Technical pentabromodiphenyl ether and hexabromocyclododecane as activators of the pregnane-X-receptor (PXR)

Toxicology

Volumn 264, Issue 1-2, 2009, Pages 45-51

  Fery, Yvonne ^a   Buschauer, Inga ^a   Salzig, Christian ^b   Lang, Patrick ^b   Schrenk, Dieter ^a  

^a Rheinland Pfälzische Technische Universität Kaiserslautern Landau   (Germany)

^b FRAUNHOFER INSTITUTE FOR INDUSTRIAL MATHEMATICS ITWM   (Germany)

Author keywords

Hexabromocyclododecane; Induction; Liver cells; Polybrominated diphenylethers; Pregnane X receptor

Indexed keywords

CYTOCHROME P450 3A; CYTOCHROME P450 3A1; DEXAMETHASONE; HEXABROMOCYCLODODECANE; POLYBROMINATED DIPHENYL ETHER; PREGNANE X RECEPTOR; RIFAMPICIN;

ANIMAL CELL; ARTICLE; CATALYSIS; CELL STRAIN HEPG2; CONTROLLED STUDY; ENZYME INDUCTION; ENZYME INHIBITION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LIVER CELL CULTURE; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; REPORTER GENE;

ANIMALS; BLOTTING, WESTERN; CATALYSIS; CELL NUCLEUS; CELLS, CULTURED; CYTOCHROME P-450 CYP3A; ENZYME INDUCTION; FLAME RETARDANTS; HALOGENATED DIPHENYL ETHERS; HEPATOCYTES; HUMANS; HYDROCARBONS, BROMINATED; INDICATORS AND REAGENTS; RATS; RECEPTORS, STEROID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEX CHARACTERISTICS; TRANSFECTION;

RATTUS;

EID: 69449090854     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2009.07.009     Document Type: Article

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