Transepithelial and endothelial transport of poly (amidoamine) dendrimers

Advanced Drug Delivery Reviews

Volumn 57, Issue 15, 2005, Pages 2163-2176

  Kitchens, Kelly M ^a   El Sayed, Mohamed E H ^b   Ghandehari, Hamidreza ^a,c  

^a UNIVERSITY OF MARYLAND   (United States)

^b University of Washington   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

Author keywords

Caco 2 cells; Endothelial barrier; Intravital microscopy; Microvascular extravasation; Oral drug delivery; PAMAM; Poly (amidoamine) dendrimers; Water soluble polymers

Indexed keywords

DRUG THERAPY; MECHANICAL PERMEABILITY; MONOLAYERS; OPTIMIZATION; POSITIVE IONS; SURFACE CHEMISTRY;

ENDOTHELIAL BARRIERS; INTRAVITAL MICROSCOPY; ORAL DRUG DELIVERY; WATER-SOLUBLE POLYMERS;

DENDRIMERS;

DENDRIMER; DRUG CARRIER; LACTATE DEHYDROGENASE; MACROGOL; MANNITOL; POLYAMIDOAMINE; POLYAMINE DERIVATIVE; POLYMER;

CELL LINE; CELL MEMBRANE PERMEABILITY; CELL VIABILITY; CHEMICAL STRUCTURE; DRUG DELIVERY SYSTEM; ELECTRIC RESISTANCE; ENDOTHELIUM; GEOMETRY; HUMAN; MOLECULAR WEIGHT; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; REVIEW;

ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; CAPILLARIES; DENDRIMERS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; EPITHELIUM; HUMANS; POLYAMINES;

EID: 28744441403     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.addr.2005.09.013     Document Type: Review

References (39)

