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Volumn 82, Issue 4-6, 2010, Pages 231-236

Unsaturated fatty acids as cytoprotective agents in the pancreatic Β-cell

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A DESATURASE; CASPASE 3; FATTY ACID; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; INITIATION FACTOR 2ALPHA; MITOGEN ACTIVATED PROTEIN KINASE; OLEIC ACID; PALMITIC ACID; TRIACYLGLYCEROL; UNSATURATED FATTY ACID;

EID: 77951975420     PISSN: 09523278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.plefa.2010.02.018     Document Type: Article
Times cited : (57)

References (69)
  • 1
    • 70549113397 scopus 로고    scopus 로고
    • Role of glucotoxicity and lipotoxicity in the pathophysiology of Type 2 diabetes mellitus and emerging treatment strategies
    • Del Prato S. Role of glucotoxicity and lipotoxicity in the pathophysiology of Type 2 diabetes mellitus and emerging treatment strategies. Diabet. Med. 2009, 26:1185-1192.
    • (2009) Diabet. Med. , vol.26 , pp. 1185-1192
    • Del Prato, S.1
  • 2
    • 70350312488 scopus 로고    scopus 로고
    • Genetic and biochemical pathways of beta-cell failure in type 2 diabetes
    • Talchai C., Lin H.V., Kitamura T., Accili D. Genetic and biochemical pathways of beta-cell failure in type 2 diabetes. Diabet. Obes. Metab. 2009, 11(Suppl 4):38-45.
    • (2009) Diabet. Obes. Metab. , vol.11 , Issue.SUPPL. 4 , pp. 38-45
    • Talchai, C.1    Lin, H.V.2    Kitamura, T.3    Accili, D.4
  • 3
    • 70349398318 scopus 로고    scopus 로고
    • Beta-cell deterioration during diabetes: what's in the gun?
    • Robertson R.P. Beta-cell deterioration during diabetes: what's in the gun?. Trends Endocrinol. Metab. 2009, 20:388-393.
    • (2009) Trends Endocrinol. Metab. , vol.20 , pp. 388-393
    • Robertson, R.P.1
  • 4
    • 43549108142 scopus 로고    scopus 로고
    • Glucolipotoxicity: fuel excess and beta-cell dysfunction
    • Poitout V., Robertson R.P. Glucolipotoxicity: fuel excess and beta-cell dysfunction. Endocr. Rev. 2008, 29:351-366.
    • (2008) Endocr. Rev. , vol.29 , pp. 351-366
    • Poitout, V.1    Robertson, R.P.2
  • 5
    • 67349228410 scopus 로고    scopus 로고
    • The beta cell lesion in type 2 diabetes: there has to be a primary functional abnormality
    • Kahn S.E., Zraika S., Utzschneider K.M., Hull R.L. The beta cell lesion in type 2 diabetes: there has to be a primary functional abnormality. Diabetologia 2009, 52:1003-1012.
    • (2009) Diabetologia , vol.52 , pp. 1003-1012
    • Kahn, S.E.1    Zraika, S.2    Utzschneider, K.M.3    Hull, R.L.4
  • 8
    • 70349988797 scopus 로고    scopus 로고
    • G-protein coupled receptors mediating long chain fatty acid signalling in the pancreatic beta-cell
    • Morgan N.G., Dhayal S. G-protein coupled receptors mediating long chain fatty acid signalling in the pancreatic beta-cell. Biochem. Pharmacol. 2009, 78:1419-1427.
    • (2009) Biochem. Pharmacol. , vol.78 , pp. 1419-1427
    • Morgan, N.G.1    Dhayal, S.2
  • 9
    • 33846267745 scopus 로고    scopus 로고
    • Life and death decisions of the pancreatic beta-cell: the role of fatty acids
    • Newsholme P., Keane D., Welters H.J., Morgan N.G. Life and death decisions of the pancreatic beta-cell: the role of fatty acids. Clin. Sci. (Lond) 2007, 112:27-42.
    • (2007) Clin. Sci. (Lond) , vol.112 , pp. 27-42
    • Newsholme, P.1    Keane, D.2    Welters, H.J.3    Morgan, N.G.4
  • 11
    • 33746190686 scopus 로고    scopus 로고
    • Fatty acid-induced toxicity and neutral lipid accumulation in insulin-producing RINm5F cells
    • zevedo-Martins A.K., Monteiro A.P., Lima C.L., Lenzen S., Curi R. Fatty acid-induced toxicity and neutral lipid accumulation in insulin-producing RINm5F cells. Toxicol. In Vitro 2006, 20:1106-1113.
