-
1
-
-
70549113397
-
Role of glucotoxicity and lipotoxicity in the pathophysiology of Type 2 diabetes mellitus and emerging treatment strategies
-
Del Prato S. Role of glucotoxicity and lipotoxicity in the pathophysiology of Type 2 diabetes mellitus and emerging treatment strategies. Diabet. Med. 2009, 26:1185-1192.
-
(2009)
Diabet. Med.
, vol.26
, pp. 1185-1192
-
-
Del Prato, S.1
-
2
-
-
70350312488
-
Genetic and biochemical pathways of beta-cell failure in type 2 diabetes
-
Talchai C., Lin H.V., Kitamura T., Accili D. Genetic and biochemical pathways of beta-cell failure in type 2 diabetes. Diabet. Obes. Metab. 2009, 11(Suppl 4):38-45.
-
(2009)
Diabet. Obes. Metab.
, vol.11
, Issue.SUPPL. 4
, pp. 38-45
-
-
Talchai, C.1
Lin, H.V.2
Kitamura, T.3
Accili, D.4
-
3
-
-
70349398318
-
Beta-cell deterioration during diabetes: what's in the gun?
-
Robertson R.P. Beta-cell deterioration during diabetes: what's in the gun?. Trends Endocrinol. Metab. 2009, 20:388-393.
-
(2009)
Trends Endocrinol. Metab.
, vol.20
, pp. 388-393
-
-
Robertson, R.P.1
-
4
-
-
43549108142
-
Glucolipotoxicity: fuel excess and beta-cell dysfunction
-
Poitout V., Robertson R.P. Glucolipotoxicity: fuel excess and beta-cell dysfunction. Endocr. Rev. 2008, 29:351-366.
-
(2008)
Endocr. Rev.
, vol.29
, pp. 351-366
-
-
Poitout, V.1
Robertson, R.P.2
-
5
-
-
67349228410
-
The beta cell lesion in type 2 diabetes: there has to be a primary functional abnormality
-
Kahn S.E., Zraika S., Utzschneider K.M., Hull R.L. The beta cell lesion in type 2 diabetes: there has to be a primary functional abnormality. Diabetologia 2009, 52:1003-1012.
-
(2009)
Diabetologia
, vol.52
, pp. 1003-1012
-
-
Kahn, S.E.1
Zraika, S.2
Utzschneider, K.M.3
Hull, R.L.4
-
6
-
-
76049113712
-
Glucolipotoxicity of the pancreatic beta cell
-
doi: 10.1016/j.bbalip.2009.08.006.
-
V. Poitout, J. Amyot, M. Semache, B. Zarrouki, D. Hagman, G. Fontes, Glucolipotoxicity of the pancreatic beta cell, Biochim. Biophys. Acta, 2009 doi: 10.1016/j.bbalip.2009.08.006.
-
(2009)
Biochim. Biophys. Acta
-
-
Poitout, V.1
Amyot, J.2
Semache, M.3
Zarrouki, B.4
Hagman, D.5
Fontes, G.6
-
7
-
-
33845517309
-
Fatty acid signaling in the beta-cell and insulin secretion
-
Nolan C.J., Madiraju M.S., ghingaro-Augusto V., Peyot M.L., Prentki M. Fatty acid signaling in the beta-cell and insulin secretion. Diabetes 2006, 55(Suppl 2):S16-S23.
-
(2006)
Diabetes
, vol.55
, Issue.SUPPL. 2
-
-
Nolan, C.J.1
Madiraju, M.S.2
ghingaro-Augusto, V.3
Peyot, M.L.4
Prentki, M.5
-
8
-
-
70349988797
-
G-protein coupled receptors mediating long chain fatty acid signalling in the pancreatic beta-cell
-
Morgan N.G., Dhayal S. G-protein coupled receptors mediating long chain fatty acid signalling in the pancreatic beta-cell. Biochem. Pharmacol. 2009, 78:1419-1427.
-
(2009)
Biochem. Pharmacol.
, vol.78
, pp. 1419-1427
-
-
Morgan, N.G.1
Dhayal, S.2
-
9
-
-
33846267745
-
Life and death decisions of the pancreatic beta-cell: the role of fatty acids
-
Newsholme P., Keane D., Welters H.J., Morgan N.G. Life and death decisions of the pancreatic beta-cell: the role of fatty acids. Clin. Sci. (Lond) 2007, 112:27-42.
