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Volumn 10, Issue 11, 2009, Pages 1162-1169

An endogenous positively selecting peptide enhances mature t cell responses and becomes an autoantigen in the absence of microrna mir-181a

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIGEN CLASS 2; LYMPHOCYTE ANTIGEN RECEPTOR; MICRORNA; MIRN181 MICRORNA, MOUSE; PEPTIDE;

EID: 70350435670     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.1797     Document Type: Article
Times cited : (227)

References (53)
  • 1
    • 0023900635 scopus 로고
    • Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes
    • Kisielow, P., Bluthmann, H., Staerz, U.D., Steinmetz, M. and von Boehmer, H. Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes. Nature 333, 742-746 (1988).
    • (1988) Nature , vol.333 , pp. 742-746
    • Kisielow, P.1    Bluthmann, H.2    Staerz, U.D.3    Steinmetz, M.4    Von Boehmer, H.5
  • 2
    • 0027478380 scopus 로고
    • Positive selection of CD8+ T cells induced by major histocompatibility complex binding peptides in fetal thymic organ culture
    • Hogquist, K.A., Gavin, M.A. and Bevan, M.J. Positive selection of CD8+ T cells induced by major histocompatibility complex binding peptides in fetal thymic organ culture. J. Exp. Med. 177, 1469-1473 (1993).
    • (1993) J. Exp. Med , vol.177 , pp. 1469-1473
    • Hogquist, K.A.1    Gavin, M.A.2    Bevan, M.J.3
  • 3
    • 0033180494 scopus 로고    scopus 로고
    • Low-affinity ligands for the TCR drive proliferation of mature CD8+ T cells in lymphopenic hosts
    • Goldrath, A.W. and Bevan, M.J. Low-affinity ligands for the TCR drive proliferation of mature CD8+ T cells in lymphopenic hosts. Immunity 11, 183-190 (1999).
    • (1999) Immunity , vol.11 , pp. 183-190
    • Goldrath, A.W.1    Bevan, M.J.2
  • 4
    • 0033180491 scopus 로고    scopus 로고
    • The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery
    • Ernst, B., Lee, D.S., Chang, J.M., Sprent, J. and Surh, C.D. The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery. Immunity 11, 173-181 (1999).
    • (1999) Immunity , vol.11 , pp. 173-181
    • Ernst, B.1    Lee, D.S.2    Chang, J.M.3    Sprent, J.4    Surh, C.D.5
  • 5
    • 0037306466 scopus 로고    scopus 로고
    • On the role of self-recognition in T cell responses to foreign antigen
    • Stefanova, I., Dorfman, J.R., Tsukamoto, M. and Germain, R.N. On the role of self-recognition in T cell responses to foreign antigen. Immunol. Rev. 191, 97-106 (2003).
    • (2003) Immunol. Rev , vol.191 , pp. 97-106
    • Stefanova, I.1    Dorfman, J.R.2    Tsukamoto, M.3    Germain, R.N.4
  • 6
    • 23944497170 scopus 로고    scopus 로고
    • Nonstimulatory peptides contribute to antigen-induced CD8-T cell receptor interaction at the immunological synapse
    • Yachi, P.P., Ampudia, J., Gascoigne, N.R. and Zal, T. Nonstimulatory peptides contribute to antigen-induced CD8-T cell receptor interaction at the immunological synapse. Nat. Immunol. 6, 785-792 (2005).
    • (2005) Nat. Immunol , vol.6 , pp. 785-792
    • Yachi, P.P.1    Ampudia, J.2    Gascoigne, N.R.3    Zal, T.4
  • 8
    • 18644365692 scopus 로고    scopus 로고
    • Rare, structurally homologous self-peptides promote thymocyte positive selection
    • Santori, F.R. et al. Rare, structurally homologous self-peptides promote thymocyte positive selection. Immunity 17, 131-142 (2002).
