cAMP-Dependent activation of mammalian target of rapamycin (mTOR) in thyroid cells. Implication in mitogenesis and activation of CDK4

Molecular Endocrinology

Volumn 24, Issue 7, 2010, Pages 1453-1468

  Blancquaert, Sara ^a   Wang, Lifu ^b   Paternot, Sabine ^a   Coulonval, Katia ^a   Dumont, Jacques E ^a   Harris, Thurl E ^b   Roger, Pierre P ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID DERIVATIVE; CYCLIC AMP; CYCLIN D3; CYCLIN DEPENDENT KINASE 4; GLYCOGEN SYNTHASE KINASE 3; INITIATION FACTOR 4E BINDING PROTEIN 1; INSULIN; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE B; PROTEIN MTORC1; PROTEIN P27; PROTEIN PRAS40; RAPAMYCIN; RETINOBLASTOMA PROTEIN; S6 KINASE; THYROTROPIN; TUBERIN; UNCLASSIFIED DRUG; MTOR PROTEIN, RAT; PROTEIN BINDING; PROTEIN SERINE THREONINE KINASE; SIGNAL PEPTIDE; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; DOG; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; IN VITRO STUDY; MITOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT; REGULATORY MECHANISM; THYROID CELL; ANIMAL; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; IMMUNOPRECIPITATION; METABOLISM; PHOSPHORYLATION; THYROID GLAND; TWO DIMENSIONAL GEL ELECTROPHORESIS; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; CYCLIC AMP; CYCLIN D3; CYCLIN-DEPENDENT KINASE 4; DOGS; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; IMMUNOPRECIPITATION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; RATS; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIROLIMUS; THYROID GLAND; THYROTROPIN; TOR SERINE-THREONINE KINASES;

CANIS FAMILIARIS; MAMMALIA; RAPTORES; RATTUS;

EID: 77954830905     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2010-0087     Document Type: Article

References (98)

1. Dumont JE, Maenhaut C, Christophe D, Vassart G, Roger PP 2005 Thyroid regulatory factors. In: DeGroot LJ, Jameson JL, eds. Endocrinology. New York: Elsevier Saunders; 1837-1860
2. Roger PP, Servais P, Dumont JE 1983 Stimulation by thyrotropin and cyclic AMP of the proliferation of quiescent canine thyroid cells cultured in a defined medium containing insulin. FEBS Lett 157:323-329
3. Roger P, Taton M, Van Sande J, Dumont JE 1988 Mitogenic effects of thyrotropin and adenosine 3′,5′-monophosphate in differentiated normal human thyroid cells in vitro. J Clin Endocrinol Metab 66:1158-1165
4. Kimura T, Van Keymeulen A, Golstein J, Fusco A, Dumont JE, Roger PP 2001 Regulation of thyroid cell proliferation by thyrotropin and other factors : a critical evaluation of in vitro models. Endocr Rev 22:631-656 (Pubitemid 32955247)
5. Furuya F, Lu C, Willingham MC, Cheng SY 2007 Inhibition of phosphatidylinositol 3-kinase delays tumor progression and blocks metastatic spread in a mouse model of thyroid cancer. Carcinogenesis 28:2451-2458
6. Miller KA, Yeager N, Baker K, Liao XH, Refetoff S, Di Cristofano A 2009 Oncogenic Kras requires simultaneous PI3K signaling to induce ERK activation and transform thyroid epithelial cells in vivo. Cancer Res 69:3689-3694
7. Yeager N, Brewer C, Cai KQ, Xu XX, Di Cristofano A 2008 Mammalian target of rapamycin is the key effector of phosphatidylinositol-3-OH-initiated proliferative signals in the thyroid follicular epithelium. Cancer Res 68:444-449
8. Guigon CJ, Zhao L, Willingham MC, Cheng SY 2009 PTEN deficiency accelerates tumour progression in a mouse model of thyroid cancer. Oncogene 28:509-517
