메뉴 건너뛰기




Volumn 65, Issue 6, 2006, Pages 592-601

Differential expression of synaptic proteins in the frontal and temporal cortex of elderly subjects with mild cognitive impairment

Author keywords

Alzheimer; Cortex; Drebrin; Mild cognitive impairment; Synaptic; Synaptophysin; Synaptotagmin

Indexed keywords

BRAIN PROTEIN; DREBRIN; SYNAPTOPHYSIN; DREBRINS; NEUROPEPTIDE; SYNAPTOTAGMIN;

EID: 33746752209     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005072-200606000-00007     Document Type: Article
Times cited : (190)

References (59)
  • 1
    • 0024364877 scopus 로고
    • Immunohistochemical quantification of the synapse-related protein synaptophysin in Alzheimer disease
    • Masliah E, Terry RD, DeTeresa RM, Hansen LA. Immunohistochemical quantification of the synapse-related protein synaptophysin in Alzheimer disease. Neurosci Lett 1989;103:234-39
    • (1989) Neurosci Lett , vol.103 , pp. 234-239
    • Masliah, E.1    Terry, R.D.2    DeTeresa, R.M.3    Hansen, L.A.4
  • 2
    • 0025217385 scopus 로고
    • Quantitative assessment of cortical synaptic density in Alzheimer's disease
    • Scheff SW, DeKosky ST, Price DA. Quantitative assessment of cortical synaptic density in Alzheimer's disease. Neurobiol Aging 1990;11:29-37
    • (1990) Neurobiol Aging , vol.11 , pp. 29-37
    • Scheff, S.W.1    DeKosky, S.T.2    Price, D.A.3
  • 3
    • 0025987048 scopus 로고
    • Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
    • Terry RD, Masliah E, Salmon DP, et al. Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment. Ann Neurol. 1991;30:572-80
    • (1991) Ann Neurol , vol.30 , pp. 572-580
    • Terry, R.D.1    Masliah, E.2    Salmon, D.P.3
  • 4
    • 0025269152 scopus 로고
    • Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity
    • DeKosky ST, Scheff SW. Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity. Ann Neurol 1990;27:457-64
    • (1990) Ann Neurol , vol.27 , pp. 457-464
    • DeKosky, S.T.1    Scheff, S.W.2
  • 5
    • 0042858417 scopus 로고    scopus 로고
    • Cell biology of the presynaptic terminal
    • Murthy VN, De Camilli P. Cell biology of the presynaptic terminal. Annu Rev Neurosci 2003;26:701-28
    • (2003) Annu Rev Neurosci , vol.26 , pp. 701-728
    • Murthy, V.N.1    De Camilli, P.2
  • 6
    • 20144383474 scopus 로고    scopus 로고
    • Integration of biochemical signalling in spines
    • Kennedy MB, Beale C, Carlisle HJ, et al. Integration of biochemical signalling in spines. Nat Rev Neurosci 2005;6:423-34
    • (2005) Nat Rev Neurosci , vol.6 , pp. 423-434
    • Kennedy, M.B.1    Beale, C.2    Carlisle, H.J.3
  • 7
    • 0026567733 scopus 로고
    • Synaptic pathology in Alzheimer's disease: Immunological data for markers of synaptic and large dense-core vesicles
    • Lassmann H, Weiler R, Fischer P, et al. Synaptic pathology in Alzheimer's disease: Immunological data for markers of synaptic and large dense-core vesicles. Neuroscience 1992;46:1-8
    • (1992) Neuroscience , vol.46 , pp. 1-8
    • Lassmann, H.1    Weiler, R.2    Fischer, P.3
  • 8
    • 0031778614 scopus 로고    scopus 로고
    • Neurochemical dissection of synaptic pathology in Alzheimer's disease
    • Davidsson P, Blennow K. Neurochemical dissection of synaptic pathology in Alzheimer's disease. Int Psychogeriatr 1998;10:11-23
    • (1998) Int Psychogeriatr , vol.10 , pp. 11-23
    • Davidsson, P.1    Blennow, K.2
  • 9
    • 0031577277 scopus 로고    scopus 로고
    • Differential involvement of synaptic vesicle and presynaptic plasma membrane proteins in Alzheimer's disease
