The Long and Winding Road to Understanding and Conquering Type 1 Diabetes

Immunity

Volumn 32, Issue 4, 2010, Pages 437-445

  Santamaria, Pere ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CD4 ANTIGEN; CD8 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DNA VACCINE; INSULIN; INTERLEUKIN 2; INTERLEUKIN 21; MAJOR HISTOCOMPATIBILITY ANTIGEN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CD20; MONOCLONAL ANTIBODY CD3; NANOPARTICLE; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 22; PEPTIDE DERIVATIVE; PROINSULIN; UNCLASSIFIED DRUG;

ANTIGEN ANTIBODY REACTION; ANTIGEN SPECIFICITY; AUTOIMMUNE DISEASE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL THERAPY; CELL TYPE; CELLULAR IMMUNITY; CLINICAL TRIAL; DIABETOGENESIS; DISEASE COURSE; DRUG DELIVERY SYSTEM; ENVIRONMENTAL FACTOR; GENE INTERACTION; GENETIC LINKAGE; GENETIC PREDISPOSITION; GENETIC SUSCEPTIBILITY; HUMAN; IMMUNE RESPONSE; IMMUNOPATHOGENESIS; IMMUNOPATHOLOGY; IMMUNOREACTIVITY; IMMUNOTHERAPY; INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE ACTIVATION; ANIMAL; ARTICLE; GENETICS; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; T LYMPHOCYTE;

ANIMALS; DIABETES MELLITUS, TYPE 1; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INSULIN; LYMPHOCYTE ACTIVATION; T-LYMPHOCYTES;

EID: 77951884435     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.immuni.2010.04.003     Document Type: Review

References (100)

1. Amrani A., Verdaguer J., Serra P., Tafuro S., Tan R., Santamaria P. Nature 2000, 406:739-742.
2. Anderson B., Park B.J., Verdaguer J., Amrani A., Santamaria P. Proc. Natl. Acad. Sci. USA 1999, 96:9311-9316.
3. Atabani S.F., Thio C.L., Divanovic S., Trompette A., Belkaid Y., Thomas D.L., Karp C.L. Eur. J. Immunol. 2005, 35:2157-2162.
4. Bennett S.T., Lucassen A.M., Gough S.C., Powell E.E., Undlien D.E., Pritchard L.E., Merriman M.E., Kawaguchi Y., Dronsfield M.J., Pociot F., et al. Nat. Genet. 1995, 9:284-292.
5. Brauner H., Elemans M., Lemos S., Broberger C., Holmberg D., Flodström-Tullberg M., Kärre K., Höglund P. J. Immunol. 2010, 184:2272-2280.
6. Burton A.R., Vincent E., Arnold P.Y., Lennon G.P., Smeltzer M., Li C.S., Haskins K., Hutton J., Tisch R.M., Sercarz E.E., et al. Diabetes 2008, 57:1321-1330.
7. Carrillo J., Puertas M.C., Alba A., Ampudia R.M., Pastor X., Planas R., Riutort N., Alonso N., Pujol-Borrell R., Santamaria P., et al. Diabetes 2005, 54:69-77.
8. Corper A.L., Stratmann T., Apostolopoulos V., Scott C.A., Garcia K.C., Kang A.S., Wilson I.A., Teyton L. Science 2000, 288:505-511.
9. D'Alise A.M., Auyeung V., Feuerer M., Nishio J., Fontenot J., Benoist C., Mathis D. Proc. Natl. Acad. Sci. USA 2008, 105:19857-19862.
10. Dendrou C.A., Plagnol V., Fung E., Yang J.H., Downes K., Cooper J.D., Nutland S., Coleman G., Himsworth M., Hardy M., et al. Nat. Genet. 2009, 41:1011-1015.
11. DiLorenzo T.P., Graser R.T., Ono T., Christianson G.J., Chapman H.D., Roopenian D.C., Nathenson S.G., Serreze D.V. Proc. Natl. Acad. Sci. USA 1998, 95:12538-12543.
