Self-reactive T cells selected on thymic cortical epithelium are polyclonal and are pathogenic in vivo

Journal of Immunology

Volumn 162, Issue 9, 1999, Pages 5078-5084

  Laufer, Terri M ^a,b,c   Fan, Lian ^a,d   Glimcher, Laurie H ^a,b  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CD4 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ANTIGEN EXPRESSION; ARTICLE; AUTOIMMUNITY; CELL SELECTION; CONTROLLED STUDY; DENDRITIC CELL; GRAFT VERSUS HOST REACTION; HELPER CELL; HYPERGAMMAGLOBULINEMIA; IMMUNOLOGICAL TOLERANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; THYMOCYTE; THYMUS;

ACUTE DISEASE; ANIMALS; AUTOANTIGENS; AUTOIMMUNE DISEASES; CD4-POSITIVE T-LYMPHOCYTES; CHRONIC DISEASE; CLONE CELLS; EPITHELIUM; GRAFT VS HOST DISEASE; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED AKR; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC; THYMUS GLAND;

EID: 0033136289     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. Spain, L. M., and L. J. Berg. 1992. Developmental regulation of thymocyte susceptibility to deletion by "self"-peptide. J. Exp. Med. 176:213.
2. Vasquez, N. J., J. Kaye, and S. M. Hedrick. 1992. In vivo and in vitro clonal deletion of double-positive thymocytes. J. Exp. Med. 175:1307.
3. Surh, C. D., E. K. Gao, H. Kosaka, D. Lo, C. Ahn, D. B. Murphy, L. Karlsson, P. Peterson, and J. Sprent. 1992. Two subsets of epithelial cells in the thymic medulla. J. Exp. Med. 176:495.
4. Burkly, L., C. Hession, L. Ogata, C. Reilly, L. A. Marconi, D. Olson, R. Tizard, R. Cate, and D. Lo. 1995. Expression of RelB is required for the development of thymic medulla and dendritic cells. Nature 373:531.
5. Oukka, M., E. Colucci-Guyon, P. L. Tran, M. Cohen-Tannoudji, C., Babinet, V., Lotteau, and K. Kosmatopoulos, K. 1996. CD4 T cell tolerance to nuclear proteins induced by medullary thymic epithelium. Immunity 4:545.
6. Oukka, M., P. Andre, P., Turmel, N. Besnard, V. Angevin, L. Karlsson, P. L. Trans, D. Charron, B. Bihain, K. Kosmatopoulos, et al. 1997. Selectivity of the major histocompatibility complex class II presentation pathway of cortical thymic epithelial cell lines. Eur. J. Immunol. 27:855.
7. Lorenz, R. G., and P. M. Allen. 1989. Thymic cortical epithelial cells lack full capacity for antigen presentation. Nature 340:557.
8. Kasai, M., K. Hirokawa, K. Kajino, K., Ogasawara, M. Tatsumi, E. Hermel, J. J. Monaco, and T. Mizuochi. 1996. Difference in antigen presentation pathways between cortical and medullary thymic epithelial cells. Eur. J. Immunol. 26:2101.
9. Berg, L. J., A. M. Pullen, B. Fazekas de St. Groth, D. Mathis, C. Benoist, and M. M. Davis. 1989. Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand. Cell 58:1035.
10. Lo, D., and J. Sprent. 1986. Identity of cells that imprint H-2-restricted T-cell specificity in the thymus. Nature 319:672.
11. Benoist, C., and D. Mathis. 1989. Positive selection of the T cell repertoire: where and when does it occur? Cell 58:1027.
12. + T cells. Int. Immunol. 4:707.
13. + T lymphocytes in class II-deficient mice. Proc. Natl. Acad. Sci. USA 90:2779.
14. lo thymocytes in vivo. Science 250: 1720.
15. Surh, C. D., and J. Sprent. 1994. T-cell apoptosis detected in situ during positive and negative selection in the thymus. Nature 372:100.
16. Marrack, P., D. Lo, R. Brinster, R. Palmiter, L. Burkly, R. H. Flavell, and J. Kappler. 1988. The effect of thymus environment on T cell development and tolerance. Cell 53:627.