    • Shimohama S, Kamiya S, Taniguchi T, et al. Differential involvement of synaptic vesicle and presynaptic plasma membrane proteins in Alzheimer's disease. Biochem Biophys Res Commun 1997;236:239-42
    • (1997) Biochem Biophys Res Commun , vol.236 , pp. 239-242
    • Shimohama, S.1    Kamiya, S.2    Taniguchi, T.3
  • 10
    • 0033033642 scopus 로고    scopus 로고
    • Loss of proteins regulating synaptic plasticity in normal aging of the human brain and in Alzheimer disease
    • Hatanpaa K, Isaacs KR, Shirao T, et al. Loss of proteins regulating synaptic plasticity in normal aging of the human brain and in Alzheimer disease. J Neuropathol Exp Neurol 1999;58:637-43
    • (1999) J Neuropathol Exp Neurol , vol.58 , pp. 637-643
    • Hatanpaa, K.1    Isaacs, K.R.2    Shirao, T.3
  • 11
    • 0033899864 scopus 로고    scopus 로고
    • Staging of cytoskeletal and beta-amyloid changes in human isocortex reveals biphasic synaptic protein response during progression of Alzheimer's disease
    • Mukaetova-Ladinska EB, Garcia-Siera F, Hurt J, et al. Staging of cytoskeletal and beta-amyloid changes in human isocortex reveals biphasic synaptic protein response during progression of Alzheimer's disease. Am J Pathol 2000;157:623-36
    • (2000) Am J Pathol , vol.157 , pp. 623-636
    • Mukaetova-Ladinska, E.B.1    Garcia-Siera, F.2    Hurt, J.3
  • 12
    • 0035830408 scopus 로고    scopus 로고
    • Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease
    • Masliah E, Mallory M, Alford M, et al. Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease. Neurology 2001;56:127-29
    • (2001) Neurology , vol.56 , pp. 127-129
    • Masliah, E.1    Mallory, M.2    Alford, M.3
  • 13
    • 0034804765 scopus 로고    scopus 로고
    • Synaptic pathology in prefrontal cortex is present only with severe dementia in Alzheimer disease
    • Minger SL, Honer WG, Esiri MM, et al. Synaptic pathology in prefrontal cortex is present only with severe dementia in Alzheimer disease. J Neuropathol Exp Neurol 2001;60:929-36
    • (2001) J Neuropathol Exp Neurol , vol.60 , pp. 929-936
    • Minger, S.L.1    Honer, W.G.2    Esiri, M.M.3
  • 14
    • 0037343844 scopus 로고    scopus 로고
    • Defects in expression of genes related to synaptic vesicle trafficking in frontal cortex of Alzheimer's disease
    • Yao PJ, Zhu M, Pyun EI, et al. Defects in expression of genes related to synaptic vesicle trafficking in frontal cortex of Alzheimer's disease. Neurobiol Dis 2003;12:97-109
    • (2003) Neurobiol Dis , vol.12 , pp. 97-109
    • Yao, P.J.1    Zhu, M.2    Pyun, E.I.3
  • 15
    • 17844378691 scopus 로고    scopus 로고
    • Differential loss of synaptic proteins in Alzheimer's disease: Implications for synaptic dysfunction
    • Reddy PH, Mani G, Park BS, et al. Differential loss of synaptic proteins in Alzheimer's disease: Implications for synaptic dysfunction. J Alzheimers Dis 2005;7:103-17; discussion 173-80
    • (2005) J Alzheimers Dis , vol.7 , pp. 103-17
    • Reddy, P.H.1    Mani, G.2    Park, B.S.3
  • 16
    • 14644416500 scopus 로고    scopus 로고
    • Mild cognitive impairment is related to Alzheimer disease pathology and cerebral infarctions
    • Bennett DA, Schneider JA, Bienias JL, et al. Mild cognitive impairment is related to Alzheimer disease pathology and cerebral infarctions. Neurology 2005;64:834-41
    • (2005) Neurology , vol.64 , pp. 834-841
    • Bennett, D.A.1    Schneider, J.A.2    Bienias, J.L.3
  • 17
    • 4544335597 scopus 로고    scopus 로고
