P-glycoprotein plays a drug-efflux-independent role in augmenting cell survival in acute myeloblastic leukemia and is associated with modulation of a sphingomyelin-ceramide apoptotic pathway

Blood

Volumn 95, Issue 9, 2000, Pages 2897-2904

  Pallis, Monica ^a   Russell, Nigel ^b  

^a NOTTINGHAM CITY HOSPITAL   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

7 AMINODACTINOMYCIN; CERAMIDE; DAUNORUBICIN; FUMONISIN B1; GLYCOPROTEIN P; SPHINGOMYELIN; VALSPODAR;

ACUTE MYELOBLASTIC LEUKEMIA; APOPTOSIS; ARTICLE; CELL SURVIVAL; CELL VIABILITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; HUMAN; HUMAN CELL; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; REGULATORY MECHANISM;

EID: 0034192163     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v95.9.2897.009k14_2897_2904     Document Type: Article

References (51)

1. Dolis D. Aminophospholipid translocase and proteins involved in transmembrane phospholipid traffic. Biophys Chem. 1997;68:221.
2. Lehnert M. Clinical Multidrug Resistance in Cancer: A Multifactorial Problem. Eur J Cancer. 1996; 32A:912-920.
3. Basara N, Radosevicradojkovic N, Colovic M, Boskovic D. Rolovic Z. In-vitro drug-sensitivity of leukemic progenitors and p-glycoprotein expression in adult acute myeloid-leukemia - correlation with induction treatment outcome. Eur J Haematol. 1995;55:83.
4. Campos L, Guyotat D, Archimbaud E, et al. Clinical significance of multidrug resistance P-glycoprotein expression on acute nonlymphoblastic leukemia cells at diagnosis. Blood. 1992;79:473.
5. Damiani D, Michieli M, Ermacora A, et al. P-glycoprotein (PGP), and not lung resistance-related protein (LRP), is a negative prognostic factor in secondary leukemias. Haematologica. 1998;83: 290.
6. Del Poeta G, Stasi R, Aronica G, et al. Clinical relevance of P-glycoprotein expression in de novo acute myeloid leukemia. Blood. 1996;87: 1997.
7. Pirker R, Walner J, Geissler K, et al. MDR-1 gene expression and treatment outcome in acute myeloid leukaemia. J Natl Cancer Inst. 1991;83:708.
8. Wood P, Burgess R, Macgregor A, Liu Yin JA. P-glycoprotein expression on acute myeloid leukaemia blast cells at diagnosis predicts response to chemotherapy and survival. Br J Haematol. 1994; 87:509.
9. Guerci A, Merlin JL, Missoum N, et al. Predictive value for treatment outcome in acute myeloid leukemia of cellular daunorubicin accumulation and P-glycoprotein expression simultaneously determined by flow cytometry. Blood. 1995;85:2147.
10. Marie J-P, Zittoun R, Sikic B. Multidrug resistance (mdr1) gene expression in adult acute leukemia: Correlation with treatment outcome and in vitro drug sensitivity. Blood. 1991;78:586.
11. Nussler V, Pelka-Fleischer R, Zwierzina H, et al. P-glycoprotein expression in patients with acute leukemia-clinical relevance. Leukemia. 1996; 10(suppl3):S23.
12. Hunault M, Zhou D, Delmer A, et al. Multidrug resistance gene expression in acute myeloid leukemia: Major prognosis significance for in vivo drug resistance to induction treatment. Ann Hematol. 1997;74:65.
13. van den Heuvel-Eibrink MM, van der Holt B, te Boekhorst PAW, et al. MDR 1 expression is an independent prognostic factor for response and survival in de novo acute myeloid leukaemia. Br J Haematol. 1997;99:76.
14. Leith CP, Kopecky KJ, Godwin J, et al. Acute myeloid leukemia in the elderly: Assessment of multidrug resistance (MDR1) and cytogenetics distinguishes biologic subgroups with remarkably distinct responses to standard chemotherapy. A southwest oncology group study. Blood. 1997;89: 3323.