17. Hoffmann, M. W., J. Allison, and J. F. Miller. 1992. Tolerance induction by thymic medullary epithelium. Proc. Natl. Acad. Sci. USA 89:2526.
18. Schonrich, G., F. Momburg, G. J. Hammerling, and B. Arnold. 1992. Anergy induced by thymic medullary epithelium. Eur. J. Immunol. 22:1687.
19. + thymocytes. J. Immunol. 152:3254.
20. Hoffmann, M. W., W. R. Heath, D. Ruschmeyer, and J. F. Miller. 1995. Deletion of high-avidity T cells by thymic epithelium. Proc. Natl. Acad. Sci. USA 92:9851.
21. Spain, L. M., and L. J. Berg. 1994. Quantitative analysis of the efficiency of clonal deletion in the thymus. Dev. Immunol. 4:43.
22. Volkmann, A., T. Zal, and B. Stockinger. 1997. Antigen-presenting cells in the thymus that can negatively select MHC class II-restricted T cells recognizing a circulating self antigen. J. Immunol. 158:693.
23. Tanaka, Y., C. Mamalaki, B. Stockinger, and D. Kioussis. 1993. In vitro negative selection of αβ T cell receptor transgenic thymocytes by conditionally immortalized thymic cortical epithelial cell lines and dendritic cells. Eur. J. Immunol. 23:2614.
24. + thymocytes in vitro does not require dedicated antigen-presenting cells. Eur. J. Immunol. 23:669.
25. Laufer, T. M., J. DeKoning, J. S. Markowitz, D. Lo, and L. H. Glimcher. 1996. Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex. Nature 383:81.
26. + T cells in major histocompatibility complex class II-deficient mice. Science 253:1417.
27. White, J., A. Herman, A. M. Pullen, R. Kubo, J. W. Kappler, and P. Marrack. 1989. The Vβ-specific superantigen staphylococcal enterotoxin B: stimulation of mature T cells and clonal deletion in neonatal mice. Cell 56:27.
28. Rock, K. L., and B. Benacerraf. 1983. Inhibition of antigen-specific T lymphocyte activation by structurally related Ir gene-controlled polymers: evidence of specific competition for accessory cell antigen presentation. J. Exp. Med. 157: 1618.
29. Sprent, J., and R. Korngold. 1994. Murine models for graft-versus-host disease. In S. J. Forman, K. G. Blume, and E. D. Thomas, eds. Bone Marrow Transplantation. Blackwell, Boston, p. 220.
30. 1 recipients carrying mutations at H-2K and/or I-A. J. Exp. Med. 157:755.
31. Gleichmann, E., E. H. Van Elven, and J. P. Van der Veen. 1982. A systemic lupus erythematosus (SLE)-like disease in mice induced by abnormal T-B cell cooperation: preferential formation of autoantibodies characteristic of SLE. Eur. J. Immunol. 12:152.
32. van Rappard-van der Veen, F. M., A. G. Rolink, and E. Gleichmann. 1982. Diseases caused by reactions of T lymphocytes towards incompatible structures of the major histocompatibility complex. VI. Autoantibodies characteristic of systemic lupus erythematosus induced by abnormal T-B cell cooperation across I-E. J. Exp. Med. 155:1555.
33. Rolink, A. G., H. Gleichmann, and E. Gleichmann. 1983. Diseases caused by reactions of T lymphocytes to incompatible structures of the major histocompatibility complex. VII. Immune-complex glomerulonephritis. J. Immunol. 130:209.
34. Zerrahn, J., W. Held, and D. H. Raulet. 1997. The MHC reactivity of the T cell repertoire prior to positive and negative selection. Cell 88:627.
35. Ignatowicz, L., J. Kappler, and P. Marrack. 1996. The repertoire of T cells shaped by a single MHC/peptide ligand. Cell 84:521.
