3,3′-Diindolymethane (DIM) induces a G1 cell cycle arrest in human breast cancer cells that is accompanied by Sp1-mediated activation of p21WAF1/CIP1 expression

Carcinogenesis

Volumn 23, Issue 8, 2002, Pages 1297-1305

  Hong, Chibo ^a   Kim, Hyeon A ^a   Firestone, Gary L ^b   Bjeldanes, Leonard F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,3' DIINDOLYLMETHANE; ANTINEOPLASTIC AGENT; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR; ESTROGEN; ESTROGEN RECEPTOR; INDOLE DERIVATIVE; MESSENGER RNA; PLANT EXTRACT; PROTEIN P21; PROTEIN P53; TRANSCRIPTION FACTOR SP1; TRANSCRIPTION FACTOR SP3; UNCLASSIFIED DRUG; 3,3'-DIINDOLYLMETHANE; CDK2 PROTEIN, HUMAN; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLINE; PRIMER DNA; PROTEIN SERINE THREONINE KINASE;

ARTICLE; BINDING SITE; BRASSICA; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CANCER INHIBITION; CELL COMPOSITION; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; DRUG EFFECT; DRUG RESPONSE; DRUG TARGETING; ELECTROPHORETIC MOBILITY; ENZYME ACTIVITY; FLOW CYTOMETRY; GENE ACTIVATION; GENE CONSTRUCT; GENE DELETION; GENE STRUCTURE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NORTHERN BLOTTING; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INDUCTION; REPORTER GENE; SIGNAL TRANSDUCTION; WESTERN BLOTTING; BREAST TUMOR; CELL CULTURE; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NUCLEOTIDE SEQUENCE; PATHOLOGY; PHYSIOLOGY;

ANTICARCINOGENIC AGENTS; BASE SEQUENCE; BREAST NEOPLASMS; CDC2-CDC28 KINASES; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASES; CYCLINS; DNA PRIMERS; G1 PHASE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INDOLES; PROMOTER REGIONS (GENETICS); PROTEIN-SERINE-THREONINE KINASES; RNA, MESSENGER; SP1 TRANSCRIPTION FACTOR; TUMOR CELLS, CULTURED;

EID: 0035984590     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/23.8.1297     Document Type: Article

References (56)

1. Vegetables, fruit, and cancer. I. Epidemiology
2. Effects of dietary indole-3-carbinol on estradiol metabolism and spontaneous mammary tumors in mice
3. Selective responsiveness of human breast cancer cells to indole-3-carbinol, a chemopreventive agent
4. 1 cell cycle arrest of human breast cancer cells independent of estrogen receptor signaling
5. Translocation of Bax to mitochondria induces apoptotic cell death in indole-3-carbinol (I3C) treated breast cancer cells
6. Cytostatic and antiestrogenic effects of 2-(indol-3-ylmethyl)-3,3′-diindolylmethane, a major in vivo product of dietary indole-3-carbinol
7. The major cyclic trimeric product of indole-3-carbinol is a strong agonist of the estrogen receptor signaling pathway
8. Oligomerization of indole-3-carbinol in aqueous acid
9. Substrate-dependent modulation of CYP3A4 catalytic activity: Analysis of 27 test compounds with four fluorometric substrates
10. Induction of hepatic CYP1A by indole-3-carbinol in protection against aflatoxin B1 hepatocarcinogenesis in rainbow trout
11. Inhibition of polycyclic aromatic hydrocarbon-induced neoplasia by naturally occurring indoles
12. Aryl hydrocarbon receptor-mediated antiestrogenic and antitumorigenic activity of diindolylmethane
13. Induces Bcl-2-mediated apoptosis in human breast cancer cells
14. WAF1, a potential mediator of p53 tumor suppression
15. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
16. Transcriptional regulation of the p21 ((WAF1/CIP1)) gene
17. The growth-regulatory role of p21 (WAF1/CIP1)
18. p21-negative regulator of the cell cycle
19. Structure-activity relationships of dietary indoles: A proposed mechanism of action as modifiers of xenobiotic metabolism
20. Aromatic hydrocarbon responsiveness-receptor agonists generated from indole-3-carbinol in vitro and in vivo: Comparisons with 2,3,7,8-tetrachlorodibenzo-p-dioxin
21. Topological control of p21 expression in normal and neoplastic tissues
22. A simple phase-extraction assay for chloramphenicol acyltransferase activity
23. Principles of CDK regulation
24. p21 is a universal inhibitor of cyclin kinases
25. Mutations in p53 as potential molecular markers for human breast cancer
26. Activation of the p21 promoter independent of p53 by the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) through the Sp1 sites
27. Anchorage and growth regulation in normal and virus-transformed cells
28. 1 events and regulation of cell proliferation
29. Inhibition of cyclin-dependent kinases by p21
30. Inhibition of CDK2 activity in vivo by an associated 20 K regulatory subunit
31. Cyclin E-a better prognostic marker for breast cancer than cyclin D?
32. p21 is a critical CDK2 regulator essential for proliferation control in Rb-deficient cells
33. Proteasomal turnover of p21CIP1 does not require p21CIP1 ubiquitination
34. AKT/PKB phosphorylation of p21CIP/WAF1 enhances protein stability of p21CIP/WAF1 and promotes cell survival
35. Absence of WAF1 mutations in a variety of human malignancies
36. p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage
37. The role of the transcription factor Sp1 in regulating the expression of the WAF1/CIP1 gene in U937 leukemic cells
38. Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21 WAF1/CIP1
39. Butyrate activates the WAF1/CIP1 gene promoter through Sp1 sites in a p53-negative human colon cancer cell line
40. Functional analysis of the transforming growth factor beta responsive elements in the WAF1/CIP1/p21 promoter
41. Sp3 encodes multiple proteins that differ in their capacity to stimulate or repress transcription
42. Histone deacetylase inhibitor activates the WAF1/CIP1 gene promoter through the Sp1 sites
43. Involvement of the Sp3 transcription factor in induction of p21Cip1/WAF1 in keratinocyte differentiation
44. Progesterone regulates transcription of the p21(WAF1) cyclin-dependent kinase inhibitor gene through Sp1 and CBP/p300
45. Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members
46. Sp1 and Sp3 activate p21 (WAF1/CIP1) gene transcription in the Caco-2 colon adenocarcinoma cell line
47. O-Glycosylation of eukaryotic transcription factors: Implications for mechanisms of transcriptional regulation
48. Modulation of transcription factor Sp1 by cAMP-dependent protein kinase
49. Sp1 phosphorylation by Erk 2 stimulates DNA binding
50. Activation of Sp1 and its functional co-operation with serum amyloid A-activating sequence binding factor in synoviocyte cells trigger synergistic action of interleukin-1 and interleukin-6 in serum amyloid A gene expression
51. Casein kinase II-mediated phosphorylation of the C terminus of Sp1 decreases its DNA binding activity
52. Indole-3-carbinol inhibits CDK6 expression in human MCF-7 breast cancer cells by disrupting Sp1 transcription factor interactions with a composite element in the CDK6 gene promoter
53. Site-specific DNA methylation in the neurofibromatosis (NF1) promoter interferes with binding of CREB and SP1 transcription factors
54. Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours
55. The p21(WAF1/CIP1) promoter is methylated in Rat-1 cells: Stable restoration of p53-dependent p21 (WAF1/CIP1) expression after transfection of a genomic clone containing the p21 (WAF1/CIP1) gene
56. Inhibition of the interferon-gamma/signal transducers and activators of transcription (STAT) pathway by hypermethylation at a STAT-binding site in the p21WAF1 promoter region