    • (2006) Toxicol. In Vitro , vol.20 , pp. 1106-1113
    • zevedo-Martins, A.K.1    Monteiro, A.P.2    Lima, C.L.3    Lenzen, S.4    Curi, R.5
  • 12
    • 0036924861 scopus 로고    scopus 로고
    • Different role of saturated unsaturated fatty acids in beta-cell apoptosis
    • Eitel K., Staiger H., Brendel M.D., et al. Different role of saturated unsaturated fatty acids in beta-cell apoptosis. Biochem. Biophys. Res. Commun. 2002, 299:853-856.
    • (2002) Biochem. Biophys. Res. Commun. , vol.299 , pp. 853-856
    • Eitel, K.1    Staiger, H.2    Brendel, M.D.3
  • 13
    • 1342286820 scopus 로고    scopus 로고
    • Mono-unsaturated fatty acids protect against beta-cell apoptosis induced by saturated fatty acids, serum withdrawal or cytokine exposure
    • Welters H.J., Tadayyon M., Scarpello J.H., Smith S.A., Morgan N.G. Mono-unsaturated fatty acids protect against beta-cell apoptosis induced by saturated fatty acids, serum withdrawal or cytokine exposure. FEBS Lett. 2004, 560:103-108.
    • (2004) FEBS Lett. , vol.560 , pp. 103-108
    • Welters, H.J.1    Tadayyon, M.2    Scarpello, J.H.3    Smith, S.A.4    Morgan, N.G.5
  • 14
    • 65949087032 scopus 로고    scopus 로고
    • Lipotoxicity: why do saturated fatty acids cause and monounsaturates protect against it?
    • Nolan C.J., Larter C.Z. Lipotoxicity: why do saturated fatty acids cause and monounsaturates protect against it?. J. Gastroenterol. Hepatol. 2009, 24:703-706.
    • (2009) J. Gastroenterol. Hepatol. , vol.24 , pp. 703-706
    • Nolan, C.J.1    Larter, C.Z.2
  • 15
    • 77449141236 scopus 로고    scopus 로고
    • Cellular Production of {omega}-3 PUFAs and Reduction of {omega}-6/{omega}-3 ratios in the Pancreatic {beta}-cells and Islets Enhance Insulin Secretion and Confer Protection against Cytokine-induced Cell Death
    • Wei D., Li J., Shen M., et al. Cellular Production of {omega}-3 PUFAs and Reduction of {omega}-6/{omega}-3 ratios in the Pancreatic {beta}-cells and Islets Enhance Insulin Secretion and Confer Protection against Cytokine-induced Cell Death. Diabetes 2009, 10.2337/db09-0284.
    • (2009) Diabetes
    • Wei, D.1    Li, J.2    Shen, M.3
  • 16
    • 40849099994 scopus 로고    scopus 로고
    • Comparison of the effect of individual saturated and unsaturated fatty acids on cell growth and death induction in the human pancreatic beta-cell line NES2Y
    • Furstova V., Kopska T., James R.F., Kovar J. Comparison of the effect of individual saturated and unsaturated fatty acids on cell growth and death induction in the human pancreatic beta-cell line NES2Y. Life Sci. 2008, 82:684-691.
    • (2008) Life Sci. , vol.82 , pp. 684-691
    • Furstova, V.1    Kopska, T.2    James, R.F.3    Kovar, J.4
  • 17
    • 42149111577 scopus 로고    scopus 로고
    • Structural requirements for the cytoprotective actions of mono-unsaturated fatty acids in the pancreatic beta-cell line, BRIN-BD11
    • Dhayal S., Welters H.J., Morgan N.G. Structural requirements for the cytoprotective actions of mono-unsaturated fatty acids in the pancreatic beta-cell line, BRIN-BD11. Br. J. Pharmacol. 2008, 153:1718-1727.
    • (2008) Br. J. Pharmacol. , vol.153 , pp. 1718-1727
    • Dhayal, S.1    Welters, H.J.2    Morgan, N.G.3
  • 18
    • 34547888676 scopus 로고    scopus 로고
    • Mechanisms involved in the cytotoxic and cytoprotective actions of saturated versus monounsaturated long-chain fatty acids in pancreatic {beta}-cells
    • Diakogiannaki E., Dhayal S., Childs C.E., Calder P.C., Welters H.J., Morgan N.G. Mechanisms involved in the cytotoxic and cytoprotective actions of saturated versus monounsaturated long-chain fatty acids in pancreatic {beta}-cells. J. Endocrinol. 2007, 194:283-291.
