Cellular production of n-3 PUFAs and reduction of n-6 -to-n-3 ratios in the pancreatic β-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death

Diabetes

Volumn 59, Issue 2, 2010, Pages 471-478

  Wei, Dong ^a,b   Li, Jie ^a,c   Shen, Miaoda ^d,e   Jia, Wei ^a,c   Chen, Nuoqi ^a   Chen, Tao ^a,c   Su, Dongming ^a   Tian, Haoming ^c   Zheng, Shusen ^e   Dai, Yifan ^f   Zhao, Allan ^a,f  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b Second People's Hospital of Chengdu   (China)

^c SICHUAN UNIVERSITY   (China)

^d UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^e ZHEJIANG UNIVERSITY   (China)

^f NANJING MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CYTOKINE; GAMMA INTERFERON; GLUCAGON LIKE PEPTIDE 1; GLUCOKINASE; GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; PROSTAGLANDIN E2; TRANSCRIPTION FACTOR PDX 1; TUMOR NECROSIS FACTOR ALPHA; ACYL COENZYME A DESATURASE; CAENORHABDITIS ELEGANS PROTEIN; COMPLEMENTARY DNA; FAT 1 PROTEIN, C ELEGANS; FAT-1 PROTEIN, C ELEGANS; GLUTAMINE; LEUCINE; PRIMER DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAENORHABDITIS ELEGANS; CELL VIABILITY; CONTROLLED STUDY; GENE; GENE EXPRESSION; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; MFAT 1 GENE; MOUSE; NONHUMAN; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; TRANSGENIC MOUSE; ANIMAL; BIOSYNTHESIS; CELL DEATH; CYTOLOGY; DNA PROBE; DRUG EFFECT; GENE VECTOR; GENETICS; METABOLISM; SECRETION;

ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CELL DEATH; CYTOKINES; DNA PRIMERS; DNA PROBES; DNA, COMPLEMENTARY; FATTY ACID DESATURASES; FATTY ACIDS, OMEGA-3; FATTY ACIDS, OMEGA-6; GENETIC VECTORS; GLUTAMINE; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; LEUCINE; MICE; MICE, TRANSGENIC; MITOGEN-ACTIVATED PROTEIN KINASE 3; NF-KAPPA B;

EID: 77449141236     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db09-0284     Document Type: Article

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