메뉴 건너뛰기




Volumn 92, Issue C, 2010, Pages 65-100

Functional development of the T cell receptor for antigen

Author keywords

Heterodimer; Immunological synapse; MHC; MicroRNA; Peptide; Positive selection; T cell receptor; Thymus

Indexed keywords

LYMPHOCYTE ANTIGEN RECEPTOR; PEPTIDE FRAGMENT;

EID: 77958127055     PISSN: 18771173     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1877-1173(10)92004-8     Document Type: Chapter
Times cited : (11)

References (167)
  • 1
    • 42649138855 scopus 로고    scopus 로고
    • Thymus organogenesis
    • H.R. Rodewald Thymus organogenesis Annu Rev Immunol 26 2008 355 388
    • (2008) Annu Rev Immunol , vol.26 , pp. 355-388
    • Rodewald, H.R.1
  • 2
    • 58149154739 scopus 로고    scopus 로고
    • Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla
    • T.M. McCaughtry, T.A. Baldwin, M.S. Wilken, and K.A. Hogquist Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla J Exp Med 205 2008 2575 2584
    • (2008) J Exp Med , vol.205 , pp. 2575-2584
    • McCaughtry, T.M.1    Baldwin, T.A.2    Wilken, M.S.3    Hogquist, K.A.4
  • 3
    • 0242636376 scopus 로고    scopus 로고
    • Cell migration and the control of post-natal T-cell lymphopoiesis in the thymus
    • H.T. Petrie Cell migration and the control of post-natal T-cell lymphopoiesis in the thymus Nat Rev Immunol 3 2003 859 866
    • (2003) Nat Rev Immunol , vol.3 , pp. 859-866
    • Petrie, H.T.1
  • 4
    • 33748992038 scopus 로고    scopus 로고
    • Receptor editing in lymphocyte development and central tolerance
    • D. Nemazee Receptor editing in lymphocyte development and central tolerance Nat Rev Immunol 6 2006 728 740
    • (2006) Nat Rev Immunol , vol.6 , pp. 728-740
    • Nemazee, D.1
  • 5
    • 33845790596 scopus 로고    scopus 로고
    • Molecular basis for pre-TCR-mediated autonomous signaling
    • S. Yamasaki, and T. Saito Molecular basis for pre-TCR-mediated autonomous signaling Trends Immunol 28 2007 39 43
    • (2007) Trends Immunol , vol.28 , pp. 39-43
    • Yamasaki, S.1    Saito, T.2
  • 6
    • 2442708080 scopus 로고    scopus 로고
    • CD4/CD8 coreceptors in thymocyte development, selection, and lineage commitment: Analysis of the CD4/CD8 lineage decision
    • A. Singer, and R. Bosselut CD4/CD8 coreceptors in thymocyte development, selection, and lineage commitment: analysis of the CD4/CD8 lineage decision Adv Immunol 83 2004 91 131
    • (2004) Adv Immunol , vol.83 , pp. 91-131
    • Singer, A.1    Bosselut, R.2
  • 7
    • 0021162031 scopus 로고
    • Genomic organization and sequence of T-cell receptor beta-chain constant- and joining-region genes
    • N.R. Gascoigne, Y. Chien, D.M. Becker, J. Kavaler, and M.M. Davis Genomic organization and sequence of T-cell receptor beta-chain constant- and joining-region genes Nature 310 1984 387 391
    • (1984) Nature , vol.310 , pp. 387-391
    • Gascoigne, N.R.1    Chien, Y.2    Becker, D.M.3    Kavaler, J.4    Davis, M.M.5
  • 8
    • 0023720148 scopus 로고
    • T-cell antigen receptor genes and T-cell recognition
    • M.M. Davis, and P.J. Bjorkman T-cell antigen receptor genes and T-cell recognition Nature 334 1988 395 402
    • (1988) Nature , vol.334 , pp. 395-402
    • Davis, M.M.1    Bjorkman, P.J.2
  • 9
    • 0025068712 scopus 로고
    • T cell receptor junctional regions and the MHC molecule affect the recognition of antigenic peptides by T cell clones
    • S.B. Sorger, Y. Paterson, P.J. Fink, and S.M. Hedrick T cell receptor junctional regions and the MHC molecule affect the recognition of antigenic peptides by T cell clones J Immunol 144 1990 1127 1135
    • (1990) J Immunol , vol.144 , pp. 1127-1135
    • Sorger, S.B.1    Paterson, Y.2    Fink, P.J.3    Hedrick, S.M.4
  • 10
    • 0027183436 scopus 로고
    • T cell receptor interaction with peptide/major histocompatibility complex (MHC) and superantigen/MHC ligands is dominated by antigen
    • E.W. Ehrich, B. Devaux, E.P. Rock, J.L. Jorgensen, M.M. Davis, and Y.H. Chien T cell receptor interaction with peptide/major histocompatibility complex (MHC) and superantigen/MHC ligands is dominated by antigen J Exp Med 178 1993 713 722
    • (1993) J Exp Med , vol.178 , pp. 713-722
    • Ehrich, E.W.1    Devaux, B.2    Rock, E.P.3    Jorgensen, J.L.4    Davis, M.M.5    Chien, Y.H.6
  • 11
    • 0028923473 scopus 로고
    • Predicted complementarity determining regions of the T cell antigen receptor determine antigen specificity
    • C.D. Katayama, F.J. Eidelman, A. Duncan, F. Hooshmand, and S.M. Hedrick Predicted complementarity determining regions of the T cell antigen receptor determine antigen specificity EMBO J 14 1995 927 938
    • (1995) EMBO J , vol.14 , pp. 927-938
    • Katayama, C.D.1    Eidelman, F.J.2    Duncan, A.3    Hooshmand, F.4    Hedrick, S.M.5
  • 12
    • 0029662223 scopus 로고    scopus 로고
    • An alphabeta T cell receptor structure at 2.5 A and its orientation in the TCRMHC complex
    • K.C. Garcia, M. Degano, R.L. Stanfield, A. Brunmark, M.R. Jackson, and P.A. Peterson An alphabeta T cell receptor structure at 2.5 A and its orientation in the TCRMHC complex Science 274 1996 209 219
    • (1996) Science , vol.274 , pp. 209-219
    • Garcia, K.C.1    Degano, M.2    Stanfield, R.L.3    Brunmark, A.4    Jackson, M.R.5    Peterson, P.A.6
  • 13
    • 0029855347 scopus 로고    scopus 로고
    • Structure of the complex between human T-cell receptor, viral peptide and HLA-A2
    • D.N. Garboczi, P. Ghosh, U. Utz, Q.R. Fan, W.E. Biddison, and D.C. Wiley Structure of the complex between human T-cell receptor, viral peptide and HLA-A2 Nature 384 1996 134 141
    • (1996) Nature , vol.384 , pp. 134-141
    • Garboczi, D.N.1    Ghosh, P.2    Utz, U.3    Fan, Q.R.4    Biddison, W.E.5    Wiley, D.C.6
  • 15
    • 58649114309 scopus 로고    scopus 로고
    • The molecular basis of TCR germline bias for MHC is surprisingly simple
    • K.C. Garcia, J.J. Adams, D. Feng, and L.K. Ely The molecular basis of TCR germline bias for MHC is surprisingly simple Nat Immunol 10 2009 143 147
    • (2009) Nat Immunol , vol.10 , pp. 143-147
    • Garcia, K.C.1    Adams, J.J.2    Feng, D.3    Ely, L.K.4
  • 16
    • 0036682133 scopus 로고    scopus 로고
    • Two-step binding mechanism for T-cell receptor recognition of peptide MHC
    • L.C. Wu, D.S. Tuot, D.S. Lyons, K.C. Garcia, and M.M. Davis Two-step binding mechanism for T-cell receptor recognition of peptide MHC Nature 418 2002 552 556
    • (2002) Nature , vol.418 , pp. 552-556
    • Wu, L.C.1    Tuot, D.S.2    Lyons, D.S.3    Garcia, K.C.4    Davis, M.M.5
  • 17
    • 77952316386 scopus 로고    scopus 로고
    • On the composition of the preimmune repertoire of T cells specific for peptide-major histocompatibility complex ligands
    • M.K. Jenkins, H.H. Chu, J.B. McLachlan, and J.J. Moon On the composition of the preimmune repertoire of T cells specific for peptide-major histocompatibility complex ligands Annu Rev Immunol 28 2010 275 294
    • (2010) Annu Rev Immunol , vol.28 , pp. 275-294
    • Jenkins, M.K.1    Chu, H.H.2    McLachlan, J.B.3    Moon, J.J.4
  • 18
    • 34548038390 scopus 로고    scopus 로고
    • Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude
    • J.J. Moon, H.H. Chu, M. Pepper, S.J. McSorley, S.C. Jameson, and R.M. Kedl Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude Immunity 27 2007 203 213
    • (2007) Immunity , vol.27 , pp. 203-213
    • Moon, J.J.1    Chu, H.H.2    Pepper, M.3    McSorley, S.J.4    Jameson, S.C.5    Kedl, R.M.6
  • 19
    • 44649127931 scopus 로고    scopus 로고