12. Fan Y., Rudert W.A., Grupillo M., He J., Sisino G., Trucco M. EMBO J. 2009, 28:2812-2824.
13. French M.B., Allison J., Cram D.S., Thomas H.E., Dempsey-Collier M., Silva A., Georgiou H.M., Kay T.W., Harrison L.C., Lew A.M. Diabetes 1997, 46:34-39.
14. Friese M.A., Jakobsen K.B., Friis L., Etzensperger R., Craner M.J., McMahon R.M., Jensen L.T., Huygelen V., Jones E.Y., Bell J.I., Fugger L. Nat. Med. 2008, 14:1227-1235.
15. Gagnerault M.C., Luan J.J., Lotton C., Lepault F. J. Exp. Med. 2002, 196:369-377.
16. Gregori S., Giarratana N., Smiroldo S., Uskokovic M., Adorini L. Diabetes 2002, 51:1367-1374.
17. Gregori S., Giarratana N., Smiroldo S., Adorini L. J. Immunol. 2003, 171:4040-4047.
18. Gur C., Porgador A., Elboim M., Gazit R., Mizrahi S., Stern-Ginossar N., Achdout H., Ghadially H., Dor Y., Nir T., et al. Nat. Immunol. 2010, 11:121-128.
19. Hamilton-Williams E.E., Serreze D.V., Charlton B., Johnson E.A., Marron M.P., Mullbacher A., Slattery R.M. Proc. Natl. Acad. Sci. USA 2001, 98:11533-11538.
20. Han B., Serra P., Amrani A., Yamanouchi J., Marée A.F., Edelstein-Keshet L., Santamaria P. Nat. Med. 2005, 11:645-652.
21. Han B., Serra P., Yamanouchi J., Amrani A., Elliott J.F., Dickie P., Dilorenzo T.P., Santamaria P. J. Clin. Invest. 2005, 115:1879-1887.
22. Herold K.C., Hagopian W., Auger J.A., Poumian-Ruiz E., Taylor L., Donaldson D., Gitelman S.E., Harlan D.M., Xu D., Zivin R.A., Bluestone J.A. N. Engl. J. Med. 2002, 346:1692-1698.
23. Herold K.C., Brooks-Worrell B., Palmer J., Dosch H.M., Peakman M., Gottlieb P., Reijonen H., Arif S., Spain L.M., Thompson C., Lachin J.M. Diabetes 2009, 58:2588-2595. Type 1 Diabetes TrialNet Research Group.
24. Höglund P., Mintern J., Waltzinger C., Heath W., Benoist C., Mathis D. J. Exp. Med. 1999, 189:331-339.
25. Husebye E.S., Anderson M.S. Immunity 2010, 32:479-487. this issue.
26. Jaeckel E., Lipes M.A., von Boehmer H. Nat. Immunol. 2004, 5:1028-1035.
27. Kamanaka M., Rainbow D., Schuster-Gossler K., Eynon E.E., Chervonsky A.V., Wicker L.S., Flavell R.A. Proc. Natl. Acad. Sci. USA 2009, 106:11236-11240.
28. Keymeulen B., Vandemeulebroucke E., Ziegler A.G., Mathieu C., Kaufman L., Hale G., Gorus F., Goldman M., Walter M., Candon S., et al. N. Engl. J. Med. 2005, 352:2598-2608.
29. Kissler S., Stern P., Takahashi K., Hunter K., Peterson L.B., Wicker L.S. Nat. Genet. 2006, 38:479-483.
30. Knip M., Veijola R., Virtanen S.M., Hyöty H., Vaarala O., Akerblom H.K. Diabetes 2005, 54(Suppl 2):S125-S136.
31. Kriegel M.A., Lohmann T., Gabler C., Blank N., Kalden J.R., Lorenz H.M. J. Exp. Med. 2004, 199:1285-1291.
32. Krishnamurthy B., Dudek N.L., McKenzie M.D., Purcell A.W., Brooks A.G., Gellert S., Colman P.G., Harrison L.C., Lew A.M., Thomas H.E., Kay T.W. J. Clin. Invest. 2006, 116:3258-3265.
33. Lang K.S., Recher M., Junt T., Navarini A.A., Harris N.L., Freigang S., Odermatt B., Conrad C., Ittner L.M., Bauer S., et al. Nat. Med. 2005, 11:138-145.
