-
1
-
-
0034696630
-
Activation of JNK3α1 requires both MKK4 and MKK7: Kinetic characterization of in vitro phosphorylated JNK3α1
-
Linock J., et al. Activation of JNK3α1 requires both MKK4 and MKK7: kinetic characterization of in vitro phosphorylated JNK3α1. Biochemistry. 39:2000;3141-3148
-
(2000)
Biochemistry
, vol.39
, pp. 3141-3148
-
-
Linock, J.1
-
2
-
-
0032054723
-
Signal transduction by the c-Jun N-terminal kinase (JNK)-from inflammation to development
-
Ip Y.T., Davis R.J., et al. Signal transduction by the c-Jun N-terminal kinase (JNK)-from inflammation to development. Curr. Opin. Cell Biol. 10:2003;205-219
-
(2003)
Curr. Opin. Cell Biol.
, vol.10
, pp. 205-219
-
-
Ip, Y.T.1
Davis, R.J.2
-
3
-
-
0344393408
-
Regulation of MAP kinase signaling modules by scaffold proteins in mammals
-
Morrison D.K., Davis R.J., et al. Regulation of MAP kinase signaling modules by scaffold proteins in mammals. Annu. Rev. Cell Dev. Biol. 19:2003;91-118
-
(2003)
Annu. Rev. Cell Dev. Biol.
, vol.19
, pp. 91-118
-
-
Morrison, D.K.1
Davis, R.J.2
-
4
-
-
0028984151
-
P493F12 Kinase: A novel MAP kinase expressed in a subset of neurons in the human nervous system
-
Mohit A.A., et al. P493F12 Kinase: a novel MAP kinase expressed in a subset of neurons in the human nervous system. Neuron. 14:1995;67-78
-
(1995)
Neuron
, vol.14
, pp. 67-78
-
-
Mohit, A.A.1
-
5
-
-
0032509479
-
Defective T cell differentiation in the absence of JNK1
-
Dong C., et al. Defective T cell differentiation in the absence of JNK1. Science. 282:1998;2092-2095
-
(1998)
Science
, vol.282
, pp. 2092-2095
-
-
Dong, C.1
-
6
-
-
0032191173
-
+ T cells to Th1 cells requires MAP kinase JNK2
-
+ T cells to Th1 cells requires MAP kinase JNK2. Immunity. 9:1998;575-585
-
(1998)
Immunity
, vol.9
, pp. 575-585
-
-
Yang, D.1
-
7
-
-
0033118607
-
The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development
-
Kuan C.Y., et al. The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development. Neuron. 22:1999;667-676
-
(1999)
Neuron
, vol.22
, pp. 667-676
-
-
Kuan, C.Y.1
-
8
-
-
0346037264
-
JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins
-
Chang L., et al. JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins. Dev. Cell. 4:2003;521-533
-
(2003)
Dev. Cell
, vol.4
, pp. 521-533
-
-
Chang, L.1
-
9
-
-
0035066332
-
Alzheimer's disease: Genes, proteins, and therapy
-
Selkoe D.J. Alzheimer's disease: genes, proteins, and therapy. Physiol. Rev. 81:2001;741-766
-
(2001)
Physiol. Rev.
, vol.81
, pp. 741-766
-
-
Selkoe, D.J.1
-
10
-
-
0035478618
-
β-Amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand
-
Morishima Y., et al. β-Amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand. J. Neurosci. 21:2001;7551-7560
-
(2001)
J. Neurosci.
, vol.21
, pp. 7551-7560
-
-
Morishima, Y.1
-
11
-
-
0035142804
-
Activation and redistribution of c-Jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease
-
Zhu X., et al. Activation and redistribution of c-Jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease. J. Neurochem. 76:2001;435-441
-
(2001)
J. Neurochem.
, vol.76
, pp. 435-441
-
-
Zhu, X.1
-
12
-
-
0030943263
-
Stress activated protein kinase/c-Jun N-terminal kinase phosphorylates τ protein
-
Renolds C.H., et al. Stress activated protein kinase/c-Jun N-terminal kinase phosphorylates τ protein. J. Neurochem. 68:1997;1736-1744
-
(1997)
J. Neurochem.
, vol.68
, pp. 1736-1744
-
-
Renolds, C.H.1
-
13
-
-
0036830458
-
Aberrant tau phosphorylation by glycogen synthase kinase-3β and JNK3 induces oligomeric tau fibrils in COS-7 cells
-
Sato S., et al. Aberrant tau phosphorylation by glycogen synthase kinase-3β and JNK3 induces oligomeric tau fibrils in COS-7 cells. J. Biol. Chem. 277:2002;42060-42065
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 42060-42065
-
-
Sato, S.1
-
14
-
-
0842309491
-
β-Secretase inhibition for the treatment of Alzheimer's disease - Promise and challenge
-
Cintron M., et al. β-Secretase inhibition for the treatment of Alzheimer's disease - promise and challenge. Trends Pharmacol. Sci. 25:2004;92-97
-
(2004)
Trends Pharmacol. Sci.