9. Richards JS 2001 New signaling pathways for hormones and cyclic adenosine 3′,5′-monophosphate action in endocrine cells. Mol Endocrinol 15:209-218
10. Stork PJ, Schmitt JM 2002 Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation. Trends Cell Biol 12:258-266
11. Rivas M, Santisteban P 2003 TSH-activated signaling pathways in thyroid tumorigenesis. Mol Cell Endocrinol 213:31-45 (Pubitemid 38229153)
12. Van Keymeulen A, Roger PP, Dumont JE, Dremier S 2000 TSH and cAMP do not signal mitogenesis through Ras activation. Biochem Biophys Res Commun 273:154-158
13. Vandeput F, Perpete S, Coulonval K, Lamy F, Dumont JE 2003 Role of the different mitogen-activated protein kinase subfamilies in the stimulation of dog and human thyroid epithelial cell proliferation by cyclic adenosine 5′-monophosphate and growth factors. Endocrinology 144:1341-1349
14. Coulonval K, Vandeput F, Stein RC, Kozma SC, Lamy F, Dumont JE 2000 Phosphatidylinositol 3-kinase, protein kinase B and ribosomal S6 kinases in the stimulation of thyroid epithelial cell proliferation by cAMP and growth factors in the presence of insulin. Biochem J 348:351-358
15. Depoortere F, Van Keymeulen A, Lukas J, Costagliola S, Bartkova J, Dumont JE, Bartek J, Roger PP, Dremier S 1998 A requirement for cyclin D3-cyclin-dependent kinase (cdk)-4 assembly in the cyclic adenosine monophosphate-dependent proliferation of thyrocytes. J Cell Biol 140:1427-1439
16. Paternot S, Dumont JE, Roger PP 2006 Differential utilization of cyclin D1 and cyclin D3 in the distinct mitogenic stimulations of human thyrocytes by growth factors and TSH. Mol Endocrinol 20:3279-3292
17. Depoortere F, Pirson I, Bartek J, Dumont JE, Roger PP 2000 Transforming growth factor β(1) selectively inhibits the cyclic AMP-dependent proliferation of primary thyroid epithelial cells by preventing the association of cyclin D3-cdk4 with nuclear p27(kip1). Mol Biol Cell 11:1061-1076
18. Motti ML, Boccia A, Belletti B, Bruni P, Troncone G, Cito L, Monaco M, Chiappetta G, Baldassarre G, Palombini L, Fusco A, Viglietto G 2003 Critical role of cyclin D3 in TSH-dependent growth of thyrocytes and in hyperproliferative diseases of the thyroid gland. Oncogene 22:7576-7586
19. Bockstaele L, Kooken H, Libert F, Paternot S, Dumont JE, de Launoit Y, Roger PP, Coulonval K 2006 Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4 (CDK4): its relationship with cyclins and CDK "inhibitors." Mol Cell Biol 26: 5070-5085
20. Paternot S, Coulonval K, Dumont JE, Roger PP 2003 Cyclic AMP-dependent phosphorylation of cyclin D3-bound CDK4 determines the passage through the cell cycle restriction point in thyroid epithelial cells. J Biol Chem 278:26533-26540
21. Paternot S, Bockstaele L, Bisteau X, Kooken H, Coulonval K, Roger PP 2010 Rb inactivation in cell cycle and cancer: the puzzle of highly regulated activating phosphorylation of CDK4 versus constitutively active CDK-activating kinase. Cell Cycle 9:689-699
22. Cass LA, Meinkoth JL 1998 Differential effects of cyclic adenosine 3′,5′-monophosphate on p70 ribosomal S6 kinase. Endocrinology 139:1991-1998 (Pubitemid 28513861)
23. Suh JM, Song JH, Kim DW, Kim H, Chung HK, Hwang JH, Kim JM, Hwang ES, Chung J, Han JH, Cho BY, Ro HK, Shong M 2003 Regulation of the phosphatidylinositol 3-kinase, Akt/protein kinase B, FRAP/mammalian target of rapamycin, and ribosomal S6 kinase 1 signaling pathways by thyroid-stimulating hormone (TSH) and stimulating type TSH receptor antibodies in the thyroid gland. J Biol Chem 278:21960-21971
