An inhibitor of c-Jun NH2-terminal kinase, SP600125, protects mice from d-galactosamine/lipopolysaccharide-induced hepatic failure by modulating BH3-only proteins

Life Sciences

Volumn 80, Issue 14, 2007, Pages 1335-1344

  Takamura, Masaaki ^a   Matsuda, Yasunobu ^a   Yamagiwa, Satoshi ^a   Tamura, Yasushi ^a   Honda, Yutaka ^a   Suzuki, Kenji ^a   Ichida, Takafumi ^b   Aoyagi, Yutaka ^a  

^a NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^b Shizuoka Hospital   (Japan)

Author keywords

Bad; Bid; Cytochrome c; Hepatic failure; Hepatocyte apoptosis; JNK; SP600125

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ASPARTATE AMINOTRANSFERASE; BH3 PROTEIN; CASPASE 3; CASPASE 9; CYTOCHROME C; GALACTOSAMINE; LIPOPOLYSACCHARIDE; MESSENGER RNA; PROTEIN BAD; PROTEIN BID; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG MECHANISM; ENZYME INHIBITION; INHIBITION KINETICS; LIVER PROTECTION; MALE; MITOCHONDRIAL RESPIRATION; MORTALITY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RNA ANALYSIS;

ALANINE TRANSAMINASE; ANIMALS; ANTHRACENES; APOPTOSIS; ASPARTATE AMINOTRANSFERASES; BCL-ASSOCIATED DEATH PROTEIN; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; DISEASE MODELS, ANIMAL; DOWN-REGULATION; DRUG THERAPY, COMBINATION; ENZYME INHIBITORS; GALACTOSAMINE; HEPATOCYTES; INJECTIONS, INTRAPERITONEAL; INJECTIONS, SUBCUTANEOUS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIPOPOLYSACCHARIDES; LIVER FAILURE; LONGEVITY; MALE; MICE; MICE, INBRED BALB C; PEPTIDE FRAGMENTS; PROTO-ONCOGENE PROTEINS;

MUS;

EID: 33847274638     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2006.12.034     Document Type: Article

References (32)