    • Mild cognitive impairment as a diagnostic entity
    • Petersen RC. Mild cognitive impairment as a diagnostic entity. J Intern Med 2004;256:183-94
    • (2004) J Intern Med , vol.256 , pp. 183-194
    • Petersen, R.C.1
  • 19
    • 2942536284 scopus 로고    scopus 로고
    • Increased proNGF levels in subjects with mild cognitive impairment and mild Alzheimer's disease
    • Peng S, Wuu J, Mufson EJ, et al. Increased proNGF levels in subjects with mild cognitive impairment and mild Alzheimer's disease. J Neuropathol Exp Neurol 2004;63:641-49
    • (2004) J Neuropathol Exp Neurol , vol.63 , pp. 641-649
    • Peng, S.1    Wuu, J.2    Mufson, E.J.3
  • 20
    • 0036156958 scopus 로고    scopus 로고
    • Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment
    • DeKosky ST, Ikonomovic MD, Styren SD, et al. Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment. Ann Neurol 2002;51:145-55
    • (2002) Ann Neurol , vol.51 , pp. 145-155
    • DeKosky, S.T.1    Ikonomovic, M.D.2    Styren, S.D.3
  • 21
    • 0031019981 scopus 로고    scopus 로고
    • Reliability of the National Institutes of Health Stroke Scale. Extension to non-neurologists in the context of a clinical trial
    • Goldstein LB, Samsa GP. Reliability of the National Institutes of Health Stroke Scale. Extension to non-neurologists in the context of a clinical trial. Stroke 1997;28:307-10
    • (1997) Stroke , vol.28 , pp. 307-310
    • Goldstein, L.B.1    Samsa, G.P.2
  • 22
    • 0031454720 scopus 로고    scopus 로고
    • Metric properties of nurses' ratings of parkinsonian signs with a modified Unified Parkinson's Disease Rating Scale
    • Bennett DA, Shannon KM, Beckett LA, et al. Metric properties of nurses' ratings of parkinsonian signs with a modified Unified Parkinson's Disease Rating Scale. Neurology 1997;49:1580-87
    • (1997) Neurology , vol.49 , pp. 1580-1587
    • Bennett, D.A.1    Shannon, K.M.2    Beckett, L.A.3
  • 23
    • 0028285127 scopus 로고
    • The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part V. A normative study of the neuropsychological battery
    • Welsh KA, Butters N, Mohs RC, et al. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part V. A normative study of the neuropsychological battery. Neurology 1994;44:609-14
    • (1994) Neurology , vol.44 , pp. 609-614
    • Welsh, K.A.1    Butters, N.2    Mohs, R.C.3
  • 28
    • 0016823810 scopus 로고
    • 'Mini-mental state.' A practical method for grading the cognitive state of patients for the clinician
    • Folstein MF, Folstein SE, McHugh PR. 'Mini-mental state.' A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189-98
    • (1975) J Psychiatr Res , vol.12 , pp. 189-198
    • Folstein, M.F.1    Folstein, S.E.2    McHugh, P.R.3
  • 29
    • 0036015012 scopus 로고    scopus 로고
    • Individual differences in rates of change in cognitive abilities of older persons
    • Wilson RS, Beckett A, Barnes LL, et al. Individual differences in rates of change in cognitive abilities of older persons. Psychol Aging 2002;17:179-93
    • (2002) Psychol Aging , vol.17 , pp. 179-193
    • Wilson, R.S.1    Beckett, A.2    Barnes, L.L.3
  • 30
    • 0021271971 scopus 로고
    • Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease
    • McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease. Neurology 1984;34:939-44
    • (1984) Neurology , vol.34 , pp. 939-944
    • McKhann, G.1    Drachman, D.2    Folstein, M.3    Katzman, R.4    Price, D.5    Stadlan, E.M.6
  • 31
    • 0035195760 scopus 로고    scopus 로고