-
(2007)
Clin. Sci. (Lond)
, vol.112
, pp. 27-42
-
-
Newsholme, P.1
Keane, D.2
Welters, H.J.3
Morgan, N.G.4
-
10
-
-
32544435755
-
New insights into fatty acid modulation of pancreatic beta-cell function
-
Haber E.P., Procopio J., Carvalho C.R., Carpinelli A.R., Newsholme P., Curi R. New insights into fatty acid modulation of pancreatic beta-cell function. Int. Rev. Cytol. 2006, 248:1-41.
-
(2006)
Int. Rev. Cytol.
, vol.248
, pp. 1-41
-
-
Haber, E.P.1
Procopio, J.2
Carvalho, C.R.3
Carpinelli, A.R.4
Newsholme, P.5
Curi, R.6
-
11
-
-
33746190686
-
Fatty acid-induced toxicity and neutral lipid accumulation in insulin-producing RINm5F cells
-
zevedo-Martins A.K., Monteiro A.P., Lima C.L., Lenzen S., Curi R. Fatty acid-induced toxicity and neutral lipid accumulation in insulin-producing RINm5F cells. Toxicol. In Vitro 2006, 20:1106-1113.
-
(2006)
Toxicol. In Vitro
, vol.20
, pp. 1106-1113
-
-
zevedo-Martins, A.K.1
Monteiro, A.P.2
Lima, C.L.3
Lenzen, S.4
Curi, R.5
-
12
-
-
0036924861
-
Different role of saturated unsaturated fatty acids in beta-cell apoptosis
-
Eitel K., Staiger H., Brendel M.D., et al. Different role of saturated unsaturated fatty acids in beta-cell apoptosis. Biochem. Biophys. Res. Commun. 2002, 299:853-856.
-
(2002)
Biochem. Biophys. Res. Commun.
, vol.299
, pp. 853-856
-
-
Eitel, K.1
Staiger, H.2
Brendel, M.D.3
-
13
-
-
1342286820
-
Mono-unsaturated fatty acids protect against beta-cell apoptosis induced by saturated fatty acids, serum withdrawal or cytokine exposure
-
Welters H.J., Tadayyon M., Scarpello J.H., Smith S.A., Morgan N.G. Mono-unsaturated fatty acids protect against beta-cell apoptosis induced by saturated fatty acids, serum withdrawal or cytokine exposure. FEBS Lett. 2004, 560:103-108.
-
(2004)
FEBS Lett.
, vol.560
, pp. 103-108
-
-
Welters, H.J.1
Tadayyon, M.2
Scarpello, J.H.3
Smith, S.A.4
Morgan, N.G.5
-
14
-
-
65949087032
-
Lipotoxicity: why do saturated fatty acids cause and monounsaturates protect against it?
-
Nolan C.J., Larter C.Z. Lipotoxicity: why do saturated fatty acids cause and monounsaturates protect against it?. J. Gastroenterol. Hepatol. 2009, 24:703-706.
-
(2009)
J. Gastroenterol. Hepatol.
, vol.24
, pp. 703-706
-
-
Nolan, C.J.1
Larter, C.Z.2
-
15
-
-
77449141236
-
Cellular Production of {omega}-3 PUFAs and Reduction of {omega}-6/{omega}-3 ratios in the Pancreatic {beta}-cells and Islets Enhance Insulin Secretion and Confer Protection against Cytokine-induced Cell Death
-
Wei D., Li J., Shen M., et al. Cellular Production of {omega}-3 PUFAs and Reduction of {omega}-6/{omega}-3 ratios in the Pancreatic {beta}-cells and Islets Enhance Insulin Secretion and Confer Protection against Cytokine-induced Cell Death. Diabetes 2009, 10.2337/db09-0284.
-
(2009)
Diabetes
-
-
Wei, D.1
Li, J.2
Shen, M.3
-
16
-
-
40849099994
-
Comparison of the effect of individual saturated and unsaturated fatty acids on cell growth and death induction in the human pancreatic beta-cell line NES2Y
-
Furstova V., Kopska T., James R.F., Kovar J. Comparison of the effect of individual saturated and unsaturated fatty acids on cell growth and death induction in the human pancreatic beta-cell line NES2Y. Life Sci. 2008, 82:684-691.
-
(2008)
Life Sci.
, vol.82
, pp. 684-691
-
-
Furstova, V.1
Kopska, T.2
James, R.F.3
Kovar, J.4
-
17
-
-
42149111577
-
Structural requirements for the cytoprotective actions of mono-unsaturated fatty acids in the pancreatic beta-cell line, BRIN-BD11
-
Dhayal S., Welters H.J., Morgan N.G. Structural requirements for the cytoprotective actions of mono-unsaturated fatty acids in the pancreatic beta-cell line, BRIN-BD11. Br. J. Pharmacol. 2008, 153:1718-1727.
