Susceptibility of pancreatic beta cells to fatty acids is regulated by LXR/PPARα-dependent stearoyl-coenzyme a desaturase

PLoS ONE

Volumn 4, Issue 9, 2009, Pages

  Hellemans, Karine H ^a   Hannaert, Jean Claude ^a   Denys, Bart ^a   Steffensen, Knut R ^b   Raemdonck, Cindy ^a   Martens, Geert A ^a   Van Veldhoven, Paul P ^c   Gustafsson, Jan Åke ^b,d   Pipeleers, Daniel ^a  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^b KAROLINSKA INSTITUTE   (Sweden)

^c UNIVERSITY OF LEUVEN   (Belgium)

^d University of Houston   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [3 [[2 CHLORO 3 (TRIFLUOROMETHYL)BENZYL](2 DIPHENYLETHYL)AMINO]PROPOXY]PHENYLACETIC ACID; ACYL COENZYME A DESATURASE; GLUCOSE; LIVER X RECEPTOR; LIVER X RECEPTOR AGONIST; LIVER X RECEPTOR ALPHA; LIVER X RECEPTOR BETA; PALMITIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; TO 1317; UNCLASSIFIED DRUG; FATTY ACID; ORPHAN NUCLEAR RECEPTOR; PALMITIC ACID DERIVATIVE; TRIACYLGLYCEROL;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL ISOLATION; CELL PROTECTION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; FATTY ACID DESATURATION; FATTY ACID TRANSPORT; GENE DELETION; GENE SILENCING; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; RAT; ANIMAL; BIOLOGICAL MODEL; GENETICS; LIPID METABOLISM; METABOLISM; MOUSE MUTANT; WISTAR RAT;

MUS; RATTUS; RODENTIA;

ANIMALS; FATTY ACIDS; INSULIN-SECRETING CELLS; LIPID METABOLISM; MALE; MICE; MICE, KNOCKOUT; MODELS, BIOLOGICAL; ORPHAN NUCLEAR RECEPTORS; PALMITIC ACIDS; PPAR ALPHA; RATS; RATS, WISTAR; STEAROYL-COA DESATURASE; TRIGLYCERIDES;

EID: 70349661825     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0007266     Document Type: Article

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