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Volumn 198, Issue 11, 2003, Pages 1741-1752

Transforming Growth Factor-β Production and Myeloid Cells Are an Effector Mechanism through Which CD1d-restricted T Cells Block Cytotoxic T Lymphocyte-mediated Tumor Immunosurveillance: Abrogation Prevents Tumor Recurrence

Author keywords

IL 13; Immunologic surveillance; Myeloid cells; NKT cells; TGF

Indexed keywords

CD1D ANTIGEN; INTERLEUKIN 13; INTERLEUKIN 4 RECEPTOR; INTERLEUKIN 4 RECEPTOR ALPHA; RAG2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

EID: 10744220561     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20022227     Document Type: Article
Times cited : (494)

References (47)
  • 2
    • 0036852191 scopus 로고    scopus 로고
    • Natural selection of tumor variants in the generation of "tumor escape" phenotypes
    • Khong, H.T., and N.P. Restifo. 2002. Natural selection of tumor variants in the generation of "tumor escape" phenotypes. Nat. Immunol. 3:999-1005.
    • (2002) Nat. Immunol. , vol.3 , pp. 999-1005
    • Khong, H.T.1    Restifo, N.P.2
  • 3
    • 0033168607 scopus 로고    scopus 로고
    • A model for CD8+ CTL tumor immunosurveillance and regulation of tumor escape by CD4 T cells through an effect on quality of CTL
    • Matsui, S., J.D. Ahlers, A.O. Vortmeyer, M. Terabe, T. Tsukui, D.P. Carbone, L.A. Liotta, and J. Berzofsky. 1999. A model for CD8+ CTL tumor immunosurveillance and regulation of tumor escape by CD4 T cells through an effect on quality of CTL. J. Immunol. 163:184-193.
    • (1999) J. Immunol. , vol.163 , pp. 184-193
    • Matsui, S.1    Ahlers, J.D.2    Vortmeyer, A.O.3    Terabe, M.4    Tsukui, T.5    Carbone, D.P.6    Liotta, L.A.7    Berzofsky, J.8
  • 5
    • 0034544609 scopus 로고    scopus 로고
    • Cutting edge: STAT6-deficient mice have enhanced tumor immunity to primary and metastatic mammary carcinoma
    • Ostrand-Rosenberg, S., M.J. Grusby, and V.K. Clements. 2000. Cutting edge: STAT6-deficient mice have enhanced tumor immunity to primary and metastatic mammary carcinoma. J. Immunol. 165:6015-6019.
    • (2000) J. Immunol. , vol.165 , pp. 6015-6019
    • Ostrand-Rosenberg, S.1    Grusby, M.J.2    Clements, V.K.3
  • 6
    • 0034545618 scopus 로고    scopus 로고
    • Spontaneous rejection of poorly immunogenic P1.HTR tumors by Stat6-deficient mice
    • Kacha, A.K., F. Fallarino, M.A. Markiewicz, and T.F. Gajewski. 2000. Spontaneous rejection of poorly immunogenic P1.HTR tumors by Stat6-deficient mice. J. Immunol. 165:6024-6028.
    • (2000) J. Immunol. , vol.165 , pp. 6024-6028
    • Kacha, A.K.1    Fallarino, F.2    Markiewicz, M.A.3    Gajewski, T.F.4
  • 7
    • 0037111416 scopus 로고    scopus 로고
    • Resistance to metastatic disease in Stat6-deficient mice requires hematopoietic and non-hematopoietic cells and is IFNγ-dependent
    • Ostrand-Rosenberg, S., V.K. Clements, M. Terabe, J.M. Park, J. Berzofsky, and S.K. Dissanayake. 2002. Resistance to metastatic disease in Stat6-deficient mice requires hematopoietic and non-hematopoietic cells and is IFNγ-dependent. J. Immunol. 169:5796-5804.