    • (2007) J. Endocrinol. , vol.194 , pp. 283-291
    • Diakogiannaki, E.1    Dhayal, S.2    Childs, C.E.3    Calder, P.C.4    Welters, H.J.5    Morgan, N.G.6
  • 19
    • 0345354674 scopus 로고    scopus 로고
    • Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function
    • Maedler K., Oberholzer J., Bucher P., Spinas G.A., Donath M.Y. Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function. Diabetes 2003, 52:726-733.
    • (2003) Diabetes , vol.52 , pp. 726-733
    • Maedler, K.1    Oberholzer, J.2    Bucher, P.3    Spinas, G.A.4    Donath, M.Y.5
  • 20
    • 0035126282 scopus 로고    scopus 로고
    • Protective action of arachidonic acid against alloxan-induced cytotoxicity and diabetes mellitus
    • Suresh Y., Das U.N. Protective action of arachidonic acid against alloxan-induced cytotoxicity and diabetes mellitus. Prostaglandins Leukot. Essent. Fatty Acids 2001, 64:37-52.
    • (2001) Prostaglandins Leukot. Essent. Fatty Acids , vol.64 , pp. 37-52
    • Suresh, Y.1    Das, U.N.2
  • 21
    • 24944526652 scopus 로고    scopus 로고
    • Adverse physicochemical properties of tripalmitin in beta cells lead to morphological changes and lipotoxicity in vitro
    • Moffitt J.H., Fielding B.A., Evershed R., Berstan R., Currie J.M., Clark A. Adverse physicochemical properties of tripalmitin in beta cells lead to morphological changes and lipotoxicity in vitro. Diabetologia 2005, 48:1819-1829.
    • (2005) Diabetologia , vol.48 , pp. 1819-1829
    • Moffitt, J.H.1    Fielding, B.A.2    Evershed, R.3    Berstan, R.4    Currie, J.M.5    Clark, A.6
  • 22
    • 77449139439 scopus 로고    scopus 로고
    • Over-expression of kinase negative protein kinase C{delta} in pancreatic {beta}-cells protects mice from diet-induced glucose intolerance and {beta}-cell dysfunction
    • Hennige A.M., Ranta F., Heinzelmann I., et al. Over-expression of kinase negative protein kinase C{delta} in pancreatic {beta}-cells protects mice from diet-induced glucose intolerance and {beta}-cell dysfunction. Diabetes 2009, 10.2337/db09-0512.
    • (2009) Diabetes
    • Hennige, A.M.1    Ranta, F.2    Heinzelmann, I.3
  • 23
    • 0036315888 scopus 로고    scopus 로고
    • Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated
    • Lupi R., Dotta F., Marselli L., et al. Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated. Diabetes 2002, 51:1437-1442.
    • (2002) Diabetes , vol.51 , pp. 1437-1442
    • Lupi, R.1    Dotta, F.2    Marselli, L.3
  • 24
    • 43149084152 scopus 로고    scopus 로고
    • Limited mitochondrial permeabilization is an early manifestation of palmitate-induced lipotoxicity in pancreatic beta-cells
    • Koshkin V., Dai F.F., Robson-Doucette C.A., Chan C.B., Wheeler M.B. Limited mitochondrial permeabilization is an early manifestation of palmitate-induced lipotoxicity in pancreatic beta-cells. J. Biol. Chem. 2008, 283:7936-7948.
    • (2008) J. Biol. Chem. , vol.283 , pp. 7936-7948
    • Koshkin, V.1    Dai, F.F.2    Robson-Doucette, C.A.3    Chan, C.B.4    Wheeler, M.B.5
  • 25
    • 47749122129 scopus 로고    scopus 로고
    • Rosiglitazone counteracts palmitate-induced beta-cell dysfunction by suppression of MAP kinase, inducible nitric oxide synthase and caspase 3 activities
    • Abaraviciene S.M., Lundquist I., Salehi A. Rosiglitazone counteracts palmitate-induced beta-cell dysfunction by suppression of MAP kinase, inducible nitric oxide synthase and caspase 3 activities. Cell Mol. Life Sci. 2008, 65:2256-2265.
    • (2008) Cell Mol. Life Sci. , vol.65 , pp. 2256-2265
    • Abaraviciene, S.M.1    Lundquist, I.2    Salehi, A.3
  • 26
    • 41949128158 scopus 로고    scopus 로고
    • Persistent activation of Akt or ERK prevents the toxicity induced by saturated and polyunsaturated fatty acids in RINm5F beta-cells
    • Simon M.N., zevedo-Martins A.K., Amanso A.M., Carvalho C.R., Curi R. Persistent activation of Akt or ERK prevents the toxicity induced by saturated and polyunsaturated fatty acids in RINm5F beta-cells. Toxicol. In Vitro 2008, 22:1018-1024.