24. Ruvinsky I, Meyuhas O 2006 Ribosomal protein S6 phosphorylation: from protein synthesis to cell size. Trends Biochem Sci 31:342-348
25. Withers DJ, Bloom SR, Rozengurt E 1995 Dissociation of cAMP-stimulated mitogenesis from activation of the mitogen-activated protein kinase cascade in Swiss 3T3 cells. J Biol Chem 270:21411-21419
26. Lécureuil C, Tesseraud S, Kara E, Martinat N, Sow A, Fontaine I, Gauthier C, Reiter E, Guillou F, Crépieux P 2005 Follicle-stimulating hormone activates p70 ribosomal protein S6 kinase by protein kinase A-mediated dephosphorylation of Thr 421/Ser 424 in primary Sertoli cells. Mol Endocrinol 19:1812-1820
27. Kayampilly PP, Menon KM 2007 Follicle-stimulating hormone increases tuberin phosphorylation and mammalian target of rapamycin signaling through an extracellular signal-regulated kinase-dependent pathway in rat granulosa cells. Endocrinology 148:3950-3957
28. Graves LM, Bornfeldt KE, Argast GM, Krebs EG, Kong X, Lin TA, Lawrence Jr JC 1995 cAMP- and rapamycin-sensitive regulation of the association of eukaryotic initiation factor 4E and the translational regulator PHAS-I in aortic smooth muscle cells. Proc Natl Acad Sci USA 92:7222-7226
29. Lin TA, Lawrence Jr JC 1996 Control of the translational regulators PHAS-I and PHAS-II by insulin and cAMP in 3T3-L1 adipocytes. J Biol Chem 271:30199-30204
30. Rocha AS, Paternot S, Coulonval K, Dumont JE, Soares P, Roger PP 2008 Cyclic AMP inhibits the proliferation of thyroid carcinoma cell lines through regulation of CDK4 phosphorylation. Mol Biol Cell 19:4814-4825
31. Harris TE, Lawrence Jr JC 2003 TOR signaling. Sci STKE 2003:re15
32. Sabatini DM 2006 mTOR and cancer: insights into a complex relationship. Nat Rev Cancer 6:729-734
33. Wullschleger S, Loewith R, Hall MN 2006 TOR signaling in growth and metabolism. Cell 124:471-484
34. Garami A, Zwartkruis FJ, Nobukuni T, Joaquin M, Roccio M, Stocker H, Kozma SC, Hafen E, Bos JL, Thomas G 2003 Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. Mol Cell 11:1457-1466
35. Inoki K, Li Y, Xu T, Guan KL 2003 Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev 17:1829-1834
36. Manning BD, Tee AR, Logsdon MN, Blenis J, Cantley LC 2002 Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Mol Cell 10:151-162
37. Zhang Y, Gao X, Saucedo LJ, Ru B, Edgar BA, Pan D 2003 Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins. Nat Cell Biol 5:578-581
38. Ma L, Teruya-Feldstein J, Bonner P, Bernardi R, Franz DN, Witte D, Cordon-Cardo C, Pandolfi PP 2007 Identification of S664 TSC2 phosphorylation as a marker for extracellular signal-regulated kinase mediated mTOR activation in tuberous sclerosis and human cancer. Cancer Res 67:7106-7112
39. Sancak Y, Thoreen CC, Peterson TR, Lindquist RA, Kang SA, Spooner E, Carr SA, Sabatini DM 2007 PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. Mol Cell 25:903-915
40. Vander Haar E, Lee SI, Bandhakavi S, Griffin TJ, Kim DH 2007 Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40. Nat Cell Biol 9:316-323 (Pubitemid 46344611)
41. Wang L, Harris TE, Roth RA, Lawrence Jr JC 2007 PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding. J Biol Chem 282:20036-20044
42. Oshiro N, Takahashi R, Yoshino K, Tanimura K, Nakashima A, Eguchi S, Miyamoto T, Hara K, Takehana K, Avruch J, Kikkawa U, Yonezawa K 2007 The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1. J Biol Chem 282:20329-20339
