Development of stably transfected human and rat hepatoma cell lines for the species-specific assessment of xenobiotic response enhancer module (XREM)-dependent induction of drug metabolism

Toxicology

Volumn 277, Issue 1-3, 2010, Pages 11-19

  Fery, Yvonne ^a   Mueller, Stefan O ^b,c   Schrenk, Dieter ^a  

^a Rheinland Pfälzische Technische Universität Kaiserslautern Landau   (Germany)

^b Merck Serono GmbH   (Germany)

^c KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

Author keywords

CYP3A; Drug metabolism; Hepatoma cells; PXR; Stable transfection; XREM

Indexed keywords

CLOTRIMAZOLE; CYTOCHROME P450 2B6; CYTOCHROME P450 3A1; CYTOCHROME P450 3A4; DEXAMETHASONE; EMD 392949; OMEPRAZOLE; PHENOBARBITAL; PREGNANE X RECEPTOR; RIFAMPICIN; UNCLASSIFIED DRUG; XENOBIOTIC AGENT; CYP3A PROTEIN, HUMAN; CYP3A1 PROTEIN, RAT; CYTOCHROME P450 3A; STEROID RECEPTOR; UNSPECIFIC MONOOXYGENASE;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG METABOLISM; GENE CONTROL; GENE EXPRESSION; GENETIC TRANSFECTION; HEPATOMA CELL; HUMAN; HUMAN CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; UNINDEXED SEQUENCE; ANIMAL; BIOSYNTHESIS; COMPARATIVE STUDY; ENZYMOLOGY; EXPERIMENTAL LIVER NEOPLASM; GENE EXPRESSION PROFILING; GENETICS; HEPG2 CELL LINE; LIVER CELL CARCINOMA; METABOLISM; PROCEDURES; SPECIES DIFFERENCE; TUMOR CELL LINE;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CYTOCHROME P-450 CYP3A; GENE EXPRESSION PROFILING; HEP G2 CELLS; HUMANS; LIVER NEOPLASMS, EXPERIMENTAL; RATS; RECEPTORS, STEROID; SPECIES SPECIFICITY; TRANSFECTION; XENOBIOTICS;

RATTUS;

EID: 77957883030     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2010.08.008     Document Type: Article

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