Sterol regulatory element-binding protein-1c knockdown protected INS-1E cells from lipotoxicity

Diabetes, Obesity and Metabolism

Volumn 12, Issue 1, 2010, Pages 35-46

  Li, J ^a   Liu, X ^a   Ran, X ^a   Chen, J ^b   Li, X ^a   Wu, W ^a   Huang, H ^a,a   Long, Y ^a   Liang, J ^a   Cheng, J ^a   Tian, H ^a  

^a SICHUAN UNIVERSITY   (China)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Apoptosis; FFA; Lipotoxicity; SREBP 1c knockdown

Indexed keywords

ADENYLATE KINASE; GLUCOSE TRANSPORTER 2; INSULIN RECEPTOR SUBSTRATE 2; OLEIC ACID; PALMITIC ACID; PROTEIN BCL 2; SMALL INTERFERING RNA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRANSCRIPTION FACTOR PDX 1; UNCOUPLING PROTEIN 2;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; GENE EXPRESSION; INSULIN RELEASE; LIPID STORAGE; LIPODYSTROPHY; LIPOTOXICITY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; RAT; UPREGULATION;

EID: 73349123190     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/j.1463-1326.2009.01093.x     Document Type: Article

References (45)

1. Ahren B. Type 2 diabetes, insulin secretion and β-cell mass. Curr Mol Med 2005, 5:275-286.
2. Wellen KE, Hotamisligil GS. Inflammation, stress and diabetes. J Clin Invest 2005, 115:1111-1119.
3. Eizirik DL, Mandrup-Poulsen T. A choice of death: the signal transduction of immune-mediated β-cell apoptosis. Diabetologia 2001, 44:2115-2133.
4. Robertson RP, Harmon J, Tran POT, Poitout V. β-Cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes. Diabetes 2004, 53:S119-S124.
5. Unger RH, Zhou YT. Lipotoxicity of β-cells in obesity and in other causes of fatty acid spillover. Diabetes 2001, 50:S118-S121.
6. Maestre I, Jordan J, Calvo S. Mitochondrial dysfunction is involved in apoptosis induced by serum withdrawal and fatty acids in the β-cell line Ins-1. Endocrinology 2003, 144:335-345.
7. Piro S, Anello M, Di Pietro C. Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: possible role of oxidative stress. Metabolism 2002, 51:1340-1347.
8. Weir GC, Bonner-Weir S. Five stages of evolving beta-cell dysfunction during progression to diabetes. Diabetes 2004, 53:S16-S21.
9. Horton JD, Goldstein JL, Brown MS. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 2002, 109:1125-1131.
10. Brown MS, Goldstein JL. The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 1997, 89:331-340.
11. Kim JB, Spotts GD, Halvorsen YD. Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain. Mol Cell Biol 1995, 15:2582-2588.
12. Amemiya-Kudo M, Shimano H, Hasty AH. Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes. J Lipid Res 2002, 43:1220-1235.
13. Pai JT, Guryev O, Brown MS, Goldstein JL. Differential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteins. J Biol Chem 1998, 273:26138-26148.
14. Foufelle F, Ferre P. New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c. Biochem J 2002, 366:377-391.
15. Foretz M, Guichard C, Ferre P, Foufelle F. Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes. Proc Natl Acad Sci USA 1999, 96:12737-12742.
16. Tovar AR, Torre-Villalvazo I, Ochoa M. Soy protein reduces hepatic lipotoxicity in hyperinsulinemic obese Zucker fa/fa rats. J Lipid Res 2005, 46:1823-1832.
17. Kakuma T, Lee Y, Higa M. Leptin, troglitazone, and the expression of sterol regulatory element binding proteins in liver and pancreatic islets. Proc Natl Acad Sci USA 2000, 97:8536-8541.
18. Kato T, Shimano H, Yamamoto T. Palmitate impairs and eicosapentaenoate restores insulin secretion through regulation of SREBP-1c in pancreatic islets. Diabetes 2008, 57:2382-2392.
19. Unger RH. Lipotoxic diseases. Annu Rev Med 2002, 53:319-336.
20. Unger RH. Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications. Diabetes 1995, 44:863-870.
21. Unger RH, Zhou YT, Orci L. Regulation of fatty acid homeostasis in cells: novel role of leptin. Proc Natl Acad Sci USA 1999, 96:2327-2332.
22. Merglen A, Theander S, Rubi B, Chaffard G, Wollheim CB, Maechler P. Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells. Endocrinology 2004, 145:667-678.
23. Karaskov E, Scott C, Zhang L, Teodoro T, Ravazzola M, Volchuk A. Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis. Endocrinology 2006, 147:3398-3407.