    • (2008) Toxicol. In Vitro , vol.22 , pp. 1018-1024
    • Simon, M.N.1    zevedo-Martins, A.K.2    Amanso, A.M.3    Carvalho, C.R.4    Curi, R.5
  • 27
    • 36249024099 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha-retinoid X receptor agonists induce beta-cell protection against palmitate toxicity
    • Hellemans K., Kerckhofs K., Hannaert J.C., Martens G., Van V.P., Pipeleers D. Peroxisome proliferator-activated receptor alpha-retinoid X receptor agonists induce beta-cell protection against palmitate toxicity. FEBS J. 2007, 274:6094-6105.
    • (2007) FEBS J. , vol.274 , pp. 6094-6105
    • Hellemans, K.1    Kerckhofs, K.2    Hannaert, J.C.3    Martens, G.4    Van, V.P.5    Pipeleers, D.6
  • 28
    • 4644287377 scopus 로고    scopus 로고
    • Evidence against the involvement of oxidative stress in fatty acid inhibition of insulin secretion
    • Moore P.C., Ugas M.A., Hagman D.K., Parazzoli S.D., Poitout V. Evidence against the involvement of oxidative stress in fatty acid inhibition of insulin secretion. Diabetes 2004, 53:2610-2616.
    • (2004) Diabetes , vol.53 , pp. 2610-2616
    • Moore, P.C.1    Ugas, M.A.2    Hagman, D.K.3    Parazzoli, S.D.4    Poitout, V.5
  • 29
    • 0042531617 scopus 로고    scopus 로고
    • Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis
    • Kelpe C.L., Moore P.C., Parazzoli S.D., Wicksteed B., Rhodes C.J., Poitout V. Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis. J. Biol. Chem. 2003, 278:30015-30021.
    • (2003) J. Biol. Chem. , vol.278 , pp. 30015-30021
    • Kelpe, C.L.1    Moore, P.C.2    Parazzoli, S.D.3    Wicksteed, B.4    Rhodes, C.J.5    Poitout, V.6
  • 30
    • 70349661825 scopus 로고    scopus 로고
    • Susceptibility of pancreatic beta cells to fatty acids is regulated by LXR/PPARalpha-dependent stearoyl-coenzyme A desaturase
    • Hellemans K.H., Hannaert J.C., Denys B., et al. Susceptibility of pancreatic beta cells to fatty acids is regulated by LXR/PPARalpha-dependent stearoyl-coenzyme A desaturase. PLoS ONE 2009, 4:e7266.
    • (2009) PLoS ONE , vol.4
    • Hellemans, K.H.1    Hannaert, J.C.2    Denys, B.3
  • 31
    • 9444234587 scopus 로고    scopus 로고
    • Signaling elements involved in the metabolic regulation of mTOR by nutrients, incretins, and growth factors in islets
    • Kwon G., Marshall C.A., Pappan K.L., Remedi M.S., McDaniel M.L. Signaling elements involved in the metabolic regulation of mTOR by nutrients, incretins, and growth factors in islets. Diabetes 2004, 53(Suppl 3):S225-S232.
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 3
    • Kwon, G.1    Marshall, C.A.2    Pappan, K.L.3    Remedi, M.S.4    McDaniel, M.L.5
  • 33
    • 0042922453 scopus 로고    scopus 로고
    • Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death
    • El-Assaad W., Buteau J., Peyot M.L., et al. Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death. Endocrinology 2003, 144:4154-4163.
    • (2003) Endocrinology , vol.144 , pp. 4154-4163
    • El-Assaad, W.1    Buteau, J.2    Peyot, M.L.3
  • 34
    • 73349123190 scopus 로고    scopus 로고
    • Sterol regulatory element-binding protein-1c knockdown protected INS-1E cells from lipotoxicity, Diabetes Obes.
    • Li J., Liu X., Ran X., et al. Sterol regulatory element-binding protein-1c knockdown protected INS-1E cells from lipotoxicity, Diabetes Obes. Metab 2009, 10.1111/j.1463-1326.2009.01093.x.