    • (2002) J. Immunol. , vol.169 , pp. 5796-5804
    • Ostrand-Rosenberg, S.1    Clements, V.K.2    Terabe, M.3    Park, J.M.4    Berzofsky, J.5    Dissanayake, S.K.6
  • 8
    • 0028176655 scopus 로고
    • Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells
    • Zurawski, G., and J.E. de Vries. 1994. Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells. Immunol. Today. 15:19-26.
    • (1994) Immunol. Today , vol.15 , pp. 19-26
    • Zurawski, G.1    De Vries, J.E.2
  • 9
    • 0033559577 scopus 로고    scopus 로고
    • Tumorigenicity of mouse thymoma is suppressed by soluble type II transforming growth factor beta receptor therapy
    • Won, J., H. Kim, E.J. Park, Y. Hong, S.J. Kim, and Y. Yun. 1999. Tumorigenicity of mouse thymoma is suppressed by soluble type II transforming growth factor beta receptor therapy. Cancer Res. 59:1273-1277.
    • (1999) Cancer Res. , vol.59 , pp. 1273-1277
    • Won, J.1    Kim, H.2    Park, E.J.3    Hong, Y.4    Kim, S.J.5    Yun, Y.6
  • 10
    • 0027137485 scopus 로고
    • Anti-transforming growth factor (TGF)-beta antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity. Implications for a possible role of tumor cell/host TGF-beta interactions in human breast cancer progression
    • Arteaga, C.L., S.D. Hurd, A.R. Winnier, M.D. Johnson, B.M. Fendly, and J.T. Forbes. 1993. Anti-transforming growth factor (TGF)-beta antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity. Implications for a possible role of tumor cell/host TGF-beta interactions in human breast cancer progression. J. Clin. Invest. 92:2569-2576.
    • (1993) J. Clin. Invest. , vol.92 , pp. 2569-2576
    • Arteaga, C.L.1    Hurd, S.D.2    Winnier, A.R.3    Johnson, M.D.4    Fendly, B.M.5    Forbes, J.T.6
  • 11
    • 0029615462 scopus 로고
    • Anti-(transforming growth factor beta) antibodies with predefined specificity inhibit metastasis of highly tumorigenic human xenotransplants in nu/nu mice
    • Hoefer, M., and F.A. Anderer. 1995. Anti-(transforming growth factor beta) antibodies with predefined specificity inhibit metastasis of highly tumorigenic human xenotransplants in nu/nu mice. Cancer Immunol. Immunother. 41:302-308.
    • (1995) Cancer Immunol. Immunother. , vol.41 , pp. 302-308
    • Hoefer, M.1    Anderer, F.A.2
  • 14
    • 0034770605 scopus 로고    scopus 로고
    • Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signaling in T cells
    • Gorelik, L., and R.A. Flavell. 2001. Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signaling in T cells. Nat. Med. 7:1118-1122.
    • (2001) Nat. Med. , vol.7 , pp. 1118-1122
    • Gorelik, L.1    Flavell, R.A.2
  • 16
    • 0024553650 scopus 로고
    • Monoclonal antibodies recognizing transforming growth factor-beta. Bioactivity neutralization and transforming growth factor beta 2 affinity purification
    • Dasch, J.R., D.R. Pace, W. Waegell, D. Inenaga, L. Ellingsworth, and J.B. Allen. 1989. Monoclonal antibodies recognizing transforming growth factor-beta. Bioactivity neutralization and transforming growth factor beta 2 affinity purification. J. Immunol. 142:1536-1541.
    • (1989) J. Immunol. , vol.142 , pp. 1536-1541
    • Dasch, J.R.1    Pace, D.R.2    Waegell, W.3    Inenaga, D.4    Ellingsworth, L.5    Allen, J.B.6
  • 17
    • 0022412562 scopus 로고
    • Characterization of monoclonal antibodies against Shiga-like toxin from Escherichia coli
    • Strockbine, N.A., L.R. Marques, R.K. Holmes, and A.D. O'Brien. 1985. Characterization of monoclonal antibodies against Shiga-like toxin from Escherichia coli. Infect. Immun. 50:695-700.
