Overexpression of wild-type human APP in mice causes cognitive deficits and pathological features unrelated to Aβ levels

Neurobiology of Disease

Volumn 33, Issue 3, 2009, Pages 369-378

  Simón, Ana María ^a,b   Schiapparelli, Lucio ^a,b   Salazar Colocho, Pablo ^a,b   Cuadrado Tejedor, Mar ^a,b   Escribano, Luis ^a,b   López de Maturana, Rakel ^a,b   Del Río, Joaquín ^a,b   Pérez Mediavilla, Alberto ^a,b   Frechilla, Diana ^a,b  

^a UNIVERSITY OF NAVARRA   (Spain)

^b CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED SOBRE ENFERMEDADES NEURODEGENERATIVAS CIBERNED   (Spain)

Author keywords

Alzheimer's disease; Amyloid; APP; Hippocampus; Memory; Synapse; Tau

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE; MICROTUBULE ASSOCIATED PROTEIN 2; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; POSTSYNAPTIC DENSITY PROTEIN 95; TAU PROTEIN; THREONINE;

AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; COGNITIVE DEFECT; CONTROLLED STUDY; ENTORHINAL CORTEX; HIPPOCAMPUS; IMMUNOREACTIVITY; MEMORY DISORDER; MOUSE; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; WILD TYPE;

AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; COGNITION; HIPPOCAMPUS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MAZE LEARNING; MEMBRANE PROTEINS; MEMORY; MICE; MICROTUBULE-ASSOCIATED PROTEINS; MUTATION; NERVE DEGENERATION; PEPTIDE FRAGMENTS; PHOSPHORYLATION; RECEPTORS, AMPA; RECEPTORS, CELL SURFACE; RECEPTORS, N-METHYL-D-ASPARTATE; RECOGNITION (PSYCHOLOGY); SYNAPSES; TAU PROTEINS;

EID: 60849128797     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2008.11.005     Document Type: Article

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