43. Sarbassov DD, Guertin DA, Ali SM, Sabatini DM 2005 Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307:1098-1101
44. Guertin DA, Stevens DM, Thoreen CC, Burds AA, Kalaany NY, Moffat J, Brown M, Fitzgerald KJ, Sabatini DM 2006 Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCα, but not S6K1. Dev Cell 11:859-871
45. Ikenoue T, Inoki K, Yang Q, Zhou X, Guan KL 2008 Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling. EMBO J 27:1919-1931
46. Dremier S, Milenkovic M, Blancquaert S, Dumont JE, Døskeland SO, Maenhaut C, Roger PP 2007 Cyclic adenosine 3′,5′-monophosphate (cAMP)-dependent protein kinases, but not exchange proteins directly activated by cAMP (Epac), mediate thyrotropin/cAMP-dependent regulation of thyroid cells. Endocrinology 148:4612-4622
47. Brewer C, Yeager N, Di Cristofano A 2007 Thyroid-stimulating hormone initiated proliferative signals converge in vivo on the mTOR kinase without activating AKT. Cancer Res 67:8002-8006
48. Lou L, Urbani J, Ribeiro-Neto F, Altschuler DL 2002 cAMP inhibition of Akt is mediated by activated and phosphorylated Rap1b. J Biol Chem 277:32799-32806
49. Cass LA, Summers SA, Prendergast GV, Backer JM, Birnbaum MJ, Meinkoth JL 1999 Protein kinase A-dependent and -independent signaling pathways contribute to cyclic AMP-stimulated proliferation. Mol Cell Biol 19:5882-5891
50. Tsygankova OM, Saavedra A, Rebhun JF, Quilliam LA, Meinkoth JL 2001 Coordinated regulation of Rap1 and thyroid differentiation by cyclic AMP and protein kinase A. Mol Cell Biol 21:1921-1929
51. Brunn GJ, Williams J, Sabers C, Wiederrecht G, Lawrence Jr JC, Abraham RT 1996 Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002. EMBO J 15:5256-5267
52. Dennis PB, Pullen N, Pearson RB, Kozma SC, Thomas G 1998 Phosphorylation sites in the autoinhibitory domain participate in p70(s6k) activation loop phosphorylation. J Biol Chem 273:14845-14852
53. Jacinto E, Lorberg A 2008 TOR regulation of AGC kinases in yeast and mammals. Biochem J 410:19-37
54. Brunn GJ, Hudson CC, Sekulić A, Williams JM, Hosoi H, Houghton PJ, Lawrence Jr JC, Abraham RT 1997 Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin. Science 277:99-101
55. McMahon LP, Choi KM, Lin TA, Abraham RT, Lawrence Jr JC 2002 The rapamycin-binding domain governs substrate selectivity by the mammalian target of rapamycin. Mol Cell Biol 22:7428-7438
56. Scott PH, Brunn GJ, Kohn AD, Roth RA, Lawrence Jr JC 1998 Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway. Proc Natl Acad Sci USA 95:7772-7777
57. Mothe-Satney I, Gautier N, Hinault C, Lawrence Jr JC, Van Obberghen E 2004 In rat hepatocytes glucagon increases mammalian target of rapamycin phosphorylation on serine 2448 but antagonizes the phosphorylation of its downstream targets induced by insulin and amino acids. J Biol Chem 279:42628-42637
58. Chiang GG, Abraham RT 2005 Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase. J Biol Chem 280:25485-25490
59. Holz MK, Blenis J 2005 Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase. J Biol Chem 280:26089-26093
60. Wang L, Rhodes CJ, Lawrence Jr JC 2006 Activation of mammalian target of rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimericmTORcomplex 1. J Biol Chem 281:24293-24303
61. Dann SG, Selvaraj A, Thomas G 2007 mTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer. Trends Mol Med 13:252-259
