Differential roles for checkpoint kinases in DNA damage-dependent degradation of the Cdc25A protein phosphatase

Journal of Biological Chemistry

Volumn 283, Issue 28, 2008, Pages 19322-19328

  Jin, Jianping ^a,c   Ang, Xiaolu L ^a   Ye, Xin ^a   Livingstone, Mark ^b,d   Harper, J Wade ^a,e  

^a HARVARD MEDICAL SCHOOL   (United States)

^b CELL SIGNALING TECHNOLOGY   (United States)

^c UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^d MCGILL UNIVERSITY   (Canada)

^e NRB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; GENES; IONIZING RADIATION; NUCLEIC ACIDS; ORGANIC ACIDS; RADIATION; RADIATION SHIELDING; RADIOACTIVITY; RNA;

CELL CYCLES; DATA SUPPORTS; DNA DAMAGES; IN VITRO; MUTANT PROTEINS; OVEREXPRESSION; PRIMARY SIGNALS; PROMOTES CELLS; PROTEIN PHOSPHATASES; RNA INTERFERENCES; SIGNALING PATHWAYS; UBIQUITINATION;

DEGRADATION;

ATM PROTEIN; ATR PROTEIN; CDC25A PROTEIN PHOSPHATASE; CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; DNA; F BOX PROTEIN; PHOSPHOPROTEIN PHOSPHATASE; SERINE; UNCLASSIFIED DRUG; ATR PROTEIN, HUMAN; BETA TRANSDUCIN REPEAT CONTAINING PROTEIN; CDC25A PROTEIN, HUMAN; CELL CYCLE PROTEIN; DNA BINDING PROTEIN; PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE PHOSPHATASE; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; DNA DAMAGE; ENZYME DEGRADATION; ENZYME KINETICS; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; IONIZING RADIATION; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; RADIATION RESPONSE; RNA INTERFERENCE; SIGNAL TRANSDUCTION; UBIQUITINATION; ANIMAL; GENE DELETION; GENETICS; METABOLISM; PHOSPHORYLATION; RADIATION EXPOSURE;

ANIMALS; BETA-TRANSDUCIN REPEAT-CONTAINING PROTEINS; CDC25 PHOSPHATASES; CELL CYCLE PROTEINS; DNA DAMAGE; DNA-BINDING PROTEINS; GENE DELETION; HUMANS; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; RADIATION, IONIZING; RNA INTERFERENCE; TUMOR SUPPRESSOR PROTEINS;

EID: 50349103243     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M802474200     Document Type: Article

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