    • (1985) Infect. Immun. , vol.50 , pp. 695-700
    • Strockbine, N.A.1    Marques, L.R.2    Holmes, R.K.3    O'Brien, A.D.4
  • 19
    • 0036676974 scopus 로고    scopus 로고
    • The unconventional lifestyle of NKT cells
    • Kronenberg, M., and L. Gapin. 2002. The unconventional lifestyle of NKT cells. Nat. Rev. Immunol. 2:557-568.
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 557-568
    • Kronenberg, M.1    Gapin, L.2
  • 20
    • 0023910914 scopus 로고
    • Transforming growth factor-beta inhibits the in vitro generation of lymphokine-activated killer cells and cytotoxic T cells
    • Mule, J.J., S.L. Schwarz, A.B. Roberts, M.B. Sporn, and S.A. Rosenberg. 1988. Transforming growth factor-beta inhibits the in vitro generation of lymphokine-activated killer cells and cytotoxic T cells. Cancer Immunol. Immunother. 26:95-100.
    • (1988) Cancer Immunol. Immunother. , vol.26 , pp. 95-100
    • Mule, J.J.1    Schwarz, S.L.2    Roberts, A.B.3    Sporn, M.B.4    Rosenberg, S.A.5
  • 21
    • 0032476615 scopus 로고    scopus 로고
    • Immune suppression by recombinant interleukin (rIL)-12 involves interferon gamma induction of nitric oxide synthase 2 (iNOS) activity: Inhibitors of NO generation reveal the extent of rIL-12 vaccine adjuvant effect
    • Koblish, H.K., C.A. Hunter, M. Wysocka, G. Trinchieri, and W.M. Lee. 1998. Immune suppression by recombinant interleukin (rIL)-12 involves interferon gamma induction of nitric oxide synthase 2 (iNOS) activity: inhibitors of NO generation reveal the extent of rIL-12 vaccine adjuvant effect. J. Exp. Med. 188:1603-1610.
    • (1998) J. Exp. Med. , vol.188 , pp. 1603-1610
    • Koblish, H.K.1    Hunter, C.A.2    Wysocka, M.3    Trinchieri, G.4    Lee, W.M.5
  • 22
    • 0036789939 scopus 로고    scopus 로고
    • A push-pull approach to maximize vaccine efficacy: Abrogating suppression with an IL-13 inhibitor while augmenting help with GM-CSF and CD40L
    • Ahlers, J.D., I.M. Belyakov, M. Terabe, R. Koka, D.D. Donaldson, E. Thomas, and J.A. Berzofsky. 2002. A push-pull approach to maximize vaccine efficacy: abrogating suppression with an IL-13 inhibitor while augmenting help with GM-CSF and CD40L. Proc. Natl. Acad. Sci. USA. 99:13020-13025.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 13020-13025
    • Ahlers, J.D.1    Belyakov, I.M.2    Terabe, M.3    Koka, R.4    Donaldson, D.D.5    Thomas, E.6    Berzofsky, J.A.7
  • 23
    • 0037133611 scopus 로고    scopus 로고
    • Disrupting the IL-4 gene rescues mice homozygous for the tight-skin mutation from embryonic death and diminishes TGF-beta production by fibroblasts
    • Kodera, T., T.L. McGaha, R. Phelps, W.E. Paul, and C.A. Bona. 2002. Disrupting the IL-4 gene rescues mice homozygous for the tight-skin mutation from embryonic death and diminishes TGF-beta production by fibroblasts. Proc. Natl. Acad. Sci. USA. 99:3800-3805.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 3800-3805
    • Kodera, T.1    McGaha, T.L.2    Phelps, R.3    Paul, W.E.4    Bona, C.A.5
  • 24
    • 0030590652 scopus 로고    scopus 로고
    • Flow cytometric identification of murine neutrophils and monocytes
    • Lagasse, E., and I.L. Weissman. 1996. Flow cytometric identification of murine neutrophils and monocytes. J. Immunol. Methods. 197:139-150.