, vol.25
, pp. 92-97
-
-
Cintron, M.1
-
15
-
-
0036580703
-
Activation of c-Jun N-terminal kinase and p38 in an Alzheimer's disease model is associated with amyloid deposition
-
Savage M.J., et al. Activation of c-Jun N-terminal kinase and p38 in an Alzheimer's disease model is associated with amyloid deposition. J. Neurosci. 22:2002;3376-3385
-
(2002)
J. Neurosci.
, vol.22
, pp. 3376-3385
-
-
Savage, M.J.1
-
16
-
-
0029030855
-
ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-Jun induction in response to genotoxic agents
-
Van Dam H., et al. ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-Jun induction in response to genotoxic agents. EMBO J. 14:1995;1798-1811
-
(1995)
EMBO J.
, vol.14
, pp. 1798-1811
-
-
Van Dam, H.1
-
17
-
-
0346374790
-
JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease
-
Hunot S., et al. JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease. Proc. Natl. Acad. Sci. U. S. A. 101:2004;665-670
-
(2004)
Proc. Natl. Acad. Sci. U. S. A.
, vol.101
, pp. 665-670
-
-
Hunot, S.1
-
18
-
-
0033843407
-
Activation of mitogen-activated protein kinases after permanent cerebral artery occlusion in mouse brain
-
Wu D.C., et al. Activation of mitogen-activated protein kinases after permanent cerebral artery occlusion in mouse brain. J. Cereb. Blood Flow Metab. 20:2000;1320-1330
-
(2000)
J. Cereb. Blood Flow Metab.
, vol.20
, pp. 1320-1330
-
-
Wu, D.C.1
-
19
-
-
0030780804
-
Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene
-
Yang D.D., et al. Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene. Nature. 389:1997;865-870
-
(1997)
Nature
, vol.389
, pp. 865-870
-
-
Yang, D.D.1
-
20
-
-
10744229507
-
A critical role of neural-specific JNK3 for ischemic apoptosis. Proc
-
Kuan C-Y., et al. A critical role of neural-specific JNK3 for ischemic apoptosis. Proc. Natl. Acad. Sci. U. S. A. 100:2003;15184-15189
-
(2003)
Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 15184-15189
-
-
Kuan, C.-Y.1
-
21
-
-
0042858567
-
A docking site in MKK4 mediates high affinity binding to JNK MAPKs and competes with similar docking sites in JNK substrates
-
Ho D.T., et al. A docking site in MKK4 mediates high affinity binding to JNK MAPKs and competes with similar docking sites in JNK substrates. J. Biol. Chem. 278:2003;32662-32672
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 32662-32672
-
-
Ho, D.T.1
-
22
-
-
0030826412
-
A cytoplasmic inhibitor of the JNK signal transduction pathway
-
Dickens M., et al. A cytoplasmic inhibitor of the JNK signal transduction pathway. Science. 277:2002;693-696
-
(2002)
Science
, vol.277
, pp. 693-696
-
-
Dickens, M.1
-
23
-
-
0032508714
-
A mammalian scaffold complex that selectively mediates MAP kinase activation
-
Whitmarsh A.J., et al. A mammalian scaffold complex that selectively mediates MAP kinase activation. Science. 281:1998;1671-1674
-
(1998)
Science
, vol.281
, pp. 1671-1674
-
-
Whitmarsh, A.J.1
-
24
-
-
0035254227
-
Hsp72 functions as a natural inhibitory protein of c-Jun N-terminal kinase
-
Park H.S., et al. Hsp72 functions as a natural inhibitory protein of c-Jun N-terminal kinase. EMBO J. 20:2002;446-456
-
(2002)
EMBO J.
, vol.20
, pp. 446-456
-
-
Park, H.S.1
-
25
-
-
0034711397
-
Beta-arrestin 2: A receptor-regulated MAPK scaffold for the activation of JNK3
-
McDonald P.H., et al. Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3. Science. 290:2000;1574-1577
-
(2000)
Science
, vol.290
, pp. 1574-1577
-
-
McDonald, P.H.1
-
26
-
-
0035958940
-
Identification of a motif in the carboxyl terminus of beta-arrestin 2 responsible for activation of JNK3
-
Miller W.E., et al. Identification of a motif in the carboxyl terminus of beta-arrestin 2 responsible for activation of JNK3. J. Biol. Chem. 276:2001;27770-27777
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 27770-27777
-
-
Miller, W.E.1
-
27
-
-
0035313703
-
Expanding roles for beta-arrestins as scaffolds and adapters in GPCR signaling and trafficking
-
Miller W.E, Lefkowitz R.J., et al. Expanding roles for beta-arrestins as scaffolds and adapters in GPCR signaling and trafficking. Curr. Opin. Cell Biol. 13:2001;139-145
-
(2001)
Curr. Opin. Cell Biol.
