006, 41:369-377.
39. Waxman D.J. P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR. Arch. Biochem. Biophys. 1999, 369:11-23.
40. Gao X., Kim K.S., Liu D. Nonviral gene delivery: what we know and what is next?. AAPS J. 2007, 9:E92-E104.
41. Kamimura K., Liu D. Physical approaches for nucleic acid delivery to liver. AAPS J. 2008, 10:589-595.
42. Watson C.S., Torres T. Expression and translocation of cloned human estrogen receptor in the Xenopus oocyte does not induce expression of the endogenous oocyte vitellogenin genes. Mol. Endocrinol. 1990, 4:565-572.
43. Blumberg B., Bolado J., Moreno T.A., Kintner C., Evans R.M., Papalopulu N. An essential role for retinoid signaling in anteroposterior neural patterning. Development 1997, 124:373-379.
44. Puzianowska-Kuznicka M., Damjanovski S., Shi Y.B. Both thyroid hormone and 9-cis retinoic acid receptors are required to efficiently mediate the effects of thyroid hormone on embryonic development and specific gene regulation in Xenopus laevis. Mol. Cell. Biol. 1997, 17:4738-4749.
45. Liu F., Song Y.K., Liu D. Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA. Gene Ther. 1999, 6:1258-1266.
46. Zhang G., Budker V., Wolff J.A. High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA. Hum. Gene Ther. 1999, 10:1735-1737.
47. Zhang G., Gao X., Song Y.K., Vollmer R., Stolz D.B., Gasiorowski J.Z., Dean D.A., Liu D. Hydroporation as the mechanism of hydrodynamic delivery. Gene Ther. 2004, 11:675-682.
48. Suda T., Gao X., Stolz D.B., Liu D. Structural impact of hydrodynamic injection on mouse liver. Gene Ther. 2007, 14:129-137.
49. Suda T., Liu D. Hydrodynamic gene delivery: its principles and applications. Mol. Ther. 2007, 15:2063-2069.
50. Schuetz E., Lan L., Yasuda K., Kim R., Kocarek T.A., Schuetz J., Strom S. Development of a real-time in vivo transcription assay: application reveals pregnane X receptor-mediated induction of CYP3A4 by cancer chemotherapeutic agents. Mol. Pharmacol. 2002, 62:439-445.
51. Rivera-Rivera I., Kim J., Kemper B. Transcriptional analysis in vivo of the hepatic genes, Cyp2b9 and Cyp2b10, by intravenous administration of plasmid DNA in mice. Biochim. Biophys. Acta 2003, 1619:254-262.
52. Al-Dosari M., Zhang G., Knapp J.E., Liu D. Direct assessment of promoter activity of human cytochrome p450 genes using optimized transfection in vitro and in vivo. Biosci. Rep. 2006, 26:217-229.
53. Al-Dosari M., Knapp J.E., Liu D. Activation of human CYP2C9 promoter and regulation by CAR and PXR in mouse liver. Mol. Pharm. 2006, 3:322-328.
54. Al-Dosari M., Zhang G., Knapp J.E., Liu D. Evaluation of viral and mammalian promoters for driving transgene expression in mouse liver. Biochem. Biophys. Res. Commun. 2006, 339:673-678.
55. De Souza A.T., Dai X., Spencer A.G., Reppen T., Menzie A., Roesch P.L., He Y., Caguyong M.J., Bloomer S., Herweijer H., Wolff J.A., Hagstrom J.E., Lewis D.L., Linsley P.S., Ulrich R.G. Transcriptional and phenotypic comparisons of PPAR alpha knockout and siRNA knockdown mice. Nucleic Acids Res. 2006, 34:4486-4494.
56. Neumann E., Schaefer-Ridder M., Wang Y., Hofschneider P.H. Gene transfer into mouse lymphoma cells by electroporation in high electric fields. EMBO J. 1982, 1:841-845.
57. Somiari S., Glasspool-Malone J., Drabick J.J., Gilbert R.A., Heller R., Jaroszeski M.J., Malone R.W. Theory and in vivo application of electroporative gene delivery. Mol. Ther. 2000, 2:178-187.