    • (1996) J. Immunol. Methods , vol.197 , pp. 139-150
    • Lagasse, E.1    Weissman, I.L.2
  • 25
    • 0035201127 scopus 로고    scopus 로고
    • Tumor-induced immune dysfunctions caused by myeloid suppressor cells
    • Bronte, V., P. Serafini, E. Apolloni, and P. Zanovello. 2001. Tumor-induced immune dysfunctions caused by myeloid suppressor cells. J. Immunother. 24:431-446.
    • (2001) J. Immunother. , vol.24 , pp. 431-446
    • Bronte, V.1    Serafini, P.2    Apolloni, E.3    Zanovello, P.4
  • 26
    • 0032533478 scopus 로고    scopus 로고
    • Apoptotic death of CD8+ T lymphocytes after immunization: Induction of a suppressive population of Mac-1+/Gr-1+ cells
    • Bronte, V., M. Wang, W.W. Overwijk, D.R. Surman, F. Pericle, S.A. Rosenberg, and N.P. Restifo. 1998. Apoptotic death of CD8+ T lymphocytes after immunization: induction of a suppressive population of Mac-1+/Gr-1+ cells. J. Immunol. 15:5313-5320.
    • (1998) J. Immunol. , vol.15 , pp. 5313-5320
    • Bronte, V.1    Wang, M.2    Overwijk, W.W.3    Surman, D.R.4    Pericle, F.5    Rosenberg, S.A.6    Restifo, N.P.7
  • 27
    • 0034551670 scopus 로고    scopus 로고
    • Identification of a CD11b(+)/Gr-1(+)/CD31(+) myeloid progenitor capable of activating or suppressing CD8(+) T cells
    • Bronte, V., E. Apolloni, A. Cabrelle, R. Ronca, P. Serafini, P. Zamboni, N.P. Restifo, and P. Zanovello. 2000. Identification of a CD11b(+)/Gr-1(+)/CD31(+) myeloid progenitor capable of activating or suppressing CD8(+) T cells. Blood. 96:3838-3846.
    • (2000) Blood , vol.96 , pp. 3838-3846
    • Bronte, V.1    Apolloni, E.2    Cabrelle, A.3    Ronca, R.4    Serafini, P.5    Zamboni, P.6    Restifo, N.P.7    Zanovello, P.8
  • 28
    • 0034651585 scopus 로고    scopus 로고
    • Resection of solid tumors reverses T cell defects and restores protective immunity
    • Salvadori, S., G. Martinelli, and K. Zier. 2000. Resection of solid tumors reverses T cell defects and restores protective immunity. J. Immunol. 164:2214-2220.
    • (2000) J. Immunol. , vol.164 , pp. 2214-2220
    • Salvadori, S.1    Martinelli, G.2    Zier, K.3
  • 29
    • 0034661719 scopus 로고    scopus 로고
    • Gr-1+ myeloid cells derived from tumor-bearing mice inhibit primary T cell activation induced through CD3/CD28 costimulation
    • Kusmartsev, S.A., Y. Li, and S.H. Chen. 2000. Gr-1+ myeloid cells derived from tumor-bearing mice inhibit primary T cell activation induced through CD3/CD28 costimulation. J. Immunol. 165:779-785.
    • (2000) J. Immunol. , vol.165 , pp. 779-785
    • Kusmartsev, S.A.1    Li, Y.2    Chen, S.H.3
  • 30
    • 0030059765 scopus 로고    scopus 로고
    • Suppression of T cell proliferation by tumor-induced granulocyte-macrophage progenitor cells producing transforming growth factor-beta and nitric oxide
    • Young, M.R., M.A. Wright, J.P. Matthews, I. Malik, and M. Prechel. 1996. Suppression of T cell proliferation by tumor-induced granulocyte-macrophage progenitor cells producing transforming growth factor-beta and nitric oxide. J. Immunol. 156:1916-1922.
