Expression of CAR in SW480 and HepG2 cells during G1 is associated with cell proliferation

Biochemical and Biophysical Research Communications

Volumn 369, Issue 4, 2008, Pages 1027-1033

  Osabe, Makoto ^a   Sugatani, Junko ^a   Takemura, Akiko ^a   Yamazaki, Yasuhiro ^a   Ikari, Akira ^a   Kitamura, Naomi ^b   Negishi, Masahiko ^c   Miwa, Masao ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

^b TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

CAR; CDK4; Cell proliferation; HGF; MDM2; UGT1A1

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; CONSTITUTIVE ANDROSTANE RECEPTOR; CYCLIN DEPENDENT KINASE 4; CYTOCHROME P450 1A1; CYTOCHROME P450 2B6; CYTOCHROME P450 3A4; GLUCURONOSYLTRANSFERASE 1A1; PREGNANE X RECEPTOR; PROTEIN MDM2; PROTEIN P21; RETINOID X RECEPTOR; SCATTER FACTOR; TRANSCRIPTION FACTOR;

ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE M PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL STRAIN HEPG2; CONTROLLED STUDY; ENZYME REPRESSION; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE; UPREGULATION;

CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASE INHIBITOR P21; G1 PHASE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GLUCURONOSYLTRANSFERASE; HUMANS; PROTO-ONCOGENE PROTEINS C-MDM2; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA INTERFERENCE; S PHASE; SERINE ENDOPEPTIDASES; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 41149097456     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.02.140     Document Type: Article

References (15)

1. Beas M., Gulick T., Choi H.-S., Martinoli M.G., Simha D., and Moore D.D. A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements. Mol. Cell. Biol. 14 (1994) 1544-1552
2. Timsit Y.E., and Negishi M. Mechanism of cytochrome P450 induction. Steroid 72 (2007) 231-246
3. Sugatani J., Kojima H., Ueda A., Kakizaki S., Yoshinari K., Gong Q.H., Owens I.S., Negishi M., and Sueyoshi T. The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR. Hepatology 33 (2001) 1232-1238
4. Swales K., and Negishi M. CAR, driving into the future. Mol. Endocrinol. 18 (2004) 1589-1598
5. Yamamoto Y., Moore R., Goldsworthy T.L., Negishi M., and Maropot R.R. The orphan nuclear receptor constitutive active/androstane receptor is essential for tumor promotion by phenobarbital in mice. Cancer Res. 64 (2004) 7197-7200
6. Huang W., Zhang J., Washington M., Liu J., John M., Lozano P.G., and Moore D.D. Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor. Mol. Endocrinol. 19 (2005) 1646-1653
7. Haupt Y., Maya R., Kazaz A., and Oren M. Mdm2 promotes the rapid degradation of p53. Nature 387 (1997) 296-299
8. Honda R., Tanaka H., and Yasuda H. Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett. 420 (1997) 25-27
9. Lundberg A.S., and Weinberg R.A. Control of the cell cycle and apoptosis. Eur. J. Cancer 35 (1999) 531-539
10. Shima N., Stolz D.B., Miyazaki M., Gohda E., Higashino K., and Michalopoulos G.K. Possible involvement of p21/waf1 in the growth inhibition of HepG2 cells induced by hepatocyte growth factor. J. Cell Physiol. 177 (1998) 130-136
11. INK4a up-regulation, leading to cell cycle arrest at G1 in HepG2 hepatoma cells. J. Biol. Chem. 280 (2005) 31548-31556
12. Sugatani J., Nishitani S., Yamakawa K., Yoshinari K., Sueyoshi T., Negishi M., and Miwa M. Transcriptional regulation of human UGT1A1 gene expression: Activated GR enhances CAR/PXR-mediated UGT1A1 regulation with GRIP1. Mol. Pharmacol. 67 (2005) 845-855
13. Marlowe J.L., and Puga A. Aryl hydrocarbon receptor, cell cycle regulation, toxicity, and tumorigenesis. J. Cell Biochem. 96 (2005) 1174-1184
14. Litvinov I.V., Griend D.J.V., Antony L., Dalrymple S., De Marzo A.M., Drake C.G., and Isaacs J.T. Androgen receptor as a licensing factor for DNA replication in androgen-sensitive prostate cancer cells. Proc. Natl. Acad. Sci. USA 103 (2006) 15085-15090
15. Phillips J.M., Yamamoto Y., Negishi M., Maronpot R.R., and Goodman J.I. Orphan nuclear receptor constitutive active/androstane receptor-mediated alterations in DNA methylation during Phenobarbital promotion of liver tumorigenesis. Toxicol. Sci. 96 (2006) 72-82