58. André F., Mir L.M. DNA electrotransfer: its principles and an updated review of its therapeutic applications. Gene Ther. 2004, 11:S33-S42.
59. Ban A., Yamanouchi K., Matsuwaki T., Nishihara M. In vivo gene transfer of PPAR gamma is insufficient to induce adipogenesis in skeletal muscle. J. Vet. Med. Sci. 2008, 70:761-767.
60. Sauma L., Stenkula K.G., Kjølhede P., Strålfors P., Söderström M., Nystrom F.H. PPAR-gamma response element activity in intact primary human adipocytes: effects of fatty acids. Nutrition 2006, 22:60-68.
61. Sauma L., Franck N., Paulsson J.F., Westermark G.T., Kjølhede P., Strålfors P., Söderström M., Nystrom F.H. Peroxisome proliferator activated receptor gamma activity is low in mature primary human visceral adipocytes. Diabetologia 2007, 50:195-201.
62. Liao W., Nguyen M.T., Yoshizaki T., Favelyukis S., Patsouris D., Imamura T., Verma I.M., Olefsky J.M. Suppression of PPAR-gamma attenuates insulin-stimulated glucose uptake by affecting both GLUT1 and GLUT4 in 3T3-L1 adipocytes. Am. J. Physiol. Endocrinol. Metab. 2007, 293:E219-E227.
63. Fujishiro K., Fukui Y., Sato O., Kawabe K., Seto K., Motojima K. Analysis of tissue-specific and PPARalpha-dependent induction of FABP gene expression in the mouse liver by an in vivo DNA electroporation method. Mol. Cell. Biochem. 2002, 239:165-172.
64. Kawana K., Ikuta T., Kobayashi Y., Gotoh O., Takeda K., Kawajiri K. Molecular mechanism of nuclear translocation of an orphan nuclear receptor, SXR. Mol. Pharmacol. 2003, 63:524-531.
65. Studer M., Filosa A., Rubenstein J.L. The nuclear receptor COUP-TFI represses differentiation of Cajal-Retzius cells. Brain Res. Bull. 2005, 66:394-401.
66. El-Naghy M., Johnson B.H., Chen H., Ansari N.H., Zhang W., Moller P., Ji Y.S., Thompson E.B. The pathway of leukemic cell death caused by glucocorticoid receptor fragment 465. Exp. Cell Res. 2001, 270:166-175.
67. Hirose T., Koga M., Saito H., Kouhara H., Sumitani S., Kasayama S., Matsumoto K., Sato B. Functional abnormality of glucocorticoid receptor in Shionogi carcinoma 115 cells as evidenced by gene transfer experiments. J. Steroid Biochem. Mol. Biol. 1991, 38:593-598.
68. Bodwell J., Swiff F., Richardson J. Long duration electroporation for achieving high level expression of glucocorticoid receptors in mammalian cell lines. J. Steroid Biochem. Mol. Biol. 1999, 68:77-82.
69. Williard R., Jammalamadaka V., Zava D., Benz C.C., Hunt C.A., Kushner P.J., Scanlan T.S. Screening and characterization of estrogenic activity from a hydroxystilbene library. Chem. Biol. 1995, 2:45-51.
70. Maxwell M.A., Cleasby M.E., Harding A., Stark A., Cooney G.J., Muscat G.E. Nur77 regulates lipolysis in skeletal muscle cells. Evidence for cross-talk between the beta-adrenergic and an orphan nuclear hormone receptor pathway. J. Biol. Chem. 2005, 280:12573-12584.
71. Li W., Sun G., Yang S., Qu Q., Nakashima K., Shi Y. Nuclear receptor TLX regulates cell cycle progression in neural stem cells of the developing brain. Mol. Endocrinol. 2008, 22:56-64.
72. Yu R.T., Chiang M.Y., Tanabe T., Kobayashi M., Yasuda K., Evans R.M., Umesono K. The orphan nuclear receptor Tlx regulates Pax2 and is essential for vision. Proc. Natl Acad. Sci. USA 2000, 97:2621-2625.
73. Yang N.S. Gene transfer into mammalian somatic cells in vivo. Crit. Rev. Biotechnol. 1992, 12:335-356.
74. Yang N.S., Burkholder J., Roberts B., Martinell B., McCabe D. In vivo and in vitro gene transfer to mammalian somatic cells by particle bombardment. Proc. Natl Acad. Sci. USA 1990, 87:9568-9572.