-
(2008)
Br. J. Pharmacol.
, vol.153
, pp. 1718-1727
-
-
Dhayal, S.1
Welters, H.J.2
Morgan, N.G.3
-
18
-
-
34547888676
-
Mechanisms involved in the cytotoxic and cytoprotective actions of saturated versus monounsaturated long-chain fatty acids in pancreatic {beta}-cells
-
Diakogiannaki E., Dhayal S., Childs C.E., Calder P.C., Welters H.J., Morgan N.G. Mechanisms involved in the cytotoxic and cytoprotective actions of saturated versus monounsaturated long-chain fatty acids in pancreatic {beta}-cells. J. Endocrinol. 2007, 194:283-291.
-
(2007)
J. Endocrinol.
, vol.194
, pp. 283-291
-
-
Diakogiannaki, E.1
Dhayal, S.2
Childs, C.E.3
Calder, P.C.4
Welters, H.J.5
Morgan, N.G.6
-
19
-
-
0345354674
-
Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function
-
Maedler K., Oberholzer J., Bucher P., Spinas G.A., Donath M.Y. Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function. Diabetes 2003, 52:726-733.
-
(2003)
Diabetes
, vol.52
, pp. 726-733
-
-
Maedler, K.1
Oberholzer, J.2
Bucher, P.3
Spinas, G.A.4
Donath, M.Y.5
-
20
-
-
0035126282
-
Protective action of arachidonic acid against alloxan-induced cytotoxicity and diabetes mellitus
-
Suresh Y., Das U.N. Protective action of arachidonic acid against alloxan-induced cytotoxicity and diabetes mellitus. Prostaglandins Leukot. Essent. Fatty Acids 2001, 64:37-52.
-
(2001)
Prostaglandins Leukot. Essent. Fatty Acids
, vol.64
, pp. 37-52
-
-
Suresh, Y.1
Das, U.N.2
-
21
-
-
24944526652
-
Adverse physicochemical properties of tripalmitin in beta cells lead to morphological changes and lipotoxicity in vitro
-
Moffitt J.H., Fielding B.A., Evershed R., Berstan R., Currie J.M., Clark A. Adverse physicochemical properties of tripalmitin in beta cells lead to morphological changes and lipotoxicity in vitro. Diabetologia 2005, 48:1819-1829.
-
(2005)
Diabetologia
, vol.48
, pp. 1819-1829
-
-
Moffitt, J.H.1
Fielding, B.A.2
Evershed, R.3
Berstan, R.4
Currie, J.M.5
Clark, A.6
-
22
-
-
77449139439
-
Over-expression of kinase negative protein kinase C{delta} in pancreatic {beta}-cells protects mice from diet-induced glucose intolerance and {beta}-cell dysfunction
-
Hennige A.M., Ranta F., Heinzelmann I., et al. Over-expression of kinase negative protein kinase C{delta} in pancreatic {beta}-cells protects mice from diet-induced glucose intolerance and {beta}-cell dysfunction. Diabetes 2009, 10.2337/db09-0512.
-
(2009)
Diabetes
-
-
Hennige, A.M.1
Ranta, F.2
Heinzelmann, I.3
-
23
-
-
0036315888
-
Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated
-
Lupi R., Dotta F., Marselli L., et al. Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated. Diabetes 2002, 51:1437-1442.
-
(2002)
Diabetes
, vol.51
, pp. 1437-1442
-
-
Lupi, R.1
Dotta, F.2
Marselli, L.3
-
24
-
-
43149084152
-
Limited mitochondrial permeabilization is an early manifestation of palmitate-induced lipotoxicity in pancreatic beta-cells
-
Koshkin V., Dai F.F., Robson-Doucette C.A., Chan C.B., Wheeler M.B. Limited mitochondrial permeabilization is an early manifestation of palmitate-induced lipotoxicity in pancreatic beta-cells. J. Biol. Chem. 2008, 283:7936-7948.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 7936-7948
-
-
Koshkin, V.1
Dai, F.F.2
Robson-Doucette, C.A.3
Chan, C.B.4
Wheeler, M.B.5
-
25
-
-
47749122129
-
Rosiglitazone counteracts palmitate-induced beta-cell dysfunction by suppression of MAP kinase, inducible nitric oxide synthase and caspase 3 activities
-
Abaraviciene S.M., Lundquist I., Salehi A. Rosiglitazone counteracts palmitate-induced beta-cell dysfunction by suppression of MAP kinase, inducible nitric oxide synthase and caspase 3 activities. Cell Mol. Life Sci. 2008, 65:2256-2265.
-
(2008)
Cell Mol. Life Sci.