    • Current concepts in mild cognitive impairment
    • Petersen RC, Doody R, Kurz A, et al. Current concepts in mild cognitive impairment. Arch Neurol 2001;58:1985-92
    • (2001) Arch Neurol , vol.58 , pp. 1985-1992
    • Petersen, R.C.1    Doody, R.2    Kurz, A.3
  • 34
    • 0025908356 scopus 로고
    • The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease
    • Mirra SS, Heyman A, McKeel D, et al. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 1991;41:479-86
    • (1991) Neurology , vol.41 , pp. 479-486
    • Mirra, S.S.1    Heyman, A.2    McKeel, D.3
  • 35
    • 0025863618 scopus 로고
    • Neuropathological stageing of Alzheimer-related changes
    • Braak H, Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 1991;82:239-59
    • (1991) Acta Neuropathol , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 36
    • 0030681215 scopus 로고    scopus 로고
    • Consensus recommendations for the postmortem diagnosis of Alzheimer's disease
    • The National Institute on Aging, and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's Disease. Consensus recommendations for the postmortem diagnosis of Alzheimer's disease. Neurobiol Aging 1997;18:S1-2
    • (1997) Neurobiol Aging , vol.18
  • 37
    • 0024364769 scopus 로고
    • Altered levels of microtubule proteins in brains of Alzheimer's disease patients
    • Berl
    • Nieto A, Montejo de Garcini E, Avila J. Altered levels of microtubule proteins in brains of Alzheimer's disease patients. Acta Neuropathol (Berl)1989;78:47-51
    • (1989) Acta Neuropathol , vol.78 , pp. 47-51
    • Nieto, A.1    Montejo De Garcini, E.2    Avila, J.3
  • 38
    • 0034656234 scopus 로고    scopus 로고
    • Selective regional loss of exocytotic presynaptic vesicle proteins in Alzheimer's disease brains
    • Sze CI, Bi H, Kleinschmidt-DeMasters BK, et al. Selective regional loss of exocytotic presynaptic vesicle proteins in Alzheimer's disease brains. J Neurol Sci 2000;175:81-90
    • (2000) J Neurol Sci , vol.175 , pp. 81-90
    • Sze, C.I.1    Bi, H.2    Kleinschmidt-DeMasters, B.K.3
  • 39
    • 0026032039 scopus 로고
    • Cortical and subcortical patterns of synaptophysinlike immunoreactivity in Alzheimer's disease
    • Masliah E, Terry RD, Alford M, et al. Cortical and subcortical patterns of synaptophysinlike immunoreactivity in Alzheimer's disease. Am J Pathol 1991;138:235-46
    • (1991) Am J Pathol , vol.138 , pp. 235-246
    • Masliah, E.1    Terry, R.D.2    Alford, M.3
  • 40
    • 0026514801 scopus 로고
    • Regional synaptic pathology in Alzheimer's disease
    • Honer WG, Dickson DW, Gleeson J, et al. Regional synaptic pathology in Alzheimer's disease. Neurobiol Aging 1992;13:375-82
    • (1992) Neurobiol Aging , vol.13 , pp. 375-382
    • Honer, W.G.1    Dickson, D.W.2    Gleeson, J.3
  • 41
    • 0344875499 scopus 로고    scopus 로고
    • Synaptophysin I controls the targeting of VAMP2/synaptobrevin II to synaptic vesicles
    • Pennuto M, Bonanomi D, Benfenati F, et al. Synaptophysin I controls the targeting of VAMP2/synaptobrevin II to synaptic vesicles. Mol Biol Cell 2003;14:4909-19
    • (2003) Mol Biol Cell , vol.14 , pp. 4909-4919
    • Pennuto, M.1    Bonanomi, D.2    Benfenati, F.3
  • 42
    • 2942556680 scopus 로고    scopus 로고
    • The synaptic vesicle cycle
    • Sudhof TC. The synaptic vesicle cycle. Annu Rev Neurosci 2004;27:509-47
    • (2004) Annu Rev Neurosci , vol.27 , pp. 509-547
    • Sudhof, T.C.1
  • 43
    • 0037027739 scopus 로고    scopus 로고
    • Synaptotagmin I functions as a calcium sensor to synchronize neurotransmitter release