24. Yamashita T, Eto K, Okazaki Y. Role of uncoupling protein-2 up-regulation and triglyceride accumulation in impaired glucose-stimulated insulin secretion in a β-cell lipotoxicity model overexpressing sterol regulatory element-binding protein-1c. Endocrinology 2004, 145:3566-3577.
25. Sun Y, Zhang L, Gu HF. Peroxisome proliferator-activated receptor-alpha regulates the expression of pancreatic/duodenal homeobox-1 in rat insulinoma (INS-1) cells and ameliorates glucose-induced insulin secretion impaired by palmitate. Endocrinology 2008, 149:662-671.
26. Renström F, Burén J, Eriksson JW. Insulin receptor substrates-1 and -2 are both depleted but via different mechanisms after down-regulation of glucose transport in rat adipocytes. Endocrinology 2005, 146:3044-3051.
27. Cnop M, Hannaert JC, Hoorsens A, Eizirik DL, Pipeleers DG. Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation. Diabetes 2001, 50:1771-1777.
28. Guillet-Deniau I, Pichard AL, Koné A. Glucose induces de novo lipogenesis in rat muscle satellite cells through a sterol-regulatory-element-binding-protein-1c-dependent pathway. J Cell Sci 2004, 117:1937-1944.
29. Joseph JW, Koshkin V, Zhang C-Y. Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet. Diabetes 2002, 51:3211-3219.
30. Green DR. Apoptotic pathways: paper wraps stone blunts scissors. Cell 2000, 102:1-4.
31. Bernardi P, Scorrano L, Colonna R, Petronili V, Di Lisa F. Mitochondria and cell death. Mechanistic aspects and methodological issues. Eur J Biochem 1999, 264:687-701.
32. McKinnon CM, Docherty K. Pancreatic duodenal homeobox-1, PDX-1, a major regulator of β-cell identity and function. Diabetologia 2001, 44:1203-1214.
33. Ahlgren U, Jonsson J, Jonsson L, Simu K, Edlund H. β-Cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the β-cell phenotype and maturity onset diabetes. Genes Dev 1998, 12:1763-1768.
34. Johnson JD, Ahmed NT, Luciani DS. Increased islet apoptosis in Pdx1 + / - mice J Clin Invest 2003, 111:1147-1160.
35. Chan CB, De Leo D, Joseph JW. Increased uncoupling protein-2 levels in β-cells are associated with impaired glucose-stimulated insulin secretion: mechanism of action. Diabetes 2001, 50:1302-1310.
36. Hong Y, Fink BD, Dillon JS, Sivitz WI. Effects of adenoviral overexpression of uncoupling protein-2 and -3 on mitochondrial respiration in insulinoma cells. Endocrinology 2001, 142:249-256.
37. Medvedev AV, Robidoux J, Bai X. Regulation of the uncoupling protein-2 gene in INS-1 β-cells by oleic acid. J Biol Chem 2002, 277:42639-42644.
38. Withers DJ, Gutierrez JS, Towery H. Disruption of IRS-2 causes type 2 diabetes in mice. Nature 1998, 391:900-904.
39. Merrill GF, Kurth EJ, Hardie DG, Winder WW. AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle. Am J Physiol 1997, 273:E1107-E1112.
40. Sullivan JE, Carey F, Carling D, Beri RK. Characterisation of 5′-AMPactivated protein kinase in human liver using specific peptide substrates and the effects of 5′-AMP analogues on enzyme activity. Biochem Biophys Res Commun 1994, 200:1551-1556.
41. Kharroubi I, Ladriere L, Cardozo AK, Dogusan Z, Cnop M, Eizirik DL. Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress. Endocrinology 2004, 145:5087-5096.
42. Wang X, Li H, De Leo D. Gene and protein kinase expression profiling of reactive oxygen species-associated lipotoxicity in the pancreatic beta-cell line MIN6. Diabetes 2004, 53:129-140.
43. Andreolas C, da Silva Xavier G, Diraison F. Stimulation of acetyl-CoA carboxylase gene expression by glucose requires insulin release and sterol regulatory element binding protein 1c in pancreatic MIN6 β-cells. Diabetes 2002, 51:2536-2545.
44. Diraison F, Parton L, Ferre P. Over-expression of sterol-regulatory-element-binding protein-1c (SREBP1c) in rat pancreatic islets induces lipogenesis and decreases glucose-stimulated insulin release: modulation by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR). Biochem J 2004, 378:769-778.
45. Takahashi A, Motomura K, Kato T. Transgenic mice overexpressing nuclear SREBP-1c in pancreatic β-cells. Diabetes 2005, 54:492-499.