, vol.13
, pp. 139-145
-
-
Miller, W.E.1
Lefkowitz, R.J.2
-
28
-
-
0029885419
-
Selective interaction of JNK protein kinase isoforms with transcription factors
-
Gupta S., et al. Selective interaction of JNK protein kinase isoforms with transcription factors. EMBO J. 15:2002;2760-2770
-
(2002)
EMBO J.
, vol.15
, pp. 2760-2770
-
-
Gupta, S.1
-
29
-
-
0037192843
-
Identification of the critical features of a small peptide inhibitor of JNK activity
-
Barr R.K., et al. Identification of the critical features of a small peptide inhibitor of JNK activity. J. Biol. Chem. 277:2002;10987-10997
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 10987-10997
-
-
Barr, R.K.1
-
30
-
-
0141724805
-
A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia
-
Borsello T., et al. A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia. Nat. Med. 9:2002;1180-1186
-
(2002)
Nat. Med.
, vol.9
, pp. 1180-1186
-
-
Borsello, T.1
-
31
-
-
3042689209
-
Structural basis for the selective inhibition of JNK1 by scaffolding protein JIP1 and SP600125
-
Heo Y.S., et al. Structural basis for the selective inhibition of JNK1 by scaffolding protein JIP1 and SP600125. EMBO J. 23:2004;2185-2195
-
(2004)
EMBO J.
, vol.23
, pp. 2185-2195
-
-
Heo, Y.S.1
-
32
-
-
0036591874
-
Structural biology in drug design: Selective protein kinase inhibitors
-
Scapin G., et al. Structural biology in drug design: selective protein kinase inhibitors. Drug Discov. Today. 7:2002;601-611
-
(2002)
Drug Discov. Today
, vol.7
, pp. 601-611
-
-
Scapin, G.1
-
33
-
-
0042915882
-
The structure of JNK3 in complex with small molecule inhibitors: Structural basis for potency and selectivity
-
Scapin G., et al. The structure of JNK3 in complex with small molecule inhibitors: structural basis for potency and selectivity. Chem. Biol. 10:2003;705-712
-
(2003)
Chem. Biol
, vol.10
, pp. 705-712
-
-
Scapin, G.1
-
34
-
-
6344263313
-
Vertex Pharmaceuticals
-
WO 9957253 A2
-
Xie X., et al. Vertex Pharmaceuticals. Crystallizable JNK complexes. 1999;2996-3007. WO 9957253 A2
-
(1999)
Crystallizable JNK Complexes
, pp. 2996-3007
-
-
Xie, X.1
-
35
-
-
0028609209
-
JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation
-
Kallunki T., et al. JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation. Genes Dev. 8:1994;2996-3007
-
(1994)
Genes Dev.
, vol.8
, pp. 2996-3007
-
-
Kallunki, T.1
-
37
-
-
3042694681
-
A JNK inhibitor with neuroprotective properties
-
AS601245:
-
Carboni S., et al. A JNK inhibitor with neuroprotective properties. J. Pharmacol. Exp. Ther. 310:2004;25-32. AS601245:
-
(2004)
J. Pharmacol. Exp. Ther.
, vol.310
, pp. 25-32
-
-
Carboni, S.1
-
55
-
-
0035923665
-
SP600125, an anthrapyrazole inhibitor of Jun N-terminal kinase
-
Bennett B., et al. SP600125, an anthrapyrazole inhibitor of Jun N-terminal kinase. Proc. Natl. Acad. Sci. U. S. A. 98:2001;13681-13686
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
, pp. 13681-13686
-
-
Bennett, B.1
-
56
-
-
0037392942
-
The specificities of protein kinase inhibitors: An update
-
Bain J., et al. The specificities of protein kinase inhibitors: an update. Biochem. J. 371:2003;199-204
-
(2003)
Biochem. J.
, vol.371
, pp. 199-204
-
-
Bain, J.1
-
57
-
-
9144220172
-
SP600125, a new JNK inhibitor, protects dopaminergic neurons in th eMPTP model of Parkison's diesease
-
Wang W., et al. SP600125, a new JNK inhibitor, protects dopaminergic neurons in th eMPTP model of Parkison's diesease. Neurosci. Res. 48:2002;195-202
-
(2002)
Neurosci. Res.
, vol.48
, pp. 195-202
-
-
Wang, W.1
|