-
1
-
-
38549152194
-
Principles of bioactive lipid signalling: Lessons from sphingolipids
-
Hannun YA, Obeid LM. Principles of bioactive lipid signalling: lessons from sphingolipids. Nat Rev Mol Cell Biol 2008;9:139-50.
-
(2008)
Nat Rev Mol Cell Biol
, vol.9
, pp. 139-150
-
-
Hannun, Y.A.1
Obeid, L.M.2
-
2
-
-
66349086742
-
Bioactive sphingolipids: Metabolism and function
-
Bartke N, Hannun YA. Bioactive sphingolipids: metabolism and function. J Lipid Res 2009;50(Suppl):S91-S96.
-
(2009)
J Lipid Res
, vol.50
, Issue.SUPPL.
-
-
Bartke, N.1
Hannun, Y.A.2
-
3
-
-
0027355755
-
Metabolic effects of inhibiting glucosylceramide synthesis with PDMP and other substances
-
Radin NS, Shayman JA, Inokuchi J. Metabolic effects of inhibiting glucosylceramide synthesis with PDMP and other substances. Adv Lipid Res 1993;26:183-213.
-
(1993)
Adv Lipid Res
, vol.26
, pp. 183-213
-
-
Radin, N.S.1
Shayman, J.A.2
Inokuchi, J.3
-
4
-
-
33845336495
-
Ceramides and other bioactive sphingolipid backbones in health and disease: Lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy
-
DOI 10.1016/j.bbamem.2006.08.009, PII S0005273606003129, Sphingolipids, Apoptosis and Disease
-
Zheng W, Kollmeyer J, Symolon H, Momin A, Munter E, Wang E, Kelly S, Allegood JC, Liu Y, Peng Q, Ramaraju H, Sullards MC, et al. Ceramides and other bioactive sphingolipid backbones in health and disease: lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy. Biochim Biophys Acta 2006;1758:1864-84. (Pubitemid 44879367)
-
(2006)
Biochimica et Biophysica Acta - Biomembranes
, vol.1758
, Issue.12
, pp. 1864-1884
-
-
Zheng, W.1
Kollmeyer, J.2
Symolon, H.3
Momin, A.4
Munter, E.5
Wang, E.6
Kelly, S.7
Allegood, J.C.8
Liu, Y.9
Peng, Q.10
Ramaraju, H.11
Sullards, M.C.12
Cabot, M.13
Merrill Jr., A.H.14
-
5
-
-
0014083339
-
Sphingomyelinase in normal human spleens and in spleens from subjects with Niemann-Pick disease
-
Schneider PB, Kennedy EP. Sphingomyelinase in normal human spleens and in spleens from subjects with Niemann-Pick disease. J Lipid Res 1967;8:202-9.
-
(1967)
J Lipid Res
, vol.8
, pp. 202-209
-
-
Schneider, P.B.1
Kennedy, E.P.2
-
6
-
-
33749009744
-
The extended family of neutral sphingomyelinases
-
Clarke CJ, Snook CF, Tani M, Matmati N, Marchesini N, Hannun YA. The extended family of neutral sphingomyelinases. Biochemistry 2006;45:11247-56.
-
(2006)
Biochemistry
, vol.45
, pp. 11247-11256
-
-
Clarke, C.J.1
Snook, C.F.2
Tani, M.3
Matmati, N.4
Marchesini, N.5
Hannun, Y.A.6
-
7
-
-
0032489554
-
TNF receptor death domain-associated proteins TRADD and FADD signal activation of acid sphingomyelinase
-
Schwandner R, Wiegmann K, Bernardo K, Kreder D, Kronke M. TNF receptor death domain-associated proteins TRADD and FADD signal activation of acid sphingomyelinase. J Biol Chem 1998;273:5916-22.
-
(1998)
J Biol Chem
, vol.273
, pp. 5916-5922
-
-
Schwandner, R.1
Wiegmann, K.2
Bernardo, K.3
Kreder, D.4
Kronke, M.5
-
8
-
-
0034708831
-
Role of acidic sphingomyelinase in Fas/CD95-mediated cell death
-
Lin T, Genestier L, Pinkoski MJ, Castro A, Nicholas S, Mogil R, Paris F, Fuks Z, Schuchman EH, Kolesnick RN, Green DR. Role of acidic sphingomyelinase in Fas/CD95-mediated cell death. J Biol Chem 2000;275:8657-63.
-
(2000)
J Biol Chem
, vol.275
, pp. 8657-8663
-
-
Lin, T.1
Genestier, L.2
Pinkoski, M.J.3
Castro, A.4
Nicholas, S.5
Mogil, R.6
Paris, F.7
Fuks, Z.8
Schuchman, E.H.9
Kolesnick, R.N.10
Green, D.R.11
-
9
-
-
0031783829
-
2 acts on cellular membranes to generate ceramide signaling and initiate apoptosis in tracheobronchial epithelial cells
-
Goldkorn T, Balaban N, Shannon M, Chea V, Matsukuma K, Gilchrist D, Wang H, Chan C. H2O2 acts on cellular membranes to generate ceramide signaling and initiate apoptosis in tracheobronchial epithelial cells. J Cell Sci 1998;111(Part 21):3209-20. (Pubitemid 28532431)
-
(1998)
Journal of Cell Science
, vol.111
, Issue.21
, pp. 3209-3220
-
-
Goldkorn, T.1
Balaban, N.2
Shannon, M.3
Chea, V.4
Matsukuma, K.5
Gilchrist, D.6
Wang, H.7
Chan, C.8
-
10
-
-
0023836942
-
Kinetics of long-chain (sphingoid) base biosynthesis in intact LM cells: Effects of varying the extracellular concentrations of serine and fatty acid precursors of this pathway
-
Merrill AH, Jr, Wang E, Mullins RE. Kinetics of long-chain (sphingoid) base biosynthesis in intact LM cells: effects of varying the extracellular concentrations of serine and fatty acid precursors of this pathway. Biochemistry 1988;27:340-5.
-
(1988)
Biochemistry
, vol.27
, pp. 340-345
-
-
Merrill Jr., A.H.1
Wang, E.2
Mullins, R.E.3
-
11
-
-
0030600475
-
Sphingolipid synthesis: Identification and characterization of mammalian cDNAs encoding the Lcb2 subunit of serine palmitoyltransferase
-
Nagiec MM, Lester RL, Dickson RC. Sphingolipid synthesis: identification and characterization of mammalian cDNAs encoding the Lcb2 subunit of serine palmitoyltransferase. Gene 1996;177:237-41.
-
(1996)
Gene
, vol.177
, pp. 237-241
-
-
Nagiec, M.M.1
Lester, R.L.2
Dickson, R.C.3
-
12
-
-
0030963660
-
Characterization of ceramide synthesis. A dihydroceramide desaturase introduces the 4,5-trans-double bond of sphingosine at the level of dihydroceramide
-
Michel C, van Echten-Deckert G, Rother J, Sandhoff K, Wang E, Merrill AH, Jr. Characterization of ceramide synthesis. A dihydroceramide desaturase introduces the 4,5-trans-double bond of sphingosine at the level of dihydroceramide. J Biol Chem 1997;272:22432-7.
-
(1997)
J Biol Chem
, vol.272
, pp. 22432-22437
-
-
Michel, C.1
Van Echten-Deckert, G.2
Rother, J.3
Sandhoff, K.4
Wang, E.5
Merrill Jr., A.H.6
-
13
-
-
42249105215
-
The sphingolipid salvage pathway in ceramide metabolism and signaling
-
Kitatani K, Idkowiak-Baldys J, Hannun YA. The sphingolipid salvage pathway in ceramide metabolism and signaling. Cell Signal 2008;20:1010-18.
-
(2008)
Cell Signal
, vol.20
, pp. 1010-1018
-
-
Kitatani, K.1
Idkowiak-Baldys, J.2
Hannun, Y.A.3
-
14
-
-
3543114272
-
Biologically active sphingolipids in cancer pathogenesis and treatment
-
Ogretmen B, Hannun YA. Biologically active sphingolipids in cancer pathogenesis and treatment. Nat Rev Cancer 2004;4:604-16.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 604-616
-
-
Ogretmen, B.1
Hannun, Y.A.2
-
15
-
-
0033575310
-
Long chain ceramides activate protein phosphatase-1 and protein phosphatase-2A: Activation is stereospecific and regulated by phosphatidic acid
-
Chalfant CE, Kishikawa K, Mumby MC, Kamibayashi C, Bielawska A, Hannun YA. Long chain ceramides activate protein phosphatase-1 and protein phosphatase-2A. Activation is stereospecific and regulated by phosphatidic acid. J Biol Chem 1999;274:20313-17. (Pubitemid 129519507)
-
(1999)
Journal of Biological Chemistry
, vol.274
, Issue.29
, pp. 20313-20317
-
-
Chalfant, C.E.1
Kishikawa, K.2
Mumby, M.C.3
Kamibayashi, C.4
Bielawska, A.5
Hannun, Y.A.6
-
16
-
-
0028122397
-
Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction
-
Wolff RA, Dobrowsky RT, Bielawska A, Obeid LM, Hannun YA. Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction. J Biol Chem 1994;269:19605-9.
-
(1994)
J Biol Chem
, vol.269
, pp. 19605-19609
-
-
Wolff, R.A.1
Dobrowsky, R.T.2
Bielawska, A.3
Obeid, L.M.4
Hannun, Y.A.5
-
17
-
-
0028934811
-
Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest
-
Dbaibo GS, Pushkareva MY, Jayadev S, Schwarz JK, Horowitz JM, Obeid LM, Hannun YA. Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest. Proc Natl Acad Sci USA 1995;92:1347-51.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 1347-1351
-
-
Dbaibo, G.S.1
Pushkareva, M.Y.2
Jayadev, S.3
Schwarz, J.K.4
Horowitz, J.M.5
Obeid, L.M.6
Hannun, Y.A.7
-
18
-
-
0034672232
-
Regulation of cyclin-dependent kinase 2 activity by ceramide
-
Lee JY, Bielawska AE, Obeid LM. Regulation of cyclin-dependent kinase 2 activity by ceramide. Exp Cell Res 2000;261:303-11.
-
(2000)
Exp Cell Res
, vol.261
, pp. 303-311
-
-
Lee, J.Y.1
Bielawska, A.E.2
Obeid, L.M.3
-
19
-
-
0029949938
-
prICE: A downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2
-
Smyth MJ, Perry DK, Zhang J, Poirier GG, Hannun YA, Obeid LM. prICE: a downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2. Biochem J 1996;316(Part 1):25-8.
