Identification of endogenous glucocorticoid repressed genes differentially regulated by a glucocorticoid receptor mutant able to separate between nuclear factor-κB and activator protein-1 repression

Molecular Pharmacology

Volumn 67, Issue 3, 2005, Pages 815-826

  Bladh, Lars Göran ^a   Lidén, Johan ^a   Dahlman Wright, Karin ^a   Reimers, Mark ^a,c   Nilsson, Stefan ^b   Okret, Sam ^a,d  

^a KAROLINSKA INSTITUTE   (Sweden)

^b Karo Bio   (Sweden)

^c NATIONAL CANCER INSTITUTE   (United States)

^d KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TRANSCRIPTION FACTOR AP 1; ZINC FINGER PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; GENE REPRESSION; NONHUMAN; NUCLEOTIDE SEQUENCE; POINT MUTATION; PRIORITY JOURNAL; REGULATORY MECHANISM; REPRESSOR GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; WESTERN BLOTTING;

ANIMALS; BASE SEQUENCE; CELL LINE; CERCOPITHECUS AETHIOPS; DEXAMETHASONE; DNA PRIMERS; GENE EXPRESSION REGULATION; GENES, REPORTER; GLUCOCORTICOIDS; HUMANS; KINETICS; NF-KAPPA B; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHOSPHATIDYLETHANOLAMINES; POINT MUTATION; RECEPTORS, GLUCOCORTICOID; TRANSCRIPTION FACTOR AP-1; ZINC FINGERS;

EID: 14944350347     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.104.005801     Document Type: Article

References (40)

