Polyelectrolyte nanoparticles with high drug loading enhance the oral uptake of hydrophobic compounds

Biomacromolecules

Volumn 7, Issue 5, 2006, Pages 1509-1520

  Cheng, Woei Ping ^a   Gray, Alexander I ^a   Tetley, Laurence ^b   Hang, Thi Le Bich ^a   Schätzlein, Andreas G ^b   Uchegbu, Ijeoma F ^a  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG PRODUCTS; HYDROPHOBICITY; MICROEMULSIONS; NANOSTRUCTURED MATERIALS; PARTICLES (PARTICULATE MATTER);

GASTROINTESTINAL TRACT DISSOLUTION; HIGH DRUG LOADING; HYDROPHOBIC COMPOUND; POLYELECTROLYTE NANOPARTICLE;

POLYELECTROLYTES;

CYCLOSPORIN A; GLYCOPROTEIN P; NANOPARTICLE; POLY(ETHYLENIMINE) DERIVATIVE; POLYELECTROLYTE; QUATERNARY AMMONIUM DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DERIVATIZATION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG INDUSTRY; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG TRANSPORT; DRUG UPTAKE; EMULSION; GASTROINTESTINAL TRACT; HUMAN; HUMAN CELL; HYDROPHOBICITY; MICELLE; MICROEMULSION; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; TRANSMISSION ELECTRON MICROSCOPY;

ADMINISTRATION, ORAL; ANIMALS; BIOPOLYMERS; CYCLOSPORINE; MALE; MODELS, MOLECULAR; NANOSTRUCTURES; PHARMACEUTICAL PREPARATIONS; RATS; RATS, WISTAR;

ANIMALIA;

EID: 33744552970     PISSN: 15257797     EISSN: None     Source Type: Journal    
DOI: 10.1021/bm060130l     Document Type: Article

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