, vol.65
, pp. 2256-2265
-
-
Abaraviciene, S.M.1
Lundquist, I.2
Salehi, A.3
-
26
-
-
41949128158
-
Persistent activation of Akt or ERK prevents the toxicity induced by saturated and polyunsaturated fatty acids in RINm5F beta-cells
-
Simon M.N., zevedo-Martins A.K., Amanso A.M., Carvalho C.R., Curi R. Persistent activation of Akt or ERK prevents the toxicity induced by saturated and polyunsaturated fatty acids in RINm5F beta-cells. Toxicol. In Vitro 2008, 22:1018-1024.
-
(2008)
Toxicol. In Vitro
, vol.22
, pp. 1018-1024
-
-
Simon, M.N.1
zevedo-Martins, A.K.2
Amanso, A.M.3
Carvalho, C.R.4
Curi, R.5
-
27
-
-
36249024099
-
Peroxisome proliferator-activated receptor alpha-retinoid X receptor agonists induce beta-cell protection against palmitate toxicity
-
Hellemans K., Kerckhofs K., Hannaert J.C., Martens G., Van V.P., Pipeleers D. Peroxisome proliferator-activated receptor alpha-retinoid X receptor agonists induce beta-cell protection against palmitate toxicity. FEBS J. 2007, 274:6094-6105.
-
(2007)
FEBS J.
, vol.274
, pp. 6094-6105
-
-
Hellemans, K.1
Kerckhofs, K.2
Hannaert, J.C.3
Martens, G.4
Van, V.P.5
Pipeleers, D.6
-
28
-
-
4644287377
-
Evidence against the involvement of oxidative stress in fatty acid inhibition of insulin secretion
-
Moore P.C., Ugas M.A., Hagman D.K., Parazzoli S.D., Poitout V. Evidence against the involvement of oxidative stress in fatty acid inhibition of insulin secretion. Diabetes 2004, 53:2610-2616.
-
(2004)
Diabetes
, vol.53
, pp. 2610-2616
-
-
Moore, P.C.1
Ugas, M.A.2
Hagman, D.K.3
Parazzoli, S.D.4
Poitout, V.5
-
29
-
-
0042531617
-
Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis
-
Kelpe C.L., Moore P.C., Parazzoli S.D., Wicksteed B., Rhodes C.J., Poitout V. Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis. J. Biol. Chem. 2003, 278:30015-30021.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 30015-30021
-
-
Kelpe, C.L.1
Moore, P.C.2
Parazzoli, S.D.3
Wicksteed, B.4
Rhodes, C.J.5
Poitout, V.6
-
30
-
-
70349661825
-
Susceptibility of pancreatic beta cells to fatty acids is regulated by LXR/PPARalpha-dependent stearoyl-coenzyme A desaturase
-
Hellemans K.H., Hannaert J.C., Denys B., et al. Susceptibility of pancreatic beta cells to fatty acids is regulated by LXR/PPARalpha-dependent stearoyl-coenzyme A desaturase. PLoS ONE 2009, 4:e7266.
-
(2009)
PLoS ONE
, vol.4
-
-
Hellemans, K.H.1
Hannaert, J.C.2
Denys, B.3
-
31
-
-
9444234587
-
Signaling elements involved in the metabolic regulation of mTOR by nutrients, incretins, and growth factors in islets
-
Kwon G., Marshall C.A., Pappan K.L., Remedi M.S., McDaniel M.L. Signaling elements involved in the metabolic regulation of mTOR by nutrients, incretins, and growth factors in islets. Diabetes 2004, 53(Suppl 3):S225-S232.
-
(2004)
Diabetes
, vol.53
, Issue.SUPPL. 3
-
-
Kwon, G.1
Marshall, C.A.2
Pappan, K.L.3
Remedi, M.S.4
McDaniel, M.L.5
-
32
-
-
0037950650
-
[Apoptosis induced by free fatty acids]
-
Eitel K., Staiger H., Brendel M.D., Brandhorst H., Bretzel R.G., Haring H.U., Kellerer M. [Apoptosis induced by free fatty acids]. Med. Klin. (Munich) 2003, 98:248-252.
-
(2003)
Med. Klin. (Munich)
, vol.98
, pp. 248-252
-
-
Eitel, K.1
Staiger, H.2
Brendel, M.D.3
Brandhorst, H.4
Bretzel, R.G.5
Haring, H.U.6
Kellerer, M.7
-
33
-
-
0042922453
-
Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death
-
El-Assaad W., Buteau J., Peyot M.L., et al. Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death. Endocrinology 2003, 144:4154-4163.