75. Schilthuis J.G., Gann A.A., Brockes J.P. Chimeric retinoic acid/thyroid hormone receptors implicate RAR-alpha 1 as mediating growth inhibition by retinoic acid. EMBO J. 1993, 12:3459-3466.
76. Maden M. Biolistics. The retinoic acid supergun affair. Curr. Biol. 1994, 4:281-284.
77. Pecorino L.T., Entwistle A., Brockes J.P. Activation of a single retinoic acid receptor isoform mediates proximodistal respecification. Curr. Biol. 1996, 6:563-569.
78. Yanai K., Hirota K., Taniguchi-Yanai K., Shigematsu Y., Shimamoto Y., Saito T., Chowdhury S., Takiguchi M., Arakawa M., Nibu Y., Sugiyama F., Yagami K., Fukamizu A. Regulated expression of human angiotensinogen gene by hepatocyte nuclear factor 4 and chicken ovalbumin upstream promoter-transcription factor. J. Biol. Chem. 1999, 274:34605-34612.
79. Tanigawa K., Tanaka K., Nagase H., Miyake H., Kiniwa M., Ikizawa K. Cell type-dependent divergence of transactivation by glucocorticoid receptor ligand. Biol. Pharm. Bull. 2002, 25:1619-1622.
80. Smirlis D., Muangmoonchai R., Edwards M., Phillips I.R., Shephard E.A. Orphan receptor promiscuity in the induction of cytochromes p450 by xenobiotics. J. Biol. Chem. 2001, 276:12822-12826.
81. Boussif O., Lezoualch F., Zanta M.A. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc. Natl Acad. Sci. USA 1995, 92:7297-7301.
82. Goula D., Remy J.S., Erbacher P. Size, diffusibility and transfection performance of linear PEI/DNA complexes in the mouse central nervous system. Gene Ther. 1998, 5:712-717.
83. Chemin I., Moradpour D., Wieland S. Liver-directed gene transfer: a linear polyethylenimine derivative mediates highly efficient DNA delivery to primary hepatocytes in vitro and in vivo. J. Viral Hepat. 1998, 5:369-375.
84. Haensler J., Szoka F.C. Polyamidoamine cascade polymers mediate efficient transfection of cells in culture. Bioconjug. Chem. 1993, 4:372-379.
85. Tang M.X., Redemann C.T., Szoka F.C. In vitro gene delivery by degraded polyamidoamine dendrimers. Bioconjug. Chem. 1996, 7:703-714.
86. Rudolph C., Lausier J., Naundorf S., Muller R.H., Rosenecker J. In vivo gene delivery to the lung using polyethylenimine and fractured polyamidoamine dendrimers. J. Gene Med. 2002, 2:269-278.
87. Schatzlein A.G., Zinselmeyer B.H., Elouzi A. Preferential liver gene expression with polypropylenimine dendrimers. J. Control. Release 2005, 101:247-258.
88. Boussif O., Delair T., Brua C., Veron L., Pavirani A., Kolbe H.V. Synthesis of polyallylamine derivatives and their use as gene transfer vectors in vitro. Bioconjug. Chem. 1999, 10:877-883.
89. Hosseinkhani H., Azzam T., Tabata Y., Domb A.J. Dextran-spermine polycation: an efficient nonviral vector for in vitro and in vivo gene transfection. Gene Ther. 2004, 11:194-203.
90. Venkatesh S., Smith T.J. Chitosan-mediated transfection of HeLa cells. Pharm. Dev. Technol. 1997, 2:417-418.
91. Leong K.W., Mao H.Q., Truong-Le V.L., Roy K., Walsh S.M., August J.T. DNA-polycation nanospheres as non-viral gene delivery vehicles. J. Control. Release 1998, 53:183-193.
92. Erbacher P., Zou S., Bettinger T., Steffan A.M., Remy J.S. Chitosanbased vector/DNA complexes for gene delivery: biophysical characteristics and transfection ability. Pharm. Res. 1998, 15:1332-1339.
