Fas-mediated apoptosis in cholangiocarcinoma cells is enhanced by 3,3′-diindolylmethane through inhibition of AKT signaling and FLICE-like inhibitory protein

American Journal of Pathology

Volumn 169, Issue 5, 2006, Pages 1833-1842

  Chen, Yabing ^a   Xu, Jianmin ^a   Jhala, Nirag ^a   Pawar, Pritish ^a   Zhu, Zeng B ^a   Ma, Liping ^a   Byon, Chang Hyun ^a   McDonald, Jay M ^b  

^a University of Alabama at Birmingham   (United States)

^b BIRMINGHAM VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 INDOLEMETHANOL; 3,3' DIINDOLYLMETHANE; CASPASE 3; CASPASE 8; CASPASE 9; FAS ANTIGEN; FLICE INHIBITORY PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE (CALCIUM,CALMODULIN) II; PROTEIN KINASE B; UNCLASSIFIED DRUG; 3,3'-DIINDOLYLMETHANE; ANTINEOPLASTIC AGENT; CALMODULIN DEPENDENT PROTEIN KINASE II; CALMODULIN-DEPENDENT PROTEIN KINASE II; CASPASE; FAS PROTEIN, HUMAN; INDOLE DERIVATIVE; INDOLE-3-CARBINOL; PROTEIN KINASE (CALCIUM,CALMODULIN);

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; AUTOLYSIS; BILE DUCT CARCINOMA; CARCINOGENESIS; CARCINOMA CELL; CELL PROLIFERATION; CONTROLLED STUDY; DRUG INHIBITION; FEMALE; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; XENOGRAFT; ADENOVIRUS; ANIMAL; BAGG ALBINO MOUSE; DOMINANT GENE; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; ENZYME ACTIVATION; METABOLISM; PATHOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADENOVIRIDAE; ANIMALS; ANTICARCINOGENIC AGENTS; ANTIGENS, CD95; APOPTOSIS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CASPASES; CHOLANGIOCARCINOMA; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; GENES, DOMINANT; HUMANS; INDOLES; MALE; MICE; MICE, INBRED BALB C; NF-KAPPA B; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 38749124678     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.2353/ajpath.2006.060234     Document Type: Article

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