-
(2003)
Endocrinology
, vol.144
, pp. 4154-4163
-
-
El-Assaad, W.1
Buteau, J.2
Peyot, M.L.3
-
34
-
-
73349123190
-
Sterol regulatory element-binding protein-1c knockdown protected INS-1E cells from lipotoxicity, Diabetes Obes.
-
Li J., Liu X., Ran X., et al. Sterol regulatory element-binding protein-1c knockdown protected INS-1E cells from lipotoxicity, Diabetes Obes. Metab 2009, 10.1111/j.1463-1326.2009.01093.x.
-
(2009)
Metab
-
-
Li, J.1
Liu, X.2
Ran, X.3
-
35
-
-
45249122276
-
Fatty acids and glucolipotoxicity in the pathogenesis of Type 2 diabetes
-
Cnop M. Fatty acids and glucolipotoxicity in the pathogenesis of Type 2 diabetes. Biochem. Soc. Trans. 2008, 36:348-352.
-
(2008)
Biochem. Soc. Trans.
, vol.36
, pp. 348-352
-
-
Cnop, M.1
-
36
-
-
34548327160
-
Anti-apoptotic effects of arachidonic acid and prostaglandin E2 in pancreatic beta-cells
-
Papadimitriou A., King A.J., Jones P.M., Persaud S.J. Anti-apoptotic effects of arachidonic acid and prostaglandin E2 in pancreatic beta-cells. Cell Physiol. Biochem. 2007, 20:607-616.
-
(2007)
Cell Physiol. Biochem.
, vol.20
, pp. 607-616
-
-
Papadimitriou, A.1
King, A.J.2
Jones, P.M.3
Persaud, S.J.4
-
37
-
-
0141989943
-
Linoleic acid and antioxidants protect against DNA damage and apoptosis induced by palmitic acid
-
Beeharry N., Lowe J.E., Hernandez A.R., et al. Linoleic acid and antioxidants protect against DNA damage and apoptosis induced by palmitic acid. Mutat. Res. 2003, 530:27-33.
-
(2003)
Mutat. Res.
, vol.530
, pp. 27-33
-
-
Beeharry, N.1
Lowe, J.E.2
Hernandez, A.R.3
-
38
-
-
0029945620
-
Arachidonic acid protects against hypoxic injury in rat proximal tubules
-
Alkhunaizi A.M., Yaqoob M.M., Edelstein C.L., et al. Arachidonic acid protects against hypoxic injury in rat proximal tubules. Kidney Int. 1996, 49:620-625.
-
(1996)
Kidney Int.
, vol.49
, pp. 620-625
-
-
Alkhunaizi, A.M.1
Yaqoob, M.M.2
Edelstein, C.L.3
-
39
-
-
58149095589
-
International Union of Pharmacology. LXXI. Free fatty acid receptors FFA1, -2, and -3: pharmacology and pathophysiological functions
-
Stoddart L.A., Smith N.J., Milligan G. International Union of Pharmacology. LXXI. Free fatty acid receptors FFA1, -2, and -3: pharmacology and pathophysiological functions. Pharmacol. Rev. 2008, 60:405-417.
-
(2008)
Pharmacol. Rev.
, vol.60
, pp. 405-417
-
-
Stoddart, L.A.1
Smith, N.J.2
Milligan, G.3
-
40
-
-
69549111756
-
Molecular pharmacology of promiscuous 7TM receptors sensing organic nutrients
-
Wellendorph P., Johansen L.D., Brauner-Osborne H. Molecular pharmacology of promiscuous 7TM receptors sensing organic nutrients. Mol. Pharmacol. 2009, 10.1124/mol.109.055244.
-
(2009)
Mol. Pharmacol.
-
-
Wellendorph, P.1
Johansen, L.D.2
Brauner-Osborne, H.3
-
41
-
-
33751520308
-
Free fatty acids increase cytosolic free calcium and stimulate insulin secretion from beta-cells through activation of GPR40
-
Schnell S., Schaefer M., Schofl C. Free fatty acids increase cytosolic free calcium and stimulate insulin secretion from beta-cells through activation of GPR40. Mol. Cell Endocrinol. 2007, 263:173-180.
-
(2007)
Mol. Cell Endocrinol.
, vol.263
, pp. 173-180
-
-
Schnell, S.1
Schaefer, M.2
Schofl, C.3
-
42
-
-
0037838892
-
The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids
-
Briscoe C.P., Tadayyon M., Andrews J.L., et al. The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids. J. Biol. Chem. 2003, 278:11303-11311.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 11303-11311
-
-
Briscoe, C.P.1
Tadayyon, M.2
Andrews, J.L.3
-
43
-
-
0037434991
-
Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40
-
Itoh Y., Kawamata Y., Harada M., et al. Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40. Nature 2003, 422:173-176.