-
(1996)
Biochem J
, vol.316
, Issue.PART 1
, pp. 25-28
-
-
Smyth, M.J.1
Perry, D.K.2
Zhang, J.3
Poirier, G.G.4
Hannun, Y.A.5
Obeid, L.M.6
-
20
-
-
0037135626
-
The ceramide-centric universe of lipid-mediated cell regulation: Stress encounters of the lipid kind
-
Hannun YA, Obeid LM. The ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind. J Biol Chem 2002;277:25847-50.
-
(2002)
J Biol Chem
, vol.277
, pp. 25847-25850
-
-
Hannun, Y.A.1
Obeid, L.M.2
-
21
-
-
2442661614
-
Cathepsin D links TNF-induced acid sphingomyelinase to Bid-mediated caspase-9 and -3 activation
-
Heinrich M, Neumeyer J, Jakob M, Hallas C, Tchikov V, Winoto-Morbach S, Wickel M, Schneider-Brachert W, Trauzold A, Hethke A, Schutze S. Cathepsin D links TNF-induced acid sphingomyelinase to Bid-mediated caspase-9 and -3 activation. Cell Death Differ 2004;11:550-63.
-
(2004)
Cell Death Differ
, vol.11
, pp. 550-563
-
-
Heinrich, M.1
Neumeyer, J.2
Jakob, M.3
Hallas, C.4
Tchikov, V.5
Winoto-Morbach, S.6
Wickel, M.7
Schneider-Brachert, W.8
Trauzold, A.9
Hethke, A.10
Schutze, S.11
-
22
-
-
0035980052
-
Molecular Mechanisms of Ceramide-mediated Telomerase Inhibition in the A549 Human Lung Adenocarcinoma Cell Line
-
DOI 10.1074/jbc.M101350200
-
Ogretmen B, Kraveka JM, Schady D, Usta J, Hannun YA, Obeid LM. Molecular mechanisms of ceramide-mediated telomerase inhibition in the A549 human lung adenocarcinoma cell line. J Biol Chem 2001;276:32506-14. (Pubitemid 33654372)
-
(2001)
Journal of Biological Chemistry
, vol.276
, Issue.35
, pp. 32506-32514
-
-
Ogretmen, B.1
Kraveka, J.M.2
Schady, D.3
Ustai, J.4
Hannun, Y.A.5
Obeid, L.M.6
-
23
-
-
7244244035
-
Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas
-
Koybasi S, Senkal CE, Sundararaj K, Spassieva S, Bielawski J, Osta W, Day TA, Jiang JC, Jazwinski SM, Hannun YA, Obeid LM, Ogretmen B. Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas. J Biol Chem 2004;279:44311-19.
-
(2004)
J Biol Chem
, vol.279
, pp. 44311-44319
-
-
Koybasi, S.1
Senkal, C.E.2
Sundararaj, K.3
Spassieva, S.4
Bielawski, J.5
Osta, W.6
Day, T.A.7
Jiang, J.C.8
Jazwinski, S.M.9
Hannun, Y.A.10
Obeid, L.M.11
Ogretmen, B.12
-
24
-
-
34548286300
-
Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): Attenuation of C(18)-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis
-
Karahatay S, Thomas K, Koybasi S, Senkal CE, Elojeimy S, Liu X, Bielawski J, Day TA, Gillespie MB, Sinha D, Norris JS, Hannun YA, et al. Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): attenuation of C(18)-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis. Cancer Lett 2007;256:101-11.
-
(2007)
Cancer Lett
, vol.256
, pp. 101-111
-
-
Karahatay, S.1
Thomas, K.2
Koybasi, S.3
Senkal, C.E.4
Elojeimy, S.5
Liu, X.6
Bielawski, J.7
Day, T.A.8
Gillespie, M.B.9
Sinha, D.10
Norris, J.S.11
Hannun, Y.A.12
-
25
-
-
75149176725
-
Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways
-
Senkal CE, Ponnusamy S, Bielawski J, Hannun YA, Ogretmen B. Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways. FASEB J 2010;24:296-308.
-
(2010)
FASEB J
, vol.24
, pp. 296-308
-
-
Senkal, C.E.1
Ponnusamy, S.2
Bielawski, J.3
Hannun, Y.A.4
Ogretmen, B.5
-
26
-
-
55849099564
-
Ceramide promotes apoptosis in chronic myelogenous leukemia-derived K562 cells by a mechanism involving caspase-8 and JNK
-
Nica AF, Tsao CC, Watt JC, Jiffar T, Kurinna S, Jurasz P, Konopleva M, Andreeff M, Radomski MW, Ruvolo PP. Ceramide promotes apoptosis in chronic myelogenous leukemia-derived K562 cells by a mechanism involving caspase-8 and JNK. Cell Cycle 2008;7:3362-70.
-
(2008)
Cell Cycle
, vol.7
, pp. 3362-3370
-
-
Nica, A.F.1
Tsao, C.C.2
Watt, J.C.3
Jiffar, T.4
Kurinna, S.5
Jurasz, P.6
Konopleva, M.7
Andreeff, M.8
Radomski, M.W.9
Ruvolo, P.P.10
-
27
-
-
70449522995
-
Long-chain ceramide produced in response to N-hexanoylsphingosine does not induce apoptosis in CHP-100 cells
-
Mancinetti A, Di Bartolomeo S, Spinedi A. Long-chain ceramide produced in response to N-hexanoylsphingosine does not induce apoptosis in CHP-100 cells. Lipids 2009;44:1039-46.
-
(2009)
Lipids
, vol.44
, pp. 1039-1046
-
-
Mancinetti, A.1
Di Bartolomeo, S.2
Spinedi, A.3
-
28
-
-
0037457652
-
Elevation of de novo ceramide synthesis in tumor masses and the role of microsomal dihydroceramide synthase
-
Koyanagi S, Kuga M, Soeda S, Hosoda Y, Yokomatsu T, Takechi H, Akiyama T, Shibuya S, Shimeno H. Elevation of de novo ceramide synthesis in tumor masses and the role of microsomal dihydroceramide synthase. Int J Cancer 2003;105:1-6.
-
(2003)
Int J Cancer
, vol.105
, pp. 1-6
-
-
Koyanagi, S.1
Kuga, M.2
Soeda, S.3
Hosoda, Y.4
Yokomatsu, T.5
Takechi, H.6
Akiyama, T.7
Shibuya, S.8
Shimeno, H.9
-
29
-
-
0027527545
-
Selectivity of ceramide-mediated biology. Lack of activity of erythro- Dihydroceramide
-
Bielawska A, Crane HM, Liotta D, Obeid LM, Hannun YA. Selectivity of ceramide-mediated biology. Lack of activity of erythro-dihydroceramide. J Biol Chem 1993;268:26226-32. (Pubitemid 23361691)
-
(1993)
Journal of Biological Chemistry
, vol.268
, Issue.35
, pp. 26226-26232
-
-
Bielawska, A.1
Crane, H.M.2
Liotta, D.3
Obeid, L.M.4
Hannun, Y.A.5
-
30
-
-
0036586089
-
Sphingoid bases and ceramide induce apoptosis in HT-29 and HCT-116 human colon cancer cells
-
Ahn EH, Schroeder JJ. Sphingoid bases and ceramide induce apoptosis in HT-29 and HCT-116 human colon cancer cells. Exp Biol Med (Maywood) 2002;227:345-53.
-
(2002)
Exp Biol Med (Maywood)
, vol.227
, pp. 345-353
-
-
Ahn, E.H.1
Schroeder, J.J.2
-
31
-
-
67649920937
-
Dihydroceramide intracellular increase in response to resveratrol treatment mediates autophagy in gastric cancer cells
-
Signorelli P, Munoz-Olaya JM, Gagliostro V, Casas J, Ghidoni R, Fabrias G. Dihydroceramide intracellular increase in response to resveratrol treatment mediates autophagy in gastric cancer cells. Cancer Lett 2009;282:238-43.
-
(2009)
Cancer Lett
, vol.282
, pp. 238-243
-
-
Signorelli, P.1
Munoz-Olaya, J.M.2
Gagliostro, V.3
Casas, J.4
Ghidoni, R.5
Fabrias, G.6
-
32
-
-
11144239577
-
gamma-Tocopherol or combinations of vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis
-
Jiang Q, Wong J, Fyrst H, Saba JD, Ames BN. gamma-Tocopherol or combinations of vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis. Proc Natl Acad Sci USA 2004;101:17825-30.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 17825-17830
-
-
Jiang, Q.1
Wong, J.2
Fyrst, H.3
Saba, J.D.4
Ames, B.N.5
-
33
-
-
34447115107
-
Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells
-
Kraveka JM, Li L, Szulc ZM, Bielawski J, Ogretmen B, Hannun YA, Obeid LM, Bielawska A. Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells. J Biol Chem 2007;282:16718-28.
-
(2007)
J Biol Chem
, vol.282
, pp. 16718-16728
-
-
Kraveka, J.M.1
Li, L.2
Szulc, Z.M.3
Bielawski, J.4
Ogretmen, B.5
Hannun, Y.A.6
Obeid, L.M.7
Bielawska, A.8
-
34
-
-
60349094120
-
Increased tumour dihydroceramide production after Photofrin-PDT alone and improved tumour response after the combination with the ceramide analogue LCL29. Evidence from mouse squamous cell carcinomas
-
Separovic D, Bielawski J, Pierce JS, Merchant S, Tarca AL, Ogretmen B, Korbelik M. Increased tumour dihydroceramide production after Photofrin-PDT alone and improved tumour response after the combination with the ceramide analogue LCL29. Evidence from mouse squamous cell carcinomas. Br J Cancer 2009;100:626-32.
-
(2009)
Br J Cancer
, vol.100
, pp. 626-632
-
-
Separovic, D.1
Bielawski, J.2
Pierce, J.S.3
Merchant, S.4
Tarca, A.L.5
Ogretmen, B.6
Korbelik, M.7
-
35
-
-
33748665711
-
Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P
-
Xu R, Jin J, Hu W, Sun W, Bielawski J, Szulc Z, Taha T, Obeid LM, Mao C. Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P. FASEB J 2006;20:1813-25.