36. Ignatowicz, L., W. Rees, R. Pacholczyk, H. Ignatowicz, E. Kushnir, J. Kappler, and P. Marrack. 1997. T cells can be activated by peptides that are unrelated in sequence to their selecting peptide. Immunity 7:179.
37. + T cells. Immunity 7:209.
38. Grubin, C. E., S. Kovats, P. deRoos, and A. Y. Rudensky. 1997. Deficient positive selection of CD4 T cells in mice displaying altered repertoires of MHC class II-bound self-peptides. Immunity 7:197.
39. Sherman, L. A., and S. Chattopadhyay. 1993. The molecular basis of allorecognition. Annu. Rev. Immunol. 11:385.
40. Morris, S. C., R. L. Cheek, P. L. Cohen, and R. A. Eisenberg. 1990. Autoantibodies in chronic graft versus host result from cognate T-B interactions. J. Exp. Med 171:503.
41. 2 microglobulin transgenic rats. J. Clin. Invest. 98:945.
42. Taurog, J. D., J. A. Richardson, J. T. Croft, W. A. Simmons, M. Zhou, J. L. Fernandez-Sueiro, E. Balish, and R. E. Hammer. 1994. The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats. J. Exp. Med. 180:2359.
43. Goverman, J., A. Woods, L. Larson, L. P. Weiner, L. Hood, and D. M. Zaller. 1993. Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity. Cell 72:551.
44. Seery, J. P., J. M. Carroll, V. Cattell, and F. M. Watt. 1997. Antinuclear auto-antibodies and lupus nephritis in transgenic mice expressing interferon γ in the epidermis. J. Exp. Med. 186:1451.
45. Treurniet, R. A., E. C. Bergijk, J. J. Baelde, E. De Heer, P. J. Hoedemaeker, and J. A. Bruijn. 1993. Gender-related influences on the development of chronic graft-versus-host disease-induced experimental lupus nephritis. Clin. Exp. Immunol. 91:442.
46. Salaun, J., A. Bandeira, I. Khazaal, F. Calman, M. Coltey, A. Coutinho, and N. M. Le Douarin. 1990. Thymic epithelium tolerizes for histocompatibility antigens. Science 247:1471.
47. Melero, I., M. C. Singhal, P. McGowan, H. S. Haugen, J. Blake, K. E. Hellstrom, G. Yang, C. H. Clegg, and L. Chen. 1997. Immunological ignorance of an E7-encoded cytolytic T-lymphocyte epitope in transgenic mice expressing the E7 and E6 oncogenes of human papillomavirus type 16. J. Virol. 71:3998.
48. Frazer, I. H., G. J. Fernando, N. Fowler, G. R. Leggatt, P. F. Lambert, A. Liem, K. Malcolm, and R. W. Tindle. 1998. Split tolerance to a viral antigen expressed in thymic epithelium and keratinocytes. Eur. J. Immunol. 28:2791.
49. Doan, T., M. Chambers, M. Street, G. J. Fernando, K. Herd, P. Lambert, and R. Tindle. 1998. Mice expressing the E7 oncogene of HPV16 in epithelium show central tolerance, and evidence of peripheral anergising tolerance, to E7-encoded cytotoxic T-lymphocyte epitopes. Virology 244:352.
50. Bonomo, A., P. J. Kehn, E. Payer, L. Rizzo, A. W. Cheever, and E. M. Shevach. 1995. Pathogenesis of post-thymectomy autoimmunity: role of syngeneic MLR-reactive T cells. J. Immunol. 154:6602.
51. Glazier, A., P. J. Tutschka, E. R. Farmer, and G. W. Santos. 1983. Graft-versus-host disease in cyclosporin A-treated rats after syngeneic and autologous bone marrow reconstitution. J. Exp. Med. 158:1.
52. Fischer, A. C., W. E. Beschorner, and A. D. Hess. 1989. Requirements for the induction and adoptive transfer of cyclosporine-induced syngeneic graft-versus-host disease. J. Exp. Med 169:1031.
53. Bonomo, A., P. J. Kehn, and E. M. Shevach. 1995. Post-thymectomy autoimmunity: abnormal T-cell homeostasis. Immunol. Today 16:61.
54. Hess, A. D., and A. C. Fischer. 1989. Immune mechanisms in cyclosporine-induced syngeneic graft-versus-host disease. Transplantation 48:895.