-
(2003)
Nature
, vol.422
, pp. 173-176
-
-
Itoh, Y.1
Kawamata, Y.2
Harada, M.3
-
44
-
-
0038363378
-
The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids
-
Brown A.J., Goldsworthy S.M., Barnes A.A., et al. The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. J. Biol. Chem. 2003, 278:11312-11319.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 11312-11319
-
-
Brown, A.J.1
Goldsworthy, S.M.2
Barnes, A.A.3
-
45
-
-
0037453280
-
Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids
-
Nilsson N.E., Kotarsky K., Owman C., Olde B. Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids. Biochem. Biophys. Res. Commun. 2003, 303:1047-1052.
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.303
, pp. 1047-1052
-
-
Nilsson, N.E.1
Kotarsky, K.2
Owman, C.3
Olde, B.4
-
46
-
-
35748937333
-
Identification of residues important for agonist recognition and activation in GPR40
-
Sum C.S., Tikhonova I.G., Neumann S., et al. Identification of residues important for agonist recognition and activation in GPR40. J. Biol. Chem. 2007, 282:29248-29255.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 29248-29255
-
-
Sum, C.S.1
Tikhonova, I.G.2
Neumann, S.3
-
47
-
-
65549142522
-
GPR119 is essential for oleoylethanolamide-induced glucagon-like peptide-1 secretion from the intestinal enteroendocrine L-cell
-
Lauffer L.M., Iakoubov R., Brubaker P.L. GPR119 is essential for oleoylethanolamide-induced glucagon-like peptide-1 secretion from the intestinal enteroendocrine L-cell. Diabetes 2009, 58:1058-1066.
-
(2009)
Diabetes
, vol.58
, pp. 1058-1066
-
-
Lauffer, L.M.1
Iakoubov, R.2
Brubaker, P.L.3
-
48
-
-
34248527678
-
A role for beta-cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucose-dependent insulin release
-
Chu Z.L., Jones R.M., He H., et al. A role for beta-cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucose-dependent insulin release. Endocrinology 2007, 148:2601-2609.
-
(2007)
Endocrinology
, vol.148
, pp. 2601-2609
-
-
Chu, Z.L.1
Jones, R.M.2
He, H.3
-
49
-
-
33644627958
-
Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents
-
Overton H.A., Babbs A.J., Doel S.M., et al. Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metab. 2006, 3:167-175.
-
(2006)
Cell Metab.
, vol.3
, pp. 167-175
-
-
Overton, H.A.1
Babbs, A.J.2
Doel, S.M.3
-
51
-
-
65549114432
-
Over expression of GPR40 in pancreatic beta-cells augments glucose-stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice
-
Nagasumi K., Esaki R., Iwachidow K., et al. Over expression of GPR40 in pancreatic beta-cells augments glucose-stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice. Diabetes 2009, 58:1067-1076.
-
(2009)
Diabetes
, vol.58
, pp. 1067-1076
-
-
Nagasumi, K.1
Esaki, R.2
Iwachidow, K.3
-
52
-
-
59849110228
-
Acute administration of GPR40 receptor agonist potentiates glucose-stimulated insulin secretion in vivo in the rat
-
Doshi L.S., Brahma M.K., Sayyed S.G., et al. Acute administration of GPR40 receptor agonist potentiates glucose-stimulated insulin secretion in vivo in the rat. Metabolism 2009, 58:333-343.
-
(2009)
Metabolism
, vol.58
, pp. 333-343
-
-
Doshi, L.S.1
Brahma, M.K.2
Sayyed, S.G.3
-
53
-
-
70350309324
-
Lipid receptors and islet function: therapeutic implications?
-
Kebede M.A., Alquier T., Latour M.G., Poitout V. Lipid receptors and islet function: therapeutic implications?. Diabetes Obes. Metab. 2009, 11(Suppl 4):10-20.
-
(2009)
Diabetes Obes. Metab.
, vol.11
, Issue.SUPPL. 4
, pp. 10-20
-
-
Kebede, M.A.1
Alquier, T.2
Latour, M.G.3
Poitout, V.4
-
54
-
-
58849161898
-
Flow cytometry-based binding assay for GPR40 (FFAR1; free fatty acid receptor 1)
-
Hara T., Hirasawa A., Sun Q., Koshimizu T.A., Itsubo C., Sadakane K., Awaji T., Tsujimoto G. Flow cytometry-based binding assay for GPR40 (FFAR1; free fatty acid receptor 1). Mol. Pharmacol. 2009, 75:85-91.