-
(2006)
FASEB J
, vol.20
, pp. 1813-1825
-
-
Xu, R.1
Jin, J.2
Hu, W.3
Sun, W.4
Bielawski, J.5
Szulc, Z.6
Taha, T.7
Obeid, L.M.8
Mao, C.9
-
36
-
-
77950890820
-
Alkaline ceramidase 3 (ACER3) hydrolyzes unsaturated long-chain ceramides, and its down-regulation inhibits both cell proliferation and apoptosis
-
Hu W, Xu R, Sun W, Szulc ZM, Bielawski J, Obeid LM, Mao C. Alkaline ceramidase 3 (ACER3) hydrolyzes unsaturated long-chain ceramides, and its down-regulation inhibits both cell proliferation and apoptosis. J Biol Chem 2010;285:7964-76.
-
(2010)
J Biol Chem
, vol.285
, pp. 7964-7976
-
-
Hu, W.1
Xu, R.2
Sun, W.3
Szulc, Z.M.4
Bielawski, J.5
Obeid, L.M.6
Mao, C.7
-
37
-
-
54049137693
-
N-(4-Hydroxyphenyl)retinamide increases dihydroceramide and synergizes with dimethylsphingosine to enhance cancer cell killing
-
Wang H, Maurer BJ, Liu YY, Wang E, Allegood JC, Kelly S, Symolon H, Liu Y, Merrill AH, Jr, Gouaze-Andersson V, Yu JY, Giuliano AE, et al. N-(4-Hydroxyphenyl)retinamide increases dihydroceramide and synergizes with dimethylsphingosine to enhance cancer cell killing. Mol Cancer Ther 2008;7:2967-76.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 2967-2976
-
-
Wang, H.1
Maurer, B.J.2
Liu, Y.Y.3
Wang, E.4
Allegood, J.C.5
Kelly, S.6
Symolon, H.7
Liu, Y.8
Merrill Jr., A.H.9
Gouaze-Andersson, V.10
Yu, J.Y.11
Giuliano, A.E.12
-
38
-
-
0037189475
-
Ceramide kinase, a novel lipid kinase: Molecular cloning and functional characterization
-
DOI 10.1074/jbc.M201535200
-
Sugiura M, Kono K, Liu H, Shimizugawa T, Minekura H, Spiegel S, Kohama T. Ceramide kinase, a novel lipid kinase. Molecular cloning and functional characterization. J Biol Chem 2002;277:23294-300. (Pubitemid 34952158)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.26
, pp. 23294-23300
-
-
Sugiura, M.1
Kono, K.2
Liu, H.3
Shimizugawa, T.4
Minekura, H.5
Spiegel, S.6
Kohama, T.7
-
39
-
-
0029014026
-
Short-chain ceramide-1-phosphates are novel stimulators of DNA synthesis and cell division: Antagonism by cell-permeable ceramides
-
Gomez-Munoz A, Duffy PA, Martin A, O'Brien L, Byun HS, Bittman R, Brindley DN. Short-chain ceramide-1-phosphates are novel stimulators of DNA synthesis and cell division: antagonism by cell-permeable ceramides. Mol Pharmacol 1995;47:833-9.
-
(1995)
Mol Pharmacol
, vol.47
, pp. 833-839
-
-
Gomez-Munoz, A.1
Duffy, P.A.2
Martin, A.3
O'Brien, L.4
Byun, H.S.5
Bittman, R.6
Brindley, D.N.7
-
40
-
-
0842282983
-
Ceramide-1-phosphate blocks apoptosis through inhibition of acid sphingomyelinase in macrophages
-
Gomez-Munoz A, Kong JY, Salh B, Steinbrecher UP. Ceramide-1-phosphate blocks apoptosis through inhibition of acid sphingomyelinase in macrophages. J Lipid Res 2004;45:99-105.
-
(2004)
J Lipid Res
, vol.45
, pp. 99-105
-
-
Gomez-Munoz, A.1
Kong, J.Y.2
Salh, B.3
Steinbrecher, U.P.4
-
41
-
-
27844517355
-
Sphingosine 1-phosphate and ceramide 1-phosphate: Expanding roles in cell signaling
-
Chalfant CE, Spiegel S. Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling. J Cell Sci 2005;118:4605-12.
-
(2005)
J Cell Sci
, vol.118
, pp. 4605-4612
-
-
Chalfant, C.E.1
Spiegel, S.2
-
42
-
-
0032509523
-
The formation of ceramide-1-phosphate during neutrophil phagocytosis and its role in liposome fusion
-
DOI 10.1074/jbc.273.50.33203
-
Hinkovska-Galcheva VT, Boxer LA, Mansfield PJ, Harsh D, Blackwood A, Shayman JA. The formation of ceramide-1-phosphate during neutrophil phagocytosis and its role in liposome fusion. J Biol Chem 1998;273:33203-9. (Pubitemid 29005692)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.50
, pp. 33203-33209
-
-
Hinkovska-Galcheva, V.T.1
Boxer, L.A.2
Mansfield, P.J.3
Harsh, D.4
Blackwood, A.5
Shayman, J.A.6
-
43
-
-
0019811223
-
Biosynthesis of galactocerebrosides and glucocerebrosides in glial cell lines
-
Neskovic NM, Rebel G, Harth S, Mandel P. Biosynthesis of galactocerebrosides and glucocerebrosides in glial cell lines. J Neurochem 1981;37:1363-70.
-
(1981)
J Neurochem
, vol.37
, pp. 1363-1370
-
-
Neskovic, N.M.1
Rebel, G.2
Harth, S.3
Mandel, P.4
-
44
-
-
0034602159
-
Cellular gangliosides promote growth factor-induced proliferation of fibroblasts
-
Li R, Manela J, Kong Y, Ladisch S. Cellular gangliosides promote growth factor-induced proliferation of fibroblasts. J Biol Chem 2000;275:34213-23.
-
(2000)
J Biol Chem
, vol.275
, pp. 34213-34223
-
-
Li, R.1
Manela, J.2
Kong, Y.3
Ladisch, S.4
-
45
-
-
0031899553
-
Glucosylceramide: A marker for multiple-drug resistant cancers
-
Lucci A, Cho WI, Han TY, Giuliano AE, Morton DL, Cabot MC. Glucosylceramide: a marker for multiple-drug resistant cancers. Anticancer Res 1998;18:475-80.
-
(1998)
Anticancer Res
, vol.18
, pp. 475-480
-
-
Lucci, A.1
Cho, W.I.2
Han, T.Y.3
Giuliano, A.E.4
Morton, D.L.5
Cabot, M.C.6
-
46
-
-
0029761340
-
Accumulation of glucosylceramides in multidrug-resistant cancer cells
-
DOI 10.1074/jbc.271.32.19530
-
Lavie Y, Cao H, Bursten SL, Giuliano AE, Cabot MC. Accumulation of glucosylceramides in multidrug-resistant cancer cells. J Biol Chem 1996;271:19530-6. (Pubitemid 26271630)
-
(1996)
Journal of Biological Chemistry
, vol.271
, Issue.32
, pp. 19530-19536
-
-
Lavie, Y.1
Cao, H.-T.2
Bursten, S.L.3
Giuliano, A.E.4
Cabot, M.C.5
-
47
-
-
0034629305
-
Uncoupling ceramide glycosylation by transfection of glucosylceramide synthase antisense reverses adriamycin resistance
-
Liu YY, Han TY, Giuliano AE, Hansen N, Cabot MC. Uncoupling ceramide glycosylation by transfection of glucosylceramide synthase antisense reverses adriamycin resistance. J Biol Chem 2000;275:7138-43.
-
(2000)
J Biol Chem
, vol.275
, pp. 7138-7143
-
-
Liu, Y.Y.1
Han, T.Y.2
Giuliano, A.E.3
Hansen, N.4
Cabot, M.C.5
-
48
-
-
0000255378
-
Expression of glucosylceramide synthase, converting ceramide to glucosylceramide, confers adriamycin resistance in human breast cancer cells
-
Liu YY, Han TY, Giuliano AE, Cabot MC. Expression of glucosylceramide synthase, converting ceramide to glucosylceramide, confers adriamycin resistance in human breast cancer cells. J Biol Chem 1999;274:1140-6.
-
(1999)
J Biol Chem
, vol.274
, pp. 1140-1146
-
-
Liu, Y.Y.1
Han, T.Y.2
Giuliano, A.E.3
Cabot, M.C.4
-
49
-
-
0028878829
-
Cell cycle arrest induced by an inhibitor of glucosylceramide synthase. Correlation with cyclin-dependent kinases
-
Rani CS, Abe A, Chang Y, Rosenzweig N, Saltiel AR, Radin NS, Shayman JA. Cell cycle arrest induced by an inhibitor of glucosylceramide synthase. Correlation with cyclin-dependent kinases. J Biol Chem 1995;270:2859-67.
-
(1995)
J Biol Chem
, vol.270
, pp. 2859-2867
-
-
Rani, C.S.1
Abe, A.2
Chang, Y.3
Rosenzweig, N.4
Saltiel, A.R.5
Radin, N.S.6
Shayman, J.A.7
-
50
-
-
0029070822
-
Purification, characterization, and biosynthesis of human acid ceramidase
-
Bernardo K, Hurwitz R, Zenk T, Desnick RJ, Ferlinz K, Schuchman EH, Sandhoff K. Purification, characterization, and biosynthesis of human acid ceramidase. J Biol Chem 1995;270:11098-102.
-
(1995)
J Biol Chem
, vol.270
, pp. 11098-11102
-
-
Bernardo, K.1
Hurwitz, R.2
Zenk, T.3
Desnick, R.J.4
Ferlinz, K.5
Schuchman, E.H.6
Sandhoff, K.7
-
51
-
-
34447107198
-
Purification and characterization of human intestinal neutral ceramidase
-
Ohlsson L, Palmberg C, Duan RD, Olsson M, Bergman T, Nilsson A. Purification and characterization of human intestinal neutral ceramidase. Biochimie 2007;89:950-60.
-
(2007)
Biochimie
, vol.89
, pp. 950-960
-
-
Ohlsson, L.1
Palmberg, C.2
Duan, R.D.3
Olsson, M.4
Bergman, T.5
Nilsson, A.6
-
52
-
-
0016682741
-
Ceramidase and ceramide synthesis in human kidney and cerebellum. Description of a new alkaline ceramidase
-
Sugita M, Willians M, Dulaney JT, Moser HW. Ceramidase and ceramide synthesis in human kidney and cerebellum. Description of a new alkaline ceramidase. Biochim Biophys Acta 1975;398:125-31.