34. Lennon G.P., Bettini M., Burton A.R., Vincent E., Arnold P.Y., Santamaria P., Vignali D.A. Immunity 2009, 31:643-653.
35. Lieberman S.M., DiLorenzo T.P. Tissue Antigens 2003, 62:359-377.
36. Lieberman S.M., Evans A.M., Han B., Takaki T., Vinnitskaya Y., Caldwell J.A., Serreze D.V., Shabanowitz J., Hunt D.F., Nathenson S.G., et al. Proc. Natl. Acad. Sci. USA 2003, 100:8384-8388.
37. Lieberman S.M., Takaki T., Han B., Santamaria P., Serreze D.V., DiLorenzo T.P. J. Immunol. 2004, 173:6727-6734.
38. Long S.A., Cerosaletti K., Bollyky P.L., Tatum M., Shilling H., Zhang S., Zhang Z.Y., Pihoker C., Sanda S., Greenbaum C., Buckner J.H. Diabetes 2010, 59:407-415.
39. Ludvigsson J., Faresjö M., Hjorth M., Axelsson S., Chéramy M., Pihl M., Vaarala O., Forsander G., Ivarsson S., Johansson C., et al. N. Engl. J. Med. 2008, 359:1909-1920.
40. Luo X., Herold K.C., Miller S.D. Immunity 2010, 32:488-499. this issue.
41. Maier L.M., Wicker L.S. Curr. Opin. Immunol. 2005, 17:601-608.
42. Malek T.R. Annu. Rev. Immunol. 2008, 26:453-479.
43. McGuire H.M., Vogelzang A., Hill N., Flodström-Tullberg M., Sprent J., King C. Proc. Natl. Acad. Sci. USA 2009, 106:19438-19443.
44. Millar D.G., Garza K.M., Odermatt B., Elford A.R., Ono N., Li Z., Ohashi P.S. Nat. Med. 2003, 9:1469-1476.
45. Miller S.D., Wetzig R.P., Claman H.N. J. Exp. Med. 1979, 149:758-773.
46. Mohan J.F., Levisetti M.G., Calderon B., Herzog J.W., Petzold S.J., Unanue E.R. Nat. Immunol. 2010, 11:350-354.
47. Mukhopadhaya A., Hanafusa T., Jarchum I., Chen Y.G., Iwai Y., Serreze D.V., Steinman R.M., Tarbell K.V., DiLorenzo T.P. Proc. Natl. Acad. Sci. USA 2008, 105:6374-6379.
48. Nakayama M., Abiru N., Moriyama H., Babaya N., Liu E., Miao D., Yu L., Wegmann D.R., Hutton J.C., Elliott J.F., Eisenbarth G.S. Nature 2005, 435:220-223.
49. Nejentsev S., Walker N., Riches D., Egholm M., Todd J.A. Science 2009, 324:387-389.
50. Nir T., Melton D.A., Dor Y. J. Clin. Invest. 2007, 117:2553-2561.
51. Novak J., Griseri T., Beaudoin L., Lehuen A. Int. Rev. Immunol. 2007, 26:49-72.
52. Ogawa N., List J.F., Habener J.F., Maki T. Diabetes 2004, 53:1700-1705.
53. Pescovitz M.D., Greenbaum C.J., Krause-Steinrauf H., Becker D.J., Gitelman S.E., Goland R., Gottlieb P.A., Marks J.B., McGee P.F., Moran A.M., et al. N. Engl. J. Med. 2009, 361:2143-2152. Type 1 Diabetes TrialNet Anti-CD20 Study Group.
54. Phillips J.M., O'Reilly L., Bland C., Foulis A.K., Cooke A. Diabetes 2007, 56:634-640.
55. Phillips B., Nylander K., Harnaha J., Machen J., Lakomy R., Styche A., Gillis K., Brown L., Lafreniere D., Gallo M., et al. Diabetes 2008, 57:1544-1555.