    • (2002) Immunity , vol.17 , pp. 131-142
    • Santori, F.R.1
  • 9
    • 0028178784 scopus 로고
    • T cell receptor antagonist peptides induce positive selection
    • Hogquist, K.A. et al. T cell receptor antagonist peptides induce positive selection. Cell 76, 17-27 (1994).
    • (1994) Cell , vol.76 , pp. 17-27
    • Hogquist, K.A.1
  • 10
    • 0024428184 scopus 로고
    • Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand
    • Berg, L.J. et al. Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand. Cell 58, 1035-1046 (1989).
    • (1989) Cell , vol.58 , pp. 1035-1046
    • Berg, L.J.1
  • 11
    • 0029041519 scopus 로고
    • The influence of invariant chain on the positive selection of single T cell receptor specificities
    • Tourne, S., Nakano, N., Viville, S., Benoist, C. and Mathis, D. The influence of invariant chain on the positive selection of single T cell receptor specificities. Eur. J. Immunol. 25, 1851-1856 (1995).
    • (1995) Eur. J. Immunol , vol.25 , pp. 1851-1856
    • Tourne, S.1    Nakano, N.2    Viville, S.3    Benoist, C.4    Mathis, D.5
  • 12
    • 0032943540 scopus 로고    scopus 로고
    • Requirement for diverse, low-abundance peptides in positive selection of T cells
    • Barton, G.M. and Rudensky, A.Y. Requirement for diverse, low-abundance peptides in positive selection of T cells. Science 283, 67-70 (1999).
    • (1999) Science , vol.283 , pp. 67-70
    • Barton, G.M.1    Rudensky, A.Y.2
  • 13
    • 37049034259 scopus 로고    scopus 로고
    • Acquisition of a functional T cell receptor during T lymphocyte development is enforced by HEB and E2A transcription factors
    • Jones, M.E. and Zhuang, Y. Acquisition of a functional T cell receptor during T lymphocyte development is enforced by HEB and E2A transcription factors. Immunity 27, 860-870 (2007).
    • (2007) Immunity , vol.27 , pp. 860-870
    • Jones, M.E.1    Zhuang, Y.2
  • 14
    • 0033637216 scopus 로고    scopus 로고
    • NF-kappa B activation by the pre-T cell receptor serves as a selective survival signal in T lymphocyte development
    • Voll, R.E. et al. NF-kappa B activation by the pre-T cell receptor serves as a selective survival signal in T lymphocyte development. Immunity 13, 677-689 (2000).
    • (2000) Immunity , vol.13 , pp. 677-689
    • Voll, R.E.1
  • 15
    • 0028448483 scopus 로고
    • Bcl-2 is upregulated at the CD4+CD8+ stage during positive selection and promotes thymocyte differentiation at several control points
    • Linette, G.P. et al. Bcl-2 is upregulated at the CD4+CD8+ stage during positive selection and promotes thymocyte differentiation at several control points. Immunity 1, 197-205 (1994).
    • (1994) Immunity , vol.1 , pp. 197-205
    • Linette, G.P.1
  • 16
    • 0346727524 scopus 로고    scopus 로고
    • MicroRNAs modulate hematopoietic lineage differentiation
    • Chen, C.Z., Li, L., Lodish, H.F. and Bartel, D.P. MicroRNAs modulate hematopoietic lineage differentiation. Science 303, 83-86 (2004).
    • (2004) Science , vol.303 , pp. 83-86
    • Chen, C.Z.1    Li, L.2    Lodish, H.F.3    Bartel, D.P.4
  • 17
    • 33947721625 scopus 로고    scopus 로고
    • MiR-181a is an intrinsic modulator of T cell sensitivity and selection
    • Li, Q.J. et al. miR-181a is an intrinsic modulator of T cell sensitivity and selection. Cell 129, 147-161 (2007).
