Overexpression of GPR40 in pancreatic β-cells augments glucose-stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice

Diabetes

Volumn 58, Issue 5, 2009, Pages 1067-1076

  Nagasumi, Kae ^a   Esaki, Ritsuko ^a   Iwachidow, Kimihiko ^a   Yasuhara, Yoshitaka ^a   Ogi, Kazuhiro ^a   Tanaka, Hideyuki ^a   Nakata, Mitsugu ^a   Yano, Takashi ^a   Shimakawa, Kozo ^a   Taketomi, Shigehisa ^b   Takeuchi, Koji ^a   Odaka, Hiroyuki ^a   Kaisho, Yoshihiko ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

^b Technology Department / Yonezawa Hamari Chemicals Ltd 2 4300 18   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; G PROTEIN COUPLED RECEPTOR; GLUCOSE; GPR40 PROTEIN; INSULIN; UNCLASSIFIED DRUG; FFAR3 PROTEIN, HUMAN; GPR40 PROTEIN, MOUSE; PRIMER DNA; RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; C57BL 6 MOUSE; CELL ISOLATION; CELL STRUCTURE; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME ACTIVATION; FATTY ACID BLOOD LEVEL; GENE EXPRESSION; GENE OVEREXPRESSION; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; IMMUNOHISTOCHEMISTRY; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN TOLERANCE TEST; LIPID DIET; METABOLIC PARAMETERS; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; REGULATORY MECHANISM; RNA EXTRACTION; TRANSGENIC MOUSE; ANIMAL; C57BL MOUSE; DRUG EFFECT; EXPERIMENTAL DIABETES MELLITUS; GENE EXPRESSION REGULATION; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; PANCREAS ISLET; PATHOPHYSIOLOGY; PHYSIOLOGY; PROMOTER REGION; REFERENCE VALUE; SECRETION;

ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; DNA PRIMERS; FATTY ACIDS, NONESTERIFIED; GENE EXPRESSION REGULATION; GLUCOSE; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PROMOTER REGIONS, GENETIC; RECEPTORS, G-PROTEIN-COUPLED; REFERENCE VALUES; RNA;

EID: 65549114432     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db08-1233     Document Type: Article

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