    • Endogenous naive CD8+ T cell precursor frequency regulates primary and memory responses to infection
    • J.J. Obar, K.M. Khanna, and L. Lefrancois Endogenous naive CD8+ T cell precursor frequency regulates primary and memory responses to infection Immunity 28 2008 859 869
    • (2008) Immunity , vol.28 , pp. 859-869
    • Obar, J.J.1    Khanna, K.M.2    Lefrancois, L.3
  • 21
    • 0024428184 scopus 로고
    • Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand
    • L.J. Berg, A.M. Pullen, Fazekas de St, B. Groth, D. Mathis, and C. Benoist Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand Cell 58 1989 1035 1046
    • (1989) Cell , vol.58 , pp. 1035-1046
    • Berg, L.J.1    Pullen, A.M.2    De St, F.3    Groth, B.4    Mathis, D.5    Benoist, C.6
  • 25
    • 0018833714 scopus 로고
    • Thymus cell migration. Quantitative aspects of cellular traffic from the thymus to the periphery in mice
    • R.G. Scollay, E.C. Butcher, and I.L. Weissman Thymus cell migration. Quantitative aspects of cellular traffic from the thymus to the periphery in mice Eur J Immunol 10 1980 210 218
    • (1980) Eur J Immunol , vol.10 , pp. 210-218
    • Scollay, R.G.1    Butcher, E.C.2    Weissman, I.L.3
  • 26
    • 0028054017 scopus 로고
    • T-cell apoptosis detected in situ during positive and negative selection in the thymus
    • C.D. Surh, and J. Sprent T-cell apoptosis detected in situ during positive and negative selection in the thymus Nature 372 1994 100 103
    • (1994) Nature , vol.372 , pp. 100-103
    • Surh, C.D.1    Sprent, J.2
  • 27
    • 0023900635 scopus 로고
    • Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes
    • P. Kisielow, H. Bluthmann, U.D. Staerz, M. Steinmetz, and H. von Boehmer Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes Nature 333 1988 742 746
    • (1988) Nature , vol.333 , pp. 742-746
    • Kisielow, P.1    Bluthmann, H.2    Staerz, U.D.3    Steinmetz, M.4    Von Boehmer, H.5
  • 29
    • 54049111388 scopus 로고    scopus 로고
    • Conformational changes and flexibility in T-cell receptor recognition of peptide-MHC complexes
    • K.M. Armstrong, K.H. Piepenbrink, and B.M. Baker Conformational changes and flexibility in T-cell receptor recognition of peptide-MHC complexes Biochem J 415 2008 183 196
    • (2008) Biochem J , vol.415 , pp. 183-196
    • Armstrong, K.M.1    Piepenbrink, K.H.2    Baker, B.M.3
  • 32
    • 0033082989 scopus 로고    scopus 로고
    • Qualitative and quantitative differences in T cell receptor binding of agonist and antagonist ligands
    • S.M. Alam, G.M. Davies, C.M. Lin, T. Zal, W. Nasholds, and S.C. Jameson Qualitative and quantitative differences in T cell receptor binding of agonist and antagonist ligands Immunity 10 1999 227 237
    • (1999) Immunity , vol.10 , pp. 227-237
    • Alam, S.M.1    Davies, G.M.2    Lin, C.M.3    Zal, T.4    Nasholds, W.5    Jameson, S.C.6
  • 33
    • 0035337136 scopus 로고    scopus 로고
    • A low affinity TCR ligand restores positive selection of CD8+ T cells in vivo
    • H.E. Stefanski, D. Mayerova, S.C. Jameson, and K.A. Hogquist A low affinity TCR ligand restores positive selection of CD8+ T cells in vivo J Immunol 166 2001 6602 6607
    • (2001) J Immunol , vol.166 , pp. 6602-6607
    • Stefanski, H.E.1    Mayerova, D.2    Jameson, S.C.3    Hogquist, K.A.4
  • 34
    • 0027230429 scopus 로고
    • + T cells in the thymus
    • DOI 10.1016/0092-8674(93)90281-T
    • P.G. Ashton-Rickardt, L. Van Kaer, T.N. Schumacher, H.L. Ploegh, and S. Tonegawa Peptide contributes to the specificity of positive selection of CD8+ T cells in the thymus Cell 73 1993 1041 1049 (Pubitemid 23165618)
    • (1993) Cell , vol.73 , Issue.5 , pp. 1041-1049
    • Ashton-Rickardt, P.G.1    Van Kaer, L.2    Schumacher, T.N.M.3    Ploegh, H.L.4    Tonegawa, S.5
  • 35
    • 0029154410 scopus 로고
    • Strong agonist ligands for the T cell receptor do not mediate positive selection of functional CD8+ T cells
    • K.A. Hogquist, S.C. Jameson, and M.J. Bevan Strong agonist ligands for the T cell receptor do not mediate positive selection of functional CD8+ T cells Immunity 3 1995 79 86
    • (1995) Immunity , vol.3 , pp. 79-86
    • Hogquist, K.A.1    Jameson, S.C.2    Bevan, M.J.3
  • 37
    • 18644365692 scopus 로고    scopus 로고
    • Rare, structurally homologous self-peptides promote thymocyte positive selection
    • F.R. Santori, W.C. Kieper, S.M. Brown, Y. Lu, T.A. Neubert, and K.L. Johnson Rare, structurally homologous self-peptides promote thymocyte positive selection Immunity 17 2002 131 142
    • (2002) Immunity , vol.17 , pp. 131-142
    • Santori, F.R.1    Kieper, W.C.2    Brown, S.M.3    Lu, Y.4    Neubert, T.A.5    Johnson, K.L.6
  • 38
    • 77953506249 scopus 로고    scopus 로고
    • Peptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selection
    • J. Juang, P.J. Ebert, D. Feng, K.C. Garcia, M. Krogsgaard, and M.M. Davis Peptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selection J Exp Med 207 2010 1223 1234
    • (2010) J Exp Med , vol.207 , pp. 1223-1234
    • Juang, J.1    Ebert, P.J.2    Feng, D.3    Garcia, K.C.4    Krogsgaard, M.5    Davis, M.M.6
  • 39
    • 70350435670 scopus 로고    scopus 로고
    • An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a
    • P.J. Ebert, S. Jiang, J. Xie, Q.J. Li, and M.M. Davis An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a Nat Immunol 10 2009 1162 1169
    • (2009) Nat Immunol , vol.10 , pp. 1162-1169
    • Ebert, P.J.1    Jiang, S.2    Xie, J.3    Li, Q.J.4    Davis, M.M.5
  • 40
    • 70350439671 scopus 로고    scopus 로고
    • An endogenous peptide-MHC ligand positively selects and augments peripheral CD4+ T cell activation and survival
    • W.-L. Lo, N.J. Felix, J.J. Walters, H. Rohrs, M.L. Gross, and P.M. Allen An endogenous peptide-MHC ligand positively selects and augments peripheral CD4+ T cell activation and survival Nat Immunol 10 2009 1155 1161
    • (2009) Nat Immunol , vol.10 , pp. 1155-1161
    • Lo, W.-L.1    Felix, N.J.2    Walters, J.J.3    Rohrs, H.4    Gross, M.L.5    Allen, P.M.6
  • 41
  • 42
    • 0028261582 scopus 로고
    • Use of global amino acid replacements to define the requirements for MHC binding and T cell recognition of moth cytochrome c (93103)
    • P.A. Reay, R.M. Kantor, and M.M. Davis Use of global amino acid replacements to define the requirements for MHC binding and T cell recognition of moth cytochrome c (93103) J Immunol 152 1994 3946 3957
    • (1994) J Immunol , vol.152 , pp. 3946-3957
    • Reay, P.A.1    Kantor, R.M.2    Davis, M.M.3
  • 43
    • 0028987213 scopus 로고
    • Crystal structure of an H-2Kb-ovalbumin peptide complex reveals the interplay of primary and secondary anchor positions in the major histocompatibility complex binding groove
    • D.H. Fremont, E.A. Stura, M. Matsumura, P.A. Peterson, and I.A. Wilson Crystal structure of an H-2Kb-ovalbumin peptide complex reveals the interplay of primary and secondary anchor positions in the major histocompatibility complex binding groove Proc Natl Acad Sci USA 92 1995 2479 2483
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 2479-2483
    • Fremont, D.H.1    Stura, E.A.2    Matsumura, M.3    Peterson, P.A.4    Wilson, I.A.5
  • 46
    • 0034176855 scopus 로고    scopus 로고
    • Positive selection is limited by available peptide-dependent MHC conformations
    • H.E. Stefanski, S.C. Jameson, and K.A. Hogquist Positive selection is limited by available peptide-dependent MHC conformations J Immunol 164 2000 3519 3526