1. Adler V., Polotskaya A., Wagner F., and Kraft A.S. Affinity-purified c-Jun amino-terminal protein kinase requires serine/threonine phosphorylation for activity. Journal of Biological Chemistry 267 24 (1992) 17001-17005
2. Baskin-Bey E.S., and Gores G.J. Death by association: BH3 domain-only proteins and liver injury. American Journal of Physiology: Gastrointestinal and Liver Physiology 289 6 (2005) G987-G990
3. Becker C., Barbulescu K., Wirtz S., Meyer zum Buschenfelde K.H., Pettersson S., and Neurath M.F. Constitutive and inducible in vivo protein-DNA interactions at the tumor necrosis factor-alpha promoter in primary human T lymphocytes. Gene Expression 8 2 (1999) 115-127
4. Bendinelli P., Piccoletti R., Maroni P., and Bernelli-Zazzara A. The MAP kinase cascades are activated during post-ischemic liver reperfusion. Federation of European Biochemical Societies Letters 398 2-3 (1996) 193-197
5. Bennett B.L., Sasaki D.T., Murray B.W., O'Leavy E.C., Sakata S.T., Xu W., Leisten J.C., Motiwala A., Pierce S., Satoh Y., Bhagwat S.S., Manning A.M., and Anderson D.W. SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proceedings of the National Academy of Sciences of the United States of America 98 24 (2001) 13681-13686
6. Bonny C., Oberson A., Negri S., Sauser C., and Schorderet D.F. Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death. Diabetes 50 1 (2001) 77-82
7. Bradham C.A., Stachlewitz R.F., Gao W., Qian T., Jayadev S., Jenkins G., Hannum Y., Lemasters J.J., Thurman R.G., and Brenner D.A. Reperfusion after liver transplantation in rats differentially activates the mitogen-activated protein kinases. Hepatology 25 5 (1997) 1128-1135
8. Chang L., Kamata H., Solinas G., Luo J.L., Maeda S., Venuprasad K., Liu Y.C., and Karin M. The E3 ubiquitin ligase itch couples JNK activation to TNF α-induced cell death by inducing c-FLIP(L) turnover. Cell 124 3 (2006) 601-613
9. Chen Y.R., Wang X., Templeton D., Davis R.J., and Tan TH. The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation. Journal of Biological Chemistry 271 50 (1996) 31929-31936
10. Danial N.N., Gramm C.F., Scorrano L., Zhang C.Y., Krauss S., Ranger A.M., Datta S.R., Greenberg M.E., Licklider L.J., Lowell B.B., Gygi S.P., and Korsmeyer S.J. BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis. Nature 424 6951 (2003) 952-956
11. Evan G., and Littlewood T. A matter of life and cell death. Science 281 5381 (1998) 1317-1322
12. Gross A., McDonnell J.M., and Korsmeyer S.J. Bcl-2 family members and the mitochondria in apoptosis. Genes and Development 13 15 (1999) 1899-1911
13. Huang D.C., and Strasser A. BH3-only proteins-essential initiators of apoptotic cell death. Cell 103 6 (2000) 839-842
14. Ip Y.T., and Davis R.J. Signal transduction by the c-Jun N-terminal kinase (JNK) - from inflammation to development. Current Opinion in Cell Biology 10 2 (1998) 205-219
15. Jacobson M.D., Weil M., and Raff M.C. Programmed cell death in animal development. Cell 88 3 (1997) 347-354
16. Lee W.M. Acute liver failure. The New England Journal of Medicine 329 25 (1993) 1862-1872
17. Lee W.M. Acute liver failure in the United States. Seminars in Liver Disease 23 3 (2003) 217-226
18. Maeda S., Chang L., Li Z.W., Luo J.L., Leffert H., and Karin M. IKK beta is required for prevention of apoptosis mediated by cell-bound but not by circulating TNF-alpha. Immunity 19 5 (2003) 725-737
19. Nakama T., Hirono S., Moriuchi A., Hasuike S., Nagata K., Hori T., Ido A., Hayashi K., and Tsubouchi H. Etoposide prevents apoptosis in mouse liver with d-galactosamine/lipopolysaccharide-induced fulminant hepatic failure resulting in reduction of lethality. Hepatology 33 6 (2001) 1441-1450
20. Pulverer B.J., Kyriakis J.M., Avruch J., Nikolakaki E., and Woodgett J.R. Phosphorylation of c-Jun mediated by MAP kinases. Nature 353 6345 (1991) 670-674
21. Putcha G.V., Moulder K.L., Golden J.P., Bouillet P., Adams J.A., Strasser A., and Johnson E.M. Induction of Bim, a proapoptotic BH3-only Bcl-2 family member, is critical for neuronal apoptosis. Neuron 29 3 (2001) 615-628
22. Schattenberg J.M., Singh R., Wang Y., Lefkowitch J.H., Rigoli R.M., Scherer P.E., and Czaja M.J. JNK1 but not JNK2 promotes the development of steatohepatitis in mice. Hepatology 43 1 (2006) 163-172
23. Schwabe R.F., Bradham C.A., Uehara T., Hatano E., Bennett B.L., Schoonhoven R., and Brenner D.A. c-Jun N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. Hepatology 37 4 (2003) 824-832
24. Takehara T., Tatsumi T., Suzuki T., Rucker III E.B., Hennighausen L., Jinushi M., Miyagi T., Kanazawa Y., and Hayashi N. Hepatocyte-specific disruption of Bcl-XL leads to continuous hepatocyte apoptosis and liver fibrotic responses. Gastroenterology 127 4 (2004) 1189-1197
25. Thompson C.B. Apoptosis in the pathogenesis and treatment of disease. Science 267 5203 (1995) 1456-1462
26. Trautwein C., Rakemann T., Brenner D.A., Streetz K., Licato L., Manns M.P., and Tiegs G. Concanavalin A-induced liver cell damage: activation of intracellular pathways triggered by tumor necrosis factor in mice. Gastroenterology 114 5 (1998) 1035-1045
27. Uehara T., Xi Peng X., Bennett B., Satoh Y., Friedman G., Currin R., Brenner D.A., and Lemasters J. c-Jun N-terminal kinase mediates hepatic injury after rat liver transplantation. Transplantation 78 3 (2004) 324-332
28. Uehara T., Bennett B., Sakata S.T., Satoh Y., Bilter G.K., Westwick J.K., and Brenner D.A. JNK mediates hepatic ischemia reperfusion injury. Journal of Hepatology 42 6 (2005) 850-859
29. Wang Y., Singh R., Lefkowitch J.H., Rigoli R.M., and Czaja M.J. Tumor necrosis factor-induced toxic liver injury results from JNK2-dependent activation of caspase-8 and the mitochondrial death pathway. Journal of Biological Chemistry 281 22 (2006) 15258-15267
30. Yamamoto K., Ichijo H., and Korsmeyer S.J. Bcl-2 is phosphorylated and inactivated by ASK1/Jun N-terminal protein kinase pathway normally activated as G(2)/M. Molecular and Cellular Biology 19 12 (1999) 8469-8478
31. Yu C., Minemoto Y., Zhang J., Liu J., Tang F., Bui T.N., Xiang J., and Lin A. JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein Bad. Molecular Cell 13 3 (2004) 329-340
32. Zhao Y., Li S., Childs E.E., Kuharsky D.K., and Yin X.M. Activation of pro-death Bcl-2 family proteins and mitochondria apoptosis pathway in tumor necrosis factor-alpha-induced liver injury. Journal of Biological Chemistry 276 29 (2001) 27432-27440