    • (2009) Metab
    • Li, J.1    Liu, X.2    Ran, X.3
  • 35
    • 45249122276 scopus 로고    scopus 로고
    • Fatty acids and glucolipotoxicity in the pathogenesis of Type 2 diabetes
    • Cnop M. Fatty acids and glucolipotoxicity in the pathogenesis of Type 2 diabetes. Biochem. Soc. Trans. 2008, 36:348-352.
    • (2008) Biochem. Soc. Trans. , vol.36 , pp. 348-352
    • Cnop, M.1
  • 36
    • 34548327160 scopus 로고    scopus 로고
    • Anti-apoptotic effects of arachidonic acid and prostaglandin E2 in pancreatic beta-cells
    • Papadimitriou A., King A.J., Jones P.M., Persaud S.J. Anti-apoptotic effects of arachidonic acid and prostaglandin E2 in pancreatic beta-cells. Cell Physiol. Biochem. 2007, 20:607-616.
    • (2007) Cell Physiol. Biochem. , vol.20 , pp. 607-616
    • Papadimitriou, A.1    King, A.J.2    Jones, P.M.3    Persaud, S.J.4
  • 37
    • 0141989943 scopus 로고    scopus 로고
    • Linoleic acid and antioxidants protect against DNA damage and apoptosis induced by palmitic acid
    • Beeharry N., Lowe J.E., Hernandez A.R., et al. Linoleic acid and antioxidants protect against DNA damage and apoptosis induced by palmitic acid. Mutat. Res. 2003, 530:27-33.
    • (2003) Mutat. Res. , vol.530 , pp. 27-33
    • Beeharry, N.1    Lowe, J.E.2    Hernandez, A.R.3
  • 38
    • 0029945620 scopus 로고    scopus 로고
    • Arachidonic acid protects against hypoxic injury in rat proximal tubules
    • Alkhunaizi A.M., Yaqoob M.M., Edelstein C.L., et al. Arachidonic acid protects against hypoxic injury in rat proximal tubules. Kidney Int. 1996, 49:620-625.
    • (1996) Kidney Int. , vol.49 , pp. 620-625
    • Alkhunaizi, A.M.1    Yaqoob, M.M.2    Edelstein, C.L.3
  • 39
    • 58149095589 scopus 로고    scopus 로고
    • International Union of Pharmacology. LXXI. Free fatty acid receptors FFA1, -2, and -3: pharmacology and pathophysiological functions
    • Stoddart L.A., Smith N.J., Milligan G. International Union of Pharmacology. LXXI. Free fatty acid receptors FFA1, -2, and -3: pharmacology and pathophysiological functions. Pharmacol. Rev. 2008, 60:405-417.
    • (2008) Pharmacol. Rev. , vol.60 , pp. 405-417
    • Stoddart, L.A.1    Smith, N.J.2    Milligan, G.3
  • 40
    • 69549111756 scopus 로고    scopus 로고
    • Molecular pharmacology of promiscuous 7TM receptors sensing organic nutrients
    • Wellendorph P., Johansen L.D., Brauner-Osborne H. Molecular pharmacology of promiscuous 7TM receptors sensing organic nutrients. Mol. Pharmacol. 2009, 10.1124/mol.109.055244.
    • (2009) Mol. Pharmacol.
    • Wellendorph, P.1    Johansen, L.D.2    Brauner-Osborne, H.3
  • 41
    • 33751520308 scopus 로고    scopus 로고
    • Free fatty acids increase cytosolic free calcium and stimulate insulin secretion from beta-cells through activation of GPR40
    • Schnell S., Schaefer M., Schofl C. Free fatty acids increase cytosolic free calcium and stimulate insulin secretion from beta-cells through activation of GPR40. Mol. Cell Endocrinol. 2007, 263:173-180.
    • (2007) Mol. Cell Endocrinol. , vol.263 , pp. 173-180
    • Schnell, S.1    Schaefer, M.2    Schofl, C.3
  • 42
    • 0037838892 scopus 로고    scopus 로고
    • The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids
    • Briscoe C.P., Tadayyon M., Andrews J.L., et al. The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids. J. Biol. Chem. 2003, 278:11303-11311.
    • (2003) J. Biol. Chem. , vol.278 , pp. 11303-11311
    • Briscoe, C.P.1    Tadayyon, M.2    Andrews, J.L.3
  • 43
    • 0037434991 scopus 로고    scopus 로고
    • Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40
    • Itoh Y., Kawamata Y., Harada M., et al. Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40. Nature 2003, 422:173-176.
    • (2003) Nature , vol.422 , pp. 173-176
    • Itoh, Y.1    Kawamata, Y.2    Harada, M.3
  • 44
    • 0038363378 scopus 로고    scopus 로고
    • The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids
    • Brown A.J., Goldsworthy S.M., Barnes A.A., et al. The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. J. Biol. Chem. 2003, 278:11312-11319.
