3,3′-Diindolylmethane is a novel mitochondrial H+-ATP synthase inhibitor that can induce p21Cip1/Waf1 expression by induction of oxidative stress in human breast cancer cells

Cancer Research

Volumn 66, Issue 9, 2006, Pages 4880-4887

  Gong, Yixuan ^a   Sohn, Heesook ^a   Xue, Ling ^b   Firestone, Gary L ^b   Bjeldanes, Leonard F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,3' DIINDOLYLMETHANE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ADENOSINE TRIPHOSPHATE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ANTIOXIDANT; CYCLIN DEPENDENT KINASE INHIBITOR 1; MESSENGER RNA; METHANE; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN C JUN; PROTEIN P21; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; 3,3'-DIINDOLYLMETHANE; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; INDOLE DERIVATIVE; RETINOBLASTOMA PROTEIN; STRESS ACTIVATED PROTEIN KINASE;

ARTICLE; BREAST CANCER; CANCER CELL; CELL STRAIN MCF 7; DRUG INHIBITION; GENE INDUCTION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HYPERPOLARIZATION; IC 50; MITOCHONDRIAL MEMBRANE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; RESPIRATORY CHAIN; UPREGULATION; BIOSYNTHESIS; BREAST TUMOR; CELL MEMBRANE POTENTIAL; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENETICS; METABOLISM; MITOCHONDRION; PHOSPHORYLATION; TUMOR CELL LINE;

ADENOSINE TRIPHOSPHATE; BREAST NEOPLASMS; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE INHIBITOR P21; HUMANS; INDOLES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MEMBRANE POTENTIALS; MITOCHONDRIA; MITOCHONDRIAL MEMBRANES; MITOCHONDRIAL PROTON-TRANSLOCATING ATPASES; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; RETINOBLASTOMA PROTEIN; RNA, MESSENGER; TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 33646428633     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-05-4162     Document Type: Article

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