    • (2000) J Immunol , vol.164 , pp. 3519-3526
    • Stefanski, H.E.1    Jameson, S.C.2    Hogquist, K.A.3
  • 47
    • 0033521599 scopus 로고    scopus 로고
    • A T cell receptor-specific blockade of positive selection
    • K.K. Baldwin, P.A. Reay, L. Wu, A. Farr, and M.M. Davis A T cell receptor-specific blockade of positive selection J Exp Med 189 1999 13 24
    • (1999) J Exp Med , vol.189 , pp. 13-24
    • Baldwin, K.K.1    Reay, P.A.2    Wu, L.3    Farr, A.4    Davis, M.M.5
  • 48
    • 0034541216 scopus 로고    scopus 로고
    • On the self-referential nature of naive MHC class II-restricted T cells
    • C. Viret, X. He, and C.A. Janeway Jr. On the self-referential nature of naive MHC class II-restricted T cells J Immunol 165 2000 6183 6192
    • (2000) J Immunol , vol.165 , pp. 6183-6192
    • Viret, C.1    He, X.2    Janeway Jr., C.A.3
  • 50
    • 0037112047 scopus 로고    scopus 로고
    • Projection of an immunological self shadow within the thymus by the aire protein
    • M.S. Anderson, E.S. Venanzi, L. Klein, Z. Chen, S.P. Berzins, and S.J. Turley Projection of an immunological self shadow within the thymus by the aire protein Science 298 2002 1395 1401
    • (2002) Science , vol.298 , pp. 1395-1401
    • Anderson, M.S.1    Venanzi, E.S.2    Klein, L.3    Chen, Z.4    Berzins, S.P.5    Turley, S.J.6
  • 51
    • 34248598295 scopus 로고    scopus 로고
    • Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells
    • K. Aschenbrenner, L.M. D'Cruz, E.H. Vollmann, M. Hinterberger, J. Emmerich, and L.K. Swee Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells Nat Immunol 8 2007 351 358
    • (2007) Nat Immunol , vol.8 , pp. 351-358
    • Aschenbrenner, K.1    D'Cruz, L.M.2    Vollmann, E.H.3    Hinterberger, M.4    Emmerich, J.5    Swee, L.K.6
  • 52
    • 35748941369 scopus 로고    scopus 로고
    • Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire
    • D. Gray, J. Abramson, C. Benoist, and D. Mathis Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire J Exp Med 204 2007 2521 2528
    • (2007) J Exp Med , vol.204 , pp. 2521-2528
    • Gray, D.1    Abramson, J.2    Benoist, C.3    Mathis, D.4
  • 53
    • 45949094459 scopus 로고    scopus 로고
    • The lymphotoxin pathway regulates Aire-independent expression of ectopic genes and chemokines in thymic stromal cells
    • N. Seach, T. Ueno, A.L. Fletcher, T. Lowen, M. Mattesich, and C.R. Engwerda The lymphotoxin pathway regulates Aire-independent expression of ectopic genes and chemokines in thymic stromal cells J Immunol 180 2008 5384 5392
    • (2008) J Immunol , vol.180 , pp. 5384-5392
    • Seach, N.1    Ueno, T.2    Fletcher, A.L.3    Lowen, T.4    Mattesich, M.5    Engwerda, C.R.6
  • 55
    • 0037141021 scopus 로고    scopus 로고
    • Cathepsin L regulates CD4+ T cell selection independently of its effect on invariant chain: A role in the generation of positively selecting peptide ligands
    • K. Honey, T. Nakagawa, C. Peters, and A. Rudensky Cathepsin L regulates CD4+ T cell selection independently of its effect on invariant chain: a role in the generation of positively selecting peptide ligands J Exp Med 195 2002 1349 1358
    • (2002) J Exp Med , vol.195 , pp. 1349-1358
    • Honey, K.1    Nakagawa, T.2    Peters, C.3    Rudensky, A.4
  • 57
    • 0027478380 scopus 로고
    • Positive selection of CD8+ T cells induced by major histocompatibility complex binding peptides in fetal thymic organ culture
    • K.A. Hogquist, M.A. Gavin, and M.J. Bevan Positive selection of CD8+ T cells induced by major histocompatibility complex binding peptides in fetal thymic organ culture J Exp Med 177 1993 1469 1473
    • (1993) J Exp Med , vol.177 , pp. 1469-1473
    • Hogquist, K.A.1    Gavin, M.A.2    Bevan, M.J.3
  • 58
    • 72949104779 scopus 로고    scopus 로고
    • Antigen presentation in the thymus for positive selection and central tolerance induction
    • L. Klein, M. Hinterberger, G. Wirnsberger, and B. Kyewski Antigen presentation in the thymus for positive selection and central tolerance induction Nat Rev Immunol 9 2009 833 844
    • (2009) Nat Rev Immunol , vol.9 , pp. 833-844
    • Klein, L.1    Hinterberger, M.2    Wirnsberger, G.3    Kyewski, B.4
  • 59
    • 0025327432 scopus 로고
    • The effects of MHC gene dosage and allelic variation on T cell receptor selection
    • L.J. Berg, G.D. Frank, and M.M. Davis The effects of MHC gene dosage and allelic variation on T cell receptor selection Cell 60 1990 1043 1053
    • (1990) Cell , vol.60 , pp. 1043-1053
    • Berg, L.J.1    Frank, G.D.2    Davis, M.M.3
  • 61
    • 0031157196 scopus 로고    scopus 로고
    • Structurally similar TCRs differ in their efficiency of positive selection
    • D. Yelon, and L.J. Berg Structurally similar TCRs differ in their efficiency of positive selection J Immunol 158 1997 5219 5228
    • (1997) J Immunol , vol.158 , pp. 5219-5228
    • Yelon, D.1    Berg, L.J.2
  • 63
    • 0030000318 scopus 로고    scopus 로고
    • Tracing interactions of thymocytes with individual stromal cell partners
    • M. Merkenschlager Tracing interactions of thymocytes with individual stromal cell partners Eur J Immunol 26 1996 892 896
    • (1996) Eur J Immunol , vol.26 , pp. 892-896
    • Merkenschlager, M.1
  • 64
    • 0142149043 scopus 로고    scopus 로고
    • Critical role for CXCR4 signaling in progenitor localization and T cell differentiation in the postnatal thymus
    • J. Plotkin, S.E. Prockop, A. Lepique, and H.T. Petrie Critical role for CXCR4 signaling in progenitor localization and T cell differentiation in the postnatal thymus J Immunol 171 2003 4521 4527
    • (2003) J Immunol , vol.171 , pp. 4521-4527
    • Plotkin, J.1    Prockop, S.E.2    Lepique, A.3    Petrie, H.T.4
  • 67
    • 0037036140 scopus 로고    scopus 로고
    • Dynamics of thymocytestromal cell interactions visualized by two-photon microscopy
    • P. Bousso, N.R. Bhakta, R.S. Lewis, and E. Robey Dynamics of thymocytestromal cell interactions visualized by two-photon microscopy Science 296 2002 1876 1880
    • (2002) Science , vol.296 , pp. 1876-1880
    • Bousso, P.1    Bhakta, N.R.2    Lewis, R.S.3    Robey, E.4
  • 68
    • 13944266418 scopus 로고    scopus 로고
    • Calcium oscillations regulate thymocyte motility during positive selection in the three-dimensional thymic environment
    • N.R. Bhakta, D.Y. Oh, and R.S. Lewis Calcium oscillations regulate thymocyte motility during positive selection in the three-dimensional thymic environment Nat Immunol 6 2005 143 151
    • (2005) Nat Immunol , vol.6 , pp. 143-151
    • Bhakta, N.R.1    Oh, D.Y.2    Lewis, R.S.3
  • 69
    • 55349122507 scopus 로고    scopus 로고
    • Low ligand requirement for deletion and lack of synapses in positive selection enforce the gauntlet of thymic T cell maturation
    • P.J. Ebert, L.I. Ehrlich, and M.M. Davis Low ligand requirement for deletion and lack of synapses in positive selection enforce the gauntlet of thymic T cell maturation Immunity 29 2008 734 745
    • (2008) Immunity , vol.29 , pp. 734-745
    • Ebert, P.J.1    Ehrlich, L.I.2    Davis, M.M.3
  • 70
    • 0032480279 scopus 로고    scopus 로고
    • Three-dimensional segregation of supramolecular activation clusters in T cells
    • C.R. Monks, B.A. Freiberg, H. Kupfer, N. Sciaky, and A. Kupfer Three-dimensional segregation of supramolecular activation clusters in T cells Nature 395 1998 82 86
    • (1998) Nature , vol.395 , pp. 82-86
    • Monks, C.R.1    Freiberg, B.A.2    Kupfer, H.3    Sciaky, N.4    Kupfer, A.5
