Activation of checkpoint kinase 2 by 3,3′-diindolylmethane is required for causing G2/M cell cycle arrest in human ovarian cancer cells

Molecular Pharmacology

Volumn 78, Issue 2, 2010, Pages 297-309

  Kandala, Prabodh K ^a   Srivastava, Sanjay K ^a  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,3' DIINDOLYLMETHANE; ACETYLCYSTEINE; CELL CYCLE PROTEIN; CHECKPOINT KINASE 2; CYCLIN DEPENDENT KINASE 1; HISTONE H2AX; PROTEIN CDC25C; REACTIVE OXYGEN METABOLITE; SERINE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DOSE TIME EFFECT RELATION; DRUG EFFECT; DRUG TARGETING; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN CELL; LYMPHOMA CELL; OVARY CANCER; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

APOPTOSIS; CELL DIVISION; CELL LINE, TUMOR; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; FEMALE; FLOW CYTOMETRY; G2 PHASE; HUMANS; IMMUNOPRECIPITATION; IN SITU NICK-END LABELING; INDOLES; OVARIAN NEOPLASMS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES;

EID: 77954946001     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.110.063750     Document Type: Article

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