93. Lee K.Y., Kwon I.C., Kim Y.H., Jo W.H., Jeong S.Y. Preparation of chitosan self-aggregates as a gene delivery system. J. Control. Release 1998, 51:213-220.
94. Balicki D., Beutler E. Histone H2A significantly enhances in vitro DNA transfection. Mol. Med. 1997, 3:782-787.
95. Martin M.E., Rice K.G. Peptide-guided gene delivery. AAPS J. 2007, 9:E18-E29.
96. Balicki D., Putnam C.D., Scaria P.V., Beutler E. Structure and function correlation in histone H2A peptide-mediated gene transfer. Proc. Natl Acad. Sci. USA 2002, 99:7467-7471.
97. Park Y.J., Liang J.F., Ko K.S., Kim S.W., Yang V.C. Low molecular weight protamine as an efficient and nontoxic gene carrier: in vitro study. J. Gene Med. 2003, 5:700-711.
98. Hwang S.J., Davis M.E. Cationic polymers for gene delivery: designs for overcoming barriers to systemic administration. Curr. Opin. Mol. Ther. 2001, 3:183-191.
99. Boussif O., Lezoualch F., Zanta M.A. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc. Natl Acad. Sci. USA 1995, 92:7297-7301.
100. Sonawane N.D., Szoka F.C., Verkman A.S. Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes. J. Biol. Chem. 2003, 278:44826-44831.
101. Guissouma H., Ghorbel M.T., Seugnet I., Ouatas T., Demeneix B.A. Physiological regulation of hypothalamic TRH transcription in vivo is T3 receptor isoform specific. FASEB J. 1998, 12:1755-1764.
102. Guissouma H., Becker N., Seugnet I., Demeneix B.A. Transcriptional repression of TRH promoter function by T3: analysis by in vivo gene transfer. Biochem. Cell Biol. 2000, 78:155-163.
103. Guissouma H., Dupré S.M., Becker N., Jeannin E., Seugnet I., Desvergne B., Demeneix B.A. Feedback on hypothalamic TRH transcription is dependent on thyroid hormone receptor N terminus. Mol. Endocrinol. 2002, 16:1652-1666.
104. Becker N., Seugnet I., Guissouma H., Dupre S.M., Demeneix B.A. Nuclear core-presser and silencing mediator of retinoic and thyroid hormone receptors core-presser expression is incompatible with T(3)-dependent TRH regulation. Endocrinology 2001, 142:5321-5331.
105. Dupré S.M., Guissouma H., Flamant F., Seugnet I., Scanlan T.S., Baxter J.D., Samarut J., Demeneix B.A., Becker N. Both thyroid hormone receptor (TR)beta 1 and TR beta 2 isoforms contribute to the regulation of hypothalamic thyrotropin-releasing hormone. Endocrinology 2004, 145:2337-2345.
106. Hassani Z., François J.C., Alfama G., Dubois G.M., Paris M., Giovannangeli C., Demeneix B.A. A hybrid CMV-H1 construct improves efficiency of PEI-delivered shRNA in the mouse brain. Nucleic Acids Res. 2007, 35:e65.
107. Kouidhi S., Seugnet I., Decherf S., Guissouma H., Elgaaied A.B., Demeneix B., Clerget-Froidevaux M.S. Peroxisome proliferator-activated receptor-gamma (PPAR gamma) modulates hypothalamic Trh regulation in vivo. Mol. Cell. Endocrinol. 2010, 317:44-52.
108. Liu D., Ren T., Gao X. Cationic transfection lipids. Curr. Med. Chem. 2003, 10:1005-1013.
109. Pedroso de Lima M.C., Simoes S., Pires P., Faneca H., Duzgunes N. Cationic lipid-DNA complexes in gene delivery: from biophysics to biological applications. Adv. Drug Deliv. Rev. 2001, 47:277-294.
110. Xu Y., Szoka F.C. Mechanism of DNA release from cationic liposome/DNA complexes used in cell transfection. Biochemistry 1996, 35:5616-5623.
111. Farhood H., Serbina N., Huang L. The role of dioleoyl phosphatidylethanolamine in cationic liposome mediated gene transfer. Biochim. Biophys. Acta 1995, 1235:289-295.