    • Yoshihara M, Littleton JT. Synaptotagmin I functions as a calcium sensor to synchronize neurotransmitter release. Neuron 2002;36:897-908
    • (2002) Neuron , vol.36 , pp. 897-908
    • Yoshihara, M.1    Littleton, J.T.2
  • 44
    • 0023793340 scopus 로고
    • Molecular cloning of a cDNA for the developmentally regulated brain protein, drebrin
    • Shirao T, Kojima N, Kato Y, et al. Molecular cloning of a cDNA for the developmentally regulated brain protein, drebrin. Brain Res 1988;464:71-74
    • (1988) Brain Res , vol.464 , pp. 71-74
    • Shirao, T.1    Kojima, N.2    Kato, Y.3
  • 45
    • 0023243989 scopus 로고
    • Localization of a developmentally regulated neuron-specific protein S54 in dendrites as revealed by immunoelectron microscopy
    • Shirao T, Inoue HK, Kano Y, et al. Localization of a developmentally regulated neuron-specific protein S54 in dendrites as revealed by immunoelectron microscopy. Brain Res 1987;413:374-78
    • (1987) Brain Res , vol.413 , pp. 374-378
    • Shirao, T.1    Inoue, H.K.2    Kano, Y.3
  • 46
    • 0029825623 scopus 로고    scopus 로고
    • Modulatory role of drebrin on the cytoskeleton within dendritic spines in the rat cerebral cortex
    • Hayashi K, Ishikawa R, Ye LH, et al. Modulatory role of drebrin on the cytoskeleton within dendritic spines in the rat cerebral cortex. J Neurosci 1996;16:7161-70
    • (1996) J Neurosci , vol.16 , pp. 7161-7170
    • Hayashi, K.1    Ishikawa, R.2    Ye, L.H.3
  • 47
    • 14644401845 scopus 로고    scopus 로고
    • Drebrin A is a postsynaptic protein that localizes in vivo to the submembranous surface of dendritic sites forming excitatory synapses
    • Aoki C, Sekino Y, Hanamura K, et al. Drebrin A is a postsynaptic protein that localizes in vivo to the submembranous surface of dendritic sites forming excitatory synapses. J Comp Neurol 2005;483:383-402
    • (2005) J Comp Neurol , vol.483 , pp. 383-402
    • Aoki, C.1    Sekino, Y.2    Hanamura, K.3
  • 48
    • 0041342023 scopus 로고    scopus 로고
    • Drebrin-dependent actin clustering in dendritic filopodia governs synaptic targeting of postsynaptic density-95 and dendritic spine morphogenesis
    • Takahashi H, Sekino Y, Tanaka S, Mizui T, Kishi S, Shirao T. Drebrin-dependent actin clustering in dendritic filopodia governs synaptic targeting of postsynaptic density-95 and dendritic spine morphogenesis. J Neurosci 2003;23:6586-95
    • (2003) J Neurosci , vol.23 , pp. 6586-6595
    • Takahashi, H.1    Sekino, Y.2    Tanaka, S.3    Mizui, T.4    Kishi, S.5    Shirao, T.6
  • 49
    • 33747871863 scopus 로고    scopus 로고
    • Down-regulation of drebrin a expression suppresses synaptic targeting of NMDA receptors in developing hippocampal neurones
    • Nov 21 [Epub ahead of print]
    • Takahashi H, Mizui T, Shirao T. Down-regulation of drebrin A expression suppresses synaptic targeting of NMDA receptors in developing hippocampal neurones. J Neurochem 2005;Nov 21 [Epub ahead of print]
    • (2005) J Neurochem
    • Takahashi, H.1    Mizui, T.2    Shirao, T.3
  • 50
    • 0037166050 scopus 로고    scopus 로고
    • Drebrin, a dendritic spine protein, is manifold decreased in brains of patients with Alzheimer's disease and Down syndrome
    • Shim KS, Lubec G. Drebrin, a dendritic spine protein, is manifold decreased in brains of patients with Alzheimer's disease and Down syndrome. Neurosci Lett 2002;324:209-12
    • (2002) Neurosci Lett , vol.324 , pp. 209-212
    • Shim, K.S.1    Lubec, G.2
