Transport mechanisms of mmePEG750P(CL-co-TMC) polymeric micelles across the intestinal barrier

Journal of Controlled Release

Volumn 124, Issue 3, 2007, Pages 134-143

  Mathot, Frédéric ^a   des Rieux, A ^a   Arien A ^b   Schneider, Y J ^a   Brewster, M ^b   Preat V ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

Caco 2; Endocytosis; FAE model; mmePEG750P(CL co TMC); Passive diffusion; Self assembling polymeric micelles

Indexed keywords

ENDOCYTOSIS; FAE MODEL; MMEPEG750P(CL-CO-TMC); PASSIVE DIFFUSION; SELF-ASSEMBLING POLYMERIC MICELLES;

CELLS; LIPIDS; MONOLAYERS; POLYETHYLENE GLYCOLS;

MICELLES;

CARBAMAZEPINE; CHLOROTHIAZIDE; COPOLYMER; GLYCOPROTEIN P; MONOMETHYLETHER POLY(ETHYLENEGLYCOL) 750 POLY(CAPROLACTONE CO TRIMETHYLENE CARBONATE) COPOLYMER; UNCLASSIFIED DRUG; MACROGOL DERIVATIVE; POLYESTER; POLYMER;

ARTICLE; CELL MEMBRANE TRANSPORT; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG ABSORPTION; DRUG DIFFUSION; DRUG FORMULATION; ENDOCYTOSIS; HUMAN; HUMAN CELL; INTESTINE ABSORPTION; ISOTOPE LABELING; MICELLIZATION; PRIORITY JOURNAL; TIGHT JUNCTION; TRANSPORT KINETICS; B LYMPHOCYTE; BIOAVAILABILITY; BIOLOGICAL MODEL; CHEMISTRY; COCULTURE; DIFFUSION; DRUG EFFECT; INTESTINE CELL; METABOLISM; MICELLE; MOLECULAR WEIGHT; ORAL DRUG ADMINISTRATION; PARTICLE SIZE; SOLUBILITY; SYNTHESIS; TRANSPORT AT THE CELLULAR LEVEL;

ADMINISTRATION, ORAL; B-LYMPHOCYTES; BIOLOGICAL AVAILABILITY; BIOLOGICAL TRANSPORT; CACO-2 CELLS; COCULTURE TECHNIQUES; DIFFUSION; ENDOCYTOSIS; ENTEROCYTES; HUMANS; INTESTINAL ABSORPTION; MICELLES; MODELS, BIOLOGICAL; MOLECULAR WEIGHT; PARTICLE SIZE; POLYESTERS; POLYETHYLENE GLYCOLS; POLYMERS; SOLUBILITY;

EID: 36148935211     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2007.09.001     Document Type: Article

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