15. Pallis M, Turzanski T, Harrison G, et al. Use of standardized flow cytometric determinants of multidrug resistance to analyze response to remission induction chemotherapy in patients with acute myeloblastic leukaemia. Br J Haematol. 1999;104:307.
16. Smyth M, Krasovskis E, Sutton V, Johstone R. The drug efflux protein, P-glycoprotein, additionally protects drug-resistant tumor cells from multiple forms of caspase-dependent apoptosis. Proc Natl Acad Sci U S A. 1998;95:7024.
17. Johnstone R, Cretney E, Smyth M. P-glycoprotein protects leukemia cells against caspase-dependent, but not caspase-independent, cell death. Blood. 1999;93:1075.
18. Robinson L, Roberts W, Ling T, Lamming D, Sternberg S, Roepe P. Human MDR1 protein expression delays the apoptotic cascade in Chinese hamster ovary fibroblasts. Biochemistry. 1997;36: 11,169.
19. Jaffrezou JP, Levade T, Bettaieb A, et al. Daunorubicin-induced apoptosis - triggering of ceramide generation through sphingomyelin hydrolysis. EMBO J. 1996;15:2417.
20. Bose R, Verhij M, Haimovitz-Friedman A, Scotto K, Fuks Z, Kolesnick R. Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating cell death signals. Cell. 1995;82:405.
21. van Helvoort A, Smith AJ, Sprang H, et al. MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine. Cell. 1996;87:507.
22. Bezombes C, Maestre N, Laurent G, Levade T, Bettaieb L, Jaffrazou J-P. Restoration of TNF-a-induced ceramide generation and apoptosis in resistant leukemia KG1a cells by the p-glycoprotein blocker PSC833. FASEB J. 1998;12:101.
23. Andrieu N, Salvayre R, Levade T. Comparative study of the metabolic pools of sphingomyelin and phosphatidylcholine sensitive to tumour necrosis factor. Eur J Biochem. 1996;236:738.
24. Linardic C, Hannun Y. Identification of a distinct pool of sphingomyelin involved in the sphingomyelin cycle. J Biol Chem. 1994;269:23,530.
25. Levade T, Jaffrezou J-P, Andrieu N, Laurent G. La voie sphingomyeline-ceramide dans la reponse cellulaire aux effecteurs antitumoraux. Medicine Sciences. 1996;12:1219.
26. Schinkel AH, Arceci RJ, Smit JJ, et al. Binding properties of monoclonal antibodies recognizing external epitopes of the human MDR1 P-glycoprotein. Int J Cancer. 1993;55:478.
27. Philpott N, Turner A, Scopes J, et al. The use of 7-amino Actinomycin D in identifying apoptosis: simplicity of use and broad spectrum of application compared with other techniques. Blood. 1996;87:2244.
28. Schmid I, Uittenbogaart CH, Keld B, Giorgi JV. A rapid method for measuring apoptosis and dual color immunofluorescence by single laser flow cytometry. J Immunol Methods. 1994;170:145.
29. Leith CP, Chen IM, Kopecky KJ, et al. Correlation of multidrug resistance (MDR1) protein expression with functional dye/drug efflux in acute myeloid leukemia by multiparameter flow cytometry: identification of discordant MDR-/efflux+ and MDR1+/efflux-cases. Blood. 1995;86:2329.
30. Donner K, Becker K, Hissong B, Ahmed S. Comparison of multiple assays for kinetic detection of apoptosis in thymocytes exposed to dexamethasone or diethylstilbesterol. Cytometry. 1999;35: 80.
31. List A, Glinsmann-Gibson B, Heaton R, Schegel S, Guzman M, Futscher B. Cyclosporines (CS) inhibit interleukin-1β (IL-1β) secretion by the ABC1 transporter, impair leukemia self-renewal and sensitize AML progenitors to antineoplastics. Blood. 1998;92:675a.
32. Hofmann K, Dixit V. Ceramide in apoptosis-does it really matter? TIBS. 1998;23:374.
