Time for a change in the research paradigm for Alzheimer's disease: The value of a chaotic matrix modeling approach

CNS Neuroscience and Therapeutics

Volumn 16, Issue 4, 2010, Pages 254-262

  Hunter, Sally ^a   Friedland, Robert P ^b   Brayne, Carol ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b University of Louisville School of Medicine   (United States)

Author keywords

Alzheimer's disease; Amyloid cascade hypothesis; Disease modeling; Presenilins

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN;

ALZHEIMER DISEASE; ANIMAL; BIOLOGICAL MODEL; BIOSYNTHESIS; DISEASE COURSE; GENETICS; HUMAN; MEDICAL RESEARCH; METABOLISM; PATHOPHYSIOLOGY; PROCEDURES; TRENDS;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BIOMEDICAL RESEARCH; DISEASE PROGRESSION; HUMANS; MODELS, NEUROLOGICAL;

EID: 77954364807     PISSN: 17555930     EISSN: 17555949     Source Type: Journal    
DOI: 10.1111/j.1755-5949.2009.00117.x     Document Type: Review

References (84)

1. Blennow K, de Leon MJ, Zetterberg H. Alzheimer's disease. Lancet 2006 368 : 387 403.
2. Brayne C. Research and Alzheimer's disease: An epidemiological perspective. Psychol Med 1993 23 : 287 296.
3. Selkoe DJ. Normal and abnormal biology of the beta-amyloid precursor protein. Annu Rev Neurosci 1994 17 : 489 517.
4. Hardy JA, Higgins GA. Alzheimer's disease: The amyloid cascade hypothesis. Science 1992 256 : 184 185.
5. Joseph J, Shukitt-Hale B, Denisova NA, Martin A, Perry G, Smith MA. Copernicus revisited: Amyloid beta in Alzheimer's disease. Neurobiol Aging 2001 22 : 131 146.
6. Bishop GM, Robinson SR. The amyloid hypothesis: Let sleeping dogmas lie? Neurobiol Aging 2002 23 : 1101 1105.
7. Selkoe DJ. Alzheimer's disease results from the cerebral accumulation and cytotoxicity of amyloid beta-protein. J Alzheimers Dis 2001 3 : 75 80.
8. Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics. Science 2002 297 : 353 356.
9. St George-Hyslop PH. Molecular genetics of Alzheimer disease. Semin Neurol 1999 19 : 371 383.
10. Zekanowski C, Religa D, Graff C, Filipek S, Kuznicki J. Genetic aspects of Alzheimer's disease. Acta Neurobiol Exp (Wars) 2004 64 : 19 31.
11. Rubinsztein DC, Hon J, Stevens F, et al. Apo E genotypes and risk of dementia in Down syndrome. Am J Med Genet 1999 88 : 344 347.
12. Dietschy JM, Turley SD. Control of cholesterol turnover in the mouse. J Biol Chem 2002 277 : 3801 3804.
13. Vetrivel KS, Thinakaran G. Amyloidogenic processing of beta-amyloid precursor protein in intracellular compartments. Neurology 2006 66 (2 Suppl 1 S69 S73.
14. Turner PR, O'Connor K, Tate WP, Abraham WC. Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory. Prog Neurobiol 2003 70 : 1 32.
15. Ancolio K, Marambaud P, Dauch P, Checler F. Alpha-secretase-derived product of beta-amyloid precursor protein is decreased by presenilin 1 mutations linked to familial Alzheimer's disease. J Neurochem 1997 69 : 2494 2499.
16. Parks AL, Curtis D. Presenilin diversifies its portfolio. Trends Genet 2007 23 : 140 150.
17. Fraser PE, Yang DS, Yu G, et al. Presenilin structure, function and role in Alzheimer disease. Biochim Biophys Acta 2000 1502 : 1 15.
18. Beglopoulos V, Sun X, Saura CA, Lemere CA, Kim RD, Shen J. Reduced beta-amyloid production and increased inflammatory responses in presenilin conditional knock-out mice. J Biol Chem 2004 279 : 46907 46914.
19. Begley JG, Duan W, Chan S, Duff K, Mattson MP. Altered calcium homeostasis and mitochondrial dysfunction in cortical synaptic compartments of presenilin-1 mutant mice. J Neurochem 1999 72 : 1030 1039.
20. Ris L, Dewachter I, Reverse D, Godaux E, Van Leuven F. Capacitative calcium entry induces hippocampal long term potentiation in the absence of presenilin-1. J Biol Chem 2003 278 : 44393 44399.
21. Chan SL, Mayne M, Holden CP, Geiger JD, Mattson MP. Presenilin-1 mutations increase levels of ryanodine receptors and calcium release in PC12 cells and cortical neurons. J Biol Chem 2000 275 : 18195 18200.