62. Inoki K, Ouyang H, Zhu T, Lindvall C, Wang Y, Zhang X, Yang Q, Bennett C, Harada Y, Stankunas K, Wang CY, He X, MacDougald OA, You M, Williams BO, Guan KL 2006 TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell 126:955-968
63. Gwinn DM, Shackelford DB, Egan DF, Mihaylova MM, Mery A, Vasquez DS, Turk BE, Shaw RJ 2008 AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell 30:214-226
64. Hurley RL, Barré LK, Wood SD, Anderson KA, Kemp BE, Means AR, Witters LA 2006 Regulation of AMP-activated protein kinase by multisite phosphorylation in response to agents that elevate cellular cAMP. J Biol Chem 281:36662-36672
65. Fang X, Yu SX, Lu Y, Bast Jr RC, Woodgett JR, Mills GB 2000 Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A. Proc Natl Acad Sci USA 97:11960-11965
66. Avruch J, Long X, Lin Y, Ortiz-Vega S, Rapley J, Papageorgiou A, Oshiro N, Kikkawa U 2009 Activation of mTORC1 in two steps: Rheb-GTP activation of catalytic function and increased binding of substrates to raptor. Biochem Soc Trans 37:223-226
67. Ma XM, Blenis J 2009 Molecular mechanisms of mTOR-mediated translational control. Nat Rev Mol Cell Biol 10:307-318
68. Inoki K, Li Y, Zhu T, Wu J, Guan KL 2002 TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol 4:648-657
69. Roux PP, Ballif BA, Anjum R, Gygi SP, Blenis J 2004 Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. Proc Natl Acad Sci USA 101:13489-13494
70. Fonseca BD, Smith EM, Lee VH, MacKintosh C, Proud CG 2007 PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex. J Biol Chem 282:24514-24524
71. Wang L, Harris TE, Lawrence Jr JC 2008 Regulation of prolinerich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation. J Biol Chem 283:15619-15627
72. Aicher LD, Campbell JS, Yeung RS 2001 Tuberin phosphorylation regulates its interaction with hamartin. Two proteins involved in tuberous sclerosis. J Biol Chem 276:21017-21021
73. Kimura T, Dumont JE, Fusco A, Golstein J 1999 Insulin and TSH promote growth in size of PC Cl3 rat thyroid cells, possibly via a pathway different from DNA synthesis: comparison with FRTL-5 cells. Eur J Endocrinol 140:94-103
74. Hleb M, Murphy S, Wagner EF, Hanna NN, Sharma N, Park J, Li XC, Strom TB, Padbury JF, Tseng YT, Sharma S 2004 Evidence for cyclin D3 as a novel target of rapamycin in human T lymphocytes. J Biol Chem 279:31948-31955
75. García-Morales P, Hernando E, Carrasco-Garcia E, Menéndez-Gutierrez MP, Saceda M, Martínez-Lacaci I 2006 Cyclin D3 is down-regulated by rapamycin in HER-2-overexpressing breast cancer cells. Mol Cancer Ther 5:2172-2181 (Pubitemid 44530453)
76. Nourse J, Firpo E, Flanagan WM, Coats S, Polyak K, Lee MH, Massague J, Crabtree GR, Roberts JM 1994 Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin. Nature 372:570-573
77. Hong F, Larrea MD, Doughty C, Kwiatkowski DJ, Squillace R, Slingerland JM 2008 mTOR-raptor binds and activates SGK1 to regulate p27 phosphorylation. Mol Cell 30:701-711
78. Paternot S, Roger PP 2009 Combined inhibition of MEK and mammalian target of rapamycin abolishes phosphorylation of cyclin-dependent kinase 4 in glioblastoma cell lines and prevents their proliferation. Cancer Res 69:4577-4581
79. Roger PP, Reuse S, Maenhaut C, Dumont JE 1995 Multiple facets of the modulation of growth by cAMP. Vitam Horm 51:59-191
80. Dumaz N, Marais R 2005 Integrating signals between cAMP and the RAS/RAF/MEK/ERK signalling pathways. FEBS J 272:3491-3504
