Elevated TGF-β1 secretion and down-modulation of NKG2D underlies impaired NK cytotoxicity in cancer patients

Journal of Immunology

Volumn 172, Issue 12, 2004, Pages 7335-7340

  Lee, June Chul ^a   Lee, Kyung Mi ^b   Kim, Dong Wan ^a   Heo, Dae Seog ^a  

^a Seoul National University College of Medicine   (South Korea)

^b Korea University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CD16 ANTIGEN; CD20 ANTIBODY; CD3 ANTIGEN; CD4 ANTIGEN; CD56 ANTIGEN; CD8 ANTIGEN; CD94 ANTIGEN; HERMES ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 4; MONOCLONAL ANTIBODY; RECOMBINANT INTERLEUKIN 15; RECOMBINANT INTERLEUKIN 2; RECOMBINANT TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA1; IMMUNOGLOBULIN RECEPTOR; NATURAL KILLER CELL ACTIVATING RECEPTORS; TGFB1 PROTEIN, HUMAN; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; BLOOD LEVEL; CANCER PATIENT; CLINICAL ARTICLE; COLORECTAL CANCER; CONTROLLED STUDY; CYTOTOXICITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LUNG CANCER; NATURAL KILLER CELL; PRIORITY JOURNAL; TUMOR CELL; BIOSYNTHESIS; BLOOD; CASE CONTROL STUDY; CELL CULTURE; COLORECTAL TUMOR; DOWN REGULATION; GENE EXPRESSION REGULATION; IMMUNOLOGY; LUNG TUMOR; LYMPHOKINE ACTIVATED KILLER CELL; PHYSIOLOGY; SECRETION;

CASE-CONTROL STUDIES; CELLS, CULTURED; COLORECTAL NEOPLASMS; CYTOTOXICITY, IMMUNOLOGIC; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; KILLER CELLS, LYMPHOKINE-ACTIVATED; KILLER CELLS, NATURAL; LUNG NEOPLASMS; RECEPTORS, IMMUNOLOGIC; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 2942588777     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.172.12.7335     Document Type: Article

References (36)

