Low levels of glutathione peroxidase 1 activity in selenium-deficient mouse liver affect c-Jun N-terminal kinase activation and p53 phosphorylation on Ser-15 in pro-oxidant-induced aponecrosis

Biochemical Journal

Volumn 370, Issue 3, 2003, Pages 927-934

  Cheng, Wen Hsing ^a   Zheng, Xinmin ^a   Quimby, Fred R ^b   Roneker, Carol A ^a   Lei, Xin Gen ^a  

^a Department of Obstetrics Gynecology   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Apoptosis; Oxidative stress; p38; Paraquat; Signalling

Indexed keywords

CELLS; OXIDATION; PHOSPHORUS; SELENIUM; STRESS ANALYSIS;

CELL DEATH;

ENZYME KINETICS;

DNA; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; HYDROGEN PEROXIDE; PARAQUAT; PROTEIN P53; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SELENIUM; SERINE; SODIUM SELENITE; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA STRAND BREAKAGE; ENZYME ACTIVATION; IMMUNOBLOTTING; IMMUNOPRECIPITATION; KNOCKOUT MOUSE; LIVER INJURY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SELENIUM DEFICIENCY; SIGNAL TRANSDUCTION;

ANIMALS; DNA; ENZYME ACTIVATION; GLUTATHIONE PEROXIDASE; HERBICIDES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIVER; MICE; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASES; NECROSIS; OXIDANTS; PARAQUAT; PHOSPHORYLATION; SELENIUM; SERINE; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA;

EID: 0037444791     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20021870     Document Type: Article

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