Critical Role for CXCR4 Signaling in Progenitor Localization and T Cell Differentiation in the Postnatal Thymus

Journal of Immunology

Volumn 171, Issue 9, 2003, Pages 4521-4527

  Plotkin, Jason ^a   Prockop, Susan E ^a   Lepique, Ana ^a   Petrie, Howard T ^a,b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b Weill Cornell Graduate School of Biomedical Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA4 INTEGRIN; CD4 ANTIGEN; CD8 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; CYTOKERATIN; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL CELL; ARTICLE; CELL COMPARTMENTALIZATION; CELL INTERACTION; CELL MIGRATION; CELL PROLIFERATION; CLONAL ANERGY; HEMATOPOIETIC CELL; LYMPHOID CELL; MALE; MOUSE; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN LOCALIZATION; STEM CELL; STROMA CELL; T LYMPHOCYTE ACTIVATION; THYMUS;

EID: 0142149043     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.171.9.4521     Document Type: Article

References (36)

1. Kondo, M., I. L. Weissman, and K. Akashi. 1997. Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell 91:661.
2. Ceredig, R., and T. Rolink. 2002. A positive look at double-negative thymocytes. Nat Rev. Immunol. 2:888.
3. Anderson, G., N. C. Moore, J. J. Owen, and E. J. Jenkinson. 1996. Cellular interactions in thymocyte development. Annu. Rev. Immunol. 14:73.
4. Lind, E. F., S. E. Prockop, H. E. Porritt, and H. T. Petrie. 2001. Mapping precursor movement through the postnatal thymus reveals specific microenvironments supporting defined stages of early lymphoid development. J. Exp. Med. 194:127.
5. Penit, C. 1988. Localization and phenotype of cycling and post-cycling murine thymocytes studied by simultaneous detection of bromodeoxyuridine and surface antigens. J. Histochem. Cytochem. 36:473.
6. Ceredig, R., and M. Schreyer. 1984. Immunohistochemical localization of host and donor-derived cells in the regenerating thymus of radiation bone marrow chimeras. Thymus 6:15.
7. Brahim, F., and D. G. Osmond. 1970. Migration of bone marrow lymphocytes demonstrated by selective bone marrow labeling with thymidine-H3. Anat. Rec. 168:139.
8. Brumby, M., and D. Metcalf. 1967. Migration of cells to the thymus demonstrated by parabiosis. Proc. Soc. Exp. Biol. Med. 124:99.
9. Kyewski, B. A. 1987. Seeding of thymic microenvironments defined by distinct thymocyte-stromal cell interactions is developmentally controlled. J. Exp. Med. 166:520.
10. Ezine, S., I. L. Weissman, and R. V. Rouse. 1984. Bone marrow cells give rise to distinct cell clones within the thymus. Nature 309:629.
11. Dunon, D., D. Courtois, O. Vainio, A. Six, C. H. Chen, M. D. Cooper, J. P. Dangy, and B. A. Imhof. 1997. Ontogeny of the immune system: γ/δ and α/β T cells migrate from thymus to the periphery in alternating waves. J. Exp. Med. 186:977.
12. Penit, C. 1986. In vivo thymocyte maturation: BUdR labeling of cycling thymocytes and phenotypic analysis of their progeny support the single lineage model. J. Immunol. 137:2115.
13. Prockop, S. E., S. Palencia, C. M. Ryan, K. Gordon, D. Gray, and H. T. Petrie. 2002. Stromal cells provide the matrix for migration of early lymphoid progenitors through the thymic cortex. J. Immunol. 169:4354.
14. Orban, P. C., D. Chui, and J. D. Marth. 1992. Tissue- and site-specific DNA recombination in transgenic mice. Proc. Natl. Acad. Sci. USA 89:6861.
15. Gordon, K. M., L. Duckett, B. Daul, and H. T. Petrie. 2003. A simple method for detecting up to five immunofluorescent parameters together with DNA staining for cell cycle or viability on a benchtop flow cytometer. J. Immunol. Methods 275:113.
16. Suzuki, G., H. Sawa, Y. Kobayashi, Y. Nakata, K. Nakagawa, A. Uzawa, H. Sakiyama, S. Kakinuma, K. Iwabuchi, and K. Nagashima. 1999. Pertussis toxin-sensitive signal controls the trafficking of thymocytes across the cortico-medullary junction in the thymus. J. Immunol. 162:5981.
