Identification of new human pregnane X receptor ligands among pesticides using a stable reporter cell system

Toxicological Sciences

Volumn 91, Issue 2, 2006, Pages 501-509

  Lemaire, Géraldine ^a,b   Mnif, Wissem ^a,b,c   Pascussi, Jean Marc ^a   Pillon, Arnaud ^a,b   Rabenoelina, Fanja ^a,b   Fenet, Hélène ^d   Gomez, Elena ^d   Casellas, Claude ^d   Nicolas, Jean Claude ^a,b   Cavaillès, Vincent ^a,b   Duchesne, Marie Josèphe ^a,b   Balaguer, Patrick ^a,b  

^a INSERM   (France)

^b UNIV MONTPELLIER   (France)

^c institut supérieur de biotechnologie   (Tunisia)

^d CNRS   (France)

Author keywords

Cytochrome P450 3A4; HeLa cell; Luciferase reporter; Nude mouse; Pesticide; Pregnane X receptor

Indexed keywords

ALACHLOR; BUPIRIMATE; CAMPHECLOR; CYTOCHROME P450 3A4; DIFLUBENZURON; ENILCONAZOLE; FENARIMOL; FENBUCONAZOLE; FIPRONIL; FUNGICIDE; HERBICIDE; HYBRID PROTEIN; INSECTICIDE; ISOPROTURON; LIGAND; LUCIFERASE; METOLACHLOR; OXADIAZON; OXICONAZOLE; PERMETHRIN; PESTICIDE; PREGNANE X RECEPTOR; PRETILACHLOR; PROCHLORAZ; PROPICONAZOLE; RIFAMPICIN; TRANSCRIPTION FACTOR GAL4; UNCLASSIFIED DRUG;

AGONIST; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING SITE; BIOAVAILABILITY; CELL ACTIVITY; CELL LINE; CLASSIFICATION; CONTROLLED STUDY; CYTOTOXICITY; DNA BINDING MOTIF; GENETIC TRANSFECTION; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIGAND BINDING; LIVER CELL; MOUSE; NONHUMAN; NUDE MOUSE; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REPORTER GENE; SCREENING; YEAST;

ANIMALS; CELL LINE; CELLS, CULTURED; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; GENE EXPRESSION REGULATION; GENES, REPORTER; HEPATOCYTES; HUMANS; LIGANDS; LUCIFERASES; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; PESTICIDES; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; RNA, MESSENGER;

MUS MUSCULUS;

EID: 33744781835     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfj173     Document Type: Article

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