33. Muller K, Pomorski P, Muller P, Zachowski A, Hermann A. Protein-dependent translocations of aminophospholipids and asymmetric bilayer distribution of phospholipids in the plasma membrane of ram sperm cells. Biochemistry. 1994;33:9968.
34. Bettaieb A, Record M, Come MG, et al. Opposite effects of tumor-necrosis-factor-alpha on the sphingomyelin-ceramide pathway in 2 myeloid-leukemia cell-lines-role of transverse sphingomyelin distribution in the plasma-membrane. Blood. 1996;88:1465.
35. Dive C, Gregory C, Phipps D, Evans D, Milner A, Wyllie A. Analysis and discrimination of necrosis and apoptosis (programmed cell death) by multiparameter flow cytometry. Biochim Biophys Acta. 1992;1133:275.
36. Darzynkiewicz Z, Bruno S, Del Bino G, et al. Features of apoptotic cells measured by flow cytometry. Cytometry. 1992;13:795.
37. Mechetner E, Roninson I. Efficient inhibition of p-glycoprotein-mediated multidrug resistance with a monoclonal antibody. Proc Natl Acad Sci U S A. 1992;89:5824.
38. Zhou Y, Gottesman MM, Pastan I. The extracellular loop between TM5 and TM6 of P-glycoprotein is required for reactivity with monoclonal antibody UIC2. Arch Biochem Biophys. 1999;367:74.
39. Mechetner EB, Schott B, Morse BS. P-glycoprotein function involves conformational transitions detectable by differential immunoreactivity. Proc Natl Acad Sci U S A. 1997;94:12,908.
40. Grey M, Borg AG, Wood P, Burgess R, Fisher A, Yin JAL. Effect on cell kill of addition of multidrug resistance modifiers cyclosporine A and PSC 833 to cytotoxic agents in acute myeloid leukaemia. Leukemia Research. 1997;21:867.
41. Hannun YA. Functions of ceramide in coordinating cellular-responses to stress. Science. 1996; 274:1855.
42. Kolesnick RN, Kronke M. Regulation of ceramide production and apoptosis. Ann Rev Physiology. 1998;60:643.
43. Cabot MC, Han TY, Giuliano AE. The multidrug resistance modulator SDZ PSC 833 is a potent activator of cellular ceramide formation. FEBS Lett. 1998;431:185.
44. Come MG, Bettaieb A, Skladanowski A, Larsen AK, Laurent G. Alteration of the daunorubicin-triggered sphingomyelin-ceramide pathway and apoptosis in MDR cells: influence of drug transport abnormalities. Int J Cancer. 1999;81:580.
45. Bailly J-D, Muller C, Jaffrezou J-P, et al. Lack of correlation between expression and function of p-glycoprotein in acute myeloid leukemia cell lines. Leukemia. 1995;9:799.
46. Fricker G, Fahr A. Mechanisms of hepatic transport of cyclosporin A: an explanation for its cholestatic action? Yale J Biol Med. 1997;1997:379.
47. Wadkins RM, Roepe PD. Biophysical aspects of P-glycoprotein-mediated multidrug resistance. Int Rev Cytol. 1997;171:121.
48. Cullis P, Hope M, Bally M, Madden T, Mayer L, DB F. Influence of pH gradients on the transbilayer transport of drugs, lipids, peptides and metal ions into large unilamellar vesicles. Biochim Biophys Acta. 1997;1331:187.
49. Bosch I, Dunussi-Joannopoulos K, Wu RL, Furlong ST, Croop J. Phosphatidylcholine and phosphatidylethanolamine behave as substrates of the human MDR1 P-glycoprotein. Biochemistry. 1997;36:5685.
50. Field FJ, Born E, Chen HS, Murthy S, Mathur SN. Esterification of plasma-membrane cholesterol and triacylglycerol-rich lipoprotein secretion in caco-2 cells - possible role of p-glycoprotein. J Lipid Research. 1995;36:1533.
51. Drach J, Gsur A, Hamilton G. Involvement of P-glycoprotein in the transmembrane transport of interleukin-2 (IL-2), IL-4, and interferon-gamma in normal human T lymphocytes. Blood. 1996;88: 1747.