Mechanism of protection by metallothionein against acetaminophen hepatotoxicity

Toxicology and Applied Pharmacology

Volumn 242, Issue 2, 2010, Pages 182-190

  Saito, Chieko ^a   Yan, Hui Min ^a   Artigues, Antonio ^a   Villar, Maria T ^a   Farhood, Anwar ^b   Jaeschke, Hartmut ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b Brackenridge Hospital   (United States)

Author keywords

Acetaminophen; Covalent binding; Hepatotoxicity; Liver failure; Metallothionein; Oxidant stress

Indexed keywords

ALANINE AMINOTRANSFERASE; CELL NUCLEUS DNA; CELL PROTEIN; GLUTATHIONE; GLUTATHIONE DISULFIDE; HYDROGEN PEROXIDE; METALLOTHIONEIN; N ACETYL 1,4 BENZOQUINONE IMINE; PARACETAMOL; PEROXYNITRITE; REACTIVE OXYGEN METABOLITE; ZINC CHLORIDE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; C57BL 6 MOUSE; CONTROLLED STUDY; COVALENT BOND; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA FRAGMENTATION; DRUG EFFICACY; DRUG MECHANISM; DRUG OVERDOSE; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; GENE INDUCTION; IN VIVO STUDY; KNOCKOUT MOUSE; LIVER CELL DAMAGE; LIVER INJURY; LIVER PROTECTION; LIVER TOXICITY; MALE; METABOLIC ACTIVATION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ACETAMINOPHEN; ANIMALS; BLOTTING, WESTERN; IMMUNOHISTOCHEMISTRY; LIVER; MALE; METALLOTHIONEIN; MICE; MICE, INBRED C57BL; OXIDATIVE STRESS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

ANIMALIA; MUS;

EID: 71049176930     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.10.006     Document Type: Article

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