-
(1975)
Biochim Biophys Acta
, vol.398
, pp. 125-131
-
-
Sugita, M.1
Willians, M.2
Dulaney, J.T.3
Moser, H.W.4
-
54
-
-
0042030874
-
The reverse activity of human acid ceramidase
-
Okino N, He X, Gatt S, Sandhoff K, Ito M, Schuchman EH. The reverse activity of human acid ceramidase. J Biol Chem 2003;278:29948-53.
-
(2003)
J Biol Chem
, vol.278
, pp. 29948-29953
-
-
Okino, N.1
He, X.2
Gatt, S.3
Sandhoff, K.4
Ito, M.5
Schuchman, E.H.6
-
55
-
-
0035907364
-
1-insensitive ceramide synthase
-
DOI 10.1074/jbc.M009331200
-
El Bawab S, Birbes H, Roddy P, Szulc ZM, Bielawska A, Hannun YA. Biochemical characterization of the reverse activity of rat brain ceramidase. A CoA-independent and fumonisin B1-insensitive ceramide synthase. J Biol Chem 2001;276:16758-66. (Pubitemid 37411468)
-
(2001)
Journal of Biological Chemistry
, vol.276
, Issue.20
, pp. 16758-16766
-
-
El Bawab, S.1
Birbes, H.2
Roddy, P.3
Szulc, Z.M.4
Bielawska, A.5
Hannun, Y.A.6
-
56
-
-
0030004270
-
Sphingosine and its methylated derivative N,N-dimethylsphingosine (DMS) induce apoptosis in a variety of human cancer cell lines
-
Sweeney EA, Sakakura C, Shirahama T, Masamune A, Ohta H, Hakomori S, Igarashi Y. Sphingosine and its methylated derivative N,N-dimethylsphingosine (DMS) induce apoptosis in a variety of human cancer cell lines. Int J Cancer 1996;66:358-66.
-
(1996)
Int J Cancer
, vol.66
, pp. 358-366
-
-
Sweeney, E.A.1
Sakakura, C.2
Shirahama, T.3
Masamune, A.4
Ohta, H.5
Hakomori, S.6
Igarashi, Y.7
-
57
-
-
0029922118
-
Induction of apoptosis and potentiation of ceramide-mediated cytotoxicity by sphingoid bases in human myeloid leukemia cells
-
Jarvis WD, Fornari FA, Traylor RS, Martin HA, Kramer LB, Erukulla RK, Bittman R, Grant S. Induction of apoptosis and potentiation of ceramide-mediated cytotoxicity by sphingoid bases in human myeloid leukemia cells. J Biol Chem 1996;271:8275-84.
-
(1996)
J Biol Chem
, vol.271
, pp. 8275-8284
-
-
Jarvis, W.D.1
Fornari, F.A.2
Traylor, R.S.3
Martin, H.A.4
Kramer, L.B.5
Erukulla, R.K.6
Bittman, R.7
Grant, S.8
-
58
-
-
0031439924
-
Coordinate regulation of stress- And mitogen-activated protein kinases in the apoptotic actions of ceramide and sphingosine
-
Jarvis WD, Fornari FA, Jr, Auer KL, Freemerman AJ, Szabo E, Birrer MJ, Johnson CR, Barbour SE, Dent P, Grant S. Coordinate regulation of stress- and mitogen-activated protein kinases in the apoptotic actions of ceramide and sphingosine. Mol Pharmacol 1997;52:935-47.
-
(1997)
Mol Pharmacol
, vol.52
, pp. 935-947
-
-
Jarvis, W.D.1
Fornari Jr., F.A.2
Auer, K.L.3
Freemerman, A.J.4
Szabo, E.5
Birrer, M.J.6
Johnson, C.R.7
Barbour, S.E.8
Dent, P.9
Grant, S.10
-
59
-
-
0028900748
-
Induction of apoptosis by sphingosine in human leukemic HL-60 cells: A possible endogenous modulator of apoptotic DNA fragmentation occurring during phorbol ester-induced differentiation
-
Ohta H, Sweeney EA, Masamune A, Yatomi Y, Hakomori S, Igarashi Y. Induction of apoptosis by sphingosine in human leukemic HL-60 cells: a possible endogenous modulator of apoptotic DNA fragmentation occurring during phorbol ester-induced differentiation. Cancer Res 1995;55:691-7.
-
(1995)
Cancer Res
, vol.55
, pp. 691-697
-
-
Ohta, H.1
Sweeney, E.A.2
Masamune, A.3
Yatomi, Y.4
Hakomori, S.5
Igarashi, Y.6
-
60
-
-
0031693199
-
Characterization of cytotoxicity induced by sphingolipids in multidrug-resistant leukemia cells
-
DOI 10.1016/S0145-2126(98)00107-6, PII S0145212698001076
-
Klostergaard J, Auzenne E, Leroux E. Characterization of cytotoxicity induced by sphingolipids in multidrug-resistant leukemia cells. Leuk Res 1998;22:1049-56. (Pubitemid 28454505)
-
(1998)
Leukemia Research
, vol.22
, Issue.11
, pp. 1049-1056
-
-
Klostergaard, J.1
Auzenne, E.2
Leroux, E.3
-
61
-
-
0031035476
-
In vitro and in vivo induction of apoptosis by sphingosine and N, N-dimethylsphingosine in human epidermoid carcinoma KB-3-1 and its multidrug-resistant cells
-
Shirahama T, Sweeney EA, Sakakura C, Singhal AK, Nishiyama K, Akiyama S, Hakomori S, Igarashi Y. In vitro and in vivo induction of apoptosis by sphingosine and N, N-dimethylsphingosine in human epidermoid carcinoma KB-3-1 and its multidrug-resistant cells. Clin Cancer Res 1997;3:257-64.
-
(1997)
Clin Cancer Res
, vol.3
, pp. 257-264
-
-
Shirahama, T.1
Sweeney, E.A.2
Sakakura, C.3
Singhal, A.K.4
Nishiyama, K.5
Akiyama, S.6
Hakomori, S.7
Igarashi, Y.8
-
62
-
-
0017134633
-
Examinations foe optimization of exposure voltage in lymphangiography
-
author's transl
-
Nitzsche H, Rosenkranz G. [Examinations foe optimization of exposure voltage in lymphangiography (author's transl)]. Radiol Diagn (Berl) 1976;17:191-200.
-
(1976)
Radiol Diagn (Berl)
, vol.17
, pp. 191-200
-
-
Nitzsche, H.1
Rosenkranz, G.2
-
63
-
-
0031864727
-
Cytotoxic effects of sphingolipids as single or multi-modality agents on human melanoma and soft tissue sarcoma in vitro
-
Auzenne E, Leroux ME, Hu M, Pollock RE, Feig B, Klostergaard J. Cytotoxic effects of sphingolipids as single or multi-modality agents on human melanoma and soft tissue sarcoma in vitro. Melanoma Res 1998;8:227-39.
-
(1998)
Melanoma Res
, vol.8
, pp. 227-239
-
-
Auzenne, E.1
Leroux, M.E.2
Hu, M.3
Pollock, R.E.4
Feig, B.5
Klostergaard, J.6
-
64
-
-
0022974603
-
Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets
-
Hannun YA, Loomis CR, Merrill AH, Jr, Bell RM. Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets. J Biol Chem 1986;261:12604-9.
-
(1986)
J Biol Chem
, vol.261
, pp. 12604-12609
-
-
Hannun, Y.A.1
Loomis, C.R.2
Merrill Jr., A.H.3
Bell, R.M.4
-
65
-
-
33845294390
-
A house divided: Ceramide, sphingosine, and sphingosine-1-phosphate in programmed cell death
-
Taha TA, Mullen TD, Obeid LM. A house divided: ceramide, sphingosine, and sphingosine-1-phosphate in programmed cell death. Biochim Biophys Acta 2006;1758:2027-36.
-
(2006)
Biochim Biophys Acta
, vol.1758
, pp. 2027-2036
-
-
Taha, T.A.1
Mullen, T.D.2
Obeid, L.M.3
-
66
-
-
0034717184
-
Involvement of sphingosine in mitochondria-dependent Fas-induced apoptosis of type II Jurkat T cells
-
Cuvillier O, Edsall L, Spiegel S. Involvement of sphingosine in mitochondria-dependent Fas-induced apoptosis of type II Jurkat T cells. J Biol Chem 2000;275:15691-700.
-
(2000)
J Biol Chem
, vol.275
, pp. 15691-15700
-
-
Cuvillier, O.1
Edsall, L.2
Spiegel, S.3
-
67
-
-
0035090339
-
Sphingosine generation, cytochrome c release, and activation of caspase-7 in doxorubicin-induced apoptosis of MCF7 breast adenocarcinoma cells
-
Cuvillier O, Nava VE, Murthy SK, Edsall LC, Levade T, Milstien S, Spiegel S. Sphingosine generation, cytochrome c release, and activation of caspase-7 in doxorubicin-induced apoptosis of MCF7 breast adenocarcinoma cells. Cell Death Differ 2001;8:162-71.
-
(2001)
Cell Death Differ
, vol.8
, pp. 162-171
-
-
Cuvillier, O.1
Nava, V.E.2
Murthy, S.K.3
Edsall, L.C.4
Levade, T.5
Milstien, S.6
Spiegel, S.7
-
68
-
-
0033558227
-
Activation of caspase-3-like proteases in apoptosis induced by sphingosine and other long-chain bases in Hep3B hepatoma cells
-
Hung WC, Chang HC, Chuang LY. Activation of caspase-3-like proteases in apoptosis induced by sphingosine and other long-chain bases in Hep3B hepatoma cells. Biochem J 1999;338(Part 1):161-6.
-
(1999)
Biochem J
, vol.338
, Issue.PART 1
, pp. 161-166
-
-
Hung, W.C.1
Chang, H.C.2
Chuang, L.Y.3
-
69
-
-
59649122434
-
Alkaline ceramidase 2 regulates beta1 integrin maturation and cell adhesion
-
Sun W, Hu W, Xu R, Jin J, Szulc ZM, Zhang G, Galadari SH, Obeid LM, Mao C. Alkaline ceramidase 2 regulates beta1 integrin maturation and cell adhesion. FASEB J 2009;23:656-66.