56. Poirot L., Benoist C., Mathis D. Proc. Natl. Acad. Sci. USA 2004, 101:8102-8107.
57. Puertas M.C., Carrillo J., Pastor X., Ampudia R.M., Planas R., Alba A., Bruno R., Pujol-Borrell R., Estanyol J.M., Vives-Pi M., Verdaguer J. J. Immunol. 2007, 178:6533-6539.
58. Razavi R., Chan Y., Afifiyan F.N., Liu X.J., Wan X., Yantha J., Tsui H., Tang L., Tsai S., Santamaria P., et al. Cell 2006, 127:1123-1135.
59. Schmidt D., Verdaguer J., Averill N., Santamaria P. J. Exp. Med. 1997, 186:1059-1075.
60. Schmidt D., Amrani A., Verdaguer J., Bou S., Santamaria P. J. Immunol. 1999, 162:4627-4636.
61. Schneider A., Rieck M., Sanda S., Pihoker C., Greenbaum C., Buckner J.H. J. Immunol. 2008, 181:7350-7355.
62. Serra P., Amrani A., Yamanouchi J., Han B., Thiessen S., Utsugi T., Verdaguer J., Santamaria P. Immunity 2003, 19:877-889.
63. Serreze D.V., Chapman H.D., Varnum D.S., Hanson M.S., Reifsnyder P.C., Richard S.D., Fleming S.A., Leiter E.H., Shultz L.D. J. Exp. Med. 1996, 184:2049-2053.
64. Sgouroudis E., Albanese A., Piccirillo C.A. J. Immunol. 2008, 181:6283-6292.
65. Sherry N.A., Chen W., Kushner J.A., Glandt M., Tang Q., Tsai S., Santamaria P., Bluestone J.A., Brillantes A.M., Herold K.C. Endocrinology 2007, 148:5136-5144.
66. Shi Y., Galusha S.A., Rock K.L. J. Immunol. 2006, 176:3905-3908.
67. Silveira P.A., Johnson E., Chapman H.D., Bui T., Tisch R.M., Serreze D.V. Eur. J. Immunol. 2002, 32:3657-3666.
68. Skowera A., Ellis R.J., Varela-Calviño R., Arif S., Huang G.C., Van-Krinks C., Zaremba A., Rackham C., Allen J.S., Tree T.I., et al. J. Clin. Invest. 2008, 118:3390-3402.
69. Solvason N., Lou Y.P., Peters W., Evans E., Martinez J., Ramirez U., Ocampo A., Yun R., Ahmad S., Liu E., et al. J. Immunol. 2008, 181:8298-8307.
70. Spolski R., Kashyap M., Robinson C., Yu Z., Leonard W.J. Proc. Natl. Acad. Sci. USA 2008, 105:14028-14033.
71. Stadinski B.D., Delong T., Reisdorph N., Reisdorph R., Powell R.L., Armstrong M., Piganelli J.D., Barbour G., Bradley B., Crawford F., et al. Nat. Immunol. 2010, 11:225-231.
72. Stadinsky B., Kappler J., Eisenbarth G.S. Immunity 2010, 32:446-456. this issue.
73. Stratmann T., Apostolopoulos V., Mallet-Designe V., Corper A.L., Scott C.A., Wilson I.A., Kang A.S., Teyton L. J. Immunol. 2000, 165:3214-3225.
74. Sutherland A.P., Van Belle T., Wurster A.L., Suto A., Michaud M., Zhang D., Grusby M.J., von Herrath M. Diabetes 2009, 58:1144-1155.
75. Tang Q., Adams J.Y., Tooley A.J., Bi M., Fife B.T., Serra P., Santamaria P., Locksley R.M., Krummel M.F., Bluestone J.A. Nat. Immunol. 2006, 7:83-92.
76. Tang Q., Adams J.Y., Penaranda C., Melli K., Piaggio E., Sgouroudis E., Piccirillo C.A., Salomon B.L., Bluestone J.A. Immunity 2008, 28:687-697.
77. Thébault-Baumont K., Dubois-Laforgue D., Krief P., Briand J.P., Halbout P., Vallon-Geoffroy K., Morin J., Laloux V., Lehuen A., Carel J.C., et al. J. Clin. Invest. 2003, 111:851-857.