81. Alam H, Maizels ET, Park Y, Ghaey S, Feiger ZJ, Chandel NS, Hunzicker-Dunn M 2004 Follicle-stimulating hormone activation of hypoxia-inducible factor-1 by the phosphatidylinositol 3-kinase/AKT/Ras homolog enriched in brain (Rheb)/mammalian target of rapamycin (mTOR) pathway is necessary for induction of select protein markers of follicular differentiation. J Biol Chem 279:19431-19440
82. Alessi DR, Cohen P 1998 Mechanism of activation and function of protein kinase B. Curr Opin Genet Dev 8:55-62 (Pubitemid 28122141)
83. Zaballos MA, Garcia B, Santisteban P 2008 Gβγ dimers released in response to thyrotropin activate phosphoinositide 3-kinase and regulate gene expression in thyroid cells. Mol Endocrinol 22:1183-1199
84. Sales KJ, Battersby S, Williams AR, Anderson RA, Jabbour HN 2004 Prostaglandin E2 mediates phosphorylation and down-regulation of the tuberous sclerosis-2 tumor suppressor (tuberin) in human endometrial adenocarcinoma cells via the Akt signaling pathway. J Clin Endocrinol Metab 89:6112-6118
85. Sancak Y, Peterson TR, Shaul YD, Lindquist RA, Thoreen CC, Bar-Peled L, Sabatini DM 2008 The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science 320:1496-1501
86. Carrière A, Cargnello M, Julien LA, Gao H, Bonneil E, Thibault P, Roux PP 2008 Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation. Curr Biol 18:1269-1277
87. McManus EJ, Collins BJ, Ashby PR, Prescott AR, Murray-Tait V, Armit LJ, Arthur JS, Alessi DR 2004 The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation. EMBO J 23:2071-2082
88. Mamane Y, Petroulakis E, LeBacquer O, Sonenberg N 2006 mTOR, translation initiation and cancer. Oncogene 25:6416-6422
89. Averous J, Proud CG 2006 When translation meets transformation: the mTOR story. Oncogene 25:6423-6435
90. Jefferies HB, Reinhard C, Kozma SC, Thomas G 1994 Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family. Proc Natl Acad Sci USA 91:4441-4445
91. Pende M, Um SH, Mieulet V, Sticker M, Goss VL, Mestan J, Mueller M, Fumagalli S, Kozma SC, Thomas G 2004 S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5′-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway. Mol Cell Biol 24:3112-3124
92. Ohanna M, Sobering AK, Lapointe T, Lorenzo L, Praud C, Petroulakis E, Sonenberg N, Kelly PA, Sotiropoulos A, Pende M 2005 Atrophy of S6K1(-/-) skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control. Nat Cell Biol 7:286-294
93. Fingar DC, Richardson CJ, Tee AR, Cheatham L, Tsou C, Blenis J 2004 mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E. Mol Cell Biol 24:200-216
94. Averous J, Fonseca BD, Proud CG 2008 Regulation of cyclin D1 expression by mTORC1 signaling requires eukaryotic initiation factor 4E-binding protein 1. Oncogene 27:1106-1113
95. Matsuoka M, Kato JY, Fisher RP, Morgan DO, Sherr CJ 1994 Activation of cyclin-dependent kinase 4 (cdk4) by mouse MO15-associated kinase. Mol Cell Biol 14:7265-7275
96. Fisher RP 2005 Secrets of a double agent: CDK7 in cell-cycle control and transcription. J Cell Sci 118:5171-5180
97. Bockstaele L, Bisteau X, Paternot S, Roger PP 2009 Differential regulation of cyclin-dependent kinase 4 (CDK4) and CDK6, evidence that CDK4 might not be activated by CDK7, and design of a CDK6 activating mutation. Mol Cell Biol 29:4188-4200
98. McMahon LP, Yue W, Santen RJ, Lawrence Jr JC 2005 Farnesylthiosalicylic acid inhibits mammalian target of rapamycin (mTOR) activity both in cells and in vitro by promoting dissociation of the mTOR-raptor complex. Mol Endocrinol 19:175-183