22. Shen J, Kelleher RJ 3rd. The presenilin hypothesis of Alzheimer's disease: Evidence for a loss-of-function pathogenic mechanism. Proc Natl Acad Sci USA 2007 104 : 403 409.
23. Mattson MP. Calcium and neurodegeneration. Aging Cell 2007 6 : 337 350.
24. Alvarez AR, Godoy JA, Mullendorff K, Olivares GH, Bronfman M, Inestrosa NC. Wnt-3a overcomes beta-amyloid toxicity in rat hippocampal neurons. Exp Cell Res 2004 297 : 186 196.
25. Quintanilla RA, Munoz FJ, Metcalfe MJ, Hitschfeld M, Olivares G, Godoy JA, Inestrosa NC. Trolox and 17beta-estradiol protect against amyloid beta-peptide neurotoxicity by a mechanism that involves modulation of the Wnt signaling pathway. J Biol Chem 2005 280 : 11615 11625.
26. Dewachter I, Filipkowski RK, Priller C, et al. Deregulation of NMDA-receptor function and down-stream signaling in APP[V717I] transgenic mice. Neurobiol Aging 2009 30 : 241 256.
27. Priller C, Dewachter I, Vassallo N, et al. Mutant presenilin 1 alters synaptic transmission in cultured hippocampal neurons. J Biol Chem 2007 282 : 1119 1127.
28. Goto Y, Niidome T, Hongo H, Akaike A, Kihara T, Sugimoto H. Impaired muscarinic regulation of excitatory synaptic transmission in the APPswe/PS1dE9 mouse model of Alzheimer's disease. Eur J Pharmacol 2008 583 : 84 91.
29. Maarouf CL, Daugs ID, Spina S, et al. Histopathological and molecular heterogeneity among individuals with dementia associated with Presenilin mutations. Mol Neurodegener 2008 3 : 20.
30. Tuppo EE, Arias HR. The role of inflammation in Alzheimer's disease. Int J Biochem Cell Biol 2005 37 : 289 305.
31. Tong L, Thornton PL, Balazs R, Cotman CW. Beta -amyloid-(1-42) impairs activity-dependent cAMP-response element-binding protein signaling in neurons at concentrations in which cell survival Is not compromised. J Biol Chem 2001 276 : 17301 17306.
32. Furukawa K, Mattson MP. Secreted amyloid precursor protein alpha selectively suppresses N-methyl-d-aspartate currents in hippocampal neurons: Involvement of cyclic GMP. Neuroscience 1998 83 : 429 438.
33. Arendt T. Synaptic plasticity and cell cycle activation in neurons are alternative effector pathways: The 'Dr. Jekyll and Mr. Hyde concept' of Alzheimer's disease or the yin and yang of neuroplasticity. Prog Neurobiol 2003 71 : 83 248.
34. Zuchner T, Perez-Polo JR, Schliebs R. Beta-secretase BACE1 is differentially controlled through muscarinic acetylcholine receptor signaling. J Neurosci Res 2004 77 : 250 257.
35. Mousavi M, Hellstrom-Lindahl E. Nicotinic receptor agonists and antagonists increase sAPPalpha secretion and decrease Abeta levels in vitro. Neurochem Int 2009 54 : 237 244.
36. Farber SA, Nitsch RM, Schulz JG, Wurtman RJ. Regulated secretion of beta-amyloid precursor protein in rat brain. J Neurosci 1995 15 : 7442 7451.
37. Puzzo D, Privitera L, Leznik E, Fa M, Staniszewski A, Palmeri A, Arancio O. Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus. J Neurosci 2008 28 : 14537 14545.
38. Croucher MJ, Patel H, Walsh DT, Moncaster JA, Gentleman SM, Fazal A, Jen LS. Up-regulation of soluble amyloid precursor protein fragment secretion in the rat retina in vivo by metabotropic glutamate receptor stimulation. Neuroreport 2003 14 : 2271 2274.
39. Taylor CJ, Ireland DR, Ballagh I, et al. Endogenous secreted amyloid precursor protein-alpha regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory. Neurobiol Dis 2008 31 : 250 260.
40. Maxim V, Sendur L, Fadili J, Suckling J, Gould R, Howard R, Bullmore E. Fractional Gaussian noise, functional MRI and Alzheimer's disease. Neuroimage 2005 25 : 141 158.
41. Adler G, Brassen S, Jajcevic A. EEG coherence in Alzheimer's dementia. J Neural Transm 2003 110 : 1051 1058.
42. Babiloni C, Ferri R, Binetti G, et al. Fronto-parietal coupling of brain rhythms in mild cognitive impairment: A multicentric EEG study. Brain Res Bull 2006 69 : 63 73. (Pubitemid 43185345)