-
(2009)
FASEB J
, vol.23
, pp. 656-666
-
-
Sun, W.1
Hu, W.2
Xu, R.3
Jin, J.4
Szulc, Z.M.5
Zhang, G.6
Galadari, S.H.7
Obeid, L.M.8
Mao, C.9
-
70
-
-
14844331766
-
Golgi fragmentation is associated with ceramide-induced cellular effects
-
Hu W, Xu R, Zhang G, Jin J, Szulc ZM, Bielawski J, Hannun YA, Obeid LM, Mao C. Golgi fragmentation is associated with ceramide-induced cellular effects. Mol Biol Cell 2005;16:1555-67.
-
(2005)
Mol Biol Cell
, vol.16
, pp. 1555-1567
-
-
Hu, W.1
Xu, R.2
Zhang, G.3
Jin, J.4
Szulc, Z.M.5
Bielawski, J.6
Hannun, Y.A.7
Obeid, L.M.8
Mao, C.9
-
71
-
-
77951991002
-
Neurons and oligodendrocytes recycle sphingosine-1-phosphate to ceramide; significance for apoptosis and multiple sclerosis
-
Qin J, Berdyshev E, Goya J, Natarajan V, Dawson G. Neurons and oligodendrocytes recycle sphingosine-1-phosphate to ceramide; significance for apoptosis and multiple sclerosis. J Biol Chem 2010;285:14134-43.
-
(2010)
J Biol Chem
, vol.285
, pp. 14134-14143
-
-
Qin, J.1
Berdyshev, E.2
Goya, J.3
Natarajan, V.4
Dawson, G.5
-
72
-
-
0034733556
-
Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform
-
Liu H, Sugiura M, Nava VE, Edsall LC, Kono K, Poulton S, Milstien S, Kohama T, Spiegel S. Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform. J Biol Chem 2000;275:19513-20.
-
(2000)
J Biol Chem
, vol.275
, pp. 19513-19520
-
-
Liu, H.1
Sugiura, M.2
Nava, V.E.3
Edsall, L.C.4
Kono, K.5
Poulton, S.6
Milstien, S.7
Kohama, T.8
Spiegel, S.9
-
73
-
-
0032508706
-
Molecular cloning and functional characterization of murine sphingosine kinase
-
DOI 10.1074/jbc.273.37.23722
-
Kohama T, Olivera A, Edsall L, Nagiec MM, Dickson R, Spiegel S. Molecular cloning and functional characterization of murine sphingosine kinase. J Biol Chem 1998;273:23722-8. (Pubitemid 28435703)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.37
, pp. 23722-23728
-
-
Kohama, T.1
Olivera, A.2
Edsall, L.3
Nagiec, M.M.4
Dickson, R.5
Spiegel, S.6
-
74
-
-
0035023404
-
Sphingosine-1-phosphate phosphatases
-
Mandala SM. Sphingosine-1-phosphate phosphatases. Prostaglandins 2001;64:143-56.
-
(2001)
Prostaglandins
, vol.64
, pp. 143-156
-
-
Mandala, S.M.1
-
75
-
-
0038218405
-
Sphingosine-1-phosphate: An enigmatic signalling lipid
-
Spiegel S, Milstien S. Sphingosine-1-phosphate: an enigmatic signalling lipid. Nat Rev Mol Cell Biol 2003;4:397-407.
-
(2003)
Nat Rev Mol Cell Biol
, vol.4
, pp. 397-407
-
-
Spiegel, S.1
Milstien, S.2
-
76
-
-
33947168769
-
FTY720, an immunomodulatory sphingolipid mimetic: Translation of a novel mechanism into clinical benefit in multiple sclerosis
-
Baumruker T, Billich A, Brinkmann V. FTY720, an immunomodulatory sphingolipid mimetic: translation of a novel mechanism into clinical benefit in multiple sclerosis. Expert Opin Investig Drugs 2007;16:283-9.
-
(2007)
Expert Opin Investig Drugs
, vol.16
, pp. 283-289
-
-
Baumruker, T.1
Billich, A.2
Brinkmann, V.3
-
77
-
-
0041703016
-
The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha
-
Pettus BJ, Bielawski J, Porcelli AM, Reames DL, Johnson KR, Morrow J, Chalfant CE, Obeid LM, Hannun YA. The sphingosine kinase 1/sphingosine-1- phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha. FASEB J 2003;17:1411-21.
-
(2003)
FASEB J
, vol.17
, pp. 1411-1421
-
-
Pettus, B.J.1
Bielawski, J.2
Porcelli, A.M.3
Reames, D.L.4
Johnson, K.R.5
Morrow, J.6
Chalfant, C.E.7
Obeid, L.M.8
Hannun, Y.A.9
-
78
-
-
0037378439
-
Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing
-
Vogler R, Sauer B, Kim DS, Schafer-Korting M, Kleuser B. Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing. J Invest Dermatol 2003;120:693-700.
-
(2003)
J Invest Dermatol
, vol.120
, pp. 693-700
-
-
Vogler, R.1
Sauer, B.2
Kim, D.S.3
Schafer-Korting, M.4
Kleuser, B.5
-
79
-
-
0001059752
-
Cytogenetic studies in chronic myeloid leukaemia and acute leukaemia associated with monogolism
-
Tough IM, Court Brown WM, Baikie AG, Buckton KE, Harnden DG, Jacobs PA, King MJ, Mc BJ. Cytogenetic studies in chronic myeloid leukaemia and acute leukaemia associated with monogolism. Lancet 1961;1:411-17.
-
(1961)
Lancet
, vol.1
, pp. 411-417
-
-
Tough, I.M.1
Court Brown, W.M.2
Baikie, A.G.3
Buckton, K.E.4
Harnden, D.G.5
Jacobs, P.A.6
King, M.J.7
Mc, B.J.8
-
80
-
-
0037093092
-
Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: Results of a phase II study
-
Sawyers CL, Hochhaus A, Feldman E, Goldman JM, Miller CB, Ottmann OG, Schiffer CA, Talpaz M, Guilhot F, Deininger MW, Fischer T, O'Brien SG, et al. Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a phase II study. Blood 2002;99:3530-9.
-
(2002)
Blood
, vol.99
, pp. 3530-3539
-
-
Sawyers, C.L.1
Hochhaus, A.2
Feldman, E.3
Goldman, J.M.4
Miller, C.B.5
Ottmann, O.G.6
Schiffer, C.A.7
Talpaz, M.8
Guilhot, F.9
Deininger, M.W.10
Fischer, T.11
O'Brien, S.G.12
-
82
-
-
0031890032
-
Molecular biology of chronic lymphocytic leukemia
-
Reed JC. Molecular biology of chronic lymphocytic leukemia. Semin Oncol 1998;25:11-18. (Pubitemid 28090907)
-
(1998)
Seminars in Oncology
, vol.25
, Issue.1
, pp. 11-18
-
-
Reed, J.C.1
-
83
-
-
0014021992
-
Radiation-related leukemia in Hiroshima and Nagasaki, 1946-1964. I. Distribution, incidence and appearance time
-
Bizzozero OJ, Jr, Johnson KG, Ciocco A. Radiation-related leukemia in Hiroshima and Nagasaki, 1946-1964. I. Distribution, incidence and appearance time. N Engl J Med 1966;274:1095-101.
-
(1966)
N Engl J Med
, vol.274
, pp. 1095-1101
-
-
Bizzozero Jr., O.J.1
Johnson, K.G.2
Ciocco, A.3
-
84
-
-
0022617302
-
Clinical and cytogenetic correlations in 63 patients with therapy-related myelodysplastic syndromes and acute nonlymphocytic leukemia: Further evidence for characteristic abnormalities of chromosomes no. 5 and 7
-
Le Beau MM, Albain KS, Larson RA, Vardiman JW, Davis EM, Blough RR, Golomb HM, Rowley JD. Clinical and cytogenetic correlations in 63 patients with therapy-related myelodysplastic syndromes and acute nonlymphocytic leukemia: further evidence for characteristic abnormalities of chromosomes no. 5 and 7. J Clin Oncol 1986;4:325-45.
-
(1986)
J Clin Oncol
, vol.4
, pp. 325-345
-
-
Le Beau, M.M.1
Albain, K.S.2
Larson, R.A.3
Vardiman, J.W.4
Davis, E.M.5
Blough, R.R.6
Golomb, H.M.7
Rowley, J.D.8
-
85
-
-
0024402407
-
Two regression models and a scoring system for predicting survival and planning treatment in myelodysplastic syndromes: A multivariate analysis of prognostic factors in 370 patients
-
Sanz GF, Sanz MA, Vallespi T, Canizo MC, Torrabadella M, Garcia S, Irriguible D, San Miguel JF. Two regression models and a scoring system for predicting survival and planning treatment in myelodysplastic syndromes: a multivariate analysis of prognostic factors in 370 patients. Blood 1989;74:395-408.
-
(1989)
Blood
, vol.74
, pp. 395-408
-
-
Sanz, G.F.1
Sanz, M.A.2
Vallespi, T.3
Canizo, M.C.4
Torrabadella, M.5
Garcia, S.6
Irriguible, D.7
San Miguel, J.F.8
-
86
-
-
33646671496
-
Transcriptional activators, repressors, and epigenetic modifiers controlling hematopoietic stem cell development
-
Teitell MA, Mikkola HK. Transcriptional activators, repressors, and epigenetic modifiers controlling hematopoietic stem cell development. Pediatr Res 2006;59:33R-39R.
-
(2006)
Pediatr Res
, vol.59
-
-
Teitell, M.A.1
Mikkola, H.K.2
-
87
-
-
69349101565
-
Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia
-
Papaemmanuil E, Hosking FJ, Vijayakrishnan J, Price A, Olver B, Sheridan E, Kinsey SE, Lightfoot T, Roman E, Irving JA, Allan JM, Tomlinson IP, et al. Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia. Nat Genet 2009;41:1006-10.
-
(2009)
Nat Genet
, vol.41
, pp. 1006-1010
-
-
Papaemmanuil, E.1
Hosking, F.J.2
Vijayakrishnan, J.3
Price, A.4
Olver, B.5
Sheridan, E.6
Kinsey, S.E.7
Lightfoot, T.8
Roman, E.9
Irving, J.A.10
Allan, J.M.11
Tomlinson, I.P.12
-
88
-
-
34347221936
-
Arsenic trioxide induces accumulation of cytotoxic levels of ceramide in acute promyelocytic leukemia and adult T-cell leukemia/lymphoma cells through de novo ceramide synthesis and inhibition of glucosylceramide synthase activity
-
Dbaibo GS, Kfoury Y, Darwiche N, Panjarian S, Kozhaya L, Nasr R, Abdallah M, Hermine O, El-Sabban M, de The H, Bazarbachi A. Arsenic trioxide induces accumulation of cytotoxic levels of ceramide in acute promyelocytic leukemia and adult T-cell leukemia/lymphoma cells through de novo ceramide synthesis and inhibition of glucosylceramide synthase activity. Haematologica 2007;92:753-62.