112. Wrobel I., Collins D. Fusion of cationic liposomes with mammalian cells occurs after endocytosis. Biochim. Biophys. Acta 1995, 1235:296-304.
113. Konno Y., Moore R., Kamiya N., Negishi M. Nuclear xenobiotic receptor PXR-null mouse exhibits hypophosphatemia and represses the Na/Pi-cotransporter SLC34A2. Pharmacogenet. Genomics 2010, 20:9-17.
114. Wang Y., Mu Y., Li H., Ding N., Wang Q., Wang Y., Wang S., Wang N. Peroxisome proliferator-activated receptor-gamma gene: a key regulator of adipocyte differentiation in chickens. Poult. Sci. 2008, 87:226-2232.
115. Dames P., Laner A., Maucksch C., Aneja M.K., Rudolph C. Targeting of the glucocorticoid hormone receptor with plasmid DNA comprising glucocorticoid response elements improves nonviral gene transfer efficiency in the lungs of mice. J. Gene Med. 2007, 9:820-829.
116. Park Y.Y., Ahn S.W., Kim H.J., Kim J.M., Lee I.K., Kang H., Choi H.S. An autoregulatory loop controlling orphan nuclear receptor DAX-1 gene expression by orphan nuclear receptor ERRgamma. Nucleic Acids Res. 2005, 33:6756-6768.
117. Bladh L.G., Lidén J., Dahlman-Wright K., Reimers M., Nilsson S., Okret S. Identification of endogenous glucocorticoid repressed genes differentially regulated by a glucocorticoid receptor mutant able to separate between nuclear factor-kappaB and activator protein-1 repression. Mol. Pharmacol. 2005, 67:815-826.
118. Graham F.L., van der Eb A.J. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 1973, 52:456-467.
119. Kingston R.E., Chen C.A., Okayama H. Calcium phosphate transfection. Curr. Protoc. Immunol. 2001, Chapter 10: Unit 10.13.
120. Loyter A., Scangos G.A., Ruddle F.H. Mechanisms of DNA uptake by mammalian cells: fate of exogenously added DNA monitored by the use of fluorescent dyes. Proc. Natl Acad. Sci. USA 1982, 79:422-426.
121. Orrantia E., Chang P.L. Intracellular distribution of DNA internalized through calcium phosphate precipitation. Exp. Cell Res. 1990, 190:170-174.
122. Batard P., Jordan M., Wurm F. Transfer of high copy number plasmid into mammalian cells by calcium phosphate transfection. Gene 2001, 270:61-68.
123. Chen C., Okayama H. High-efficiency transformation of mammalian cells by plasmid DNA. Mol. Cell. Biol. 1987, 7:2745-2752.
124. O'Mahoney J.V., Adams T.E. Optimization of experimental variables influencing reporter gene expression in hepatoma cells following calcium phosphate transfection. DNA Cell Biol. 1994, 13:1227-1232.
125. Wilson S.P., Liu F., Wilson R.E., Housley P.R. Optimization of calcium phosphate transfection for bovine chromaffin cells: relationship to calcium phosphate precipitate formation. Anal. Biochem. 1995, 226:212-220.
126. Jordan M., Schallhorn A., Wurm F.M. Transfecting mammalian cells: optimization of critical parameters affecting calcium-phosphate precipitate formation. Nucleic Acids Res. 1996, 24:596-601.
127. Pasco D.S., Fagan J.B. Efficient DNA-mediated gene transfer into primary cultures of adult rat hepatocytes. DNA 1989, 8:535-541.
128. Keown W.A., Campbell C.R., Kucherlapati R.S. Methods for introducing DNA into mammalian cells. Methods Enzymol. 1990, 185:527-537.
129. Milnes M.R., Garcia A., Grossman E., Grün F., Shiotsugu J., Tabb M.M., Kawashima Y., Katsu Y., Watanabe H., Iguchi T., Blumberg B. Activation of steroid and xenobiotic receptor (SXR, NR1I2) and its orthologs in laboratory, toxicologic, and genome model species. Environ. Health Perspect. 2008, 116:880-885.
