Cutting edge: Elimination of an endogenous adjuvant reduces the activation of CD8 T lymphocytes to transplanted cells and in an autoimmune diabetes model

Journal of Immunology

Volumn 176, Issue 7, 2006, Pages 3905-3908

  Shi, Yan ^a   Galusha, Shelly A ^a   Rock, Kenneth L ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; IMMUNOLOGICAL ADJUVANT; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CD40; UNCLASSIFIED DRUG; URIC ACID; ANTIGEN; URATE OXIDASE;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTING CELL; ARTICLE; AUTOIMMUNE DISEASE; CD8+ T LYMPHOCYTE; CELL TRANSPLANTATION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DISEASE MODEL; IMMUNE RESPONSE; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TRANSGENIC MOUSE; ADOPTIVE TRANSFER; ANIMAL; AUTOIMMUNITY; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; CYTOLOGY; DRUG EFFECT; EXPERIMENTAL DIABETES MELLITUS; IMMUNOLOGY; INSULIN DEPENDENT DIABETES MELLITUS; LYMPHOCYTE ACTIVATION; METABOLISM;

ADJUVANTS, IMMUNOLOGIC; ADOPTIVE TRANSFER; ANIMALS; ANTIGEN-PRESENTING CELLS; ANTIGENS; AUTOIMMUNITY; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; LYMPHOCYTE ACTIVATION; MICE; URATE OXIDASE; URIC ACID;

EID: 33646022583     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.176.7.3905     Document Type: Article

References (23)

1. Glenny, A. T., C. G. Pope, H. Waddington, and V. Wallace. 1926. The antigenic value of toxoid precipitated by potassium alum: receptors control activation of adaptive immune responses. J. Pathol. Bacteriol. 29: 38-45.
2. Dresser, D. W. 1961. Effectiveness of lipid and lipidophilic substances as adjuvants. Nature 191: 1169-1171.
3. Janeway, C. A., Jr. 1989. Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb. Symp. Quant. Biol. 54: 1-13.
4. Janeway, C. A., Jr. 1992. The immune system evolved to discriminate infectious non-self from noninfectious self. Immunol. Today 13: 11-16.
5. Matzinger, P. 1994. Tolerance, danger, and the extended family. Annu. Rev. Immunol. 12: 991-1045.
6. Matzinger, P. 1998. An innate sense of danger. Semin. Immunol. 10: 399-415.
7. Gallucci, S., M. Lolkema, and P. Matzinger. 1999. Natural adjuvants: endogenous activators of dendritic cells. Nat. Med. 5: 1249-1255.
8. Shi, Y., and K. L. Rock. 2002. Cell death releases endogenous adjuvants that selectively enhance immune surveillance of particulate antigens. Eur. J. Immunol. 32: 155-162.
9. Shi, Y., W. Zheng, and K. L. Rock. 2000. Cell injury releases endogenous adjuvants that stimulate cytotoxic T cell responses. Proc. Natl. Acad. Sci. USA 97: 14590-14595.
10. Santamaria, P. 2001. Effector lymphocytes in autoimmunity. Curr. Opin. Immunol. 13: 663-669.
11. Like, A. A., and A. A. Rossini. 1976. Streptozotocin-induced pancreatic insulitis: new model of diabetes mellitus. Science 193: 415-417.
12. Horwitz, M. S., A. Ilic, C. Fine, E. Rodriguez, and N. Sarvetnick. 2002. Presented antigen from damaged pancreatic β cells activates autoreactive T cells in virus-mediated autoimmune diabetes. J. Clin. Invest. 109: 79-87.
13. Kurts, C., J. F. Miller, R. M. Subramaniam, F. R. Carbone, and W. R. Heath. 1998. Major histocompatibility complex class I-restricted cross-presentation is biased towards high dose antigens and those released during cellular destruction. J. Exp. Med. 188: 409-414.
14. Horwitz, M. S., L. M. Bradley, J. Harbertson, T. Krahl, J. Lee, and N. Sarvetnick. 1998. Diabetes induced by Coxsackie virus: initiation by bystander damage and not molecular mimicry. Nat. Med. 4: 781-785.
15. Turley, S., L. Poirot, M. Hattoti, C. Benoist, and D. Mathis. 2003. Physiological β cell death triggers priming of self-reactive T cells by dendritic cells in a type-1 diabetes model. J. Exp. Med. 198: 1527-1537.
16. Shi, Y., J. E. Evans, and K. L. Rock. 2003. Molecular identification of a danger signal that alerts the immune system to dying cells. Nature 425: 516-521.
17. Scaffidi, P., T. Misteli, and M. E. Bianchi. 2002. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 418: 191-195.
18. Kurts, C., W. R. Heath, F. R. Carbone, J. Allison, J. F. Miller, and H. Kosaka. 1996. Constitutive class I-restricted exogenous presentation of self antigens in vivo. J. Exp. Med. 184: 923-930.
19. Hu, D. E., A. M. Moore, L. L. Thomsen, and K. M. Brindle. 2004. Uric acid promotes tumor immune rejection. Cancer Res. 64: 5059-5062.
20. + T cells. J. Exp. Med. 186: 239-245.
21. Dor, Y., J. Brown, O. I. Martinez, and D. A. Melton. 2004. Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation. Nature 429: 41-46.
22. Rovere-Querini, P., A. Capobianco, P. Scaffidi, B. Valentinis, F. Catalanotti, M. Giazzon, I. E. Dumitriu, S. Muller, M. Iannacone, C. Traversari, et al. 2004. HMGB1 is an endogenous immune adjuvant released by necrotic cells. EMBO Rep. 5: 825-830.
23. Barnden, M. J., W. R. Heath, S. Rodda, and F. R. Carbone. 1994. Peptide antagonists that promote positive selection are inefficient at T cell activation and thymocyte deletion. Eur. J. Immunol. 24: 2452-2456.