1. Trinchieri, G. 1989. Biology of natural killer cells. Adv. Immunol. 47:187.
2. Biron, C. A., K. B. Nguyen, G. C. Pien, L. P. Cousens, and T. P. Salazar-Mather. 1999. Natural killer cells in antiviral defense: function and regulation by innate cytokines. Annu. Rev. Immunol. 17:189.
3. Lanier, L. L. 1998. NK cell receptors. Annu. Rev. Immunol. 16:359.
4. Long, E. O. 1999. Regulation of immune responses through inhibitory receptors. Annu. Rev. Immunol. 17:875.
5. Moretta, A., C. Bottino, M. Vitale, D. Pende, C. Cantoni, M. C. Mingari, R. Biassoni, and L. Moretta. 2001. Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis. Annu. Rev. Immunol. 19:197.
6. Lanier, L. L. 2003. Natural killer cell receptor signaling. Curr. Opin. Immunol. 15:308.
7. Bauer, S., V. Groh, J. Wu, A. Steinle, J. H. Phillips, L. L. Lanier, and T. Spies. 1999. Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science 285:727.
8. Raulet, D. H. 2003. Roles of the NKG2D immunoreceptor and its ligands. Nat. Rev. Immunol. 3:781.
9. Vivier, E., E. Tomasello, and P. Paul. 2002. Lymphocyte activation via NKG2D: towards a new paradigm in immune recognition? Curr. Opin. Immunol. 14:306.
10. Groh, V., S. Bahram, S. Bauer, A. Herman, M. Beauchamp, and T. Spies. 1996. Cell stress-regulated human major histocompatibility complex class 1 gene expressed in gastrointestinal epithelium. Proc. Natl. Acad. Sci. USA 93:12445.
11. Groh, V., R. Rhinehart, J. Randolph-Habecker, M. S. Topp, S. R. Riddell, and T. Spies. 2001. Costimulation of CD8αβ T cells by NKG2D via engagement by MIC induced on virus-infected cells. Nat. Immunol. 2:255.
12. Cerwenka, A., J. L. Baron, and L. L. Lanier. 2001. Ectopic expression of retinoic acid early inducible-1 gene (RAE-1) permits natural killer cell-mediated rejection of a MHC class 1-bearing tumor in vivo. Proc. Natl. Acad. Sci. USA 98:11521.
13. Diefenbach, A., E. R. Jensen, A. M. Jamieson, and D. H. Raulet. 2001. Rael and H60 ligands of the NKG2D receptor stimulate tumour immunity. Nature 413:165.
14. Groh, V., R. Rhinehart, H. Secrist, S. Bauer, K. H. Grabstein, and T. Spies. 1999. Broad tumor-associated expression and recognition by tumor-derived γδ T cells of MICA and MICB. Proc. Natl. Acad. Sci. USA 96:6879.
15. Rook, A. H., J. H. Kehrl, L. M. Wakefield, A. B. Roberts, M. B. Sporn, D. B. Burlington, H. C. Lane, and A. S. Fauci. 1986. Effects of transforming growth factor β on the functions of natural killer cells: depressed cytolytic activity and blunting of interferon responsiveness. J. Immunol. 136:3916.
16. Bellone, G., M. Aste-Amezaga, G. Trinchieri, and U. Rodeck. 1995. Regulation of NK cell functions by TGF-β1. J. Immunol. 155:1066.
17. Pierson, B. A., K. Gupta, W. S. Hu, and J. S. Miller. 1996. Human natural killer cell expansion is regulated by thrombospondin-mediated activation of transforming growth factor-β1 and independent accessory cell-derived contact and soluble factors. Blood 87:180.
18. 2. Scand. J. Immunol. 37:71.
19. Arteaga, C. L., S. D. Hurd, A. R. Winnier, M. D. Johnson, B. M. Fendly, and J. T. Forbes. 1993. Anti-transforming growth factor (TGF)-β antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity: implications for a possible role of tumor cell/host TGF-β interactions in human breast cancer progression. J. Clin. Invest. 92:2569.
20. Wallick, S. C., I. S. Figari, R. E. Morris, A. D. Levinson, and M. A. Palladino. 1990. Immunoregulatory role of transforming growth factor β (TGF-β) in development of killer cells: comparison of active and latent TGF-β1. J. Exp. Med. 172:1777.
21. Hasegawa, Y., S. Takanashi, Y. Kanehira, T. Tsushima, T. Imai, and K. Okumura. 2001. Transforming growth factor-β1 level correlates with angiogenesis, tumor progression, and prognosis in patients with nonsmall cell lung carcinoma. Cancer 91:964.
22. Kong, F. M., M. K. Washington, R. L. Jirtle, and M. S. Anscher. 1996. Plasma transforming growth factor-β1 reflects disease status in patients with lung cancer after radiotherapy: a possible tumor marker. Lung Cancer 16:47.
23. Narai, S., M. Watanabe, H. Hasegawa, H. Nishibori, T. Endo, T. Kubota, and M. Kitajima. 2002. Significance of transforming growth factor β1 as a new tumor marker for colorectal cancer. Int. J. Cancer 97:508.
24. Espi, A., J. Arenas, E. Garcia-Granero, E. Marti, and S. Lledo. 1996. Relationship of curative surgery on natural killer cell activity in colorectal cancer. Dis. Colon Rectum 39:429.
25. Kastelan, M., K. Kovacic, R. Tarle, I. Kraljic, and M. Tarle. 1997. Analysis of NK cell activity, lymphocyte reactivity to mitogens and serotest PSA and TPS values in patients with primary and disseminated prostate cancer, PIN and BPH. Anticancer Res. 17:1671.
26. Koda, K., N. Saito, N. Takiguchi, K. Oda, M. Nunomura, and N. Nakajima. 1997. Preoperative natural killer cell activity: correlation with distant metastases in curatively research colorectal carcinomas. Int. Surg. 82:190.
27. Kubin, M., L. Cassiano, J. Chalupny, W. Chin, D. Cosman, W. Fanslow, J. Mullberg, A. M. Rousseau, D. Ulrich, and R. Armitage. 2001. ULBP1, 2, 3: novel MHC class I-related molecules that bind to human cytomegalovirus glycoprotein UL16, activate NK cells. Eur. J. Immunol. 31:1428.
28. Pende, D., P. Rivera, S. Marcenaro, C. C. Chang, R. Biassoni, R. Conte, M. Kubin, D. Cosman, S. Ferrone, L. Moretta, et al. 2002. Major histocompatibility complex class I-related chain A and UL16-binding protein expression on tumor cell lines of different histotypes: analysis of tumor susceptibility to NKG2D-dependent natural killer cell cytotoxicity. Cancer Res. 62:6178.
29. Wojtowicz-Praga, S. 1997. Reversal of tumor-induced immunosuppression: a new approach to cancer therapy. J. Immunother. 20:165.
30. Elgert, K. D., D. G. Alleva, and D. W. Mullins. 1998. Tumor-induced immune dysfunction: the macrophage connection. J. Leukocyte Biol. 64:275.
31. Letterio, J. J., and A. B. Roberts. 1998. Regulation of immune responses by TGF-β. Annu. Rev. Immunol. 16:137.
32. Bertone, S., F. Schiavetti, R. Bellomo, C. Vitale, M. Ponte, L. Moretta, and M. C. Mingari. 1999. Transforming growth factor-β-induced expression of CD94/NKG2A inhibitory receptors in human T lymphocytes. Eur. J. Immunol. 29:23.
33. Castriconi, R., C. Cantoni, M. Della Chiesa, M. Vitale, E. Marcenaro, R. Conte, R. Biassoni, C. Bottino, L. Moretta, and A. Moretta. 2003. Transforming growth factor β1 inhibits expression of NKp30 and NKG2D receptors: consequences for the NK-mediated killing of dendritic cells. Proc. Natl. Acad. Sci. USA 100:4120.
34. Diefenbach, A., E. Tomasello, M. Lucas, A. M. Jamieson, J. K. Hsia, E. Vivier, and D. H. Raulet. 2002. Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D. Nat. Immunol. 3:1142.
35. Salih, H. R., H. G. Rammensee, and A. Steinle. 2002. Cutting edge: down-regulation of MICA on human tumors by proteolytic shedding. J. Immunol. 169:4098.
36. Groh, V., J. Wu, C. Yee, and T. Spies. 2002. Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation. Nature 419:734.