  • 71
    • 0033538574 scopus 로고    scopus 로고
    • The immunological synapse: A molecular machine controlling T cell activation
    • DOI 10.1126/science.285.5425.221
    • A. Grakoui, S.K. Bromley, C. Sumen, M.M. Davis, A.S. Shaw, and P.M. Allen The immunological synapse: a molecular machine controlling T cell activation Science 285 1999 221 227 (Pubitemid 29329988)
    • (1999) Science , vol.285 , Issue.5425 , pp. 221-227
    • Grakoui, A.1    Bromley, S.K.2    Sumen, C.3    Davis, M.M.4    Shaw, A.S.5    Allen, P.M.6    Dustin, M.L.7
  • 72
    • 0033666324 scopus 로고    scopus 로고
    • Antigen presentation in extracellular matrix: Interactions of T cells with dendritic cells are dynamic, short lived, and sequential
    • M. Gunzer, A. Schafer, S. Borgmann, S. Grabbe, K.S. Zanker, and E.B. Brocker Antigen presentation in extracellular matrix: interactions of T cells with dendritic cells are dynamic, short lived, and sequential Immunity 13 2000 323 332
    • (2000) Immunity , vol.13 , pp. 323-332
    • Gunzer, M.1    Schafer, A.2    Borgmann, S.3    Grabbe, S.4    Zanker, K.S.5    Brocker, E.B.6
  • 73
    • 0029007317 scopus 로고
    • Positive selection of T cells: Rescue from programmed cell death and differentiation require continual engagement of the T cell receptor
    • P. Kisielow, and A. Miazek Positive selection of T cells: rescue from programmed cell death and differentiation require continual engagement of the T cell receptor J Exp Med 181 1995 1975 1984
    • (1995) J Exp Med , vol.181 , pp. 1975-1984
    • Kisielow, P.1    Miazek, A.2
  • 74
    • 1542377327 scopus 로고    scopus 로고
    • Duration of TCR signaling controls CD4-CD8 lineage differentiation in vivo
    • X. Liu, and R. Bosselut Duration of TCR signaling controls CD4-CD8 lineage differentiation in vivo Nat Immunol 5 2004 280 288
    • (2004) Nat Immunol , vol.5 , pp. 280-288
    • Liu, X.1    Bosselut, R.2
  • 75
    • 0035313076 scopus 로고    scopus 로고
    • A role for accessibility to self-peptide-self-MHC complexes in intrathymic negative selection
    • C. Viret, D.B. Sant'Angelo, X. He, H. Ramaswamy, and C.A. Janeway Jr. A role for accessibility to self-peptide-self-MHC complexes in intrathymic negative selection J Immunol 166 2001 4429 4437
    • (2001) J Immunol , vol.166 , pp. 4429-4437
    • Viret, C.1    Sant'Angelo, D.B.2    He, X.3    Ramaswamy, H.4    Janeway Jr., C.A.5
  • 76
    • 0032538986 scopus 로고    scopus 로고
    • Preselection thymocytes are more sensitive to T cell receptor stimulation than mature T cells
    • G.M. Davey, S.L. Schober, B.T. Endrizzi, A.K. Dutcher, S.C. Jameson, and K.A. Hogquist Preselection thymocytes are more sensitive to T cell receptor stimulation than mature T cells J Exp Med 188 1998 1867 1874
    • (1998) J Exp Med , vol.188 , pp. 1867-1874
    • Davey, G.M.1    Schober, S.L.2    Endrizzi, B.T.3    Dutcher, A.K.4    Jameson, S.C.5    Hogquist, K.A.6
  • 77
    • 0033559135 scopus 로고    scopus 로고
    • Cutting edge: Negative selection of immature thymocytes by a few peptide-MHC complexes: Differential sensitivity of immature and mature T cells
    • D.A. Peterson, R.J. DiPaolo, O. Kanagawa, and E.R. Unanue Cutting edge: negative selection of immature thymocytes by a few peptide-MHC complexes: differential sensitivity of immature and mature T cells J Immunol 162 1999 3117 3120
    • (1999) J Immunol , vol.162 , pp. 3117-3120
    • Peterson, D.A.1    Dipaolo, R.J.2    Kanagawa, O.3    Unanue, E.R.4
  • 78
    • 0027957577 scopus 로고
    • Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28
    • J.A. Punt, B.A. Osborne, Y. Takahama, S.O. Sharrow, and A. Singer Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28 J Exp Med 179 1994 709 713
    • (1994) J Exp Med , vol.179 , pp. 709-713
    • Punt, J.A.1    Osborne, B.A.2    Takahama, Y.3    Sharrow, S.O.4    Singer, A.5
  • 79
    • 0029835390 scopus 로고    scopus 로고
    • Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex
    • T.M. Laufer, J. DeKoning, J.S. Markowitz, D. Lo, and L.H. Glimcher Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex Nature 383 1996 81 85
    • (1996) Nature , vol.383 , pp. 81-85
    • Laufer, T.M.1    Dekoning, J.2    Markowitz, J.S.3    Lo, D.4    Glimcher, L.H.5
  • 80
    • 0033136289 scopus 로고    scopus 로고
    • Self-reactive T cells selected on thymic cortical epithelium are polyclonal and are pathogenic in vivo
    • T.M. Laufer, L. Fan, and L.H. Glimcher Self-reactive T cells selected on thymic cortical epithelium are polyclonal and are pathogenic in vivo J Immunol 162 1999 5078 5084
    • (1999) J Immunol , vol.162 , pp. 5078-5084
    • Laufer, T.M.1    Fan, L.2    Glimcher, L.H.3
  • 81
    • 50249171702 scopus 로고    scopus 로고
    • TSCOT+ thymic epithelial cell-mediated sensitive CD4 tolerance by direct presentation
    • S. Ahn, G. Lee, S.J. Yang, D. Lee, S. Lee, and H.S. Shin TSCOT+ thymic epithelial cell-mediated sensitive CD4 tolerance by direct presentation PLoS Biol 6 2008 e191
    • (2008) PLoS Biol , vol.6 , pp. 191
    • Ahn, S.1    Lee, G.2    Yang, S.J.3    Lee, D.4    Lee, S.5    Shin, H.S.6
  • 82
    • 0036225013 scopus 로고    scopus 로고
    • Imaging synapse formation during thymocyte selection: Inability of CD3zeta to form a stable central accumulation during negative selection
    • L.I. Richie, P.J. Ebert, L.C. Wu, M.F. Krummel, J.J. Owen, and M.M. Davis Imaging synapse formation during thymocyte selection: inability of CD3zeta to form a stable central accumulation during negative selection Immunity 16 2002 595 606
    • (2002) Immunity , vol.16 , pp. 595-606
    • Richie, L.I.1    Ebert, P.J.2    Wu, L.C.3    Krummel, M.F.4    Owen, J.J.5    Davis, M.M.6
  • 83
    • 0036063264 scopus 로고    scopus 로고
    • Immature CD4(+)CD8(+) thymocytes form a multifocal immunological synapse with sustained tyrosine phosphorylation
    • E. Hailman, W.R. Burack, A.S. Shaw, M.L. Dustin, and P.M. Allen Immature CD4(+)CD8(+) thymocytes form a multifocal immunological synapse with sustained tyrosine phosphorylation Immunity 16 2002 839 848
    • (2002) Immunity , vol.16 , pp. 839-848
    • Hailman, E.1    Burack, W.R.2    Shaw, A.S.3    Dustin, M.L.4    Allen, P.M.5
  • 85
    • 0030732750 scopus 로고    scopus 로고
    • T cell receptor (TCR)-induced death of immature CD4+CD8+ thymocytes by two distinct mechanisms differing in their requirement for CD28 costimulation: Implications for negative selection in the thymus
    • J.A. Punt, W. Havran, R. Abe, A. Sarin, and A. Singer T cell receptor (TCR)-induced death of immature CD4+CD8+ thymocytes by two distinct mechanisms differing in their requirement for CD28 costimulation: implications for negative selection in the thymus J Exp Med 186 1997 1911 1922
    • (1997) J Exp Med , vol.186 , pp. 1911-1922
    • Punt, J.A.1    Havran, W.2    Abe, R.3    Sarin, A.4    Singer, A.5
  • 86
    • 0041695164 scopus 로고    scopus 로고
    • Continuous T cell receptor signaling required for synapse maintenance and full effector potential
    • J.B. Huppa, M. Gleimer, C. Sumen, and M.M. Davis Continuous T cell receptor signaling required for synapse maintenance and full effector potential Nat Immunol 4 2003 749 755
    • (2003) Nat Immunol , vol.4 , pp. 749-755
    • Huppa, J.B.1    Gleimer, M.2    Sumen, C.3    Davis, M.M.4
  • 87
    • 59649094661 scopus 로고    scopus 로고
    • Reductive isolation from bone marrow and blood implicates common lymphoid progenitors as the major source of thymopoiesis