    • (2003) J. Biol. Chem. , vol.278 , pp. 11312-11319
    • Brown, A.J.1    Goldsworthy, S.M.2    Barnes, A.A.3
  • 45
    • 0037453280 scopus 로고    scopus 로고
    • Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids
    • Nilsson N.E., Kotarsky K., Owman C., Olde B. Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids. Biochem. Biophys. Res. Commun. 2003, 303:1047-1052.
    • (2003) Biochem. Biophys. Res. Commun. , vol.303 , pp. 1047-1052
    • Nilsson, N.E.1    Kotarsky, K.2    Owman, C.3    Olde, B.4
  • 46
    • 35748937333 scopus 로고    scopus 로고
    • Identification of residues important for agonist recognition and activation in GPR40
    • Sum C.S., Tikhonova I.G., Neumann S., et al. Identification of residues important for agonist recognition and activation in GPR40. J. Biol. Chem. 2007, 282:29248-29255.
    • (2007) J. Biol. Chem. , vol.282 , pp. 29248-29255
    • Sum, C.S.1    Tikhonova, I.G.2    Neumann, S.3
  • 47
    • 65549142522 scopus 로고    scopus 로고
    • GPR119 is essential for oleoylethanolamide-induced glucagon-like peptide-1 secretion from the intestinal enteroendocrine L-cell
    • Lauffer L.M., Iakoubov R., Brubaker P.L. GPR119 is essential for oleoylethanolamide-induced glucagon-like peptide-1 secretion from the intestinal enteroendocrine L-cell. Diabetes 2009, 58:1058-1066.
    • (2009) Diabetes , vol.58 , pp. 1058-1066
    • Lauffer, L.M.1    Iakoubov, R.2    Brubaker, P.L.3
  • 48
    • 34248527678 scopus 로고    scopus 로고
    • A role for beta-cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucose-dependent insulin release
    • Chu Z.L., Jones R.M., He H., et al. A role for beta-cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucose-dependent insulin release. Endocrinology 2007, 148:2601-2609.
    • (2007) Endocrinology , vol.148 , pp. 2601-2609
    • Chu, Z.L.1    Jones, R.M.2    He, H.3
  • 49
    • 33644627958 scopus 로고    scopus 로고
    • Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents
    • Overton H.A., Babbs A.J., Doel S.M., et al. Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metab. 2006, 3:167-175.
    • (2006) Cell Metab. , vol.3 , pp. 167-175
    • Overton, H.A.1    Babbs, A.J.2    Doel, S.M.3
  • 51
    • 65549114432 scopus 로고    scopus 로고
    • Over expression of GPR40 in pancreatic beta-cells augments glucose-stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice
    • Nagasumi K., Esaki R., Iwachidow K., et al. Over expression of GPR40 in pancreatic beta-cells augments glucose-stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice. Diabetes 2009, 58:1067-1076.
    • (2009) Diabetes , vol.58 , pp. 1067-1076
    • Nagasumi, K.1    Esaki, R.2    Iwachidow, K.3
  • 52
    • 59849110228 scopus 로고    scopus 로고
    • Acute administration of GPR40 receptor agonist potentiates glucose-stimulated insulin secretion in vivo in the rat
    • Doshi L.S., Brahma M.K., Sayyed S.G., et al. Acute administration of GPR40 receptor agonist potentiates glucose-stimulated insulin secretion in vivo in the rat. Metabolism 2009, 58:333-343.
    • (2009) Metabolism , vol.58 , pp. 333-343
    • Doshi, L.S.1    Brahma, M.K.2    Sayyed, S.G.3
  • 53
    • 70350309324 scopus 로고    scopus 로고
    • Lipid receptors and islet function: therapeutic implications?
    • Kebede M.A., Alquier T., Latour M.G., Poitout V. Lipid receptors and islet function: therapeutic implications?. Diabetes Obes. Metab. 2009, 11(Suppl 4):10-20.
    • (2009) Diabetes Obes. Metab. , vol.11 , Issue.SUPPL. 4 , pp. 10-20
    • Kebede, M.A.1    Alquier, T.2    Latour, M.G.3    Poitout, V.4
  • 55
    • 47749128507 scopus 로고    scopus 로고
    • Seven transmembrane-spanning receptors for free fatty acids as therapeutic targets for diabetes mellitus: pharmacological, phylogenetic, and drug discovery aspects
    • Costanzi S., Neumann S., Gershengorn M.C. Seven transmembrane-spanning receptors for free fatty acids as therapeutic targets for diabetes mellitus: pharmacological, phylogenetic, and drug discovery aspects. J. Biol. Chem. 2008, 283:16269-16273.