-
(2009)
Mol. Pharmacol.
, vol.75
, pp. 85-91
-
-
Hara, T.1
Hirasawa, A.2
Sun, Q.3
Koshimizu, T.A.4
Itsubo, C.5
Sadakane, K.6
Awaji, T.7
Tsujimoto, G.8
-
55
-
-
47749128507
-
Seven transmembrane-spanning receptors for free fatty acids as therapeutic targets for diabetes mellitus: pharmacological, phylogenetic, and drug discovery aspects
-
Costanzi S., Neumann S., Gershengorn M.C. Seven transmembrane-spanning receptors for free fatty acids as therapeutic targets for diabetes mellitus: pharmacological, phylogenetic, and drug discovery aspects. J. Biol. Chem. 2008, 283:16269-16273.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 16269-16273
-
-
Costanzi, S.1
Neumann, S.2
Gershengorn, M.C.3
-
56
-
-
0027275837
-
Interactions of long-chain fatty acids and albumin: determination of free fatty acid levels using the fluorescent probe ADIFAB
-
Richieri G.V., Anel A., Kleinfeld A.M. Interactions of long-chain fatty acids and albumin: determination of free fatty acid levels using the fluorescent probe ADIFAB. Biochemistry 1993, 32:7574-7580.
-
(1993)
Biochemistry
, vol.32
, pp. 7574-7580
-
-
Richieri, G.V.1
Anel, A.2
Kleinfeld, A.M.3
-
57
-
-
0028821009
-
Unbound free fatty acid levels in human serum
-
Richieri G.V., Kleinfeld A.M. Unbound free fatty acid levels in human serum. J. Lipid Res. 1995, 36:229-240.
-
(1995)
J. Lipid Res.
, vol.36
, pp. 229-240
-
-
Richieri, G.V.1
Kleinfeld, A.M.2
-
58
-
-
73749085921
-
Facilitation of fatty acid uptake by CD36 in insulin-producing cells reduces fatty-acid-induced insulin secretion and glucose regulation of fatty acid oxidation
-
doi:10.1016/j.bbalip.2009.11.002.
-
T. Wallin, Z. Ma, H. Ogata et al., Facilitation of fatty acid uptake by CD36 in insulin-producing cells reduces fatty-acid-induced insulin secretion and glucose regulation of fatty acid oxidation, Biochim. Biophys. Acta, 2009, doi:10.1016/j.bbalip.2009.11.002.
-
(2009)
Biochim. Biophys. Acta
-
-
Wallin, T.1
Ma, Z.2
Ogata, H.3
-
59
-
-
51649099019
-
Uptake of long chain fatty acids is regulated by dynamic interaction of FAT/CD36 with cholesterol/sphingolipid enriched microdomains (lipid rafts)
-
Ehehalt R., Sparla R., Kulaksiz H., Herrmann T., Fullekrug J., Stremmel W. Uptake of long chain fatty acids is regulated by dynamic interaction of FAT/CD36 with cholesterol/sphingolipid enriched microdomains (lipid rafts). BMC. Cell Biol. 2008, 9:45.
-
(2008)
BMC. Cell Biol.
, vol.9
, pp. 45
-
-
Ehehalt, R.1
Sparla, R.2
Kulaksiz, H.3
Herrmann, T.4
Fullekrug, J.5
Stremmel, W.6
-
60
-
-
33947140482
-
Importance of the carboxyl terminus of FAT/CD36 for plasma membrane localization and function in long-chain fatty acid uptake
-
Eyre N.S., Cleland L.G., Tandon N.N., Mayrhofer G. Importance of the carboxyl terminus of FAT/CD36 for plasma membrane localization and function in long-chain fatty acid uptake. J. Lipid Res. 2007, 48:528-542.
-
(2007)
J. Lipid Res.
, vol.48
, pp. 528-542
-
-
Eyre, N.S.1
Cleland, L.G.2
Tandon, N.N.3
Mayrhofer, G.4
-
61
-
-
26444485985
-
Long-chain fatty acid uptake and FAT/CD36 translocation in heart and skeletal muscle
-
Koonen D.P., Glatz J.F., Bonen A., Luiken J.J. Long-chain fatty acid uptake and FAT/CD36 translocation in heart and skeletal muscle. Biochim. Biophys. Acta 2005, 1736:163-180.
