Rat PXR reporter-gene activity correlates with the induction of CYP3A in rat precision-cut liver slices

Combinatorial Chemistry and High Throughput Screening

Volumn 8, Issue 4, 2005, Pages 341-346

  Cui, Xiaoming ^a   Thomas, Ann ^a   Montgomery, Diana ^a   Gu, Chunyan ^a   Morrison, Richard A ^a   White, Ronald E ^a   Cheng, K C ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

And liver slice; CYP2B; CYP3A; Induction; PXR

Indexed keywords

CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450 2B; CYTOCHROME P450 3A; LUCIFERASE; MESSENGER RNA; PREGNANE X RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ENZYME ACTIVITY; ENZYME INDUCTION; HIGH THROUGHPUT SCREENING; LINEAR REGRESSION ANALYSIS; LIVER MICROSOME; LIVER SLICE; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PXR REPORTER GENE; RAT; REAL TIME POLYMERASE CHAIN REACTION; REPORTER GENE;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BIOLOGICAL ASSAY; CYTOCHROME P-450 CYP2B1; CYTOCHROME P-450 CYP3A; DRUG EVALUATION, PRECLINICAL; ENZYME ACTIVATION; GENES, REPORTER; LIVER; LUCIFERASES; MALE; OXIDOREDUCTASES, N-DEMETHYLATING; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; RNA, MESSENGER;

STAPHYLOCOCCUS PHAGE 3A;

EID: 18844379968     PISSN: 13862073     EISSN: None     Source Type: Journal    
DOI: 10.2174/1386207054020822     Document Type: Article

References (17)

1. Kliewer, S.A.; Moore, J.T.; Wade, L.; Staudinger, J.L.; Watson, M.A. Cell 1998, 92, 73-82.
2. Forman, B.M.; Tzameli, I.; Choi, H.S.; Martinoli, M.G.; Simha, D.; Moore, D.D.; Nature 1998, 407, 920-923.
3. Xie, W.; Berwick, J.L.; Simon, C.M.; Pierce, A.M.; Safe, S.; Blumberg, B.; Guzelian, P.S.; Evans, R.M. Gene Dev. 2000, 14, 3014-3023.
4. Murphy, L.; Cherlet, T.; Lewis, A.; Banu, Y.; Watson, P. Ann. Med. 2003, 35, 614-31.
5. Honkakoski, P.; Negisgi, M. J. Biol. Chem. 1997, 272, 14943-14949.
6. Sueyoshi, T.; Negishi, M. Annu. Rev. Pharmacol. Toxicol. 2001, 42, 123-143.
7. Moore, L.B.; Parks, D.J.; Jones, S.A.; Bledsoe, R.K.; Consler, T.G.; Stimmel J.B.; Goodwin, B.; Liddle, C.; Blanchard, S.G.; Wilson, T.M.; Collons, J.L.; Kliewer, S.A. J. Biol. Chem. 2000, 275, 15122-15127.
8. Goodsaid, P.M.; Palamanda, J.R.; Montgomery, D.; Mandakas-Gu, C.; Li, Z.; You, X.; Norton, L.; Smith, R.; Chu, I.; Soares, T.; Alton, K.; Kishnani, N.S.; Rosenblum, I.V.; Pharm. Res. 2003, 20, 9-16.
9. Ekins, S.; Mirny, L.; Schuetz, E.G. Pharmaceut. Res. 2002, 19, 1788-1800.
10. Smirlis, D.; Muangmoonchai, R.; Edwards, M.; Phillips, I.R.; Shephard, E.A. J. Biol. Chem. 2001, 276, 12822-12326.
11. Makinen, J.; Frank, C.; Jyrkkarinne, J.; Gynther, J.; Carlberg, C.; Honkakoski P. Mol. Pharmacol. 2002, 62, 366-78.
12. Ogg, M.S.; Williams, J.M.; Tarbit, M.; Goldfarb, F.S.; Gray, T.J.; Gibson, G.G. Xenobiotica 1999, 29, 269-279.
13. El-Sankary, W.; Gibson, G.G.; Ayrton, A.; Plant, N.; Drug Metab. Disp. 2001, 29, 1499-1504.
14. Cui, X.; Palamanda, J.; Norton, L.; Thomas, A.; Lau, Y.Y.; White, R.E.; Cheng, K.C. J. Pharmacol. Toxicol. Methods 2002, 47, 143-51.
15. Raucy, J.; Warfe, L.; Yueh, M.F.; Allen, S.W. J. Pharmacol. Exp. Ther. 2002, 303, 412-423.
16. Vignati, L.A.; Bogni, A.; Grossi, P.; Monshouwer, M. Toxicology 2004, 199, 23-33.
17. Heuman, D.M.; Gallagher, E.J.; Barwick, J.L.; Elshourbagy, N.A.; Guzelian, P.S. Mol. Pharmacol. 1982, 21, 753-760.