Homodimeric enzymes as drug targets

Current Medicinal Chemistry

Volumn 17, Issue 9, 2010, Pages 826-846

  Cardinale, D ^a   Salo Ahen, O M H ^b   Ferrari, S ^a   Ponterini, G ^a   Cruciani, G ^c   Carosati, E ^c   Tochowicz, A M ^d   Mangani, S ^e   Wade, R C ^b   Costi, M P ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b EML Research gGmbH   (Germany)

^c UNIVERSITY OF PERUGIA   (Italy)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF SIENA   (Italy)

Author keywords

Dimeric proteins; Dissociative inhibition model; Drug target; Homodimeric enzyme; Inhibitors design; Protein protein interactions

Indexed keywords

AMINO ACID; DIMER; ENZYME; GLUTATHIONE REDUCTASE; HETERODIMER; HOMODIMER; INDUCIBLE NITRIC OXIDE SYNTHASE; INTEGRASE; INTEGRASE INHIBITOR; OLIGOMER; PEPTIDOMIMETIC AGENT; PROTEINASE; PROTEINASE INHIBITOR; THYMIDYLATE SYNTHASE; TRIOSEPHOSPHATE ISOMERASE;

ANALYTIC METHOD; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DIMERIZATION; DRUG BINDING SITE; DRUG MECHANISM; DRUG TARGETING; ENZYME ACTIVE SITE; IN VIVO STUDY; LIGAND BINDING; MOLECULAR MODEL; MOLECULAR STABILITY; NONHUMAN; PROTEIN DATA BANK; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; PROTEIN QUATERNARY STRUCTURE; REVIEW; X RAY CRYSTALLOGRAPHY;

ANTI-HIV AGENTS; BINDING SITES; BIOMIMETIC MATERIALS; DIMERIZATION; ENZYME INHIBITORS; ENZYMES; HIV INTEGRASE; HIV PROTEASE; PROTEIN BINDING;

EID: 77950662472     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986710790712156     Document Type: Review

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