-
(2007)
Haematologica
, vol.92
, pp. 753-762
-
-
Dbaibo, G.S.1
Kfoury, Y.2
Darwiche, N.3
Panjarian, S.4
Kozhaya, L.5
Nasr, R.6
Abdallah, M.7
Hermine, O.8
El-Sabban, M.9
De The, H.10
Bazarbachi, A.11
-
89
-
-
0034708594
-
Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis
-
Perry DK, Carton J, Shah AK, Meredith F, Uhlinger DJ, Hannun YA. Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis. J Biol Chem 2000;275:9078-84.
-
(2000)
J Biol Chem
, vol.275
, pp. 9078-9084
-
-
Perry, D.K.1
Carton, J.2
Shah, A.K.3
Meredith, F.4
Uhlinger, D.J.5
Hannun, Y.A.6
-
90
-
-
0033537839
-
Ceramide generation in nitric oxide-induced apoptosis: Activation of magnesium-dependent neutral sphingomyelinase via caspase-3
-
DOI 10.1074/jbc.274.15.10654
-
Takeda Y, Tashima M, Takahashi A, Uchiyama T, Okazaki T. Ceramide generation in nitric oxide-induced apoptosis. Activation of magnesium-dependent neutral sphingomyelinase via caspase-3. J Biol Chem 1999;274:10654-60. (Pubitemid 29180950)
-
(1999)
Journal of Biological Chemistry
, vol.274
, Issue.15
, pp. 10654-10660
-
-
Takeda, Y.1
Tashima, M.2
Takahashi, A.3
Uchiyama, T.4
Okazaki, T.5
-
91
-
-
33744913027
-
The CB2 cannabinoid receptor signals apoptosis via ceramide-dependent activation of the mitochondrial intrinsic pathway
-
Herrera B, Carracedo A, Diez-Zaera M, Gomez del Pulgar T, Guzman M, Velasco G. The CB2 cannabinoid receptor signals apoptosis via ceramide-dependent activation of the mitochondrial intrinsic pathway. Exp Cell Res 2006;312:2121-31.
-
(2006)
Exp Cell Res
, vol.312
, pp. 2121-2131
-
-
Herrera, B.1
Carracedo, A.2
Diez-Zaera, M.3
Gomez Del Pulgar, T.4
Guzman, M.5
Velasco, G.6
-
92
-
-
0036100132
-
N-(4-hydroxyphenyl)retinamide increases ceramide and is cytotoxic to acute lymphoblastic leukemia cell lines, but not to non-malignant lymphocytes
-
O'Donnell PH, Guo WX, Reynolds CP, Maurer BJ. N-(4-hydroxyphenyl) retinamide increases ceramide and is cytotoxic to acute lymphoblastic leukemia cell lines, but not to non-malignant lymphocytes. Leukemia 2002;16:902-10.
-
(2002)
Leukemia
, vol.16
, pp. 902-910
-
-
O'Donnell, P.H.1
Guo, W.X.2
Reynolds, C.P.3
Maurer, B.J.4
-
93
-
-
30044434594
-
The histone deacetylase inhibitor LAQ824 induces human leukemia cell death through a process involving XIAP down-regulation, oxidative injury, and the acid sphingomyelinase-dependent generation of ceramide
-
Rosato RR, Maggio SC, Almenara JA, Payne SG, Atadja P, Spiegel S, Dent P, Grant S. The histone deacetylase inhibitor LAQ824 induces human leukemia cell death through a process involving XIAP down-regulation, oxidative injury, and the acid sphingomyelinase-dependent generation of ceramide. Mol Pharmacol 2006;69:216-25.
-
(2006)
Mol Pharmacol
, vol.69
, pp. 216-225
-
-
Rosato, R.R.1
Maggio, S.C.2
Almenara, J.A.3
Payne, S.G.4
Atadja, P.5
Spiegel, S.6
Dent, P.7
Grant, S.8
-
94
-
-
0034706927
-
Changes in ceramide and sphingomyelin following fludarabine treatment of human chronic B-cell leukemia cells
-
Biswal SS, Datta K, Acquaah-Mensah GK, Kehrer JP. Changes in ceramide and sphingomyelin following fludarabine treatment of human chronic B-cell leukemia cells. Toxicology 2000;154:45-53.
-
(2000)
Toxicology
, vol.154
, pp. 45-53
-
-
Biswal, S.S.1
Datta, K.2
Acquaah-Mensah, G.K.3
Kehrer, J.P.4
-
95
-
-
0346992148
-
Sphingomyelin synthase as a potential target for D609-induced apoptosis in U937 human monocytic leukemia cells
-
DOI 10.1016/j.yexcr.2003.10.001
-
Meng A, Luberto C, Meier P, Bai A, Yang X, Hannun YA, Zhou D. Sphingomyelin synthase as a potential target for D609-induced apoptosis in U937 human monocytic leukemia cells. Exp Cell Res 2004;292:385-92. (Pubitemid 38018853)
-
(2004)
Experimental Cell Research
, vol.292
, Issue.2
, pp. 385-392
-
-
Meng, A.1
Luberto, C.2
Meier, P.3
Bai, A.4
Yang, X.5
Hannun, Y.A.6
Zhou, D.7
-
96
-
-
33947427915
-
Resveratrol impairs the formation of MDA-MB-231 multicellular tumor spheroids concomitant with ceramide accumulation
-
Dolfini E, Roncoroni L, Dogliotti E, Sala G, Erba E, Sacchi N, Ghidoni R. Resveratrol impairs the formation of MDA-MB-231 multicellular tumor spheroids concomitant with ceramide accumulation. Cancer Lett 2007;249:143-7.
-
(2007)
Cancer Lett
, vol.249
, pp. 143-147
-
-
Dolfini, E.1
Roncoroni, L.2
Dogliotti, E.3
Sala, G.4
Erba, E.5
Sacchi, N.6
Ghidoni, R.7
-
97
-
-
0642364447
-
Resveratrol induces growth inhibition and apoptosis in metastatic breast cancer cells via de novo ceramide signaling
-
Scarlatti F, Sala G, Somenzi G, Signorelli P, Sacchi N, Ghidoni R. Resveratrol induces growth inhibition and apoptosis in metastatic breast cancer cells via de novo ceramide signaling. FASEB J 2003;17:2339-41.
-
(2003)
FASEB J
, vol.17
, pp. 2339-2341
-
-
Scarlatti, F.1
Sala, G.2
Somenzi, G.3
Signorelli, P.4
Sacchi, N.5
Ghidoni, R.6
-
98
-
-
0031742058
-
CML and apoptosis: The ceramide pathway
-
Maguer-Satta V. CML and apoptosis: the ceramide pathway. Hematol Cell Ther 1998;40:233-6.
-
(1998)
Hematol Cell Ther
, vol.40
, pp. 233-236
-
-
Maguer-Satta, V.1
-
99
-
-
0026773819
-
Modulation of cell growth and differentiation by ceramide
-
Bielawska A, Linardic CM, Hannun YA. Modulation of cell growth and differentiation by ceramide. FEBS Lett 1992;307:211-14.
-
(1992)
FEBS Lett
, vol.307
, pp. 211-214
-
-
Bielawska, A.1
Linardic, C.M.2
Hannun, Y.A.3
-
100
-
-
33644507727
-
Caspase-dependent and -independent cell death of Jurkat human leukemia cells induced by novel synthetic ceramide analogs
-
DOI 10.1038/sj.leu.2404084, PII 2404084
-
Granot T, Milhas D, Carpentier S, Dagan A, Segui B, Gatt S, Levade T. Caspase-dependent and -independent cell death of Jurkat human leukemia cells induced by novel synthetic ceramide analogs. Leukemia 2006;20:392-9. (Pubitemid 43291734)
-
(2006)
Leukemia
, vol.20
, Issue.3
, pp. 392-399
-
-
Granot, T.1
Milhas, D.2
Carpentier, S.3
Dagan, A.4
Segui, B.5
Gatt, S.6
Levade, T.7
-
101
-
-
0033561621
-
Ceramide-induced killing of normal and malignant human lymphocytes is by a non-apoptotic mechanism
-
Mengubas K, Riordan FA, Bravery CA, Lewin J, Owens DL, Mehta AB, Hoffbrand AV, Wickremasinghe RG. Ceramide-induced killing of normal and malignant human lymphocytes is by a non-apoptotic mechanism. Oncogene 1999;18:2499-506.
-
(1999)
Oncogene
, vol.18
, pp. 2499-2506
-
-
Mengubas, K.1
Riordan, F.A.2
Bravery, C.A.3
Lewin, J.4
Owens, D.L.5
Mehta, A.B.6
Hoffbrand, A.V.7
Wickremasinghe, R.G.8
-
102
-
-
0142106832
-
Synthetic, non-natural sphingolipid analogs inhibit the biosynthesis of cellular sphingolipids, elevate ceramide and induce apoptotic cell death
-
Dagan A, Wang C, Fibach E, Gatt S. Synthetic, non-natural sphingolipid analogs inhibit the biosynthesis of cellular sphingolipids, elevate ceramide and induce apoptotic cell death. Biochim Biophys Acta 2003;1633:161-9.
-
(2003)
Biochim Biophys Acta
, vol.1633
, pp. 161-169
-
-
Dagan, A.1
Wang, C.2
Fibach, E.3
Gatt, S.4
-
103
-
-
0032112125
-
Association of Ceramide Accumulation with Photodynamic Treatment-Induced Cell Death
-
Separovic D, Mann KJ, Oleinick NL. Association of ceramide accumulation with photodynamic treatment-induced cell death. Photochem Photobiol 1998;68:101-9. (Pubitemid 128472339)
-
(1998)
Photochemistry and Photobiology
, vol.68
, Issue.1
, pp. 101-109
-
-
Separovic, D.1
Mann, K.J.2
Oleinick, N.L.3
-
104
-
-
61349188950
-
Diversity and complexity of ceramide generation after exposure of jurkat leukemia cells to irradiation
-
Ardail D, Maalouf M, Boivin A, Chapet O, Bodennec J, Rousson R, Rodriguez-Lafrasse C. Diversity and complexity of ceramide generation after exposure of jurkat leukemia cells to irradiation. Int J Radiat Oncol Biol Phys 2009;73:1211-18.
