Species-specific activation of nuclear receptors correlates with the response of liver drug metabolizing enzymes to EMD 392949 in vitro

Toxicology Letters

Volumn 193, Issue 1, 2010, Pages 120-123

  Mueller, Stefan O ^a,b   Fery, Yvonne ^c   Tuschl, Gregor ^a   Schrenk, Dieter ^c  

^a Merck Serono GmbH   (Germany)

^b KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

^c France   (Germany)

Author keywords

AhR; Cytochrome P450; Nuclear receptor; PPAR; PXR

Indexed keywords

4 O TOLYLSULFANYL 2 (4 TRIFLUORMETHYL PHENOXY)BUTYRIC ACID; ARYLHYDROCARBON RECEPTOR; CELL NUCLEUS RECEPTOR; CYTOCHROME P450; CYTOCHROME P450 1A; CYTOCHROME P450 3A; DRUG METABOLIZING ENZYME; EMD 392949; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PREGNANE X RECEPTOR; RIFAMPICIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL STRAIN HEPG2; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME REGULATION; GENE ACTIVATION; HUMAN; HUMAN CELL; HUMAN VERSUS ANIMAL COMPARISON; IN VITRO STUDY; LIVER METABOLISM; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPORTER GENE; SPECIES DIFFERENCE;

ANIMALS; BUTYRIC ACIDS; CELLS, CULTURED; CYTOCHROME P-450 CYP1A1; DNA PRIMERS; HUMANS; LIVER; LUCIFERASES; MICE; PHARMACEUTICAL PREPARATIONS; RATS; RECEPTORS, ARYL HYDROCARBON; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPECIES SPECIFICITY; TRANSFECTION;

RATTUS;

EID: 75749083948     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2009.12.014     Document Type: Article

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