Bcl-2 family-mediated apoptotic effects of 3,3′-diindolylmethane (DIM) in human breast cancer cells

Biochemical Pharmacology

Volumn 63, Issue 6, 2002, Pages 1085-1097

  Hong, Chibo ^a   Firestone, Gary L ^b   Bjeldanes, Leonard F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Apoptosi; Bax; Bcl 2; Breast cancer; Coimmunoprecipitation; Dietary indole

Indexed keywords

3 INDOLEMETHANOL; 3,3' DIINDOLYLMETHANE; ANTINEOPLASTIC AGENT; DNA; DNA FRAGMENT; ESTROGEN RECEPTOR; INDOLE DERIVATIVE; PHOSPHATIDYLSERINE; PROTEIN BAX; PROTEIN BCL 2; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CARCINOMA; CANCER CELL CULTURE; CELL DEATH; CELL PROLIFERATION; CHROMATIN CONDENSATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; DRUG SCREENING; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MITOSIS INHIBITION; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; WESTERN BLOTTING;

ANTICARCINOGENIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BREAST NEOPLASMS; CELL DIVISION; CELL SURVIVAL; GENE EXPRESSION; HUMANS; INDOLES; PRECIPITIN TESTS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR CELLS, CULTURED;

EID: 0037087501     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)00856-0     Document Type: Article

References (45)

1. Inhibition of polycyclic aromatic hydrocarbon-induced neoplasia by naturally occurring indoles
2. Chemoprevention of chemically-induced mammary carcinogenesis by indole-3-carbinol
3. Effects of dietary indole-3-carbinol on estradiol metabolism and spontaneous mammary tumors in mice
4. Screening of potential chemopreventive agents using biochemical markers of carcinogenesis
5. 1 cell cycle arrest of human breast cancer cells independent of estrogen receptor signaling
6. Translocation of Bax to mitochondria induces apoptotic cell death in indole-3-carbinol (I3C) treated breast cancer cells
7. Enhancement of carcinogenesis by the natural anticarcinogen indole-3-carbinol
8. Multiple dietary factors in the enhancement of dimethylhydrazine carcinogenesis: Main effect of indole-3-carbinol
9. Enhancement by indole-3-carbinol of liver and thyroid gland neoplastic development in a rat medium-term multiorgan carcinogenesis model
10. Antitumour promoting activity of indole-3-carbinol in mouse skin carcinogenesis
11. Cytostatic and antiestrogenic effects of 2-(indol-3-ylmethyl)-3,3′-diindolylmethane, a major in vivo product of dietary indole-3-carbinol
12. The major cyclic trimeric product of indole-3-carbinol is a strong agonist of the estrogen receptor signaling pathway
13. Oligomerization of indole-3-carbinol in aqueous acid
14. Induction of hepatic CYP1A by indole-3-carbinol in protection against aflatoxin B1 hepatocarcinogenesis in rainbow trout
15. Mechanisms of tumor modulation by indole-3-carbinol. Disposition and excretion in male Fischer 344 rats
16. Aryl hydrocarbon receptor-mediated antiestrogenic and antitumorigenic activity of diindolylmethane
17. Ligand-independent activation of estrogen receptor function by 3,3′-diindolylmethane in human breast cancer cells
18. Structure-activity relationships of dietary indoles: A proposed mechanism of action as modifiers of xenobiotic metabolism
19. Aromatic hydrocarbon responsiveness-receptor agonists generated from indole-3-carbinol in vitro and in vivo: Comparisons with 2,3,7,8-tetrachlorodibenzo-p-dioxin
20. Estrogen receptor in a human cell line (MCF-7) from breast carcinoma
21. Differential sensitivity of human breast cancer cell lines to the growth-inhibitory effects of tamoxifen
22. Apoptosis and hepatobiliary disease
23. Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages
24. Regulators of cell death
25. Differences in susceptibility to tumor necrosis factor alpha-induced apoptosis among MCF-7 breast cancer cell variants
26. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
27. Induction of the death-promoting gene bax-α sensitizes cultured breast-cancer cells to drug-induced apoptosis
28. Overexpression of bax sensitizes human breast cancer MCF-7 cells to radiation-induced apoptosis
29. Overexpression of the death-promoting gene bax-α which is downregulated in breast cancer restores sensitivity to different apoptotic stimuli and reduces tumor growth in SCID mice
30. Expression of the bcl-2 gene family in normal and malignant breast tissue: Low bax-α expression in tumor cells correlates with resistance towards apoptosis
31. Bcl-2 overexpression enhances the metastatic potential of a human breast cancer line
32. Bcl-2 overexpression and hypoxia synergistically act to modulate vascular endothelial growth factor expression and in vivo angiogenesis in a breast carcinoma line
33. Enforced dimerization of bax results in its translocation, mitochondrial dysfunction and apoptosis
34. Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations
35. The Bcl-2 protein family
36. Heterodimerization-independent function of cell death regulatory proteins Bax and Bcl-2 in yeast and mammalian cells
37. Calpain activation in apoptosis
38. Bcl-2 and the regulation of programmed cell death
39. The binding properties and biological activities of Bcl-2 and Bax in cells exposed to apoptotic stimuli
40. Induction of apoptosis in MCF-7 cells by indole-3-carbinol is independent of p53 and Bax
41. Metabolism of indole-3-carbinol by MCF-7 breast cancer cells
42. L, without alteration of p53 protein levels
43. Effective tamoxifen therapy of breast cancer involves both antiproliferative and pro-apoptotic changes
44. Placebo-controlled trial of indole-3-carbinol in the treatment of CIN
45. Preliminary results of the use of indole-3-carbinol for recurrent respiratory papillomatosis