    • (2008) J. Biol. Chem. , vol.283 , pp. 16269-16273
    • Costanzi, S.1    Neumann, S.2    Gershengorn, M.C.3
  • 56
    • 0027275837 scopus 로고
    • Interactions of long-chain fatty acids and albumin: determination of free fatty acid levels using the fluorescent probe ADIFAB
    • Richieri G.V., Anel A., Kleinfeld A.M. Interactions of long-chain fatty acids and albumin: determination of free fatty acid levels using the fluorescent probe ADIFAB. Biochemistry 1993, 32:7574-7580.
    • (1993) Biochemistry , vol.32 , pp. 7574-7580
    • Richieri, G.V.1    Anel, A.2    Kleinfeld, A.M.3
  • 57
    • 0028821009 scopus 로고
    • Unbound free fatty acid levels in human serum
    • Richieri G.V., Kleinfeld A.M. Unbound free fatty acid levels in human serum. J. Lipid Res. 1995, 36:229-240.
    • (1995) J. Lipid Res. , vol.36 , pp. 229-240
    • Richieri, G.V.1    Kleinfeld, A.M.2
  • 58
    • 73749085921 scopus 로고    scopus 로고
    • Facilitation of fatty acid uptake by CD36 in insulin-producing cells reduces fatty-acid-induced insulin secretion and glucose regulation of fatty acid oxidation
    • doi:10.1016/j.bbalip.2009.11.002.
    • T. Wallin, Z. Ma, H. Ogata et al., Facilitation of fatty acid uptake by CD36 in insulin-producing cells reduces fatty-acid-induced insulin secretion and glucose regulation of fatty acid oxidation, Biochim. Biophys. Acta, 2009, doi:10.1016/j.bbalip.2009.11.002.
    • (2009) Biochim. Biophys. Acta
    • Wallin, T.1    Ma, Z.2    Ogata, H.3
  • 59
    • 51649099019 scopus 로고    scopus 로고
    • Uptake of long chain fatty acids is regulated by dynamic interaction of FAT/CD36 with cholesterol/sphingolipid enriched microdomains (lipid rafts)
    • Ehehalt R., Sparla R., Kulaksiz H., Herrmann T., Fullekrug J., Stremmel W. Uptake of long chain fatty acids is regulated by dynamic interaction of FAT/CD36 with cholesterol/sphingolipid enriched microdomains (lipid rafts). BMC. Cell Biol. 2008, 9:45.
    • (2008) BMC. Cell Biol. , vol.9 , pp. 45
    • Ehehalt, R.1    Sparla, R.2    Kulaksiz, H.3    Herrmann, T.4    Fullekrug, J.5    Stremmel, W.6
  • 60
    • 33947140482 scopus 로고    scopus 로고
    • Importance of the carboxyl terminus of FAT/CD36 for plasma membrane localization and function in long-chain fatty acid uptake
    • Eyre N.S., Cleland L.G., Tandon N.N., Mayrhofer G. Importance of the carboxyl terminus of FAT/CD36 for plasma membrane localization and function in long-chain fatty acid uptake. J. Lipid Res. 2007, 48:528-542.
    • (2007) J. Lipid Res. , vol.48 , pp. 528-542
    • Eyre, N.S.1    Cleland, L.G.2    Tandon, N.N.3    Mayrhofer, G.4
  • 61
    • 26444485985 scopus 로고    scopus 로고
    • Long-chain fatty acid uptake and FAT/CD36 translocation in heart and skeletal muscle
    • Koonen D.P., Glatz J.F., Bonen A., Luiken J.J. Long-chain fatty acid uptake and FAT/CD36 translocation in heart and skeletal muscle. Biochim. Biophys. Acta 2005, 1736:163-180.
    • (2005) Biochim. Biophys. Acta , vol.1736 , pp. 163-180
    • Koonen, D.P.1    Glatz, J.F.2    Bonen, A.3    Luiken, J.J.4
  • 62
    • 0036812863 scopus 로고    scopus 로고
    • Sulfo-N-succinimidyl esters of long chain fatty acids specifically inhibit fatty acid translocase (FAT/CD36)-mediated cellular fatty acid uptake
    • Coort S.L., Willems J., Coumans W.A., van der Vusse G.J., Bonen A., Glatz J.F., Luiken J.J. Sulfo-N-succinimidyl esters of long chain fatty acids specifically inhibit fatty acid translocase (FAT/CD36)-mediated cellular fatty acid uptake. Mol. Cell Biochem. 2002, 239:213-219.
