Regulation of α- and β-secretase activity by oxysterols: Cerebrosterol stimulates processing of APP via the α-secretase pathway

Biochemical and Biophysical Research Communications

Volumn 359, Issue 1, 2007, Pages 46-50

  Famer, D ^a   Meaney, S ^a   Mousavi, M ^a   Nordberg, A ^a   Bjorkhem I ^a   Crisby, M ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Secretase activity ratio; 24S Hydroxycholesterol; 27 Hydroxycholesterol; Alzheimer's disease; Amyloid precursor protein; APP processing

Indexed keywords

24 HYDROXYCHOLESTEROL; 26 HYDROXYCHOLESTEROL; ALPHA SECRETASE; AMYLOID PRECURSOR PROTEIN; AMYLOID PRECURSOR PROTEIN ALPHA; BETA SECRETASE; BRAIN PROTEIN; CELL PROTEIN; CHOLESTEROL DERIVATIVE; OXYSTEROL; UNCLASSIFIED DRUG;

ARTICLE; BRAIN CIRCULATION; CELL CULTURE; CONTROLLED STUDY; DNA POLYMORPHISM; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME REGULATION; HUMAN; HUMAN CELL; NEUROBLASTOMA CELL; PRIORITY JOURNAL;

AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; HYDROXYCHOLESTEROLS; NEUROBLASTOMA; SIGNAL TRANSDUCTION;

EID: 34249828178     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.05.033     Document Type: Article

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