  • 51
    • 0030025216 scopus 로고    scopus 로고
    • Disappearance of actin-binding protein, drebrin, from hippocampal synapses in Alzheimer's disease
    • Harigaya Y, Shoji M, Shirao T, et al. Disappearance of actin-binding protein, drebrin, from hippocampal synapses in Alzheimer's disease. J Neurosci Res 1996;43:87-92
    • (1996) J Neurosci Res , vol.43 , pp. 87-92
    • Harigaya, Y.1    Shoji, M.2    Shirao, T.3
  • 52
    • 0022847561 scopus 로고
    • Cell-specific pathology in neural systems of the temporal lobe in Alzheimer's disease
    • Van Hoesen GW, Hyman BT, Damasio AR. Cell-specific pathology in neural systems of the temporal lobe in Alzheimer's disease. Prog Brain Res 1986;70:321-35
    • (1986) Prog Brain Res , vol.70 , pp. 321-335
    • Van Hoesen, G.W.1    Hyman, B.T.2    Damasio, A.R.3
  • 53
    • 0025717816 scopus 로고
    • The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer's disease
    • Arnold SE, Hyman BT, Flory J, et al. The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer's disease. Cereb Cortex 1991;1:103-16
    • (1991) Cereb Cortex , vol.1 , pp. 103-116
    • Arnold, S.E.1    Hyman, B.T.2    Flory, J.3
  • 54
    • 0028989895 scopus 로고
    • Neurons bearing neurofibrillary tangles are responsible for selected synaptic deficits in Alzheimer's disease
    • Callahan LM, Coleman PD, Neurons bearing neurofibrillary tangles are responsible for selected synaptic deficits in Alzheimer's disease. Neurobiol Aging 1995;16:311-14
    • (1995) Neurobiol Aging , vol.16 , pp. 311-314
    • Callahan, L.M.1    Coleman, P.D.2
  • 55
    • 0033933738 scopus 로고    scopus 로고
    • Expression profile of transcripts in Alzheimer's disease tangle-bearing CA1 neurons
    • Ginsberg SD, Hemby SE, Lee VM, et al. Expression profile of transcripts in Alzheimer's disease tangle-bearing CA1 neurons. Ann Neurol 2000;48:77-87
    • (2000) Ann Neurol , vol.48 , pp. 77-87
    • Ginsberg, S.D.1    Hemby, S.E.2    Lee, V.M.3
  • 56
    • 1842510004 scopus 로고    scopus 로고
    • Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain
    • Ingelsson M, Fukumoto H, Newell KL, et al. Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain. Neurology 2004;62:925-31
    • (2004) Neurology , vol.62 , pp. 925-931
    • Ingelsson, M.1    Fukumoto, H.2    Newell, K.L.3
  • 57
    • 0020424541 scopus 로고
    • Choline acetyltransferase activity and histopathology of frontal neocortex from biopsies of demented patients
    • Bowen DM, Benton S, Spillane JA, et al. Choline acetyltransferase activity and histopathology of frontal neocortex from biopsies of demented patients. J Neurol Sci 1982;57:191-202
    • (1982) J Neurol Sci , vol.57 , pp. 191-202
    • Bowen, D.M.1    Benton, S.2    Spillane, J.A.3
  • 58
    • 0033591017 scopus 로고    scopus 로고
    • Cholinergic markers in elderly patients with early signs of Alzheimer disease
    • Davis KL, Mohs RC, Marin D, et al. Cholinergic markers in elderly patients with early signs of Alzheimer disease. JAMA 1999;281:1401-6
    • (1999) JAMA , vol.281 , pp. 1401-1406
    • Davis, K.L.1    Mohs, R.C.2    Marin, D.3
  • 59
    • 0344845129 scopus 로고    scopus 로고
    • Pathology of presynaptic proteins in Alzheimer's disease: More than simple loss of terminals
    • Honer WG. Pathology of presynaptic proteins in Alzheimer's disease: More than simple loss of terminals. Neurobiol Aging 2003;24:1047-62
    • (2003) Neurobiol Aging , vol.24 , pp. 1047-1062
    • Honer, W.G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.