1. H. Ringsdorf Structure and properties of pharmacologically active polymers J. Polym. Sci., Polym. Symp. 51 1975 135 153
2. R. Duncan The dawning era of polymer therapeutics Nat. Rev. Drug Discov. 2 2003 347 360
3. J. Kopecek, P. Kopeckova, T. Minko, Z.R. Lu, and C.M. Peterson Water soluble polymers in tumor targeted delivery J. Control. Release 74 2001 147 158
4. Y. Luo, and G.D. Prestwich Cancer-targeted polymeric drugs Curr. Cancer Drug Targets 2 2002 209 226
5. R. Duncan, and F. Spreafico Polymer conjugates. Pharmacokinetic considerations for design and development Clin. Pharmacokinet. 27 1994 290 306
6. R. Tomlinson, J. Heller, S. Brocchini, and R. Duncan Polyacetal- doxorubicin conjugates designed for pH-dependent degradation Bioconjug. Chem. 14 2003 1096 1106
7. R. Esfand, and D.A. Tomailia Poly (amidoamine) (PAMAM) dendrimers: from biomimicry to drug delivery and biomedical applications Drug Discov. Today 6 2001 427 436
8. D.A. Tomalia, A.M. Naylor, and W.A. Goddard III Starburst dendrimers. Molecular-level control of size, shape, surface chemistry, topology, and flexibility from atoms to macroscopic matter Angew. Chem. Int. Ed. Engl. 29 1990 138 175
9. D.A. Tomalia Starburst™/Cascade dendrimers: fundamental building blocks for a new nanoscopic chemistry set Aldrichimica Acta 26 1993 91 101
10. D.A. Tomalia Dendrimer molecules Sci. Am. 272 1995 62 66
11. C.R. DeMatti, B. Huang, and D.A. Tomalia Designed dendrimer syntheses by self-assembly of single-site, ssDNA functionalized dendrons Nano. Lett. 4 2004 771 777
12. R. DeLong, K. Stephenson, T. Loftus, M. Fisher, S. Alahari, A. Nolting, and R.L. Juliano Characterization of complexes of oligonucleotides with polyamidoamine starburst dendrimers and effects on intracellular delivery J. Pharm. Sci. 86 1997 762 764
13. H. Yoo, P. Sazani, and R.L. Juliano PAMAM dendrimers as delivery agents for antisense oligonucleotides Pharm. Res. 16 1999 1799 1804
14. H. Yoo, and R.L. Juliano Enhanced delivery of antisense oligonucleotides with fluorophore-conjugated PAMAM dendrimers Nucleic Acids Res. 28 2000 4225 4231
15. T. Sakthivel, I. Toth, and A.T. Florence Distribution of a lipidic 2.5 nm diameter dendrimer carrier after oral administration Int. J. Pharm. 183 1999 51 55
16. A.T. Florence, T. Sakthivel, and I. Toth Oral uptake and translocation of a polylysine dendrimer with a lipid surface J. Control. Release 65 2000 253 259
17. A.T. Florence The oral absorption of micro- and nanoparticles: neither exceptional nor unusual Pharm. Res. 14 1997 259 266
18. B. Singh, and A.T. Florence Hydrophobic dendrimer-derived nanoparticles Int. J. Pharm. 298 2005 348 353
19. R. Wiwattanapatapee, B. Carrreño-Gómez, N. Malik, and R. Duncan Anionic PAMAM dendrimers rapidly cross adult rat intestine in vitro: a potential oral drug delivery system? Pharm. Res. 17 2000 991 998
20. F. Tajarobi, M. El-Sayed, B.D. Rege, J.E. Polli, and H. Ghandehari Transport of poly amidoamine dendrimers across Madin-Darby Canine Kidney cells Int. J. Pharm. 215 2001 263 267
21. M. El-Sayed, M. Ginski, C. Rhodes, and H. Ghandehari Transepithelial transport of poly (amidoamine) dendrimers across Caco-2 cell monolayers J. Control. Release 81 2002 355 365
22. M. El-Sayed, M. Ginski, C. Rhodes, and H. Ghandehari Influence of surface chemistry of poly (amidoamine) dendrimers on Caco-2 cell monolayers J. Bioact. Compat. Polym. 18 2003 7 22
23. M. El-Sayed, C.A. Rhodes, M. Ginski, and H. Ghandehari Transport mechanism(s) of poly (amidoamine) dendrimers across Caco-2 cell monolayers Int. J. Pharm. 265 2003 151 157
24. M. El-Sayed, M. Kiani, M.D. Naimark, A.H. Hikal, and H. Ghandehari Extravasation of poly (amidoamine) (PAMAM) dendrimers across microvascular network endothelium Pharm. Res. 18 2001 23 28
25. R. Jevprasesphant, J. Penny, R. Jalal, D. Attwood, N.B. McKeown, and A. D'Emanuele The influence of surface modification on the cytotoxicity of PAMAM dendrimers Int. J. Pharm. 252 2003 263 266
26. R. Jevprasesphant, J. Penny, D. Attwood, N.B. McKeown, and A. D'Emanuele Engineering of dendrimer surfaces to enhance transepithelial transport and reduce cytotoxicity Pharm. Res. 20 2003 1543 1550
27. R. Jevprasesphant, J. Penny, D. Attwood, and A. D'Emanuele Transport of dendrimer nanocarriers through epithelial cells via the transcellular route J. Control. Release 97 2004 259 267
28. A. D'Emanuele, R. Jevprasesphant, J. Penny, and D. Attwood The use of dendrimer-propanolol prodrug to bypass efflux transporters and enhance oral bioavailability J. Control. Release 95 2004 447 453
29. A.B.J. Noach, Y. Kurosaki, M.C.M. Blom-Roosemalen, A.G.D. Boer, and D.D. Breimer Cell-polarity dependant effect of chelation on the paracellular permeability of confluent Caco-2 cell monolayers Int. J. Pharm. 90 1993 229 237
30. B.E. Hull, and L.A. Staehelin The terminal web. A reevaluation of its structure and function J. Cell Biol. 81 1979 67 82
31. M.G. Farquar, and G.E. Palade Junctional complexes in various epithelia J. Cell Biol. 17 1963 375 412
32. H. Ghandehari, P.L. Smith, H. Ellens, P.-Y. Yeh, and J. Kopecek Size-dependent permeability of hydrophilic probes across rabbit colonic epithelium J. Pharmacol. Exp. Ther. 280 1997 747 753
33. Y. Sai, M. Kajita, I. Tamai, J. Wakama, T. Wakamiya, and A. Tsuji Adsorptive-mediated endocytosis of a basic peptide in enterocyte-like Caco-2 cells Am. J. Physiol. 275 1998 G514 G520
34. B.J. Aungst Intestinal permeation enhancers J. Pharm. Sci. 89 2000 429 442
35. Y. Takakura, R.I. Mahato, and M. Hashida Extravasation of macromolecules Adv. Drug Deliv. Rev. 34 1998 93 108
36. M.G. Davidson, and W.M. Deen Hindered diffusion of water-soluble macromolecules in membranes Macromolecules 21 1988 3474 3481
37. F.N.E. Gavins, and B.E. Chatterjee Intravital microscopy for the study of mouse microcirculation in anti-inflammatory drug research: focus on the mesentery and cremaster preparations J. Pharmacol. Toxicol. Methods 49 2004 1 14
38. A.S. de Vriese, and N.H. Lameire Intravital microscopy: an integrated evaluation of peritoneal function and structure Nephrol. Dial. Transplant. 16 2001 657 660
39. R.H. Adamson, and G. Clough Plasma proteins modify the endothelial cell glycocalyx of frog mesenteric microvessels J. Physiol. 445 1992 473 486