Loss of TGFβ Signaling Destabilizes Homeostasis and Promotes Squamous Cell Carcinomas in Stratified Epithelia

Cancer Cell

Volumn 12, Issue 4, 2007, Pages 313-327

  Guasch, Géraldine ^a   Schober, Markus ^a   Pasolli, H Amalia ^a   Conn, Emily Belmont ^a   Polak, Lisa ^a   Fuchs, Elaine ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

CELLCYCLE; DEVBIO

Indexed keywords

FOCAL ADHESION KINASE; INTEGRIN; PROTEIN TYROSINE KINASE; RAS PROTEIN; TRANSFORMING GROWTH FACTOR BETA; CYTOKERATIN 14; KRT14 PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA TYPE II RECEPTOR; TRANSFORMING GROWTH FACTOR-BETA TYPE II RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER GROWTH; CELL MOTILITY; CONTROLLED STUDY; EPIDERMIS; EPITHELIUM; FEMALE; GENE MUTATION; GENITAL SYSTEM; HOMEOSTASIS; HUMAN; HUMAN TISSUE; KERATINOCYTE; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RECTUM; SIGNAL TRANSDUCTION; SQUAMOUS CELL CARCINOMA; WOUND HEALING; ANIMAL; ANUS TUMOR; CANCER INVASION; CELL CULTURE; CELL MOTION; CELL PROLIFERATION; CELL TRANSFORMATION; ENZYMOLOGY; EPITHELIUM CELL; EXTRACELLULAR MATRIX; GENETICS; METABOLISM; MOUSE MUTANT; MUTATION; PAPILLOMA; PATHOLOGY; PATHOPHYSIOLOGY; PROMOTER REGION; SKIN; SKIN TUMOR; TIME; UROGENITAL TRACT TUMOR;

ANIMALS; ANUS NEOPLASMS; APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CELL MOVEMENT; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; EPITHELIAL CELLS; EXTRACELLULAR MATRIX; FOCAL ADHESION PROTEIN-TYROSINE KINASES; HOMEOSTASIS; HUMANS; INTEGRINS; KERATIN-14; KERATINOCYTES; MALE; MICE; MICE, KNOCKOUT; MUTATION; NEOPLASM INVASIVENESS; PAPILLOMA; PROMOTER REGIONS (GENETICS); PROTEIN-SERINE-THREONINE KINASES; RAS PROTEINS; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; SKIN; SKIN NEOPLASMS; SRC-FAMILY KINASES; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA; UROGENITAL NEOPLASMS; WOUND HEALING;

EID: 35148832173     PISSN: 15356108     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ccr.2007.08.020     Document Type: Article

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