    • T. Serwold, L.I. Ehrlich, and I.L. Weissman Reductive isolation from bone marrow and blood implicates common lymphoid progenitors as the major source of thymopoiesis Blood 113 2008 807 815
    • (2008) Blood , vol.113 , pp. 807-815
    • Serwold, T.1    Ehrlich, L.I.2    Weissman, I.L.3
  • 88
    • 0031054632 scopus 로고    scopus 로고
    • Negative selection in the thymus includes semimature T cells
    • H. Kishimoto, and J. Sprent Negative selection in the thymus includes semimature T cells J Exp Med 185 1997 263 271
    • (1997) J Exp Med , vol.185 , pp. 263-271
    • Kishimoto, H.1    Sprent, J.2
  • 89
    • 4344668118 scopus 로고    scopus 로고
    • CCR7 signals are essential for cortex-medulla migration of developing thymocytes
    • T. Ueno, F. Saito, D.H. Gray, S. Kuse, K. Hieshima, and H. Nakano CCR7 signals are essential for cortex-medulla migration of developing thymocytes J Exp Med 200 2004 493 505
    • (2004) J Exp Med , vol.200 , pp. 493-505
    • Ueno, T.1    Saito, F.2    Gray, D.H.3    Kuse, S.4    Hieshima, K.5    Nakano, H.6
  • 90
    • 76949084912 scopus 로고    scopus 로고
    • Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells
    • J.H. Park, S. Adoro, T. Guinter, B. Erman, A.S. Alag, and M. Catalfamo Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells Nat Immunol 11 2010 257 264
    • (2010) Nat Immunol , vol.11 , pp. 257-264
    • Park, J.H.1    Adoro, S.2    Guinter, T.3    Erman, B.4    Alag, A.S.5    Catalfamo, M.6
  • 91
  • 92
    • 71749104649 scopus 로고    scopus 로고
    • Differential contribution of chemotaxis and substrate restriction to segregation of immature and mature thymocytes
    • L.I. Ehrlich, D.Y. Oh, I.L. Weissman, and R.S. Lewis Differential contribution of chemotaxis and substrate restriction to segregation of immature and mature thymocytes Immunity 31 2009 986 998
    • (2009) Immunity , vol.31 , pp. 986-998
    • Ehrlich, L.I.1    Oh, D.Y.2    Weissman, I.L.3    Lewis, R.S.4
  • 93
    • 0037223065 scopus 로고    scopus 로고
    • Cutting edge: Identification of the targets of clonal deletion in an unmanipulated thymus
    • H.J. Cho, S.G. Edmondson, A.D. Miller, M. Sellars, S.T. Alexander, and S. Somersan Cutting edge: identification of the targets of clonal deletion in an unmanipulated thymus J Immunol 170 2003 10 13
    • (2003) J Immunol , vol.170 , pp. 10-13
    • Cho, H.J.1    Edmondson, S.G.2    Miller, A.D.3    Sellars, M.4    Alexander, S.T.5    Somersan, S.6
  • 95
    • 32244432265 scopus 로고    scopus 로고
    • CCR7-dependent cortex-to-medulla migration of positively selected thymocytes is essential for establishing central tolerance
    • H. Kurobe, C. Liu, T. Ueno, F. Saito, I. Ohigashi, and N. Seach CCR7-dependent cortex-to-medulla migration of positively selected thymocytes is essential for establishing central tolerance Immunity 24 2006 165 177
    • (2006) Immunity , vol.24 , pp. 165-177
    • Kurobe, H.1    Liu, C.2    Ueno, T.3    Saito, F.4    Ohigashi, I.5    Seach, N.6
  • 96
    • 70350131707 scopus 로고    scopus 로고
    • CCR7-mediated migration of developing thymocytes to the medulla is essential for negative selection to tissue-restricted antigens
    • T. Nitta, S. Nitta, Y. Lei, M. Lipp, and Y. Takahama CCR7-mediated migration of developing thymocytes to the medulla is essential for negative selection to tissue-restricted antigens Proc Natl Acad Sci USA 106 2009 17129 17133
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 17129-17133
    • Nitta, T.1    Nitta, S.2    Lei, Y.3    Lipp, M.4    Takahama, Y.5
  • 97
    • 0025761241 scopus 로고
    • Lower receptor avidity required for thymic clonal deletion than for effector T-cell function
    • H. Pircher, U.H. Rohrer, D. Moskophidis, R.M. Zinkernagel, and H. Hengartner Lower receptor avidity required for thymic clonal deletion than for effector T-cell function Nature 351 1991 482 485
    • (1991) Nature , vol.351 , pp. 482-485
    • Pircher, H.1    Rohrer, U.H.2    Moskophidis, D.3    Zinkernagel, R.M.4    Hengartner, H.5
  • 98
    • 0037167816 scopus 로고    scopus 로고
    • Direct observation of ligand recognition by T cells
    • D.J. Irvine, M.A. Purbhoo, M. Krogsgaard, and M.M. Davis Direct observation of ligand recognition by T cells Nature 419 2002 845 849
    • (2002) Nature , vol.419 , pp. 845-849
    • Irvine, D.J.1    Purbhoo, M.A.2    Krogsgaard, M.3    Davis, M.M.4
  • 99
    • 2442651482 scopus 로고    scopus 로고
    • T cell killing does not require the formation of a stable mature immunological synapse
    • M.A. Purbhoo, D.J. Irvine, J.B. Huppa, and M.M. Davis T cell killing does not require the formation of a stable mature immunological synapse Nat Immunol 5 2004 524 530
    • (2004) Nat Immunol , vol.5 , pp. 524-530
    • Purbhoo, M.A.1    Irvine, D.J.2    Huppa, J.B.3    Davis, M.M.4
  • 100
    • 0142149044 scopus 로고    scopus 로고
    • Thymocyte sensitivity and supramolecular activation cluster formation are developmentally regulated: A partial role for sialylation
    • T.K. Starr, M.A. Daniels, M.M. Lucido, S.C. Jameson, and K.A. Hogquist Thymocyte sensitivity and supramolecular activation cluster formation are developmentally regulated: a partial role for sialylation J Immunol 171 2003 4512 4520
    • (2003) J Immunol , vol.171 , pp. 4512-4520
    • Starr, T.K.1    Daniels, M.A.2    Lucido, M.M.3    Jameson, S.C.4    Hogquist, K.A.5
  • 102
    • 77949962019 scopus 로고    scopus 로고
    • CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development
    • J. Zikherman, C. Jenne, S. Watson, K. Doan, W. Raschke, and C.C. Goodnow CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development Immunity 32 2010 342 354
    • (2010) Immunity , vol.32 , pp. 342-354
    • Zikherman, J.1    Jenne, C.2    Watson, S.3    Doan, K.4    Raschke, W.5    Goodnow, C.C.6
  • 103
    • 0346727524 scopus 로고    scopus 로고
    • MicroRNAs modulate hematopoietic lineage differentiation
    • C.Z. Chen, L. Li, H.F. Lodish, and D.P. Bartel MicroRNAs modulate hematopoietic lineage differentiation Science 303 2004 83 86
    • (2004) Science , vol.303 , pp. 83-86
    • Chen, C.Z.1    Li, L.2    Lodish, H.F.3    Bartel, D.P.4
  • 104
    • 1942435249 scopus 로고    scopus 로고
    • Micromanagers of gene expression: The potentially widespread influence of metazoan microRNAs
    • D.P. Bartel, and C.Z. Chen Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs Nat Rev 5 2004 396 400
    • (2004) Nat Rev , vol.5 , pp. 396-400
    • Bartel, D.P.1    Chen, C.Z.2
  • 105
    • 33947721625 scopus 로고    scopus 로고
    • MiR-181a is an intrinsic modulator of T cell sensitivity and selection
    • Q.J. Li, J. Chau, P.J. Ebert, G. Sylvester, H. Min, and G. Liu miR-181a is an intrinsic modulator of T cell sensitivity and selection Cell 129 2007 147 161
    • (2007) Cell , vol.129 , pp. 147-161
    • Li, Q.J.1    Chau, J.2    Ebert, P.J.3    Sylvester, G.4    Min, H.5    Liu, G.6
  • 106
    • 33744949634 scopus 로고    scopus 로고
    • Identification of substrates of human protein-tyrosine phosphatase PTPN22
    • J. Wu, A. Katrekar, L.A. Honigberg, A.M. Smith, M.T. Conn, and J. Tang Identification of substrates of human protein-tyrosine phosphatase PTPN22 J Biol Chem 281 2006 11002 11010
    • (2006) J Biol Chem , vol.281 , pp. 11002-11010
    • Wu, J.1    Katrekar, A.2    Honigberg, L.A.3    Smith, A.M.4    Conn, M.T.5    Tang, J.6
  • 107
    • 64249119896 scopus 로고    scopus 로고
    • PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background