    • (1996) J. Immunol. , vol.156 , pp. 1916-1922
    • Young, M.R.1    Wright, M.A.2    Matthews, J.P.3    Malik, I.4    Prechel, M.5
  • 31
    • 0034548004 scopus 로고    scopus 로고
    • Superantigen-induced CD4 T cell tolerance mediated by myeloid cells and IFN-gamma
    • Cauley, L.S., E.E. Miller, M. Yen, and S.L. Swain. 2000. Superantigen-induced CD4 T cell tolerance mediated by myeloid cells and IFN-gamma. J. Immunol. 165:6056-6066.
    • (2000) J. Immunol. , vol.165 , pp. 6056-6066
    • Cauley, L.S.1    Miller, E.E.2    Yen, M.3    Swain, S.L.4
  • 32
    • 0033844685 scopus 로고    scopus 로고
    • Unresponsiveness of intrahepatic lymphocytes to bacterial superantigen: Rapid development of suppressive Mac-1(high) cells in the mouse liver
    • Terabe, M., M. Shimizu, A. Mabuchi, S. Matui, H. Morikawa, K. Kaneda, T. Kakiuchi, and K. Yokomuro. 2000. Unresponsiveness of intrahepatic lymphocytes to bacterial superantigen: rapid development of suppressive Mac-1(high) cells in the mouse liver. Hepatology. 32:507-513.
    • (2000) Hepatology , vol.32 , pp. 507-513
    • Terabe, M.1    Shimizu, M.2    Mabuchi, A.3    Matui, S.4    Morikawa, H.5    Kaneda, K.6    Kakiuchi, T.7    Yokomuro, K.8
  • 34
    • 17544401819 scopus 로고    scopus 로고
    • Cyclophosphamide induces the development of early myeloid cells suppressing tumor cell growth by a nitric oxide-dependent mechanism
    • Pelaez, B., J.A. Campillo, J.A. Lopez-Asenjo, and J.L. Subiza. 2001. Cyclophosphamide induces the development of early myeloid cells suppressing tumor cell growth by a nitric oxide-dependent mechanism. J. Immunol. 166:6608-6615.
    • (2001) J. Immunol. , vol.166 , pp. 6608-6615
    • Pelaez, B.1    Campillo, J.A.2    Lopez-Asenjo, J.A.3    Subiza, J.L.4
  • 35
    • 0343185921 scopus 로고    scopus 로고
    • Nitric oxide-producing CD11b(+)Ly-6G(Gr-1)(+)CD31(ER-MP12)(+) cells in the spleen of cyclophosphamide-treated mice: Implications for T-cell responses in immunosuppressed mice
    • Angulo, I., F.G. de las Heras, J.F. Garcia-Bustos, D. Gargallo, M.A. Munoz-Fernandez, and M. Fresno. 2000. Nitric oxide-producing CD11b(+)Ly-6G(Gr-1)(+)CD31(ER-MP12)(+) cells in the spleen of cyclophosphamide-treated mice: implications for T-cell responses in immunosuppressed mice. Blood. 95:212-220.
    • (2000) Blood , vol.95 , pp. 212-220
    • Angulo, I.1    De Las Heras, F.G.2    Garcia-Bustos, J.F.3    Gargallo, D.4    Munoz-Fernandez, M.A.5    Fresno, M.6
  • 36
    • 0033993917 scopus 로고    scopus 로고
    • Antigen-presenting cells recruited by Brugia malayi induce Th2 differentiation of naive CD4(+) T cells
    • Loke, P., A.S. MacDonald, and J.E. Allen. 2000. Antigen-presenting cells recruited by Brugia malayi induce Th2 differentiation of naive CD4(+) T cells. Eur. J. Immunol. 30:1127-1135.
    • (2000) Eur. J. Immunol. , vol.30 , pp. 1127-1135
    • Loke, P.1    MacDonald, A.S.2    Allen, J.E.3
  • 37
    • 0035171172 scopus 로고    scopus 로고
    • Mice infected with Schistosoma mansoni develop a novel non-T lymphocyte suppressor population which inhibits virus-specific CTL induction via a soluble factor
    • Marshall, M.A., D. Jankovic, V.E. Maher, A. Sher, and J.A. Berzofsky. 2001. Mice infected with Schistosoma mansoni develop a novel non-T lymphocyte suppressor population which inhibits virus-specific CTL induction via a soluble factor. Microbes Infect. 3:1051-1061.