    • (2007) Cell , vol.129 , pp. 147-161
    • Li, Q.J.1
  • 18
    • 34250637210 scopus 로고    scopus 로고
    • Function and localization of microRNAs in mammalian cells. Cold Spring Harb. Symp. Quant
    • Leung, A.K. and Sharp, P.A. Function and localization of microRNAs in mammalian cells. Cold Spring Harb. Symp. Quant. Biol. 71, 29-38 (2006).
    • (2006) Biol , vol.71 , pp. 29-38
    • Leung, A.K.1    Sharp, P.A.2
  • 19
    • 0032538986 scopus 로고    scopus 로고
    • Preselection thymocytes are more sensitive to T cell receptor stimulation than mature T cells
    • Davey, G.M. et al. Preselection thymocytes are more sensitive to T cell receptor stimulation than mature T cells. J. Exp. Med. 188, 1867-1874 (1998).
    • (1998) J. Exp. Med , vol.188 , pp. 1867-1874
    • Davey, G.M.1
  • 20
    • 55349122507 scopus 로고    scopus 로고
    • Low ligand requirement for deletion and lack of synapses in positive selection enforce the gauntlet of thymic T cell maturation
    • Ebert, P.J., Ehrlich, L.I. and Davis, M.M. Low ligand requirement for deletion and lack of synapses in positive selection enforce the gauntlet of thymic T cell maturation. Immunity 29, 734-745 (2008).
    • (2008) Immunity , vol.29 , pp. 734-745
    • Ebert, P.J.1    Ehrlich, L.I.2    Davis, M.M.3
  • 21
    • 0037167816 scopus 로고    scopus 로고
    • Direct observation of ligand recognition by T cells
    • Irvine, D.J., Purbhoo, M.A., Krogsgaard, M. and Davis, M.M. Direct observation of ligand recognition by T cells. Nature 419, 845-849 (2002).
    • (2002) Nature , vol.419 , pp. 845-849
    • Irvine, D.J.1    Purbhoo, M.A.2    Krogsgaard, M.3    Davis, M.M.4
  • 22
    • 4444298148 scopus 로고    scopus 로고
    • CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse
    • Li, Q.J. et al. CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse. Nat. Immunol. 5, 791-799 (2004).
    • (2004) Nat. Immunol , vol.5 , pp. 791-799
    • Li, Q.J.1
  • 23
    • 2442651482 scopus 로고    scopus 로고
    • T cell killing does not require the formation of a stable mature immunological synapse
    • Purbhoo, M.A., Irvine, D.J., Huppa, J.B. and Davis, M.M. T cell killing does not require the formation of a stable mature immunological synapse. Nat. Immunol. 5, 524-530 (2004).
    • (2004) Nat. Immunol , vol.5 , pp. 524-530
    • Purbhoo, M.A.1    Irvine, D.J.2    Huppa, J.B.3    Davis, M.M.4
  • 24
    • 34248572342 scopus 로고    scopus 로고
    • Alloreactive T cells respond specifically to multiple distinct peptide- MHC complexes
    • Felix, N.J. et al. Alloreactive T cells respond specifically to multiple distinct peptide- MHC complexes. Nat. Immunol. 8, 388-397 (2007).
    • (2007) Nat. Immunol , vol.8 , pp. 388-397
    • Felix, N.J.1
  • 26
    • 0026766954 scopus 로고
    • Molecular cloning and characterization of the gene encoding mouse melanoma antigen by cDNA library transfection
    • Hayashi, H. et al. Molecular cloning and characterization of the gene encoding mouse melanoma antigen by cDNA library transfection. J. Immunol. 149, 1223-1229 (1992).
    • (1992) J. Immunol , vol.149 , pp. 1223-1229
    • Hayashi, H.1
  • 27
    • 22544472436 scopus 로고    scopus 로고
    • Rmcf2, a xenotropic provirus in the Asian mouse species Mus castaneus, blocks infection by polytropic mouse gammaretroviruses
    • Wu, T., Yan, Y. and Kozak, C.A. Rmcf2, a xenotropic provirus in the Asian mouse species Mus castaneus, blocks infection by polytropic mouse gammaretroviruses. J. Virol. 79, 9677-9684 (2005).