    • J. Zikherman, M. Hermiston, D. Steiner, K. Hasegawa, A. Chan, and A. Weiss PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background J Immunol 182 2009 4093 4106
    • (2009) J Immunol , vol.182 , pp. 4093-4106
    • Zikherman, J.1    Hermiston, M.2    Steiner, D.3    Hasegawa, K.4    Chan, A.5    Weiss, A.6
  • 108
    • 58749088416 scopus 로고    scopus 로고
    • SIT and TRIM determine T cell fate in the thymus
    • U. Koelsch, B. Schraven, and L. Simeoni SIT and TRIM determine T cell fate in the thymus J Immunol 181 2008 5930 5939
    • (2008) J Immunol , vol.181 , pp. 5930-5939
    • Koelsch, U.1    Schraven, B.2    Simeoni, L.3
  • 110
    • 9144247189 scopus 로고    scopus 로고
    • Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
    • J. Soutschek, A. Akinc, B. Bramlage, K. Charisse, R. Constien, and M. Donoghue Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs Nature 432 2004 173 178
    • (2004) Nature , vol.432 , pp. 173-178
    • Soutschek, J.1    Akinc, A.2    Bramlage, B.3    Charisse, K.4    Constien, R.5    Donoghue, M.6
  • 111
    • 37049034259 scopus 로고    scopus 로고
    • Acquisition of a functional T cell receptor during T lymphocyte development is enforced by HEB and E2A transcription factors
    • M.E. Jones, and Y. Zhuang Acquisition of a functional T cell receptor during T lymphocyte development is enforced by HEB and E2A transcription factors Immunity 27 2007 860 870
    • (2007) Immunity , vol.27 , pp. 860-870
    • Jones, M.E.1    Zhuang, Y.2
  • 112
    • 50149090966 scopus 로고    scopus 로고
    • Variability and robustness in T cell activation from regulated heterogeneity in protein levels
    • O. Feinerman, J. Veiga, J.R. Dorfman, R.N. Germain, and G. Altan-Bonnet Variability and robustness in T cell activation from regulated heterogeneity in protein levels Science 321 2008 1081 1084
    • (2008) Science , vol.321 , pp. 1081-1084
    • Feinerman, O.1    Veiga, J.2    Dorfman, J.R.3    Germain, R.N.4    Altan-Bonnet, G.5
  • 113
    • 0032572720 scopus 로고    scopus 로고
    • Csk controls antigen receptor-mediated development and selection of T-lineage cells
    • C. Schmedt, K. Saijo, T. Niidome, R. Kuhn, S. Aizawa, and A. Tarakhovsky Csk controls antigen receptor-mediated development and selection of T-lineage cells Nature 394 1998 901 904
    • (1998) Nature , vol.394 , pp. 901-904
    • Schmedt, C.1    Saijo, K.2    Niidome, T.3    Kuhn, R.4    Aizawa, S.5    Tarakhovsky, A.6
  • 114
    • 0035927093 scopus 로고    scopus 로고
    • Dynamic tuning of T cell reactivity by self-peptide-major histocompatibility complex ligands
    • P. Wong, G.M. Barton, K.A. Forbush, and A.Y. Rudensky Dynamic tuning of T cell reactivity by self-peptide-major histocompatibility complex ligands J Exp Med 193 2001 1179 1187
    • (2001) J Exp Med , vol.193 , pp. 1179-1187
    • Wong, P.1    Barton, G.M.2    Forbush, K.A.3    Rudensky, A.Y.4
  • 115
    • 42949153447 scopus 로고    scopus 로고
    • Dissecting microRNA-mediated gene regulation and function in T-cell development
    • T.K. Mao, and C.Z. Chen Dissecting microRNA-mediated gene regulation and function in T-cell development Methods Enzymol 427 2007 171 189
    • (2007) Methods Enzymol , vol.427 , pp. 171-189
    • Mao, T.K.1    Chen, C.Z.2
  • 116
    • 29244457799 scopus 로고    scopus 로고
    • Mechanistic basis of pre-T cell receptor-mediated autonomous signaling critical for thymocyte development
    • S. Yamasaki, E. Ishikawa, M. Sakuma, K. Ogata, K. Sakata-Sogawa, and M. Hiroshima Mechanistic basis of pre-T cell receptor-mediated autonomous signaling critical for thymocyte development Nat Immunol 7 2006 67 75
    • (2006) Nat Immunol , vol.7 , pp. 67-75
    • Yamasaki, S.1    Ishikawa, E.2    Sakuma, M.3    Ogata, K.4    Sakata-Sogawa, K.5    Hiroshima, M.6
  • 117
    • 0018197431 scopus 로고
    • The influence of thymus H-2 antigens on the specificity of maturing killer and helper cells
    • M.J. Bevan, and P.J. Fink The influence of thymus H-2 antigens on the specificity of maturing killer and helper cells Immunol Rev 42 1978 3 19
    • (1978) Immunol Rev , vol.42 , pp. 3-19
    • Bevan, M.J.1    Fink, P.J.2
  • 118
    • 0018085532 scopus 로고
    • On the thymus in the differentiation of "h-2 self-recognition" by T cells: Evidence for dual recognition?
    • R.M. Zinkernagel, G.N. Callahan, A. Althage, S. Cooper, P.A. Klein, and J. Klein On the thymus in the differentiation of "H-2 self- recognition" by T cells: evidence for dual recognition? J Exp Med 147 1978 882 896
    • (1978) J Exp Med , vol.147 , pp. 882-896
    • Zinkernagel, R.M.1    Callahan, G.N.2    Althage, A.3    Cooper, S.4    Klein, P.A.5    Klein, J.6
  • 119
    • 0024505586 scopus 로고
    • Positive selection of CD4-CD8+ T cells in the thymus of normal mice
    • J.C. Zuniga-Pflucker, D.L. Longo, and A.M. Kruisbeek Positive selection of CD4-CD8+ T cells in the thymus of normal mice Nature 338 1989 76 78
    • (1989) Nature , vol.338 , pp. 76-78
    • Zuniga-Pflucker, J.C.1    Longo, D.L.2    Kruisbeek, A.M.3
  • 120
    • 0023683669 scopus 로고
    • Positive selection of antigen-specific T cells in thymus by restricting MHC molecules
    • P. Kisielow, H.S. Teh, H. Bluthmann, and H. von Boehmer Positive selection of antigen-specific T cells in thymus by restricting MHC molecules Nature 335 1988 730 733
    • (1988) Nature , vol.335 , pp. 730-733
    • Kisielow, P.1    Teh, H.S.2    Bluthmann, H.3    Von Boehmer, H.4
  • 121
    • 0028215702 scopus 로고
    • The ligand for positive selection of T lymphocytes in the thymus
    • K.A. Hogquist, S.C. Jameson, and M.J. Bevan The ligand for positive selection of T lymphocytes in the thymus Curr Opin Immunol 6 1994 273 278
    • (1994) Curr Opin Immunol , vol.6 , pp. 273-278
    • Hogquist, K.A.1    Jameson, S.C.2    Bevan, M.J.3
  • 122
    • 67349280397 scopus 로고    scopus 로고
    • Germline-encoded amino acids in the alphabeta T-cell receptor control thymic selection
    • J.P. Scott-Browne, J. White, J.W. Kappler, L. Gapin, and P. Marrack Germline-encoded amino acids in the alphabeta T-cell receptor control thymic selection Nature 458 2009 1043 1046
    • (2009) Nature , vol.458 , pp. 1043-1046
    • Scott-Browne, J.P.1    White, J.2    Kappler, J.W.3    Gapin, L.4    Marrack, P.5
  • 123
    • 0025978232 scopus 로고
    • The role of polymorphic amino acids of the MHC molecule in the selection of the T cell repertoire
    • H.R. Bhayani, and S.M. Hedrick The role of polymorphic amino acids of the MHC molecule in the selection of the T cell repertoire J Immunol 146 1991 1093 1098
    • (1991) J Immunol , vol.146 , pp. 1093-1098
    • Bhayani, H.R.1    Hedrick, S.M.2
  • 124
    • 0033394323 scopus 로고    scopus 로고
    • Evaluating peptide repertoires within the context of thymocyte development
    • G.M. Barton, and A.Y. Rudensky Evaluating peptide repertoires within the context of thymocyte development Semin Immunol 11 1999 417 422
    • (1999) Semin Immunol , vol.11 , pp. 417-422
    • Barton, G.M.1    Rudensky, A.Y.2
  • 125
    • 0032943540 scopus 로고    scopus 로고
    • Requirement for diverse, low-abundance peptides in positive selection of T cells
    • G.M. Barton, and A.Y. Rudensky Requirement for diverse, low-abundance peptides in positive selection of T cells Science 283 1999 67 70
    • (1999) Science , vol.283 , pp. 67-70
    • Barton, G.M.1    Rudensky, A.Y.2
  • 126
    • 0030935007 scopus 로고    scopus 로고