17. van Ewijk, W., B. Wang, G. Hollander, H. Kawamoto, E. Spanopoulou, M. Itoi, T. Amagai, Y. F. Jiang, W. T. Germeraad, W. F. Chen, et al. 1999. Thymic microenvironments. 3-D versus 2-D? Semin. Immunol. 11:57.
18. Perlmutter, R. M., J. D. Marth, D. B. Lewis, R. Peet, S. F. Ziegler, and C. B. Wilson. 1988. Structure and expression of lck transcripts in human lymphoid cells. J. Cell Biochem. 38:117.
19. lck with the pre-T cell receptor during thymocyte development. Eur. J. Immunol. 30:8.
20. Norment, A. M., and M. J. Bevan. 2000. Role of chemokines in thymocyte development. Semin. Immunol. 12:445.
21. Bleul, C. C., and T. Boehm. 2000. Chemokines define distinct microenvironments in the developing thymus. Eur. J. Immunol. 30:3371.
22. Wilkinson, B., J. J. Owen, and E. J. Jenkinson. 1999. Factors regulating stem cell recruitment to the fetal thymus. J. Immunol. 162:3873.
23. Kim, C. H., L. M. Pelus, J. R. White, and H. E. Broxmeyer. 1998. Differential chemotactic behavior of developing T cells in response to thymic chemokines. Blood 91:4434.
24. Norment, A. M., L. Y. Bogatzki, B. N. Gantner, and M. J. Bevan. 2000. Murine CCR9, a chemokine receptor for thymus-expressed chemokine that is up-regulated following pre-TCR signaling. J. Immunol. 164:639.
25. + thymocytes preferentially respond to CCL25. J. Immunol. 168:134.
26. Campbell, J. J., J. Pan, and E. C. Butcher. 1999. Cutting edge: developmental switches in chemokine responses during T cell maturation. J. Immunol. 163:2353.
27. Poznansky, M. C., I. T. Olszak, R. H. Evans, Z. Wang, R. B. Foxall, D. P. Olson, K. Weibrecht, A. D. Luster, and D. T. Scadden. 2002. Thymocyte emigration is mediated by active movement away from stroma-derived factors. J. Clin. Invest. 109:1101.
28. Ueno, T., K. Hara, M. S. Willis, M. A. Malin, U. E. Hopken, D. H. Gray, K. Matsushima, M. Lipp, T. A. Springer, R. L. Boyd, et al. 2002. Role for CCR7 ligands in the emigration of newly generated T lymphocytes from the neonatal thymus. Immunity 16:205.
29. Suniara, R. K., E. J. Jenkinson, and J. J. Owen. 1999. Studies on the phenotype of migrant thymic stem cells. Eur. J. Immunol. 29:75.
30. Zou, Y. R., A. H. Kottmann, M. Kuroda, I. Taniuchi, and D. R. Littman. 1998. Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature 393:595.
31. Egawa, T., K. Kawabata, H. Kawamoto, K. Amada, R. Okamoto, N. Fujii, T. Kishimoto, Y. Katsura, and T. Nagasawa. 2001. The earliest stages of B cell development require a chemokine stromal cell-derived factor/pre-B cell growth-stimulating factor. Immunity 15:323.
32. Ara, T., M. Itoi, K. Kawabata, T. Egawa, K. Tokoyoda, T. Sugiyama, N. Fujii, T. Amagai, and T. Nagasawa. 2003. A role of CXC chemokine ligand 12/stromal cell-derived factor-1/pre-B cell growth stimulating factor and its receptor CXCR4 in fetal and adult T cell development in vivo. J. Immunol. 170:4649.
33. Onai, N., Y. Zhang, H. Yoneyama, T. Kitamura, S. Ishikawa, and K. Matsushima. 2000. Impairment of lymphopoiesis and myelopoiesis in mice reconstituted with bone marrow-hematopoietic progenitor cells expressing SDF-1-intrakine. Blood 96:2074.
34. Pelletier, A. J., L. J. van der Laan, P. Hildbrand, M. A. Siani, D. A. Thompson, P. E. Dawson, B. E. Torbett, and D. R. Salomon. 2000. Presentation of chemokine SDF-1α by fibronectin mediates directed migration of T cells. Blood 96:2682.
35. Springer, T. A. 1994. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 76:301.
36. Porritt, H. E., K. Gordon, and H. T. Petrie. 2003. Kinetics of steady-state differentiation and mapping of intrathymic signaling environments by stem cell transplantation in non-irradiated mice. J. Exp. Med. 198:957.