    • (2001) Microbes Infect. , vol.3 , pp. 1051-1061
    • Marshall, M.A.1    Jankovic, D.2    Maher, V.E.3    Sher, A.4    Berzofsky, J.A.5
  • 38
    • 0027382922 scopus 로고
    • Suppressor macrophages in African trypanosomiasis inhibit T cell proliferative responses by nitric oxide and prostaglandins
    • Schleifer, K.W., and J.M. Mansfield. 1993. Suppressor macrophages in African trypanosomiasis inhibit T cell proliferative responses by nitric oxide and prostaglandins. J. Immunol. 151:5492-5503.
    • (1993) J. Immunol. , vol.151 , pp. 5492-5503
    • Schleifer, K.W.1    Mansfield, J.M.2
  • 39
    • 0025877717 scopus 로고
    • Immunosuppression induced by attenuated Salmonella. Evidence for mediation by macrophage precursors
    • al-Ramadi, B.K., M.A. Brodkin, D.M. Mosser, and T.K. Eisenstein. 1991. Immunosuppression induced by attenuated Salmonella. Evidence for mediation by macrophage precursors. J. Immunol. 146:2737-2746.
    • (1991) J. Immunol. , vol.146 , pp. 2737-2746
    • Al-Ramadi, B.K.1    Brodkin, M.A.2    Mosser, D.M.3    Eisenstein, T.K.4
  • 41
    • 0035874990 scopus 로고    scopus 로고
    • Activated granulocytes and granulocyte-derived hydrogen peroxide are the underlying mechanism of suppression of T-cell function in advanced cancer patients
    • Schmielau, J., and O.J. Finn. 2001. Activated granulocytes and granulocyte-derived hydrogen peroxide are the underlying mechanism of suppression of T-cell function in advanced cancer patients. Cancer Res. 61:4756-4760.
    • (2001) Cancer Res. , vol.61 , pp. 4756-4760
    • Schmielau, J.1    Finn, O.J.2
  • 42
    • 0029833732 scopus 로고    scopus 로고
    • Mechanisms of immune suppression in patients with head and neck cancer: Influence on the immune infiltrate of the cancer
    • Young, M.R., M.A. Wright, Y. Lozano, J.P. Matthews, J. Benefield, and M.M. Prechel. 1996. Mechanisms of immune suppression in patients with head and neck cancer: influence on the immune infiltrate of the cancer. Int. J. Cancer. 67:333-338.
    • (1996) Int. J. Cancer , vol.67 , pp. 333-338
    • Young, M.R.1    Wright, M.A.2    Lozano, Y.3    Matthews, J.P.4    Benefield, J.5    Prechel, M.M.6
  • 44
    • 0038152830 scopus 로고    scopus 로고
    • Cross-presentation of disialoganglioside GD3 to natural killer T cells
    • Wu, D.Y., N.H. Segal, S. Sidobre, M. Kronenberg, and P.B. Chapman. 2003. Cross-presentation of disialoganglioside GD3 to natural killer T cells. J. Exp. Med. 198:173-181.
    • (2003) J. Exp. Med. , vol.198 , pp. 173-181
    • Wu, D.Y.1    Segal, N.H.2    Sidobre, S.3    Kronenberg, M.4    Chapman, P.B.5
  • 46
    • 0032697042 scopus 로고    scopus 로고
    • An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response
    • Chiaramonte, M.G., D.D. Donaldson, A.W. Cheever, and T.A. Wynn. 1999. An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response. J. Clin. Invest. 104:777-785.
    • (1999) J. Clin. Invest. , vol.104 , pp. 777-785
    • Chiaramonte, M.G.1    Donaldson, D.D.2    Cheever, A.W.3    Wynn, T.A.4


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