    • The MHC reactivity of the T cell repertoire prior to positive and negative selection
    • J. Zerrahn, W. Held, and D.H. Raulet The MHC reactivity of the T cell repertoire prior to positive and negative selection Cell 88 1997 627 636
    • (1997) Cell , vol.88 , pp. 627-636
    • Zerrahn, J.1    Held, W.2    Raulet, D.H.3
  • 127
    • 7144255543 scopus 로고    scopus 로고
    • CD4+ T cells mature in the absence of MHC class i and class II expression in Ly-6A.2 transgenic mice
    • S.C. Henderson, A. Berezovskaya, A. English, D. Palliser, K.L. Rock, and A. Bamezai CD4+ T cells mature in the absence of MHC class I and class II expression in Ly-6A.2 transgenic mice J Immunol 161 1998 175 182
    • (1998) J Immunol , vol.161 , pp. 175-182
    • Henderson, S.C.1    Berezovskaya, A.2    English, A.3    Palliser, D.4    Rock, K.L.5    Bamezai, A.6
  • 128
    • 0141593568 scopus 로고    scopus 로고
    • Negative selection imparts peptide specificity to the mature T cell repertoire
    • E.S. Huseby, F. Crawford, J. White, J. Kappler, and P. Marrack Negative selection imparts peptide specificity to the mature T cell repertoire Proc Natl Acad Sci USA 100 2003 11565 11570
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 11565-11570
    • Huseby, E.S.1    Crawford, F.2    White, J.3    Kappler, J.4    Marrack, P.5
  • 130
    • 18844365885 scopus 로고    scopus 로고
    • Coevolution of TCRMHC interactions: Conserved MHC tertiary structure is not sufficient for interactions with the TCR
    • H.J. Kim, D. Guo, and D.B. Sant'Angelo Coevolution of TCRMHC interactions: conserved MHC tertiary structure is not sufficient for interactions with the TCR Proc Natl Acad Sci USA 102 2005 7263 7267
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 7263-7267
    • Kim, H.J.1    Guo, D.2    Sant'Angelo, D.B.3
  • 132
    • 0026598333 scopus 로고
    • Involvement of the same region of the T cell antigen receptor in thymic selection and foreign peptide recognition
    • J. Kaye, N.J. Vasquez, and S.M. Hedrick Involvement of the same region of the T cell antigen receptor in thymic selection and foreign peptide recognition J Immunol 148 1992 3342 3353
    • (1992) J Immunol , vol.148 , pp. 3342-3353
    • Kaye, J.1    Vasquez, N.J.2    Hedrick, S.M.3
  • 133
    • 0033180491 scopus 로고    scopus 로고
    • The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery
    • B. Ernst, D.S. Lee, J.M. Chang, J. Sprent, and C.D. Surh The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery Immunity 11 1999 173 181
    • (1999) Immunity , vol.11 , pp. 173-181
    • Ernst, B.1    Lee, D.S.2    Chang, J.M.3    Sprent, J.4    Surh, C.D.5
  • 134
    • 0033180494 scopus 로고    scopus 로고
    • Low-affinity ligands for the TCR drive proliferation of mature CD8+ T cells in lymphopenic hosts
    • A.W. Goldrath, and M.J. Bevan Low-affinity ligands for the TCR drive proliferation of mature CD8+ T cells in lymphopenic hosts Immunity 11 1999 183 190
    • (1999) Immunity , vol.11 , pp. 183-190
    • Goldrath, A.W.1    Bevan, M.J.2
  • 135
    • 0033581935 scopus 로고    scopus 로고
    • Selecting and maintaining a diverse T-cell repertoire
    • A.W. Goldrath, and M.J. Bevan Selecting and maintaining a diverse T-cell repertoire Nature 402 1999 255 262
    • (1999) Nature , vol.402 , pp. 255-262
    • Goldrath, A.W.1    Bevan, M.J.2
  • 136
    • 0037191792 scopus 로고    scopus 로고
    • Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes
    • I. Stefanova, J.R. Dorfman, and R.N. Germain Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes Nature 420 2002 429 434
    • (2002) Nature , vol.420 , pp. 429-434
    • Stefanova, I.1    Dorfman, J.R.2    Germain, R.N.3
  • 138
    • 31144479383 scopus 로고    scopus 로고
    • CD8 T cells, like CD4 T cells, are triggered by multivalent engagement of TCRs by MHC-peptide ligands but not by monovalent engagement
    • J.D. Stone, and L.J. Stern CD8 T cells, like CD4 T cells, are triggered by multivalent engagement of TCRs by MHC-peptide ligands but not by monovalent engagement J Immunol 176 2006 1498 1505
    • (2006) J Immunol , vol.176 , pp. 1498-1505
    • Stone, J.D.1    Stern, L.J.2
  • 139
    • 0033710093 scopus 로고    scopus 로고
    • The relationship of MHC-peptide binding and T cell activation probed using chemically defined MHC class II oligomers
    • J.R. Cochran, T.O. Cameron, and L.J. Stern The relationship of MHC-peptide binding and T cell activation probed using chemically defined MHC class II oligomers Immunity 12 2000 241 250
    • (2000) Immunity , vol.12 , pp. 241-250
    • Cochran, J.R.1    Cameron, T.O.2    Stern, L.J.3
  • 140
    • 0035958907 scopus 로고    scopus 로고
    • Receptor proximity, not intermolecular orientation, is critical for triggering T-cell activation
    • J.R. Cochran, T.O. Cameron, J.D. Stone, J.B. Lubetsky, and L.J. Stern Receptor proximity, not intermolecular orientation, is critical for triggering T-cell activation J Biol Chem 276 2001 28068 28074
    • (2001) J Biol Chem , vol.276 , pp. 28068-28074
    • Cochran, J.R.1    Cameron, T.O.2    Stone, J.D.3    Lubetsky, J.B.4    Stern, L.J.5
  • 141
    • 15044358353 scopus 로고    scopus 로고
    • Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity
    • M. Krogsgaard, Q.J. Li, C. Sumen, J.B. Huppa, M. Huse, and M.M. Davis Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity Nature 434 2005 238 243
    • (2005) Nature , vol.434 , pp. 238-243
    • Krogsgaard, M.1    Li, Q.J.2    Sumen, C.3    Huppa, J.B.4    Huse, M.5    Davis, M.M.6
  • 143
    • 34447281286 scopus 로고    scopus 로고
    • A role for "self" in T-cell activation
    • M. Krogsgaard, J. Juang, and M.M. Davis A role for "self" in T-cell activation Semin Immunol 19 2007 236 244
    • (2007) Semin Immunol , vol.19 , pp. 236-244
    • Krogsgaard, M.1    Juang, J.2    Davis, M.M.3
  • 144
    • 67650497725 scopus 로고    scopus 로고
    • Positive selection optimizes the number and function of MHCII-restricted CD4+ T cell clones in the naive polyclonal repertoire
    • H.H. Chu, J.J. Moon, K. Takada, M. Pepper, J.A. Molitor, and T.W. Schacker Positive selection optimizes the number and function of MHCII-restricted CD4+ T cell clones in the naive polyclonal repertoire Proc Natl Acad Sci USA 106 2009 11241 11245
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 11241-11245
    • Chu, H.H.1    Moon, J.J.2    Takada, K.3    Pepper, M.4    Molitor, J.A.5    Schacker, T.W.6
  • 145
    • 0037306466 scopus 로고    scopus 로고
    • On the role of self-recognition in T cell responses to foreign antigen
    • I. Stefanova, J.R. Dorfman, M. Tsukamoto, and R.N. Germain On the role of self-recognition in T cell responses to foreign antigen Immunol Rev 191 2003 97 106
    • (2003) Immunol Rev , vol.191 , pp. 97-106
    • Stefanova, I.1    Dorfman, J.R.2    Tsukamoto, M.3    Germain, R.N.4
  • 146
    • 0036857211 scopus 로고    scopus 로고
    • Self peptide/MHC class i complexes have a negligible effect on the response of some CD8+ T cells to foreign antigen
    • R. Sporri, and C. Reis e Sousa Self peptide/MHC class I complexes have a negligible effect on the response of some CD8+ T cells to foreign antigen Eur J Immunol 32 2002 3161 3317
    • (2002) Eur J Immunol , vol.32 , pp. 3161-3317
    • Sporri, R.1    Reis Sousa, E.C.2
  • 148
    • 23944497170 scopus 로고    scopus 로고
    • Nonstimulatory peptides contribute to antigen-induced CD8-T cell receptor interaction at the immunological synapse