78. Thiessen S., Serra P., Amrani A., Verdaguer J., Santamaria P. Diabetes 2002, 51:325-338.
79. Tisch R., McDevitt H. Cell 1996, 85:291-297.
80. Todd J.A. Immunity 2010, 32:457-467. this issue.
81. Trudeau J.D., Kelly-Smith C., Verchere C.B., Elliott J.F., Finegood D.T., Santamaria P., Tan R. J. Clin. Invest. 2003, 111:217-223.
82. Tsai S., Shameli A., Santamaria P. Adv. Immunol. 2008, 100:79-124.
83. Tsai S., Shameli A., Yamanouchi J., Clemente-Casares X., Wang J., Serra P., Yang Y., Medarova Z., Moore A., Santamaria P. Immunity 2010, 32:568-580. this issue.
84. Tsui H., Chan Y., Tang L., Winer S., Cheung R.K., Paltser G., Selvanantham T., Elford A.R., Ellis J.R., Becker D.J., et al. Diabetes 2008, 57:918-928.
85. Vafiadis P., Bennett S.T., Todd J.A., Nadeau J., Grabs R., Goodyer C.G., Wickramasinghe S., Colle E., Polychronakos C. Nat. Genet. 1997, 15:289-292.
86. Vang T., Congia M., Macis M.D., Musumeci L., Orrú V., Zavattari P., Nika K., Tautz L., Taskén K., Cucca F., et al. Nat. Genet. 2005, 37:1317-1319.
87. Vella A., Cooper J.D., Lowe C.E., Walker N., Nutland S., Widmer B., Jones R., Ring S.M., McArdle W., Pembrey M.E., et al. Am. J. Hum. Genet. 2005, 76:773-779.
88. Verdaguer J., Yoon J.W., Anderson B., Averill N., Utsugi T., Park B.J., Santamaria P. J. Immunol. 1996, 157:4726-4735.
89. Verdaguer J., Schmidt D., Amrani A., Anderson B., Averill N., Santamaria P. J. Exp. Med. 1997, 186:1663-1676.
90. Vyse T.J., Todd J.A. Cell 1996, 85:311-318.
91. Wen L., Ley R.E., Volchkov P.Y., Stranges P.B., Avanesyan L., Stonebraker A.C., Hu C., Wong F.S., Szot G.L., Bluestone J.A., et al. Nature 2008, 455:1109-1113.
92. Wicker L.S., Chamberlain G., Hunter K., Rainbow D., Howlett S., Tiffen P., Clark J., Gonzalez-Munoz A., Cumiskey A.M., Rosa R.L., et al. J. Immunol. 2004, 173:164-173.
93. Wong F.S., Karttunen J., Dumont C., Wen L., Visintin I., Pilip I.M., Shastri N., Pamer E.G., Janeway C.A. Nat. Med. 1999, 5:1026-1031.
94. Wucherpfennig K.W., Call M.J., Deng L., Mariuzza R. Curr. Opin. Immunol. 2009, 21:590-595.
95. Yamanouchi J., Verdaguer J., Han B., Amrani A., Serra P., Santamaria P. J. Immunol. 2003, 171:6900-6909.
96. Yamanouchi J., Rainbow D., Serra P., Howlett S., Hunter K., Garner V.E., Gonzalez-Munoz A., Clark J., Veijola R., Cubbon R., et al. Nat. Genet. 2007, 39:329-337.
97. Yamanouchi J., Puertas M.C., Verdaguer J., Lyons P.A., Rainbow D.B., Chamberlain G., Hunter K.M., Peterson L.B., Wicker L.S., Santamaria P. Diabetes 2010, 59:272-281.
98. You S., Belghith M., Cobbold S., Alyanakian M.A., Gouarin C., Barriot S., Garcia C., Waldmann H., Bach J.F., Chatenoud L. Diabetes 2005, 54:1415-1422.
99. Zhang Y., O'Brien B., Trudeau J., Tan R., Santamaria P., Dutz J.P. J. Immunol. 2002, 168:1466-1472.
100. Ziegler A.-G., Nepom G.T. Immunity 2010, 32:468-478. this issue.