-
(2005)
Biochim. Biophys. Acta
, vol.1736
, pp. 163-180
-
-
Koonen, D.P.1
Glatz, J.F.2
Bonen, A.3
Luiken, J.J.4
-
62
-
-
0036812863
-
Sulfo-N-succinimidyl esters of long chain fatty acids specifically inhibit fatty acid translocase (FAT/CD36)-mediated cellular fatty acid uptake
-
Coort S.L., Willems J., Coumans W.A., van der Vusse G.J., Bonen A., Glatz J.F., Luiken J.J. Sulfo-N-succinimidyl esters of long chain fatty acids specifically inhibit fatty acid translocase (FAT/CD36)-mediated cellular fatty acid uptake. Mol. Cell Biochem. 2002, 239:213-219.
-
(2002)
Mol. Cell Biochem.
, vol.239
, pp. 213-219
-
-
Coort, S.L.1
Willems, J.2
Coumans, W.A.3
van der Vusse, G.J.4
Bonen, A.5
Glatz, J.F.6
Luiken, J.J.7
-
63
-
-
25844454854
-
Increased fatty acid desaturation and enhanced expression of stearoyl coenzyme A desaturase protects pancreatic beta-cells from lipoapoptosis
-
Busch A.K., Gurisik E., Cordery D.V., et al. Increased fatty acid desaturation and enhanced expression of stearoyl coenzyme A desaturase protects pancreatic beta-cells from lipoapoptosis. Diabetes 2005, 54:2917-2924.
-
(2005)
Diabetes
, vol.54
, pp. 2917-2924
-
-
Busch, A.K.1
Gurisik, E.2
Cordery, D.V.3
-
64
-
-
70349871409
-
Reduced endoplasmic reticulum (ER)-to-Golgi protein trafficking contributes to ER stress in lipotoxic mouse beta cells by promoting protein overload
-
Preston A.M., Gurisik E., Bartley C., Laybutt D.R., Biden T.J. Reduced endoplasmic reticulum (ER)-to-Golgi protein trafficking contributes to ER stress in lipotoxic mouse beta cells by promoting protein overload. Diabetologia 2009, 10.1007/s00125-009-1506-5.
-
(2009)
Diabetologia
-
-
Preston, A.M.1
Gurisik, E.2
Bartley, C.3
Laybutt, D.R.4
Biden, T.J.5
-
65
-
-
39149104320
-
The role for endoplasmic reticulum stress in diabetes mellitus
-
Eizirik D.L., Cardozo A.K., Cnop M. The role for endoplasmic reticulum stress in diabetes mellitus. Endocr. Rev. 2008, 29:42-61.
-
(2008)
Endocr. Rev.
, vol.29
, pp. 42-61
-
-
Eizirik, D.L.1
Cardozo, A.K.2
Cnop, M.3
-
66
-
-
44949214679
-
Differential regulation of the endoplasmic reticulum stress response in pancreatic beta-cells exposed to long-chain saturated and monounsaturated fatty acids
-
Diakogiannaki E., Welters H.J., Morgan N.G. Differential regulation of the endoplasmic reticulum stress response in pancreatic beta-cells exposed to long-chain saturated and monounsaturated fatty acids. J. Endocrinol. 2008, 197:553-563.
-
(2008)
J. Endocrinol.
, vol.197
, pp. 553-563
-
-
Diakogiannaki, E.1
Welters, H.J.2
Morgan, N.G.3
-
67
-
-
40449106191
-
Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic beta-cells
-
Lai E., Bikopoulos G., Wheeler M.B., Rozakis-Adcock M., Volchuk A. Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic beta-cells. Am. J. Physiol. Endocrinol. Metab. 2008, 294:E540-E550.
-
(2008)
Am. J. Physiol. Endocrinol. Metab.
, vol.294
-
-
Lai, E.1
Bikopoulos, G.2
Wheeler, M.B.3
Rozakis-Adcock, M.4
Volchuk, A.5
-
68
-
-
49649084031
-
Initiation and execution of lipotoxic ER stress in pancreatic beta-cells
-
Cunha D.A., Hekerman P., Ladriere L., et al. Initiation and execution of lipotoxic ER stress in pancreatic beta-cells. J. Cell Sci. 2008, 121:2308-2318.
-
(2008)
J. Cell Sci.
, vol.121
, pp. 2308-2318
-
-
Cunha, D.A.1
Hekerman, P.2
Ladriere, L.3
-
69
-
-
33745116619
-
Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis
-
Karaskov E., Scott C., Zhang L., Teodoro T., Ravazzola M., Volchuk A. Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis. Endocrinology 2006, 147:3398-3407.
-
(2006)
Endocrinology
, vol.147
, pp. 3398-3407
-
-
Karaskov, E.1
Scott, C.2
Zhang, L.3
Teodoro, T.4
Ravazzola, M.5
Volchuk, A.6
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