    • P.P. Yachi, J. Ampudia, N.R. Gascoigne, and T. Zal Nonstimulatory peptides contribute to antigen-induced CD8-T cell receptor interaction at the immunological synapse Nat Immunol 6 2005 785 792
    • (2005) Nat Immunol , vol.6 , pp. 785-792
    • Yachi, P.P.1    Ampudia, J.2    Gascoigne, N.R.3    Zal, T.4
  • 149
    • 35748961134 scopus 로고    scopus 로고
    • T cell activation enhancement by endogenous pMHC acts for both weak and strong agonists but varies with differentiation state
    • P.P. Yachi, C. Lotz, J. Ampudia, and N.R. Gascoigne T cell activation enhancement by endogenous pMHC acts for both weak and strong agonists but varies with differentiation state J Exp Med 204 2007 2747 2757
    • (2007) J Exp Med , vol.204 , pp. 2747-2757
    • Yachi, P.P.1    Lotz, C.2    Ampudia, J.3    Gascoigne, N.R.4
  • 150
    • 23044469067 scopus 로고    scopus 로고
    • Interaction between the CD8 coreceptor and major histocompatibility complex class i stabilizes T cell receptor-antigen complexes at the cell surface
    • L. Wooldridge, H.A. van den Berg, M. Glick, E. Gostick, B. Laugel, and S.L. Hutchinson Interaction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surface J Biol Chem 280 2005 27491 27501
    • (2005) J Biol Chem , vol.280 , pp. 27491-27501
    • Wooldridge, L.1    Van Den Berg, H.A.2    Glick, M.3    Gostick, E.4    Laugel, B.5    Hutchinson, S.L.6
  • 152
    • 0035033216 scopus 로고    scopus 로고
    • Strength of signaling by CD4 and CD8 coreceptor tails determines the number but not the lineage direction of positively selected thymocytes
    • R. Bosselut, L. Feigenbaum, S.O. Sharrow, and A. Singer Strength of signaling by CD4 and CD8 coreceptor tails determines the number but not the lineage direction of positively selected thymocytes Immunity 14 2001 483 494
    • (2001) Immunity , vol.14 , pp. 483-494
    • Bosselut, R.1    Feigenbaum, L.2    Sharrow, S.O.3    Singer, A.4
  • 153
    • 0034669979 scopus 로고    scopus 로고
    • Immature CD4+CD8+ thymocytes do not polarize lipid rafts in response to TCR-mediated signals
    • P.J. Ebert, J.F. Baker, and J.A. Punt Immature CD4+CD8+ thymocytes do not polarize lipid rafts in response to TCR-mediated signals J Immunol 165 2000 5435 5442
    • (2000) J Immunol , vol.165 , pp. 5435-5442
    • Ebert, P.J.1    Baker, J.F.2    Punt, J.A.3
  • 154
    • 14944346245 scopus 로고    scopus 로고
    • How T cells 'see' antigen
    • M. Krogsgaard, and M.M. Davis How T cells 'see' antigen Nat Immunol 6 2005 239 245
    • (2005) Nat Immunol , vol.6 , pp. 239-245
    • Krogsgaard, M.1    Davis, M.M.2
  • 155
    • 0141455869 scopus 로고    scopus 로고
    • Visualizing thymocyte motility using 2-photon microscopy
    • E.A. Robey, and P. Bousso Visualizing thymocyte motility using 2-photon microscopy Immunol Rev 195 2003 51 57
    • (2003) Immunol Rev , vol.195 , pp. 51-57
    • Robey, E.A.1    Bousso, P.2
  • 156
    • 71749103257 scopus 로고    scopus 로고
    • Spatial mapping of thymic stromal microenvironments reveals unique features influencing T lymphoid differentiation
    • A.V. Griffith, M. Fallahi, H. Nakase, M. Gosink, B. Young, and H.T. Petrie Spatial mapping of thymic stromal microenvironments reveals unique features influencing T lymphoid differentiation Immunity 31 2009 999 1009
    • (2009) Immunity , vol.31 , pp. 999-1009
    • Griffith, A.V.1    Fallahi, M.2    Nakase, H.3    Gosink, M.4    Young, B.5    Petrie, H.T.6
  • 157
    • 0029041519 scopus 로고
    • The influence of invariant chain on the positive selection of single T cell receptor specificities
    • S. Tourne, N. Nakano, S. Viville, C. Benoist, and D. Mathis The influence of invariant chain on the positive selection of single T cell receptor specificities Eur J Immunol 25 1995 1851 1856
    • (1995) Eur J Immunol , vol.25 , pp. 1851-1856
    • Tourne, S.1    Nakano, N.2    Viville, S.3    Benoist, C.4    Mathis, D.5
  • 158
    • 0030058657 scopus 로고    scopus 로고
    • The repertoire of T cells shaped by a single MHC/peptide ligand
    • L. Ignatowicz, J. Kappler, and P. Marrack The repertoire of T cells shaped by a single MHC/peptide ligand Cell 84 1996 521 529
    • (1996) Cell , vol.84 , pp. 521-529
    • Ignatowicz, L.1    Kappler, J.2    Marrack, P.3
  • 159
    • 56749105120 scopus 로고    scopus 로고
    • The variable immunological self: Genetic variation and nongenetic noise in Aire-regulated transcription
    • E.S. Venanzi, R. Melamed, D. Mathis, and C. Benoist The variable immunological self: genetic variation and nongenetic noise in Aire-regulated transcription Proc Natl Acad Sci USA 105 2008 15860 15865
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 15860-15865
    • Venanzi, E.S.1    Melamed, R.2    Mathis, D.3    Benoist, C.4
  • 160
    • 0142155578 scopus 로고    scopus 로고
    • Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramers
    • C.L. Day, N.P. Seth, M. Lucas, H. Appel, L. Gauthier, and G.M. Lauer Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramers J Clin Invest 112 2003 831 842
    • (2003) J Clin Invest , vol.112 , pp. 831-842
    • Day, C.L.1    Seth, N.P.2    Lucas, M.3    Appel, H.4    Gauthier, L.5    Lauer, G.M.6
  • 161
    • 0035070797 scopus 로고    scopus 로고
    • A kinetic window constricts the T cell receptor repertoire in the thymus
    • P.A. Savage, and M.M. Davis A kinetic window constricts the T cell receptor repertoire in the thymus Immunity 14 2001 243 252
    • (2001) Immunity , vol.14 , pp. 243-252
    • Savage, P.A.1    Davis, M.M.2
  • 162
    • 0037148840 scopus 로고    scopus 로고
    • BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes
    • P. Bouillet, J.F. Purton, D.I. Godfrey, L.C. Zhang, L. Coultas, and H. Puthalakath BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes Nature 415 2002 922 926
    • (2002) Nature , vol.415 , pp. 922-926
    • Bouillet, P.1    Purton, J.F.2    Godfrey, D.I.3    Zhang, L.C.4    Coultas, L.5    Puthalakath, H.6
  • 163
    • 77649252927 scopus 로고    scopus 로고
    • A novel TCR transgenic model reveals that negative selection involves an immediate, Bim-dependent pathway and a delayed, Bim-independent pathway
    • D. Kovalovsky, M. Pezzano, B.D. Ortiz, and D.B. Sant'Angelo A novel TCR transgenic model reveals that negative selection involves an immediate, Bim-dependent pathway and a delayed, Bim-independent pathway PLoS ONE 5 2010 e8675
    • (2010) PLoS ONE , vol.5 , pp. 8675
    • Kovalovsky, D.1    Pezzano, M.2    Ortiz, B.D.3    Sant'Angelo, D.B.4
  • 165
    • 77953781329 scopus 로고    scopus 로고
    • Identifying coevolutionary patterns in human leukocyte antigen (Hla) molecules
    • X. Jiang, and M.A. Fares Identifying coevolutionary patterns in human leukocyte antigen (Hla) molecules Evolution; Int J Org Evol 64 2009 1429 1445
    • (2009) Evolution; Int J Org Evol , vol.64 , pp. 1429-1445
    • Jiang, X.1    Fares, M.A.2
  • 166
    • 0023475192 scopus 로고
    • The T cell receptor
    • P. Marrack, and J. Kappler The T cell receptor Science 238 1987 1073 1079
    • (1987) Science , vol.238 , pp. 1073-1079
    • Marrack, P.1    Kappler, J.2
  • 167
    • 40149108609 scopus 로고    scopus 로고
    • Surface-anchored monomeric agonist pMHCs alone trigger TCR with high sensitivity
    • Z. Ma, K.A. Sharp, P.A. Janmey, and T.H. Finkel Surface-anchored monomeric agonist pMHCs alone trigger TCR with high sensitivity PLoS Biol 6 2008 e43
    • (2008) PLoS Biol , vol.6 , pp. 43
    • Ma, Z.1    Sharp, K.A.2    Janmey, P.A.3    Finkel, T.H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.