43. Babiloni C, Ferri R, Moretti DV, et al. Abnormal fronto-parietal coupling of brain rhythms in mild Alzheimer's disease: A multicentric EEG study. Eur J Neurosci 2004 19 : 2583 2590. (Pubitemid 38621856)
44. Holmes C, Boche D, Wilkinson D, et al. Long-term effects of Abeta42 immunisation in Alzheimer's disease: Follow-up of a randomised, placebo-controlled phase I trial. Lancet 2008 372 : 216 223.
45. Wang Y, Greig NH, Yu QS, Mattson MP. Presenilin-1 mutation impairs cholinergic modulation of synaptic plasticity and suppresses NMDA currents in hippocampus slices. Neurobiol Aging 2009 30 : 1061 1068.
46. Dewachter I, Reverse D, Caluwaerts N, et al. Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V717I] transgenic mice. J Neurosci 2002 22 : 3445 3453.
47. Simon AM, Schiapparelli L, Salazar-Colocho P, et al. Overexpression of wild-type human APP in mice causes cognitive deficits and pathological features unrelated to Abeta levels. Neurobiol Dis 2009 33 : 369 378.
48. Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales. Neuropathology Group of the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS). Lancet 2001 357 : 169 175.
49. Kar S, Slowikowski SP, Westaway D, Mount HT. Interactions between beta-amyloid and central cholinergic neurons: Implications for Alzheimer's disease. J Psychiatry Neurosci 2004 29 : 427 441.
50. Shimohama S. Nicotinic receptor-mediated neuroprotection in neurodegenerative disease models. Biol Pharm Bull 2009 32 : 332 336.
51. Parameshwaran K, Dhanasekaran M, Suppiramaniam V. Amyloid beta peptides and glutamatergic synaptic dysregulation. Exp Neurol 2008 210 : 7 13.
52. Yamin G. NMDA receptor-dependent signaling pathways that underlie amyloid beta-protein disruption of LTP in the hippocampus. J Neurosci Res 2009 87 : 1729 1736.
53. Chin JH, Ma L, MacTavish D, Jhamandas JH. Amyloid beta protein modulates glutamate-mediated neurotransmission in the rat basal forebrain: Involvement of presynaptic neuronal nicotinic acetylcholine and metabotropic glutamate receptors. J Neurosci 2007 27 : 9262 9269.
54. Snyder EM, Nong Y, Almeida CG, et al. Regulation of NMDA receptor trafficking by amyloid-beta. Nat Neurosci 2005 8 : 1051 1058.
55. Arevalo-Serrano J, Sanz-Anquela JM, Gonzalo-Ruiz A. Beta-amyloid peptide-induced modifications in alpha7 nicotinic acetylcholine receptor immunoreactivity in the hippocampus of the rat: Relationship with GABAergic and calcium-binding proteins perikarya. Brain Res Bull 2008 75 : 533 544.
56. Gonzalez I, Arevalo-Serrano J, Perez JL, Gonzalo P, Gonzalo-Ruiz A. Effects of beta-amyloid peptide on the density of M2 muscarinic acetylcholine receptor protein in the hippocampus of the rat: Relationship with GABA-, calcium-binding protein and somatostatin-containing cells. Neuropathol Appl Neurobiol 2008 34 : 506 522.
57. Abramov AY, Canevari L, Duchen MR. Calcium signals induced by amyloid beta peptide and their consequences in neurons and astrocytes in culture. Biochim Biophys Acta 2004 1742 : 81 87.
58. Atwood CS, Obrenovich ME, Liu T, Chan H, Perry G, Smith MA, Martins RN. Amyloid-β: A chameleon walking in two worlds: A review of the trophic and toxic properties of amyloid-beta. Brain Res Brain Res Rev 2003 43 : 1 16.
59. Lee HG, Zhu X, Nunomura A, Perry G, Smith MA. Amyloid β: The alternate hypothesis. Curr Alzheimer Res 2006 3 : 75 80.
60. Tabaton M, Tamagno E. The molecular link between beta- and gamma-secretase activity on the amyloid beta precursor protein. Cell Mol Life Sci 2007 64 : 2211 2218.
61. Sultana R, Perluigi M, Butterfield DA. Oxidatively modified proteins in Alzheimer's disease (AD), mild cognitive impairment and animal models of AD: Role of Abeta in pathogenesis. Acta Neuropathol 2009 118 : 131 150.
62. Perry G, Nunomura A, Hirai K, et al. Is oxidative damage the fundamental pathogenic mechanism of Alzheimer's and other neurodegenerative diseases? Free Radic Biol Med 2002 33 : 1475 1479.
63. Smith MA, Rottkamp CA, Nunomura A, Raina AK, Perry G. Oxidative stress in Alzheimer's disease. Biochim Biophys Acta 2000 1502 : 139 144.