-
(2009)
Int J Radiat Oncol Biol Phys
, vol.73
, pp. 1211-1218
-
-
Ardail, D.1
Maalouf, M.2
Boivin, A.3
Chapet, O.4
Bodennec, J.5
Rousson, R.6
Rodriguez-Lafrasse, C.7
-
105
-
-
42649083647
-
Suppression of sphingomyelin synthase 1 by small interference RNA is associated with enhanced ceramide production and apoptosis after photodamage
-
Separovic D, Semaan L, Tarca AL, Awad Maitah MY, Hanada K, Bielawski J, Villani M, Luberto C. Suppression of sphingomyelin synthase 1 by small interference RNA is associated with enhanced ceramide production and apoptosis after photodamage. Exp Cell Res 2008;314:1860-8.
-
(2008)
Exp Cell Res
, vol.314
, pp. 1860-1868
-
-
Separovic, D.1
Semaan, L.2
Tarca, A.L.3
Awad Maitah, M.Y.4
Hanada, K.5
Bielawski, J.6
Villani, M.7
Luberto, C.8
-
106
-
-
33646865692
-
Effects of ceramide inhibition on radiation-induced apoptosis in human leukemia MOLT-4 cells
-
Takahashi E, Inanami O, Asanuma T, Kuwabara M. Effects of ceramide inhibition on radiation-induced apoptosis in human leukemia MOLT-4 cells. J Radiat Res (Tokyo) 2006;47:19-25.
-
(2006)
J Radiat Res (Tokyo)
, vol.47
, pp. 19-25
-
-
Takahashi, E.1
Inanami, O.2
Asanuma, T.3
Kuwabara, M.4
-
107
-
-
0028930533
-
Role for ceramide in cell cycle arrest
-
Jayadev S, Liu B, Bielawska AE, Lee JY, Nazaire F, Pushkareva M, Obeid LM, Hannun YA. Role for ceramide in cell cycle arrest. J Biol Chem 1995;270:2047-52.
-
(1995)
J Biol Chem
, vol.270
, pp. 2047-2052
-
-
Jayadev, S.1
Liu, B.2
Bielawska, A.E.3
Lee, J.Y.4
Nazaire, F.5
Pushkareva, M.6
Obeid, L.M.7
Hannun, Y.A.8
-
108
-
-
0027403876
-
Placental aspergillosis: Myth or reality? Apropos of a case with fetal death in utero
-
Ben Rejeb A, Boubaker S, Turki I, Massaoudi L, Chibani M, Khouja H. [Placental aspergillosis: myth or reality? Apropos of a case with fetal death in utero]. J Gynecol Obstet Biol Reprod (Paris) 1993;22:85-9.
-
(1993)
J Gynecol Obstet Biol Reprod (Paris)
, vol.22
, pp. 85-89
-
-
Ben Rejeb, A.1
Boubaker, S.2
Turki, I.3
Massaoudi, L.4
Chibani, M.5
Khouja, H.6
-
109
-
-
0030670626
-
Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis
-
Herr I, Wilhelm D, Bohler T, Angel P, Debatin KM. Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis. EMBO J 1997;16:6200-8.
-
(1997)
EMBO J
, vol.16
, pp. 6200-6208
-
-
Herr, I.1
Wilhelm, D.2
Bohler, T.3
Angel, P.4
Debatin, K.M.5
-
110
-
-
0028964917
-
FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway
-
Gulbins E, Bissonnette R, Mahboubi A, Martin S, Nishioka W, Brunner T, Baier G, Baier-Bitterlich G, Byrd C, Lang F, Kolesnick R, Altman A, et al. FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway. Immunity 1995;2:341-51.
-
(1995)
Immunity
, vol.2
, pp. 341-351
-
-
Gulbins, E.1
Bissonnette, R.2
Mahboubi, A.3
Martin, S.4
Nishioka, W.5
Brunner, T.6
Baier, G.7
Baier-Bitterlich, G.8
Byrd, C.9
Lang, F.10
Kolesnick, R.11
Altman, A.12
-
111
-
-
38849093984
-
Ceramide kinase expression is altered during macrophage-like cell differentiation of the leukemia cell line HL-60
-
DOI 10.1007/s11626-007-9063-z
-
Date T, Mitsutake S, Igarashi Y. Ceramide kinase expression is altered during macrophage-like cell differentiation of the leukemia cell line HL-60. In Vitro Cell Dev Biol Anim 2007;43:321-3. (Pubitemid 351195182)
-
(2007)
In Vitro Cellular and Developmental Biology - Animal
, vol.43
, Issue.10
, pp. 321-323
-
-
Date, T.1
Mitsutake, S.2
Igarashi, Y.3
-
112
-
-
36448975827
-
Enhancing effects of ceramide derivatives on 1,25-dihydroxyvitamin D(3)-induced differentiation of human HL-60 leukemia cells
-
Kim DS, Kim SH, Song JH, Chang YT, Hwang SY, Kim TS. Enhancing effects of ceramide derivatives on 1,25-dihydroxyvitamin D(3)-induced differentiation of human HL-60 leukemia cells. Life Sci 2007;81:1638-44.
-
(2007)
Life Sci
, vol.81
, pp. 1638-1644
-
-
Kim, D.S.1
Kim, S.H.2
Song, J.H.3
Chang, Y.T.4
Hwang, S.Y.5
Kim, T.S.6
-
113
-
-
0032939630
-
Ceramide potentiates, but sphingomyelin inhibits, vitamin D-induced keratinocyte differentiation: Comparison between keratinocytes and HL-60 cells
-
Pillai S, Mahajan M, Carlomusto M. Ceramide potentiates, but sphingomyelin inhibits, vitamin D-induced keratinocyte differentiation: comparison between keratinocytes and HL-60 cells. Arch Dermatol Res 1999;291:284-9.
-
(1999)
Arch Dermatol Res
, vol.291
, pp. 284-289
-
-
Pillai, S.1
Mahajan, M.2
Carlomusto, M.3
-
114
-
-
0037155897
-
Up-regulation of acid sphingomyelinase during retinoic acid-induced myeloid differentiation of NB4, a human acute promyelocytic leukemia cell line
-
Murate T, Suzuki M, Hattori M, Takagi A, Kojima T, Tanizawa T, Asano H, Hotta T, Saito H, Yoshida S, Tamiya-Koizumi K. Up-regulation of acid sphingomyelinase during retinoic acid-induced myeloid differentiation of NB4, a human acute promyelocytic leukemia cell line. J Biol Chem 2002;277:9936-43.
-
(2002)
J Biol Chem
, vol.277
, pp. 9936-9943
-
-
Murate, T.1
Suzuki, M.2
Hattori, M.3
Takagi, A.4
Kojima, T.5
Tanizawa, T.6
Asano, H.7
Hotta, T.8
Saito, H.9
Yoshida, S.10
Tamiya-Koizumi, K.11
-
115
-
-
34249737950
-
Alterations of ceramide/sphingosine 1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells
-
Baran Y, Salas A, Senkal CE, Gunduz U, Bielawski J, Obeid LM, Ogretmen B. Alterations of ceramide/sphingosine 1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells. J Biol Chem 2007;282:10922-34.
-
(2007)
J Biol Chem
, vol.282
, pp. 10922-10934
-
-
Baran, Y.1
Salas, A.2
Senkal, C.E.3
Gunduz, U.4
Bielawski, J.5
Obeid, L.M.6
Ogretmen, B.7
-
116
-
-
12244284610
-
Possible role of ceramide as an indicator of chemoresistance: Decrease of the ceramide content via activation of glucosylceramide synthase and sphingomyelin synthase in chemoresistant leukemia
-
Itoh M, Kitano T, Watanabe M, Kondo T, Yabu T, Taguchi Y, Iwai K, Tashima M, Uchiyama T, Okazaki T. Possible role of ceramide as an indicator of chemoresistance: decrease of the ceramide content via activation of glucosylceramide synthase and sphingomyelin synthase in chemoresistant leukemia. Clin Cancer Res 2003;9:415-23.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 415-423
-
-
Itoh, M.1
Kitano, T.2
Watanabe, M.3
Kondo, T.4
Yabu, T.5
Taguchi, Y.6
Iwai, K.7
Tashima, M.8
Uchiyama, T.9
Okazaki, T.10
-
117
-
-
0034192163
-
P-glycoprotein plays a drug-efflux-independent role in augmenting cell survival in acute myeloblastic leukemia and is associated with modulation of a sphingomyelin-ceramide apoptotic pathway
-
Pallis M, Russell N. P-glycoprotein plays a drug-efflux-independent role in augmenting cell survival in acute myeloblastic leukemia and is associated with modulation of a sphingomyelin-ceramide apoptotic pathway. Blood 2000;95:2897-904. (Pubitemid 30235901)
-
(2000)
Blood
, vol.95
, Issue.9
, pp. 2897-2904
-
-
Pallis, M.1
Russell, N.2
-
118
-
-
4444364174
-
Overexpression of glucosylceramide synthase and P-glycoprotein in cancer cells selected for resistance to natural product chemotherapy
-
Gouaze V, Yu JY, Bleicher RJ, Han TY, Liu YY, Wang H, Gottesman MM, Bitterman A, Giuliano AE, Cabot MC. Overexpression of glucosylceramide synthase and P-glycoprotein in cancer cells selected for resistance to natural product chemotherapy. Mol Cancer Ther 2004;3:633-9.
-
(2004)
Mol Cancer Ther
, vol.3
, pp. 633-639
-
-
Gouaze, V.1
Yu, J.Y.2
Bleicher, R.J.3
Han, T.Y.4
Liu, Y.Y.5
Wang, H.6
Gottesman, M.M.7
Bitterman, A.8
Giuliano, A.E.9
Cabot, M.C.10
-
119
-
-
12344336357
-
P-glycoprotein is implicated in the inhibition of ceramide-induced apoptosis in TF-1 acute myeloid leukemia cells by modulation of the glucosylceramide synthase pathway
-
Turzanski J, Grundy M, Shang S, Russell N, Pallis M. P-glycoprotein is implicated in the inhibition of ceramide-induced apoptosis in TF-1 acute myeloid leukemia cells by modulation of the glucosylceramide synthase pathway. Exp Hematol 2005;33:62-72.
