Unique autoreactive T cells recognize insulin peptides generated within the islets of Langerhans in autoimmune diabetes

Nature Immunology

Volumn 11, Issue 4, 2010, Pages 350-354

  Mohan, James F ^a   Levisetti, Matteo G ^a,b   Calderon, Boris ^a   Herzog, Jeremy W ^a   Petzold, Shirley J ^a   Unanue, Emil R ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; AUTOIMMUNE DISEASE; BINDING AFFINITY; CD4+ T LYMPHOCYTE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DENDRITIC CELL; DIABETES MELLITUS; INSULIN SENSITIVITY; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; SECRETORY GRANULE; T LYMPHOCYTE;

ANIMALS; ANTIGEN PRESENTATION; ANTIGEN-PRESENTING CELLS; ANTIGENS; AUTOIMMUNITY; CD4-POSITIVE T-LYMPHOCYTES; DIABETES MELLITUS, TYPE 1; FLUORESCENT ANTIBODY TECHNIQUE; INSULIN; ISLETS OF LANGERHANS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED NOD; MICROSCOPY, CONFOCAL; PEPTIDES; T-LYMPHOCYTE SUBSETS;

EID: 77949872804     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.1850     Document Type: Article

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