Phosphorylation of actin-depolymerizing factor/cofilin by LIM-kinase mediates amyloid β-induced degeneration: A potential mechanism of neuronal dystrophy in Alzheimer's disease

Journal of Neuroscience

Volumn 26, Issue 24, 2006, Pages 6533-6542

  Heredia, Lorena ^a   Helguera, Pablo ^b   De Olmos, Soledad ^a   Kedikian, Gabriela ^a   Vigo, Francisco Solá ^a   LaFerla, Frank ^b   Staufenbiel, Matthias ^c   De Olmos, José ^a   Busciglio, Jorge ^b   Cáceres, Alfredo ^a   Lorenzo, Alfredo ^a  

^a Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Novartis Institute for BioMedical Research Basel   (Switzerland)

Author keywords

A ; ADF cofilin; Alzheimer's disease; Amyloid ; Dystrophic neuritis; LIMK1; Neuronal neurodegeneration

Indexed keywords

ACTIN BINDING PROTEIN; ACTIN DEPOLYMERIZING FACTOR; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; COFILIN; PROTEIN KINASE; PROTEIN LIMK1; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA-PROTEIN (1-42); ENZYME INHIBITOR; LIM KINASE; PEPTIDE FRAGMENT;

ACTIN FILAMENT; ALZHEIMER DISEASE; AMYLOID NEUROPATHY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CELL DEATH; CONTROLLED STUDY; CYTOSKELETON; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; IN VITRO STUDY; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEINASE INHIBITION; RAT; ANALYSIS OF VARIANCE; ANIMAL; BRAIN CORTEX; CASE CONTROL STUDY; CELL CULTURE; CELL SURVIVAL; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; CYTOLOGY; DRUG EFFECT; DRUG INTERACTION; EMBRYO; FLUORESCENT ANTIBODY TECHNIQUE; HIPPOCAMPUS; METABOLISM; METHODOLOGY; NERVE CELL; PATHOLOGY; PHOSPHORYLATION; TIME; WESTERN BLOTTING;

ACTIN DEPOLYMERIZING FACTORS; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANALYSIS OF VARIANCE; ANIMALS; BLOTTING, WESTERN; CASE-CONTROL STUDIES; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; DRUG INTERACTIONS; EMBRYO; ENZYME INHIBITORS; FLUORESCENT ANTIBODY TECHNIQUE; HIPPOCAMPUS; HUMANS; NERVE DEGENERATION; NEURONS; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PROTEIN KINASES; RATS; TIME FACTORS;

EID: 33745780575     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5567-05.2006     Document Type: Article

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