4-(Phenylsulfonamidomethyl)benzamides as potent and selective inhibitors of the 11β-hydroxysteroid dehydrogenase type 1 with efficacy in diabetic ob/ob mice

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 15, 2009, Pages 4455-4458

  Zhang, Xu ^a   Zhou, Zhou ^a   Yang, Huaiyu ^a   Chen, Junhua ^a   Feng, Ying ^a   Du, Lili ^a   Leng, Ying ^a   Shen, Jianhua ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

11 HSD1 inhibitors; 4 (Phenylsulfonamidomethyl)benzamide; Type 2 diabetes

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; 4 (PHENYLSULFONAMIDOMETHYL)BENZAMIDE DERIVATIVE; ENZYME INHIBITOR; LIPID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG SYNTHESIS; GLYCEMIC CONTROL; INSULIN SENSITIVITY; LIPID BLOOD LEVEL; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; STRUCTURE ACTIVITY RELATION;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ANIMALS; BENZAMIDES; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; DRUG DISCOVERY; HUMANS; HYDROLYSIS; INHIBITORY CONCENTRATION 50; MICE; MICE, OBESE; MODELS, CHEMICAL; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

MUS;

EID: 67650178262     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.05.033     Document Type: Article

References (13)

1. Wild S., Roglic G., Green A., Sicree R., and King H. Diabetes Care 27 (2004) 1047
2. Skyler J.S. J. Med. Chem. 47 (2004) 4113
3. Tomlinson J.W., Walker E.A., Bujalska I.J., Draper N., Lavery G.G., Cooper M.S., Hewison M., and Stewart P.M. Endocr. Rev. 25 (2004) 831
4. Stulnig T.M., and Waldhausl W. Diabetologia 47 (2004) 1
5. Masuzaki H., Paterson J., Shinyama H., Morton N.M., Mullins J.J., Seckl J.R., and Flier J.S. Science 294 (2001) 2166
6. Paterson J.M., Morton N.M., Fievet C., Kenyon C.J., Holmes M.C., Staels B., Seckl J.R., and Mullins J.J. Proc. Natl. Acad. Sci. U.S.A. 101 (2004) 7088
7. Morton N.M., Paterson J.M., Masuzaki H., Holmes M.C., Staels B., Fievet C., Walker B.R., Flier J.S., Mullins J.J., and Seckl J.R. Diabetes 53 (2004) 931
8. Kotelevtsev Y., Holmes M.C., Burchell A., Houston P.M., Schmoll D., Jamieson P., Best R., Brown R., Edwards C.R.W., Seckl J.R., and Mullins J.J. Proc. Natl. Acad. Sci. U.S.A. 94 (1997) 14924
9. Fotsch C., and Wang M.H. J. Med. Chem. 51 (2008) 4851
10. Yang H.Y., Shen Y., Chen J.H., Jiang Q.F., Leng Y., and Shen J.H. Eur. J. Med. Chem. 44 (2009) 1167
11. Mattson R.J., Pham K.M., Leuck D.J., and Cowen K.A. J. Org. Chem. 55 (1990) 2552
12. Mundt S., Solly K., Thieringer R., and Hermanowski-Vosatka A. Assay Drug Dev. Technol. 3 (2005) 367
13. Barf T., Vallgarda J., Emond R., Haggstrom C., Kurz G., Nygren A., Larwood V., Mosialou E., Axelsson K., Olsson R., Engblom L., Edling N., Ronquist-Nii Y., Ohman B., Alberts P., and Abrahmsen L. J. Med. Chem. 45 (2002) 3813