    • (2005) J. Virol , vol.79 , pp. 9677-9684
    • Wu, T.1    Yan, Y.2    Kozak, C.A.3
  • 28
    • 0037255081 scopus 로고    scopus 로고
    • Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries
    • Okazaki, N. et al. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 10, 35-48 (2003).
    • (2003) DNA Res , vol.10 , pp. 35-48
    • Okazaki, N.1
  • 29
    • 70350439671 scopus 로고    scopus 로고
    • An endogenous peptide positively selects and augments the activation and survival of peripheral CD4+ T cells
    • advance online publication, doi:10.1038/ni.1796 (4 October 2009)
    • Lo, W.-L., Felix, N.J., Walters, J.J., Rohrs, H., Gross, M.L. and Allen, P.M. An endogenous peptide positively selects and augments the activation and survival of peripheral CD4+ T cells. Nat. Immunol. advance online publication, doi:10.1038/ni.1796 (4 October 2009).
    • Nat. Immunol
    • Lo, W.-L.1    Felix, N.J.2    Walters, J.J.3    Rohrs, H.4    Gross, M.L.5    Allen, P.M.6
  • 30
    • 15044358353 scopus 로고    scopus 로고
    • Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity
    • Krogsgaard, M. et al. Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity. Nature 434, 238-243 (2005).
    • (2005) Nature , vol.434 , pp. 238-243
    • Krogsgaard, M.1
  • 31
    • 40149108609 scopus 로고    scopus 로고
    • Surface-anchored monomeric agonist pMHCs alone trigger TCR with high sensitivity
    • Ma, Z., Sharp, K.A., Janmey, P.A. and Finkel, T.H. Surface-anchored monomeric agonist pMHCs alone trigger TCR with high sensitivity. PLoS Biol. 6, e43 (2008).
    • (2008) Plos Biol , vol.6
    • Ma, Z.1    Sharp, K.A.2    Janmey, P.A.3    Finkel, T.H.4
  • 32
    • 0033521599 scopus 로고    scopus 로고
    • A. T cell receptor-specific blockade of positive selection
    • Baldwin, K.K., Reay, P.A., Wu, L., Farr, A. and Davis, M. M. A. T cell receptor-specific blockade of positive selection. J. Exp. Med. 189, 13-24 (1999).
    • (1999) J. Exp. Med , vol.189 , pp. 13-24
    • Baldwin, K.K.1    Reay, P.A.2    Wu, L.3    Farr, A.4    Davis, M.M.5
  • 33
    • 28444469246 scopus 로고    scopus 로고
    • Silencing of microRNAs in vivo with ‘antagomirs’
    • Krutzfeldt, J. et al. Silencing of microRNAs in vivo with ‘antagomirs’. Nature 438, 685-689 (2005).
    • (2005) Nature , vol.438 , pp. 685-689
    • Krutzfeldt, J.1
  • 34
    • 34447098797 scopus 로고    scopus 로고
    • Multistep pathogenesis of autoimmune disease
    • Goodnow, C.C. Multistep pathogenesis of autoimmune disease. Cell 130, 25-35 (2007).
    • (2007) Cell , vol.130 , pp. 25-35
    • Goodnow, C.C.1
  • 35
    • 0037438615 scopus 로고    scopus 로고
    • Detection of autoreactive myelin proteolipid protein 139-151-specific T cells by using MHC II (IAs) tetramers
    • Reddy, J. et al. Detection of autoreactive myelin proteolipid protein 139-151-specific T cells by using MHC II (IAs) tetramers. J. Immunol. 170, 870-877 (2003).
    • (2003) J. Immunol , vol.170 , pp. 870-877
    • Reddy, J.1
  • 37
    • 50149090966 scopus 로고    scopus 로고
    • Variability and robustness in T cell activation from regulated heterogeneity in protein levels
    • Feinerman, O., Veiga, J., Dorfman, J.R., Germain, R.N. and Altan-Bonnet, G. Variability and robustness in T cell activation from regulated heterogeneity in protein levels. Science 321, 1081-1084 (2008).