1. Auphan N, DiDonato JA, Rosette C, Helmberg A, and Karin M (1995) Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis. Science (Wash DC) 270:286-290.
2. Balliet AG, Hatton KS, Hoffman B, and Liebermann DA (2001) Comparative analysis of the genetic structure and chromosomal location of the murine MyD118 (Gadd45beta) gene. DNA Cell Biol 20:239-247.
3. Barkhem T, Carlsson B, Nilsson Y, Enmark E, Gustafsson JÅ, and Nilsson S (1998) Differential response of estrogen receptor alpha and estrogen receptor beta to partial estrogen agonists/antagonists. Mol Pharmacol 54:105-112.
4. Belvisi MG, Wicks SL, Battram CH, Bottoms SE, Redford JE, Woodman P, Brown TJ, Webber SE, and Foster ML (2001) Therapeutic benefit of a dissociated glucocorticoid and the relevance of in vitro separation of transrepression from transactivation activity. J Immunol 166:1975-1982.
5. Benbow U and Brinckerhoff CE (1997) The AP-1 site and MMP gene regulation: what is all the fuss about? Matrix Biol 15:519-526.
6. Berger J, Hauber J, Hauber R, Geiger R, and Cullen BR (1988) Secreted placental alkaline phosphatase: a powerful new quantitative indicator of gene expression in eukaryotic cells. Gene 66:1-10.
7. Brüggemeier U, Rogge L, Winnacker EL, and Beato M (1990) Nuclear factor I acts as a transcription factor on the MMTV promoter but competes with steroid hormone receptors for DNA binding. EMBO (Eur Mol Biol Organ) J 9:2233-2239.
8. Caldenhoven E, Lidén J, Wissink S, Van de Stolpe A, Raaijmakers J, Koenderman L, Okret S, Gustafsson JÅ, and Van der Saag PT (1995) Negative cross-talk between RelA and the glucocorticoid receptor: a possible mechanism for the antiinflammatory action of glucocorticoids. Mol Endocrinol 9:401-412.
9. De Bosscher K, Vanden Berghe W, and Haegeman G (2001) Glucocorticoid repression of AP-1 is not mediated by competition for nuclear coactivators. Mol Endocrinol 15:219-227.
10. De Bosscher K, Vanden Berghe W, and Haegeman G (2003) The interplay between the blucocorticoid receptor and nuclear factor-kappaB or activator protein-1: molecular mechanisms for gene repression. Endocr Rev 24:488-522.
11. De Bosscher K, Vanden Berghe W, Vermeulen L, Plaisance S, Boone E, and Haegeman G (2000) Glucocorticoids repress NF-kappaB-driven genes by disturbing the interaction of p65 with the basal transcription machinery, irrespective of coactivator levels in the cell. Proc Natl Acad Sci USA 97:3919-3924.
12. Frazier-Jessen MR, Thompson CD, Brown R, Rawat R, Nordan RP, and Feldman GM (2002) NF-kappaB elements contribute to junB inducibility by lipopolysaccharide in the murine macrophage cell line RAW264.7. FEBS Lett 513:203-207.
13. Ghosh S and Karin M (2002) Missing pieces in the NF-kappaB puzzle. Cell 109:S81-S96.
14. Heck S, Kullmann M, Gast A, Ponta H, Rahmsdorf HJ, Herrlich P, and Cato AC (1994) A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1. EMBO (Eur Mol Biol Organ) J 13:4087-4095.
15. Inoue H, Yokoyama C, Hara S, Tone Y, and Tanabe T (1995) Transcriptional regulation of human prostaglandin-endoperoxide synthase-2 gene by lipopolysaccharide and phorbol ester in vascular endothelial cells. J Biol Chem 270:24965-24971.
16. Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, Scherf U, and Speed TP (2003) Exploration, normalization and summaries of high density oligonucleotide array probe level data. Biostatistics 4:249-264.
17. Jonat C, Rahmsdorf HJ, Park KK, Cato AC, Gebel S, Ponta H, and Herrlich P (1990) Antitumor promotion and antiinflammation: down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone. Cell 62:1189-1204.
18. Kamei Y, Xu L, Heinzel T, Torchia J, Kurokawa R, Gloss B, Lin SC, Heyman RA, Rose DW, Glass CK, et al. (1996) A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell 85:403-414.
19. Karin M, Cao Y, Greten FR, and Li ZW (2002) NF-kappaB in cancer: from innocent bystander to major culprit. Nat Rev Cancer 2:301-310.
20. Karin M and Chang L (2001) AP-1-glucocorticoid receptor crosstalk taken to a higher level. J Endocrinol 169:447-451.
21. Lidén J, Delaunay F, Rafter I, Gustafsson JÅ and Okret S (1997) A new function for the C-terminal zinc finger of the glucocorticoid receptor. Repression of RelA transactivation. J Biol Chem 272:21467-22172.
22. McEvoy AN, Murphy EA, Ponnio T, Conneely OM, Bresnihan B, FitzGerald O, and Murphy EP (2002) Activation of nuclear orphan receptor NURR1 transcription by NF-kappa B and cyclic adenosine 5′-monophosphate response element-binding protein in rheumatoid arthritis synovial tissue. J Immunol 168:2979-2987.
23. Newton R, Kuitert LM, Bergmann M, Adcock IM, and Barnes PJ (1997) Evidence for involvement of NF-kappaB in the transcriptional control of COX-2 gene expression by IL-1beta. Biochem Biophys Res Commun 237:28-32.
24. Nissen RM and Yamamoto KR (2000) The glucocorticoid receptor inhibits NFkappaB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain. Genes Dev 14:2314-2329.
25. Okret S, Wikström AC, Wrange Ö, Andersson B, and Gustafsson JÅ (1984) Monoclonal antibodies against the rat liver glucocorticoid receptor. Proc Natl Acad Sci USA 81:1609-1613.
26. Reichardt HM, Tuckermann JP, Gottlicher M, Vujic M, Weih F, Angel P, Herrlich P, and Schutz G (2001) Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptor. EMBO (Eur Mol Biol Organ) J 20:7168-7173.
27. Rogatsky I, Zarember KA, and Yamamoto KR (2001) Factor recruitment and TIF2/GRIP1 corepressor activity at a collagenase-3 response element that mediates regulation by phorbol esters and hormones. EMBO (Eur Mol Biol Organ) J 20:6071-6083.
28. Schäcke H, Docke WD, and Asadullah K (2002) Mechanisms involved in the side effects of glucocorticoids. Pharmacol Ther 96:23-43.
29. Scheinman RI, Cogswell PC, Lofquist AK, and Baldwin AS Jr (1995) Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoids. Science (Wash DC) 270:283-286.
30. Schmedtje JF Jr, Ji YS, Liu WL, DuBois RN, and Runge MS (1997) Hypoxia induces cyclooxygenase-2 via the NF-kappaB p65 transcription factor in human vascular endothelial cells. J Biol Chem 272:601-608.
31. Schüle R, Rangarajan P, Kliewer S, Ransone LJ, Bolado J, Yang N, Verma IM, and Evans RM (1990) Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor. Cell 62:1217-1226.
32. Shaulian E and Karin M (2001) AP-1 in cell proliferation and survival. Oncogene 20:2390-2400.
33. Sheppard KA, Phelps KM, Williams AJ, Thanos D, Glass CK, Rosenfeld MG, Gerritsen ME, and Collins T (1998) Nuclear integration of glucocorticoid receptor and nuclear factor-kappaB signaling by CREB-binding protein and steroid receptor coactivator-1. J Biol Chem 273:29291-29294.
34. Stöcklin E, Wissler M, Gouilleux F, and Groner B (1996) Functional interactions between Stat5 and the glucocorticoid receptor. Nature (Lond) 383:726-728.
35. Subramaniam N, Campiôn J, Rafter I, and Okret S (2003) Cross-talk between glucocorticoid and retinoic acid signals involving glucocorticoid receptor interaction with the homoeodomain protein Pbx1. Biochem J 370:1087-1095.
36. Tanimoto K, Yoshida E, Mita S, Nibu Y, Murakami K, and Fukamizu A (1996) Human activin betaA gene. Identification of novel 5′ exon, functional promoter and enhancers. J Biol Chem 271:32760-32769.
37. Tao Y, Williams-Skipp C, and Scheinman RI (2001) Mapping of glucocorticoid receptor DNA binding domain surfaces contributing to transrepression of NF-kappa B and induction of apoptosis. J Biol Chem 276:2329-2332.
38. van de Stolpe A, Caldenhoven E, Stade BG, Koenderman L, Raaijmakers JA, Johnson JP, and van der Saag PT (1994) 12-O-tetradecanoylphorbol-13-acetate- and tumor necrosis factor alpha-mediated induction of intercellular adhesion molecule-1 is inhibited by dexamethasone. Functional analysis of the human intercellular adhesion molecular-1 promoter. J Biol Chem 269:6185-6192.
39. Wu J, Li Y, Dietz J, and Lala DS (2004) Repression of p65 transcriptional activation by the glucocorticoid receptor in the absence of receptor-coactivator interactions. Mol Endocrinol 18:53-62.
40. Yang-Yen HF, Chambard JC, Sun YL, Smeal T, Schmidt TJ, Drouin J, and Karin M (1990) Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction. Cell 62:1205-1215.