-
(2005)
Exp Hematol
, vol.33
, pp. 62-72
-
-
Turzanski, J.1
Grundy, M.2
Shang, S.3
Russell, N.4
Pallis, M.5
-
120
-
-
0031851003
-
Lack of ceramide generation in TF-1 human myeloid leukemic cells resistant to ionizing radiation
-
Bruno AP, Laurent G, Averbeck D, Demur C, Bonnet J, Bettaieb A, Levade T, Jaffrezou JP. Lack of ceramide generation in TF-1 human myeloid leukemic cells resistant to ionizing radiation. Cell Death Differ 1998;5:172-82.
-
(1998)
Cell Death Differ
, vol.5
, pp. 172-182
-
-
Bruno, A.P.1
Laurent, G.2
Averbeck, D.3
Demur, C.4
Bonnet, J.5
Bettaieb, A.6
Levade, T.7
Jaffrezou, J.P.8
-
121
-
-
0030769389
-
Resistance to radiation-induced apoptosis in Burkitt's lymphoma cells is associated with defective ceramide signaling
-
Michael JM, Lavin MF, Watters DJ. Resistance to radiation-induced apoptosis in Burkitt's lymphoma cells is associated with defective ceramide signaling. Cancer Res 1997;57:3600-5.
-
(1997)
Cancer Res
, vol.57
, pp. 3600-3605
-
-
Michael, J.M.1
Lavin, M.F.2
Watters, D.J.3
-
123
-
-
0031013786
-
Ceramides induce a form of apoptosis in human acute lymphoblastic leukemia cells that is inhibited by Bcl-2, but not by CrmA
-
DOI 10.1016/S0014-5793(96)01284-7, PII S0014579396012847
-
Geley S, Hartmann BL, Kofler R. Ceramides induce a form of apoptosis in human acute lymphoblastic leukemia cells that is inhibited by Bcl-2, but not by CrmA. FEBS Lett 1997;400:15-18. (Pubitemid 27046813)
-
(1997)
FEBS Letters
, vol.400
, Issue.1
, pp. 15-18
-
-
Geley, S.1
Hartmann, B.L.2
Kofler, R.3
-
124
-
-
0037205757
-
Sphingosine-induced c-jun expression: Differences between sphingosine- and C2-ceramide-mediated signaling pathways
-
Sawai H, Okazaki T, Domae N. Sphingosine-induced c-jun expression: differences between sphingosine- and C2-ceramide-mediated signaling pathways. FEBS Lett 2002;524:103-6.
-
(2002)
FEBS Lett
, vol.524
, pp. 103-106
-
-
Sawai, H.1
Okazaki, T.2
Domae, N.3
-
125
-
-
43749123266
-
Sphingosine kinase-1 is a downstream regulator of imatinib-induced apoptosis in chronic myeloid leukemia cells
-
Bonhoure E, Lauret A, Barnes DJ, Martin C, Malavaud B, Kohama T, Melo JV, Cuvillier O. Sphingosine kinase-1 is a downstream regulator of imatinib-induced apoptosis in chronic myeloid leukemia cells. Leukemia 2008;22:971-9.
-
(2008)
Leukemia
, vol.22
, pp. 971-979
-
-
Bonhoure, E.1
Lauret, A.2
Barnes, D.J.3
Martin, C.4
Malavaud, B.5
Kohama, T.6
Melo, J.V.7
Cuvillier, O.8
-
126
-
-
46149100507
-
Implications of sphingosine kinase 1 expression level for the cellular sphingolipid rheostat: Relevance as a marker for daunorubicin sensitivity of leukemia cells
-
Sobue S, Nemoto S, Murakami M, Ito H, Kimura A, Gao S, Furuhata A, Takagi A, Kojima T, Nakamura M, Ito Y, Suzuki M, et al. Implications of sphingosine kinase 1 expression level for the cellular sphingolipid rheostat: relevance as a marker for daunorubicin sensitivity of leukemia cells. Int J Hematol 2008;87:266-75.
-
(2008)
Int J Hematol
, vol.87
, pp. 266-275
-
-
Sobue, S.1
Nemoto, S.2
Murakami, M.3
Ito, H.4
Kimura, A.5
Gao, S.6
Furuhata, A.7
Takagi, A.8
Kojima, T.9
Nakamura, M.10
Ito, Y.11
Suzuki, M.12
-
127
-
-
74949143796
-
Cytotoxic effects of novel phytosphingosine derivatives, including N,N-dimethylphytosphingosine and N-monomethylphytosphingosine, in human leukemia cell line HL60
-
Park SR, Cho HJ, Moon KJ, Chun KH, Kong SY, Yoon SS, Lee JS, Park S. Cytotoxic effects of novel phytosphingosine derivatives, including N,N-dimethylphytosphingosine and N-monomethylphytosphingosine, in human leukemia cell line HL60. Leuk Lymphoma 2010;51:132-45.
-
(2010)
Leuk Lymphoma
, vol.51
, pp. 132-145
-
-
Park, S.R.1
Cho, H.J.2
Moon, K.J.3
Chun, K.H.4
Kong, S.Y.5
Yoon, S.S.6
Lee, J.S.7
Park, S.8
-
128
-
-
51649122574
-
A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia
-
Paugh SW, Paugh BS, Rahmani M, Kapitonov D, Almenara JA, Kordula T, Milstien S, Adams JK, Zipkin RE, Grant S, Spiegel S. A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia. Blood 2008;112:1382-91.
-
(2008)
Blood
, vol.112
, pp. 1382-1391
-
-
Paugh, S.W.1
Paugh, B.S.2
Rahmani, M.3
Kapitonov, D.4
Almenara, J.A.5
Kordula, T.6
Milstien, S.7
Adams, J.K.8
Zipkin, R.E.9
Grant, S.10
Spiegel, S.11
-
129
-
-
67650667412
-
N,N-dimethyl phytosphingosine induces caspase-8-dependent cytochrome c release and apoptosis through ROS generation in human leukemia cells
-
Kim BM, Choi YJ, Han Y, Yun YS, Hong SH. N,N-dimethyl phytosphingosine induces caspase-8-dependent cytochrome c release and apoptosis through ROS generation in human leukemia cells. Toxicol Appl Pharmacol 2009;239:87-97.
-
(2009)
Toxicol Appl Pharmacol
, vol.239
, pp. 87-97
-
-
Kim, B.M.1
Choi, Y.J.2
Han, Y.3
Yun, Y.S.4
Hong, S.H.5
-
130
-
-
33644974376
-
Overcoming MDR-associated chemoresistance in HL-60 acute myeloid leukemia cells by targeting sphingosine kinase-1
-
Bonhoure E, Pchejetski D, Aouali N, Morjani H, Levade T, Kohama T, Cuvillier O. Overcoming MDR-associated chemoresistance in HL-60 acute myeloid leukemia cells by targeting sphingosine kinase-1. Leukemia 2006;20:95-102.
-
(2006)
Leukemia
, vol.20
, pp. 95-102
-
-
Bonhoure, E.1
Pchejetski, D.2
Aouali, N.3
Morjani, H.4
Levade, T.5
Kohama, T.6
Cuvillier, O.7
-
131
-
-
58449109188
-
In vitro anti-leukaemia activity of sphingosine kinase inhibitor
-
Ricci C, Onida F, Servida F, Radaelli F, Saporiti G, Todoerti K, Deliliers GL, Ghidoni R. In vitro anti-leukaemia activity of sphingosine kinase inhibitor. Br J Haematol 2009;144:350-7.
-
(2009)
Br J Haematol
, vol.144
, pp. 350-357
-
-
Ricci, C.1
Onida, F.2
Servida, F.3
Radaelli, F.4
Saporiti, G.5
Todoerti, K.6
Deliliers, G.L.7
Ghidoni, R.8
-
132
-
-
37149032222
-
Sphingosine kinase-1 mediates BCR/ABL-induced upregulation of Mcl-1 in chronic myeloid leukemia cells
-
Li QF, Huang WR, Duan HF, Wang H, Wu CT, Wang LS. Sphingosine kinase-1 mediates BCR/ABL-induced upregulation of Mcl-1 in chronic myeloid leukemia cells. Oncogene 2007;26:7904-8.
-
(2007)
Oncogene
, vol.26
, pp. 7904-7908
-
-
Li, Q.F.1
Huang, W.R.2
Duan, H.F.3
Wang, H.4
Wu, C.T.5
Wang, L.S.6
-
133
-
-
34547647448
-
Activation of sphingosine kinase mediates suppressive effect of interleukin-6 on human multiple myeloma cell apoptosis
-
Li QF, Wu CT, Duan HF, Sun HY, Wang H, Lu ZZ, Zhang QW, Liu HJ, Wang LS. Activation of sphingosine kinase mediates suppressive effect of interleukin-6 on human multiple myeloma cell apoptosis. Br J Haematol 2007;138:632-9.
-
(2007)
Br J Haematol
, vol.138
, pp. 632-639
-
-
Li, Q.F.1
Wu, C.T.2
Duan, H.F.3
Sun, H.Y.4
Wang, H.5
Lu, Z.Z.6
Zhang, Q.W.7
Liu, H.J.8
Wang, L.S.9
-
134
-
-
0032056362
-
3 inhibits programmed cell death in HL-60 cells by activation of sphingosine kinase
-
Kleuser B, Cuvillier O, Spiegel S. 1Alpha,25-dihydroxyvitamin D3 inhibits programmed cell death in HL-60 cells by activation of sphingosine kinase. Cancer Res 1998;58:1817-24. (Pubitemid 28217453)
-
(1998)
Cancer Research
, vol.58
, Issue.9
, pp. 1817-1824
-
-
Kleuser, B.1
Cuvillier, O.2
Spiegel, S.3
-
135
-
-
0035525748
-
Sphingosine 1- Phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria
-
Cuvillier O, Levade T. Sphingosine 1- phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria. Blood 2001;98:2828-36.
-
(2001)
Blood
, vol.98
, pp. 2828-2836
-
-
Cuvillier, O.1
Levade, T.2
-
136
-
-
48749121214
-
Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a "come-and-get-me" signal
-
Gude DR, Alvarez SE, Paugh SW, Mitra P, Yu J, Griffiths R, Barbour SE, Milstien S, Spiegel S. Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a "come-and-get-me" signal. FASEB J 2008;22:2629-38.
-
(2008)
FASEB J
, vol.22
, pp. 2629-2638
-
-
Gude, D.R.1
Alvarez, S.E.2
Paugh, S.W.3
Mitra, P.4
Yu, J.5
Griffiths, R.6
Barbour, S.E.7
Milstien, S.8
Spiegel, S.9
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