    • (2008) Science , vol.321 , pp. 1081-1084
    • Feinerman, O.1    Veiga, J.2    Dorfman, J.R.3    Germain, R.N.4    Altan-Bonnet, G.5
  • 38
    • 0034732334 scopus 로고    scopus 로고
    • The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate
    • Yasutomo, K., Doyle, C., Miele, L., Fuchs, C. and Germain, R.N. The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate. Nature 404, 506-510 (2000).
    • (2000) Nature , vol.404 , pp. 506-510
    • Yasutomo, K.1    Doyle, C.2    Miele, L.3    Fuchs, C.4    Germain, R.N.5
  • 39
    • 0028261582 scopus 로고
    • Use of global amino acid replacements to define the requirements for MHC binding and T cell recognition of moth cytochrome c (93-103)
    • Reay, P.A., Kantor, R.M. and Davis, M.M. Use of global amino acid replacements to define the requirements for MHC binding and T cell recognition of moth cytochrome c (93-103). J. Immunol. 152, 3946-3957 (1994).
    • (1994) J. Immunol , vol.152 , pp. 3946-3957
    • Reay, P.A.1    Kantor, R.M.2    Davis, M.M.3
  • 40
    • 0034176855 scopus 로고    scopus 로고
    • Positive selection is limited by available peptide-dependent MHC conformations
    • Stefanski, H.E., Jameson, S.C. and Hogquist, K.A. Positive selection is limited by available peptide-dependent MHC conformations. J. Immunol. 164, 3519-3526 (2000).
    • (2000) J. Immunol , vol.164 , pp. 3519-3526
    • Stefanski, H.E.1    Jameson, S.C.2    Hogquist, K.A.3
  • 41
    • 22744441535 scopus 로고    scopus 로고
    • How the T cell repertoire becomes peptide and MHC specific
    • Huseby, E.S. et al. How the T cell repertoire becomes peptide and MHC specific. Cell 122, 247-260 (2005).
    • (2005) Cell , vol.122 , pp. 247-260
    • Huseby, E.S.1
  • 42
    • 0036857211 scopus 로고    scopus 로고
    • C. Self peptide/MHC class I complexes have a negligible effect on the response of some CD8+ T cells to foreign antigen
    • Sporri, R. and Reis e Sousa, C. Self peptide/MHC class I complexes have a negligible effect on the response of some CD8+ T cells to foreign antigen. Eur. J. Immunol. 32, 3161-3170 (2002).
    • (2002) Eur. J. Immunol , vol.32 , pp. 3161-3170
    • Sporri, R.1    Sousa, R.E.2
  • 43
    • 35748961134 scopus 로고    scopus 로고
    • T cell activation enhancement by endogenous pMHC acts for both weak and strong agonists but varies with differentiation state
    • Yachi, P.P., Lotz, C., Ampudia, J. and Gascoigne, N.R. T cell activation enhancement by endogenous pMHC acts for both weak and strong agonists but varies with differentiation state. J. Exp. Med. 204, 2747-2757 (2007).
    • (2007) J. Exp. Med , vol.204 , pp. 2747-2757
    • Yachi, P.P.1    Lotz, C.2    Ampudia, J.3    Gascoigne, N.R.4
  • 44
    • 0029807351 scopus 로고    scopus 로고
    • CD8 enhances formation of stable -cel T-cell receptor/MHC class I molecule complexes
    • Garcia, K.C. et al. CD8 enhances formation of stable -cel T-cell receptor/MHC class I molecule complexes. Nature 384, 577-581 (1996).
    • (1996) Nature , vol.384 , pp. 577-581
    • Garcia, K.C.1
  • 45
    • 34247847666 scopus 로고    scopus 로고
    • T cells as a self-referential, sensory organ
    • Davis, M.M. et al. T cells as a self-referential, sensory organ. Annu. Rev. Immunol. 25, 681-695 (2007).