    • (2002) Mol. Cell Biochem. , vol.239 , pp. 213-219
    • Coort, S.L.1    Willems, J.2    Coumans, W.A.3    van der Vusse, G.J.4    Bonen, A.5    Glatz, J.F.6    Luiken, J.J.7
  • 63
    • 25844454854 scopus 로고    scopus 로고
    • Increased fatty acid desaturation and enhanced expression of stearoyl coenzyme A desaturase protects pancreatic beta-cells from lipoapoptosis
    • Busch A.K., Gurisik E., Cordery D.V., et al. Increased fatty acid desaturation and enhanced expression of stearoyl coenzyme A desaturase protects pancreatic beta-cells from lipoapoptosis. Diabetes 2005, 54:2917-2924.
    • (2005) Diabetes , vol.54 , pp. 2917-2924
    • Busch, A.K.1    Gurisik, E.2    Cordery, D.V.3
  • 64
    • 70349871409 scopus 로고    scopus 로고
    • Reduced endoplasmic reticulum (ER)-to-Golgi protein trafficking contributes to ER stress in lipotoxic mouse beta cells by promoting protein overload
    • Preston A.M., Gurisik E., Bartley C., Laybutt D.R., Biden T.J. Reduced endoplasmic reticulum (ER)-to-Golgi protein trafficking contributes to ER stress in lipotoxic mouse beta cells by promoting protein overload. Diabetologia 2009, 10.1007/s00125-009-1506-5.
    • (2009) Diabetologia
    • Preston, A.M.1    Gurisik, E.2    Bartley, C.3    Laybutt, D.R.4    Biden, T.J.5
  • 65
    • 39149104320 scopus 로고    scopus 로고
    • The role for endoplasmic reticulum stress in diabetes mellitus
    • Eizirik D.L., Cardozo A.K., Cnop M. The role for endoplasmic reticulum stress in diabetes mellitus. Endocr. Rev. 2008, 29:42-61.
    • (2008) Endocr. Rev. , vol.29 , pp. 42-61
    • Eizirik, D.L.1    Cardozo, A.K.2    Cnop, M.3
  • 66
    • 44949214679 scopus 로고    scopus 로고
    • Differential regulation of the endoplasmic reticulum stress response in pancreatic beta-cells exposed to long-chain saturated and monounsaturated fatty acids
    • Diakogiannaki E., Welters H.J., Morgan N.G. Differential regulation of the endoplasmic reticulum stress response in pancreatic beta-cells exposed to long-chain saturated and monounsaturated fatty acids. J. Endocrinol. 2008, 197:553-563.
    • (2008) J. Endocrinol. , vol.197 , pp. 553-563
    • Diakogiannaki, E.1    Welters, H.J.2    Morgan, N.G.3
  • 67
    • 40449106191 scopus 로고    scopus 로고
    • Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic beta-cells
    • Lai E., Bikopoulos G., Wheeler M.B., Rozakis-Adcock M., Volchuk A. Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic beta-cells. Am. J. Physiol. Endocrinol. Metab. 2008, 294:E540-E550.
    • (2008) Am. J. Physiol. Endocrinol. Metab. , vol.294
    • Lai, E.1    Bikopoulos, G.2    Wheeler, M.B.3    Rozakis-Adcock, M.4    Volchuk, A.5
  • 68
    • 49649084031 scopus 로고    scopus 로고
    • Initiation and execution of lipotoxic ER stress in pancreatic beta-cells
    • Cunha D.A., Hekerman P., Ladriere L., et al. Initiation and execution of lipotoxic ER stress in pancreatic beta-cells. J. Cell Sci. 2008, 121:2308-2318.
    • (2008) J. Cell Sci. , vol.121 , pp. 2308-2318
    • Cunha, D.A.1    Hekerman, P.2    Ladriere, L.3
  • 69
    • 33745116619 scopus 로고    scopus 로고
    • Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis
    • Karaskov E., Scott C., Zhang L., Teodoro T., Ravazzola M., Volchuk A. Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis. Endocrinology 2006, 147:3398-3407.
    • (2006) Endocrinology , vol.147 , pp. 3398-3407
    • Karaskov, E.1    Scott, C.2    Zhang, L.3    Teodoro, T.4    Ravazzola, M.5    Volchuk, A.6


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