64. Shelat PB, Chalimoniuk M, Wang JH, et al. Amyloid beta peptide and NMDA induce ROS from NADPH oxidase and AA release from cytosolic phospholipase A2 in cortical neurons. J Neurochem 2008 106 : 45 55.
65. Puzzo D, Vitolo O, Trinchese F, Jacob JP, Palmeri A, Arancio O. Amyloid-beta peptide inhibits activation of the nitric oxide/cGMP/cAMP- responsive element-binding protein pathway during hippocampal synaptic plasticity. J Neurosci 2005 25 : 6887 6897.
66. de la Torre JC, Pappas BA, Prevot V, et al. Hippocampal nitric oxide upregulation precedes memory loss and A beta 1-40 accumulation after chronic brain hypoperfusion in rats. Neurol Res 2003 25 : 635 641.
67. Keil U, Bonert A, Marques CA, et al. Amyloid beta-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis. J Biol Chem 2004 279 : 50310 50320.
68. Tamagno E, Guglielmotto M, Aragno M, et al. Oxidative stress activates a positive feedback between the gamma- and beta-secretase cleavages of the beta-amyloid precursor protein. J Neurochem 2008 104 : 683 695.
69. Reid PC, Urano Y, Kodama T, Hamakubo T. Alzheimer's disease: Cholesterol, membrane rafts, isoprenoids and statins. J Cell Mol Med 2007 11 : 383 392.
70. Hartmann T. Role of amyloid precursor protein, amyloid-beta and gamma-secretase in cholesterol maintenance. Neurodegener Dis 2006 3 : 305 311.
71. Vaya J, Schipper HM. Oxysterols, cholesterol homeostasis, and Alzheimer disease. J Neurochem 2007 102 : 1727 1737.
72. Tamboli IY, Prager K, Barth E, Heneka M, Sandhoff K, Walter J. Inhibition of glycosphingolipid biosynthesis reduces secretion of the beta-amyloid precursor protein and amyloid beta-peptide. J Biol Chem 2005 280 : 28110 28117.
73. Famer D, Meaney S, Mousavi M, Nordberg A, Bjorkhem I, Crisby M. Regulation of alpha- and beta-secretase activity by oxysterols: Cerebrosterol stimulates processing of APP via the alpha-secretase pathway. Biochem Biophys Res Commun 2007 359 : 46 50.
74. Hoe HS, Pocivavsek A, Dai H, Chakraborty G, Harris DC, Rebeck GW. Effects of apoE on neuronal signaling and APP processing in rodent brain. Brain Res 2006 1112 : 70 79.
75. Ye S, Huang Y, Mullendorff K, et al. Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: ApoE structure as a potential therapeutic target. Proc Natl Acad Sci USA 2005 102 : 18700 18705.
76. Irizarry MC, Deng A, Lleo A, et al. Apolipoprotein E modulates gamma-secretase cleavage of the amyloid precursor protein. J Neurochem 2004 90 : 1132 1143.
77. Fuentealba RA, Barria MI, Lee J, et al. ApoER2 expression increases Abeta production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of gamma-secretase activity. Mol Neurodegener 2007 2 : 14.
78. Tamboli IY, Prager K, Thal DR, et al. Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis. J Neurosci 2008 28 : 12097 12106.
79. Hone E, Martins IJ, Jeoung M, Ji TH, Gandy SE, Martins RN. Alzheimer's disease amyloid-beta peptide modulates apolipoprotein E isoform specific receptor binding. J Alzheimers Dis 2005 7 : 303 314.
80. Mattson MP, Gary DS, Chan SL, Duan W. Perturbed endoplasmic reticulum function, synaptic apoptosis and the pathogenesis of Alzheimer's disease. Biochem Soc Symp 2001 67 : 151 162.
81. Nunomura A, Moreira PI, Lee HG, Zhu X, Castellani RJ, Smith MA, Perry G. Neuronal death and survival under oxidative stress in Alzheimer and Parkinson diseases. CNS Neurol Disord Drug Targets 2007 6 : 411 423.
82. Buxbaum JD, Ruefli AA, Parker CA, Cypess AM, Greengard P. Calcium regulates processing of the Alzheimer amyloid protein precursor in a protein kinase C-independent manner. Proc Natl Acad Sci USA 1994 91 : 4489 4493.
83. Pierrot N, Ghisdal P, Caumont AS, Octave JN. Intraneuronal amyloid-beta1-42 production triggered by sustained increase of cytosolic calcium concentration induces neuronal death. J Neurochem 2004 88 : 1140 1150.
84. Leissring MA, Akbari Y, Fanger CM, Cahalan MD, Mattson MP, LaFerla FM. Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice. J Cell Biol 2000 149 : 793 798.