    • (2007) Annu. Rev. Immunol , vol.25 , pp. 681-695
    • Davis, M.M.1
  • 46
    • 0018126188 scopus 로고
    • H-2 antigens of the thymus determine lymphocyte specificity
    • Fink, P.J. and Bevan, M.J. H-2 antigens of the thymus determine lymphocyte specificity. J. Exp. Med. 148, 766-775 (1978).
    • (1978) J. Exp. Med , vol.148 , pp. 766-775
    • Fink, P.J.1    Bevan, M.J.2
  • 47
    • 67349280397 scopus 로고    scopus 로고
    • Germline-encoded amino acids in the ap T-cell receptor control thymic selection
    • Scott-Browne, J.P., White, J., Kappler, J.W., Gapin, L. and Marrack, P. Germline-encoded amino acids in the ap T-cell receptor control thymic selection. Nature 458, 1043-1046 (2009).
    • (2009) Nature , vol.458 , pp. 1043-1046
    • Scott-Browne, J.P.1    White, J.2    Kappler, J.W.3    Gapin, L.4    Marrack, P.5
  • 48
    • 0030935007 scopus 로고    scopus 로고
    • The MHC reactivity of the T cell repertoire prior to positive and negative selection
    • Zerrahn, J., Held, W. and Raulet, D.H. The MHC reactivity of the T cell repertoire prior to positive and negative selection. Cell 88, 627-636 (1997).
    • (1997) Cell , vol.88 , pp. 627-636
    • Zerrahn, J.1    Held, W.2    Raulet, D.H.3
  • 49
    • 67650497725 scopus 로고    scopus 로고
    • Positive selection optimizes the number and function of MHCII-restricted CD4+ T cell clones in the naive polyclonal repertoire
    • Chu, H.H. et al. Positive selection optimizes the number and function of MHCII-restricted CD4+ T cell clones in the naive polyclonal repertoire. Proc. Natl. Acad. Sci. USA 106, 11241-11245 (2009).
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 11241-11245
    • Chu, H.H.1
  • 50
    • 34447281286 scopus 로고    scopus 로고
    • A role for “self” in T-cell activation. Semin
    • Krogsgaard, M., Juang, J. and Davis, M.M. A role for “self” in T-cell activation. Semin. Immunol. 19, 236-244 (2007).
    • (2007) Immunol , vol.19 , pp. 236-244
    • Krogsgaard, M.1    Juang, J.2    Davis, M.M.3
  • 51
    • 0036225013 scopus 로고    scopus 로고
    • Imaging synapse formation during thymocyte selection: Inability of CD3Z to form a stable central accumulation during negative selection
    • Richie, L.I. et al. Imaging synapse formation during thymocyte selection: Inability of CD3Z to form a stable central accumulation during negative selection. Immunity 16, 595-606 (2002).
    • (2002) Immunity , vol.16 , pp. 595-606
    • Richie, L.I.1
  • 52
    • 0029743737 scopus 로고    scopus 로고
    • Phenotypic analysis of antigen-specific T lymphocytes
    • Altman, J.D. et al. Phenotypic analysis of antigen-specific T lymphocytes. Science 274, 94-96 (1996).
    • (1996) Science , vol.274 , pp. 94-96
    • Altman, J.D.1
  • 53
    • 0033136945 scopus 로고    scopus 로고
    • Dynamics and requirements of T cell clonal expansion in vivo at the single-cell level: Effector function is linked to proliferative capacity
    • Gudmundsdottir, H., Wells, A.D. and Turka, L.A. Dynamics and requirements of T cell clonal expansion in vivo at the single-cell level: Effector function is linked to proliferative capacity. J. Immunol. 162, 5212-5223 (1999).
    • (1999) J. Immunol , vol.162 , pp. 5212-5223
    • Gudmundsdottir, H.1    Wells, A.D.2    Turka, L.A.3


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