130. Endo K., Uno S., Seki T., Ariga T., Kusumi Y., Mitsumata M., Yamada S., Makishima M. Inhibition of aryl hydrocarbon receptor transactivation and DNA adduct formation by CYP1 isoform-selective metabolic deactivation of benzo[a]pyrene. Toxicol. Appl. Pharmacol. 2008, 230:135-143.
131. Ekins S., Reschly E.J., Hagey L.R., Krasowski M.D. Evolution of pharmacologic specificity in the pregnane X receptor. BMC Evol. Biol. 2008, 8:103.
132. Wieneke N., Hirsch-Ernst K.I., Kuna M., Kersten S., Püschel G.P. PPARalpha-dependent induction of the energy homeostasis-regulating nuclear receptor NR1i3 (CAR) in rat hepatocytes: potential role in starvation adaptation. FEBS Lett. 2007, 581:5617-5626.
133. Shimizu M., Akter M.H., Emi Y., Sato R., Yamaguchi T., Hirose F., Osumi T. Peroxisome proliferator-activated receptor subtypes differentially cooperate with other transcription factors in selective transactivation of the perilipin/PEX11 alpha gene pair. J. Biochem. 2006, 139:563-573.
134. Katoh Y., Iida K., Kang M.I., Kobayashi A., Mizukami M., Tong K.I., McMahon M., Hayes J.D., Itoh K., Yamamoto M. Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome. Arch. Biochem. Biophys. 2005, 433:342-350.
135. Monden T., Yamada M., Nihei Y., Kishi M., Tomaru T., Ishii S., Hashida T., Shibusawa N., Hashimoto K., Satoh T., Kasai K., Mori M. Unliganded RXR acts as an inhibitory factor on troglitazone-induced activation. Life Sci. 2004, 76:731-741.
136. Huang W., Zhang J., Wei P., Schrader W.T., Moore D.D. Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for human CAR. Mol. Endocrinol. 2004, 18:2402-2408.
137. Pendaries V., Verrecchia F., Michel S., Mauviel A. Retinoic acid receptors interfere with the TGF-beta/Smad signaling pathway in a ligand-specific manner. Oncogene 2003, 22:8212-8220.
138. Ferguson S.S., LeCluyse E.L., Negishi M., Goldstein J.A. Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding site. Mol. Pharmacol. 2002, 62:737-746.
139. Lundin K.E., Simonson O.E., Moreno P.M.D., Zaghloul E.M., Oprea I.I., M.G.S., Smith C.I.E. Nanotechnology approaches for gene transfer. Genetica 2009, 137:47-56.
140. Cheung C., Gonzalez F.J. Humanized mouse lines and their application for prediction of human drug metabolism and toxicological risk assessment. J. Pharmacol. Exp. Ther. 2008, 327:288-299.
141. Gonzalez F.J. Animal models for human risk assessment: the peroxisome proliferator-activated receptor alpha-humanized mouse. Nutr. Rev. 2007, 65:S2-S6.
142. Gonzalez F.J. CYP3A4 and pregnane X receptor humanized mice. J. Biochem. Mol. Toxicol. 2007, 21:158-162.
143. Gonzalez F.J., Yu A.M. Cytochrome P450 and xenobiotic receptor humanized mice. Annu. Rev. Pharmacol. Toxicol. 2006, 46:41-64.
144. Gong H., Sinz M.W., Feng Y., Chen T., Venkataramanan R., Xie W. Animal models of xenobiotic receptors in drug metabolism and diseases. Methods Enzymol. 2005, 400:598-618.
145. Dai G., Wan Y.J. Animal models of xenobiotic receptors. Curr. Drug Metab. 2005, 6:341-355.
146. Xie W., Uppal H., Saini S.P., Mu Y., Little J.M., Radominska-Pandya A., Zemaitis MA M.A. Orphan nuclear receptor-mediated xenobiotic regulation in drug metabolism. Drug Discov. Today 2004, 9:442-449.
147. Xie W., Evans R.M. Pharmaceutical use of mouse models humanized for the xenobiotic receptor. Drug Discov. Today 2002, 7:509-515.
148. Suda T., Suda K., Liu D. Computer-assisted hydrodynamic gene delivery. Mol. Ther. 2008, 16:1098-1104.